Abstract：
:Half a century of research on membrane-containing phages has had a major impact on virology, providing new insights into virus diversity, evolution and ecological importance. The recent revolutionary technical advances in imaging, sequencing and lipid analysis have significantly boosted the depth and volume of knowledge on these viruses. This has resulted in new concepts of virus assembly, understanding of virion stability and dynamics, and the description of novel processes for viral genome packaging and membrane-driven genome delivery to the host. The detailed analyses of such processes have given novel insights into DNA transport across the protein-rich lipid bilayer and the transformation of spherical membrane structures into tubular nanotubes, resulting in the description of unexpectedly dynamic functions of the membrane structures. Membrane-containing phages have provided a framework for understanding virus evolution. The original observation on membrane-containing bacteriophage PRD1 and human pathogenic adenovirus has been fundamental in delineating the concept of "viral lineages", postulating that the fold of the major capsid protein can be used as an evolutionary fingerprint to trace long-distance evolutionary relationships that are unrecognizable from the primary sequences. This has brought the early evolutionary paths of certain eukaryotic, bacterial, and archaeal viruses together, and potentially enables the reorganization of the nearly immeasurable virus population (~1 × 1031) on Earth into a reasonably low number of groups representing different architectural principles. In addition, the research on membrane-containing phages can support the development of novel tools and strategies for human therapy and crop protection.
journal_name
Virusesjournal_title
Virusesauthors
Mäntynen S,Sundberg LR,Oksanen HM,Poranen MMdoi
10.3390/v11010076subject
Has Abstractpub_date
2019-01-18 00:00:00issue
1issn
1999-4915pii
v11010076journal_volume
11pub_type
杂志文章,评审相关文献
Viruses-Basel文献大全abstract：:The Gammacoronavirus infectious bronchitis virus (IBV) causes a highly contagious and economically important respiratory disease in poultry. In the laboratory, most IBV strains are restricted to replication in ex vivo organ cultures or in ovo and do not replicate in cell culture, making the study of their basic virolo...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12101102
更新日期：2020-09-29 00:00:00
abstract：:Arthropod-borne flaviviruses are human pathogens of global medical importance, against which no effective small molecule-based antiviral therapy has currently been reported. Arbidol (umifenovir) is a broad-spectrum antiviral compound approved in Russia and China for prophylaxis and treatment of influenza. This compoun...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10040184
更新日期：2018-04-10 00:00:00
abstract：:There is an ongoing global pandemic of human respiratory syncytial virus (RSV) infection that results in substantial annual morbidity and mortality. In Australia, RSV is a major cause of acute lower respiratory tract infections (ALRI). Nevertheless, little is known about the extent and origins of the genetic diversity...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10090476
更新日期：2018-09-06 00:00:00
abstract：:Bovine viral diarrhea virus (BVDV) is an important pathogen belonging to the Pestivirus genus, Flaviviridae family, which comprises viral species that causes an economic impact in animal production. Cattle are the natural host of BVDV and the main source of infection for pigs and other animal species. Due to its antig...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12060600
更新日期：2020-05-31 00:00:00
abstract：:With ongoing colony losses driven in part by the Varroa mite and the associated exacerbation of the virus load, there is an urgent need to protect honey bees (Apis mellifera) from fatal levels of virus infection and from the non-target effects of insecticides used in agricultural settings. A continuously replicating c...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12020236
更新日期：2020-02-20 00:00:00
abstract：:Human cytomegalovirus (HCMV) encodes a number of viral proteins with homology to cellular G protein-coupled receptors (GPCRs). These viral GPCRs, including US27, US28, UL33, and UL78, have been ascribed numerous functions during infection, including activating diverse cellular pathways, binding to immunomodulatory che...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v6031202
更新日期：2014-03-12 00:00:00
abstract：:An outbreak of winter dysentery, complicated by severe respiratory syndrome, occurred in January 2020 in a high production dairy cow herd located in a hilly area of the Calabria region. Of the 52 animals belonging to the farm, 5 (9.6%) died with severe respiratory distress, death occurring 3-4 days after the appearanc...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12111331
更新日期：2020-11-19 00:00:00
abstract：:Negative strand RNA viruses (NSVs) include many important human pathogens, such as influenza virus, Ebola virus, and rabies virus. One of the unique characteristics that NSVs share is the assembly of the nucleocapsid and its role in viral RNA synthesis. In NSVs, the single strand RNA genome is encapsidated in the line...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12080835
更新日期：2020-07-30 00:00:00
abstract：:In response to viral infection, host cells activate various antiviral responses to inhibit virus replication. While feline herpesvirus 1 (FHV-1) manipulates the host early innate immune response in many different ways, the host could activate the antiviral response to counteract it through some unknown mechanisms. Mic...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12010002
更新日期：2019-12-18 00:00:00
abstract：:Recently, Alves-Freitas and colleagues [...]. ...
