Abstract:
:For the past two decades, norovirus pandemic variants have emerged every 3⁻5 years, and dominate until they are replaced by alternate strains. However, this scenario changed in 2016 with the co-circulation of six prevalent viruses, three of which possessed the pandemic GII.4 Sydney 2012 capsid. An increased number of institutional gastroenteritis outbreaks were reported within the Oceania region in mid-2017. This study identified emerging noroviruses circulating in Australia and New Zealand in 2017 to assess the changing dynamics of the virus infection. RT-PCR-based methods, next generation sequencing, and phylogenetic analyses were used to genotype noroviruses from both clinical and wastewater samples. Antigenic changes were observed between the capsid of pandemic Sydney 2012 variant and the two new Sydney recombinant viruses. The combination of these antigenic changes and the acquisition of a new ORF1 through recombination could both facilitate their ongoing persistence in the population. Overall, an increased prevalence of GII.P16/GII.4 Sydney 2012 viruses was observed in 2017, replacing the GII.P16/GII.2 recombinant that dominated in the region at the end of 2016. This shift in strain dominance was also observed in wastewater samples, demonstrating the reliability of wastewater as a molecular surveillance tool.
journal_name
Virusesjournal_title
Virusesauthors
Lun JH,Hewitt J,Yan GJH,Enosi Tuipulotu D,Rawlinson WD,White PAdoi
10.3390/v10100548subject
Has Abstractpub_date
2018-10-09 00:00:00issue
10issn
1999-4915pii
v10100548journal_volume
10pub_type
杂志文章相关文献
Viruses-Basel文献大全abstract::Around 257 million people are living with hepatitis B virus (HBV) chronic infection and 71 million with hepatitis C virus (HCV) chronic infection. Both HBV and HCV infections can lead to liver complications such as cirrhosis and hepatocellular carcinoma (HCC). To take care of these chronically infected patients, one s...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12121440
更新日期:2020-12-14 00:00:00
abstract::Half a century of research on membrane-containing phages has had a major impact on virology, providing new insights into virus diversity, evolution and ecological importance. The recent revolutionary technical advances in imaging, sequencing and lipid analysis have significantly boosted the depth and volume of knowled...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11010076
更新日期:2019-01-18 00:00:00
abstract::Influenza virus infections can lead to viral pneumonia and acute respiratory distress syndrome in severe cases, causing significant morbidity and mortality and posing a great threat to human health. Because of the diversity of influenza virus strains and drug resistance to the current direct antiviral agents, there ha...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12050557
更新日期:2020-05-18 00:00:00
abstract::A wide gap exists between the rapid acceptance of genetically modified (GM) crops for cultivation by farmers in many countries and in the global markets for food and feed, and the often-limited acceptance by consumers. This review contrasts the advances of practical applications of agricultural biotechnology with the ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v7082819
更新日期:2015-07-30 00:00:00
abstract::Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research l...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4123754
更新日期:2012-12-14 00:00:00
abstract::Despite tremendous efforts over the course of many years, the quest for an effective HIV vaccine by the classical method of active immunization remains largely elusive. However, two recent studies in mice and macaques have now demonstrated a new strategy designated as Vectored ImmunoProphylaxis (VIP), which involves p...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v6020428
更新日期:2014-01-27 00:00:00
abstract::Enteroviruses, the most common human viral pathogens worldwide, have been associated with serous meningitis, encephalitis, syndrome of acute flaccid paralysis, myocarditis and the onset of diabetes type 1. In the future, the rapid identification of the etiological agent would allow to adjust the therapy promptly and t...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8010010
更新日期:2016-01-06 00:00:00
abstract::Persistent circulative transmission of plant viruses involves complex interactions between the transmitted virus and its insect vector. Several studies have shown that insect vector proteins are involved in the passage and the transmission of the virus. Interestingly, proteins expressed by bacterial endosymbionts that...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v5061516
更新日期:2013-06-19 00:00:00
abstract::Tumor-targeted immunomodulation using oncolytic viral vectors is currently being investigated as a promising strategy in cancer therapy. In a previous study, we showed that a measles virus Schwarz vaccine strain (MeVac) vector encoding an interleukin-12 fusion protein (FmIL-12) is an effective immunotherapy in the MC3...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11100914
更新日期:2019-10-03 00:00:00
abstract::Measles virus (MeV) is a paramyxovirus that infects humans, principally children. Despite the existence of an effective and safe vaccine, the number of cases of measles has increased due to lack of vaccination coverage. The World Health Organization (WHO) reports that the number of cases worldwide multiplied fourfold ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11121111
更新日期:2019-11-30 00:00:00
abstract::Cotton leaf curl disease (CLCuD) is one of the most economically important diseases and is a constraint to cotton production in major producers, Pakistan and India. CLCuD is caused by monopartite plant viruses belonging to the family Geminiviridae (genus Begomovirus), in association with an essential, disease-specific...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9100280
更新日期:2017-09-29 00:00:00
abstract::Paramyxoviruses comprise a large number of diverse viruses which in part give rise to severe diseases in affected hosts. A new genotype of feline morbillivirus, tentatively named feline morbillivirus genotype 2 (FeMV-GT2), was isolated from urine of cats with urinary tract diseases. Whole genome sequencing showed abou...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020146
更新日期:2019-02-09 00:00:00
abstract::Begomoviruses are one of the major groups of plant viruses with an important economic impact on crop production in tropical and subtropical regions. The global spread of its polyphagous vector, the whitefly Bemisia tabaci, has contributed to the emergence and diversification of species within this genus. In this study...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11040327
更新日期:2019-04-04 00:00:00
