Recombinant Modified Vaccinia Virus Ankara (MVA) Vaccines Efficiently Protect Cockatiels Against Parrot Bornavirus Infection and Proventricular Dilatation Disease.

abstract：:Enteroviruses are small RNA viruses that affect millions of people each year by causing an important burden of disease with a broad spectrum of symptoms. In routine diagnostic laboratories, enteroviruses are identified by PCR-based methods, often combined with partial sequencing for genotyping. In this proof-of-princi...

journal_title：Viruses

authors： Grädel C,Terrazos Miani MA,Baumann C,Barbani MT,Neuenschwander S,Leib SL,Suter-Riniker F,Ramette A

更新日期：2020-07-31 00:00:00

abstract：:The development of effective yet nontoxic strategies to target the latent human immunodeficiency virus-1 (HIV-1) reservoir in antiretroviral therapy (ART)-suppressed individuals poses a critical barrier to a functional cure. The 'kick and kill' approach to HIV eradication entails proviral reactivation during ART, coup...

journal_title：Viruses

authors： Kristoff J,Rinaldo CR,Mailliard RB

更新日期：2019-12-28 00:00:00

abstract：:We mapped the hemagglutinin-esterase (HE) antigenic epitopes of the influenza C virus on the three-dimensional (3D) structure of the HE glycoprotein using 246 escape mutants that were selected by a panel of nine anti-HE monoclonal antibodies (MAbs), including seven of the C/Ann Arbor/1/50 virus and two of the C/Yamaga...

journal_title：Viruses

authors： Matsuzaki Y,Sugawara K,Furuse Y,Shimotai Y,Hongo S,Mizuta K,Nishimura H

更新日期：2018-08-09 00:00:00

abstract：:The emergence of phage-resistant mutants is a key aspect of lytic phages-bacteria interaction and the main driver for the co-evolution between both organisms. Here, we analyze the impact of PA5oct jumbo phage treatment on planktonic/cell line associated and sessile P. aeruginosa population. Besides its broad-spectrum ...

journal_title：Viruses

authors： Olszak T,Danis-Wlodarczyk K,Arabski M,Gula G,Maciejewska B,Wasik S,Lood C,Higgins G,Harvey BJ,Lavigne R,Drulis-Kawa Z

更新日期：2019-11-23 00:00:00

abstract：:Potato virus Y (PVY) is the most economically important virus infecting cultivated potato (Solanum tuberosum L.). Accurate diagnosis is crucial to regulate the trade of tubers and for the sanitary selection of plant material for propagation. However, high genetic diversity of PVY represents a challenge for the detecti...

journal_title：Viruses

authors： Della Bartola M,Byrne S,Mullins E

更新日期：2020-04-23 00:00:00

abstract：:Since the human immunodeficiency virus (HIV) was discovered as the etiological agent of acquired immunodeficiency syndrome (AIDS), it has encouraged much research into antiviral compounds. The reverse transcriptase (RT) of HIV has been a main target for antiviral drugs. However, all drugs developed so far inhibit the ...

journal_title：Viruses

authors： Beilhartz GL,Götte M

更新日期：2010-04-01 00:00:00

abstract：:Lactococcus lactis is one of the most important bacteria in dairy fermentations, being used in the production of cheese and buttermilk. The processes are vulnerable to phage attacks, and undefined mixtures of lactococcal strains are often used to reduce the risk of bacteriophage caused fermentation failure. Other prev...

journal_title：Viruses

authors： Frantzen CA,Holo H

更新日期：2019-05-16 00:00:00

abstract：:Highly pathogenic avian influenza (HPAI) and Newcastle disease are economically important avian diseases worldwide. Effective vaccination is critical to control these diseases in poultry. Live attenuated Newcastle disease virus (NDV) vectored vaccines have been developed for bivalent vaccination against HPAI viruses a...

journal_title：Viruses

authors： Kim SH,Samal SK

更新日期：2019-03-26 00:00:00

abstract：:HIV continues to spread among vulnerable heterosexual (HET), Men-having-Sex with Men (MSM) and intravenous drug user (IDU) populations, influenced by a complex array of biological, behavioral and societal factors. Phylogenetics analyses of large sequence datasets from national drug resistance testing programs reveal t...

journal_title：Viruses

authors： Brenner BG,Ibanescu RI,Hardy I,Roger M

更新日期：2017-12-28 00:00:00

abstract：:The HIV-1 Gag p6 protein regulates the final abscission step of nascent virions from the cell membrane by the action of its two late (L-) domains, which recruit Tsg101 and ALIX, components of the ESCRT system. Even though p6 consists of only 52 amino acids, it is encoded by one of the most polymorphic regions of the H...