journal_title：Viruses
pub_type： 评论,信件
doi：10.3390/v11030230
更新日期：2019-03-07 00:00:00
abstract：:African swine fever is a highly lethal hemorrhagic fever of Suidae, threatening pig production globally. Suidae can be infected by different ways like ingestion of contaminated feed, direct contact with infected animals or fomites, and biting by infected soft tick bites. As already described, European soft ticks (Orni...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12030300
更新日期：2020-03-11 00:00:00
abstract：:Double-stranded DNA viruses package their genomes into pre-assembled protein procapsids. This process is driven by macromolecular motors that transiently assemble at a unique vertex of the procapsid and utilize homomeric ring ATPases to couple genome encapsidation to ATP hydrolysis. Here, we describe the biochemical a...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v13010015
更新日期：2020-12-23 00:00:00
abstract：:Hepatitis B virus (HBV) persistence is at the basis of HBV reactivation as a consequence of chemotherapy and immunosuppressive treatments. The identification of early viral replication indicators and markers of effective HBV immunological control would be useful in monitoring patients who are at risk of potential vira...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v11090783
更新日期：2019-08-25 00:00:00
abstract：:Bombyx mori nuclear polyhedrosis virus (BmNPV) is an important pathogen of silkworms. Despite extensive studies in recent decades, the interaction between BmNPV and host cells is still not clearly understood. Autophagy is an intrinsic innate immune mechanism and it controls infection autonomously in virus-infected cel...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10010014
更新日期：2017-12-30 00:00:00
abstract：:Because of its ecological characteristics, the Caxiuanã National Forest (FLONA) is a potential area of arbovirus circulation. The present study aimed to investigate the occurrence of arbovirus transmission cycles at FLONA de Caxiuanã. Five field trips were performed to capture mosquitoes and sylvatic vertebrates. For ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11090774
更新日期：2019-08-22 00:00:00
abstract：:Rotavirus causes severe gastroenteritis in children. Although vaccines are implemented, rotavirus-related diarrhea still claims ~200,000 lives annually worldwide, mainly in low-income settings, pointing to a need for improved vaccine tactics. To meet such a public health need, a P24-VP8* nanoparticle displaying the gl...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v13010072
更新日期：2021-01-06 00:00:00
abstract：:The outbreak of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China has been brought to global attention and declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Scientific advancements since the pandemic of severe acute respiratory syndrome (SARS)...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12040372
更新日期：2020-03-27 00:00:00
abstract：:Puumala virus (PUUV) is the agent of nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) in Europe. NE incidence presents a high spatial variation throughout France, while the geographical distribution of the wild reservoir of PUUV, the bank vole, is rather continuous. A missing pi...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v7102884
更新日期：2015-10-22 00:00:00
abstract：:As more cases of COVID-19 are studied and treated worldwide, it had become apparent that the lethal and most severe cases of pneumonia are due to an out-of-control inflammatory response to the SARS-CoV-2 virus. I explored the putative causes of this specific feature through a detailed genomic comparison with the close...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12060646
更新日期：2020-06-15 00:00:00
abstract：:Background: Bats are known to host a number of nonpathogenic viruses, as well as highly pathogenic viruses causing fatal diseases like rabies. Serological surveys as part of active and passive bat rabies surveillance mainly use seroneutralization assays, demonstrating the presence of lyssavirus-specific antibodies in ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12030271
更新日期：2020-02-28 00:00:00
abstract：:The two human oncogenic -herpesviruses, Epstein Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV), are prototypic pathogens that are controlled by T cell responses. Despite their ubiquitous distribution, persistent infections and transforming potential, most carriers' immune systems control them for li...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v11121125
更新日期：2019-12-05 00:00:00
abstract：:Influenza is a serious public health concern worldwide, as it causes significant morbidity and mortality. The emergence of drug-resistant viral strains requires new approaches for the treatment of influenza. In this study, Rubus coreanus seed (RCS) that is left over from the production of wine or juice was found to sh...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v8060157
更新日期：2016-06-06 00:00:00
abstract：:Progression of HIV infection is variable among individuals, and definition disease progression biomarkers is still needed. Here, we aimed to categorize the predictive potential of several variables using feature selection methods and decision trees. A total of seventy-five treatment-naïve subjects were enrolled during...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10010034
更新日期：2018-01-13 00:00:00
abstract：:Zika virus (ZIKV) is a vertically and sexually transmissible virus resulting in severe congenital malformation. The goal of this study was to develop an ovine model of ZIKV infection. Between 28-35 days gestation (DG), four pregnant animals were infected with two doses of 6 × 106 PFU of ZIKV; four control animals rece...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11090795
更新日期：2019-08-29 00:00:00
abstract：:Cyclophilins are peptidyl-prolyl cis/trans isomerases important in the proper folding of certain proteins. Mounting evidence supports varied roles of cyclophilins, either positive or negative, in the life cycles of diverse viruses, but the nature and mechanisms of these roles are yet to be defined. The potential for c...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v5071684
更新日期：2013-07-11 00:00:00
abstract：:Hematopoietic stem cell transplantation from anti-cytomegalovirus immunoglobulin G (anti-CMV-IgG) positive donors facilitated immunological recovery post-transplant, which may indicate that chronic CMV infection has an effect on the immune system. This can be seen in the recipients after reconstitution with donor lymp...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v7031391
更新日期：2015-03-23 00:00:00
abstract：:For the past two decades, norovirus pandemic variants have emerged every 3⁻5 years, and dominate until they are replaced by alternate strains. However, this scenario changed in 2016 with the co-circulation of six prevalent viruses, three of which possessed the pandemic GII.4 Sydney 2012 capsid. An increased number of ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10100548
更新日期：2018-10-09 00:00:00
abstract：:Influenza A virus is a successful parasite and requires host factors to complete its life cycle. Prop5 is an antisense oligonucleotide, targeting programmed cell death protein 5 (PDCD5). In this study, we tested the antiviral activity of prop5 against mouse-adapted A/FM/1/47 strain of influenza A virus in a mouse mode...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v6020573
更新日期：2014-02-06 00:00:00
abstract：:The Middle East respiratory syndrome coronavirus (MERS-CoV) was first isolated in 2012, and circulated worldwide with high mortality. The continual outbreaks of MERS-CoV highlight the importance of developing antiviral therapeutics. Here, we rationally designed a novel fusion inhibitor named MERS-five-helix bundle (ME...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v9090255
更新日期：2017-09-14 00:00:00
abstract：:Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and activated to restrict v...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12040376
更新日期：2020-03-29 00:00:00