abstract::Influenza A virus is a successful parasite and requires host factors to complete its life cycle. Prop5 is an antisense oligonucleotide, targeting programmed cell death protein 5 (PDCD5). In this study, we tested the antiviral activity of prop5 against mouse-adapted A/FM/1/47 strain of influenza A virus in a mouse mode...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v6020573
更新日期:2014-02-06 00:00:00
abstract::Photodynamic inactivation (PDI) has been used to inactivate microorganisms through the use of photosensitizers. The inactivation of mammalian viruses and bacteriophages by photosensitization has been applied with success since the first decades of the last century. Due to the fact that mammalian viruses are known to p...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4071034
更新日期:2012-07-01 00:00:00
abstract::Mycoviruses infect a large number of diverse fungal species, but considering their prevalence, relatively few high-quality genome sequences have been determined. Many mycoviruses have linear double-stranded RNA genomes, which makes it technically challenging to ascertain their nucleotide sequence using conventional se...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010070
更新日期:2019-01-16 00:00:00
abstract::The APOBEC3 family of proteins in mammals consists of cellular cytosine deaminases and well-known restriction factors against retroviruses, including lentiviruses. APOBEC3 genes are highly amplified and diversified in mammals, suggesting that their evolution and diversification have been driven by conflicts with ancie...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v13010124
更新日期:2021-01-17 00:00:00
abstract::Parrot bornaviruses (PaBVs) are the causative agents of proventricular dilatation disease (PDD), a chronic and often fatal neurologic disorder in Psittaciformes. The disease is widely distributed in private parrot collections and threatens breeding populations of endangered species. Thus, immunoprophylaxis strategies ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11121130
更新日期:2019-12-06 00:00:00
abstract::Abstract: Since 2007, highly pathogenic clade 2.3.2 H5N1 avian influenza A (A(H5N1)) viruses have evolved to clade 2.3.2.1a, b, and c; currently only 2.3.2.1c A(H5N1) viruses circulate in wild birds and poultry. During antigenic evolution, clade 2.3.2.1a and c A(H5N1) viruses acquired both S144N and V223I mutations ar...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11100923
更新日期:2019-10-09 00:00:00
abstract::Double-stranded DNA viruses package their genomes into pre-assembled protein procapsids. This process is driven by macromolecular motors that transiently assemble at a unique vertex of the procapsid and utilize homomeric ring ATPases to couple genome encapsidation to ATP hydrolysis. Here, we describe the biochemical a...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010015
更新日期:2020-12-23 00:00:00
abstract::Porcine Reproductive and Respiratory Syndrome (PRRS) is a contagious viral (PRRSV) disease in pigs characterized by poor reproductive health, increased mortality, and reductions in growth rates. PRRSV is known to implement immuno-antagonistic mechanisms to evade detection and mute host responses to infection. To bette...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111299
更新日期:2020-11-12 00:00:00
abstract::Laboratories throughout the world that perform work with Risk Group 4 Pathogens generally adopt one of two approaches within BSL-4 environments: either the use of positive pressure air-fed suits or using Class III microbiological safety cabinets and isolators for animal work. Within the UK at present, all laboratories...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v4081202
更新日期:2012-08-01 00:00:00
abstract::Direct-acting antiviral drugs (DAAs) are currently replacing antiviral therapy for Hepatitis C infection. Treatment related side effects are even worse and the emergence of resistant viruses must be avoided because of the direct-antiviral action. Altogether it remains a challenge to take treatment decisions in a clini...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4123281
更新日期:2012-12-01 00:00:00
abstract::Viral lysis is a main mortality factor for bacteria in deep-sea sediments, leading to changing microbial community structures and the release of cellular components to the environment. Nature and fate of these compounds and the role of viruses for microbial diversity is largely unknown. We investigated the effect of v...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12090922
更新日期:2020-08-22 00:00:00
abstract::Cervical cancer is the fourth most frequently occurring cancer in women around the world and can affect them during their reproductive years. Since the development of the Papanicolaou (Pap) test, screening has been essential in identifying cervical cancer at a treatable stage. With the identification of the human papi...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10120729
更新日期:2018-12-19 00:00:00
abstract::Filovirus serological diagnosis and epidemiological investigations are hampered due to the unavailability of validated immunoassays. Diagnostic performance of three indirect enzyme-linked immunosorbent assays (I-ELISA) was evaluated for the detection of IgG antibody to Ebola virus (EBOV) in human sera. One I-ELISA was...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11080678
更新日期:2019-07-24 00:00:00
abstract::Between January 2012 and March 2012, the infection rates of porcine epidemic diarrhea virus (PEDV) increased substantially in vaccinated swine herds in many porcine farms in Gansu Province, China. The spike (S) glycoprotein is an important determinant for PEDV biological properties. To determine the distribution profi...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v5081991
更新日期:2013-08-15 00:00:00
abstract::The family Totiviridae currently contains five genera Totivirus, Victorivirus, Leishmavirus, Trichomonasvirus, and Giardiavirus. Members in this family generally have a set of two-open reading frame (ORF) elements in their genome with the 5'-proximal ORF (ORF1) encoding a capsid protein (CP) and the 3'-proximal one (O...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11060577
更新日期:2019-06-25 00:00:00
abstract::The progressive loss of immunological memory during aging correlates with a reduced proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that this phenotype is recapitulated during chronic viral infection. The antigenic volume imposed by persistent and latent viruses exposes the immune ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9100289
更新日期:2017-10-05 00:00:00
abstract::Arthropod-borne flaviviruses are human pathogens of global medical importance, against which no effective small molecule-based antiviral therapy has currently been reported. Arbidol (umifenovir) is a broad-spectrum antiviral compound approved in Russia and China for prophylaxis and treatment of influenza. This compoun...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10040184
更新日期:2018-04-10 00:00:00