journal_title：Viruses

authors： Friedrich M,Setz C,Hahn F,Matthaei A,Fraedrich K,Rauch P,Henklein P,Traxdorf M,Fossen T,Schubert U

更新日期：2016-04-25 00:00:00

abstract：:Timely implementation of antiviral treatment and other public health based responses are dependent on accurate and rapid diagnosis of the novel pandemic influenza A(H1N1) strain. In this study we developed a duplex real-time PCR (RT-PCR) (dFLU-TM) assay for the simultaneous detection of a broad range of influenza A su...

journal_title：Viruses

authors： Rockett RJ,Bialasiewicz S,Whiley DM,Bletchly C,Faux CE,Lambert SB,Nimmo GR,Nissen MD,Sloots TP

更新日期：2009-12-01 00:00:00

abstract：:Persistent circulative transmission of plant viruses involves complex interactions between the transmitted virus and its insect vector. Several studies have shown that insect vector proteins are involved in the passage and the transmission of the virus. Interestingly, proteins expressed by bacterial endosymbionts that...

journal_title：Viruses

authors： Kliot A,Ghanim M

更新日期：2013-06-19 00:00:00

abstract：:Chronic HBV + HDV infection is associated with greater risk of liver fibrosis, earlier hepatic decompensation, and liver cirrhosis hepatocellular carcinoma compared to HBV mono-infection. However, to-date no direct anti-HDV drugs are available in clinical practice. Here, we identified conserved and variable regions in...

journal_title：Viruses

authors： Colagrossi L,Salpini R,Scutari R,Carioti L,Battisti A,Piermatteo L,Bertoli A,Fabeni L,Minichini C,Trimoulet P,Fleury H,Nebuloso E,De Cristofaro M,Cappiello G,Spanò A,Malagnino V,Mari T,Barlattani A,Iapadre N,Lichtne

更新日期：2018-07-09 00:00:00

abstract：:Bovine viral diarrhea virus (BVDV) is an important pathogen belonging to the Pestivirus genus, Flaviviridae family, which comprises viral species that causes an economic impact in animal production. Cattle are the natural host of BVDV and the main source of infection for pigs and other animal species. Due to its antig...

journal_title：Viruses

authors： de Oliveira LG,Mechler-Dreibi ML,Almeida HMS,Gatto IRH

更新日期：2020-05-31 00:00:00

abstract：:A wide gap exists between the rapid acceptance of genetically modified (GM) crops for cultivation by farmers in many countries and in the global markets for food and feed, and the often-limited acceptance by consumers. This review contrasts the advances of practical applications of agricultural biotechnology with the ...

journal_title：Viruses

authors： Lucht JM

更新日期：2015-07-30 00:00:00

abstract：:Countries rely on good diagnostic tests and appropriate testing schemes to fight against economically important small ruminant lentivirus (SRLV) infections. We undertook an extensive comparative analysis of seven commercially available serological tests and one in-house real-time PCR (qPCR) detecting genotype A and B ...

journal_title：Viruses

authors： Michiels R,Van Mael E,Quinet C,Adjadj NR,Cay AB,De Regge N

更新日期：2018-12-08 00:00:00

abstract：:Cytoskeleton defines the shape and structural organization of the cell. Its elements participate in cell motility, intracellular transport and chromosome movement during mitosis. Papillomaviruses (PV) are strictly epitheliotropic and induce self-limiting benign tumors of skin and mucosa, which may progress to malignan...

journal_title：Viruses

authors： Bienkowska-Haba M,Sapp M

更新日期：2011-03-01 00:00:00

abstract：:Hepatitis C is a major global health burden with an estimated 160 million infected individuals worldwide. This long-term disease evolves slowly, often leading to chronicity and potentially to liver failure. There is no anti-HCV vaccine, and, until recently, the only treatment available, based on pegylated interferon a...

journal_title：Viruses

authors： Calland N,Dubuisson J,Rouillé Y,Séron K

更新日期：2012-10-17 00:00:00

abstract：:Paramyxoviruses comprise a large number of diverse viruses which in part give rise to severe diseases in affected hosts. A new genotype of feline morbillivirus, tentatively named feline morbillivirus genotype 2 (FeMV-GT2), was isolated from urine of cats with urinary tract diseases. Whole genome sequencing showed abou...

journal_title：Viruses

authors： Sieg M,Busch J,Eschke M,Böttcher D,Heenemann K,Vahlenkamp A,Reinert A,Seeger J,Heilmann R,Scheffler K,Vahlenkamp TW

更新日期：2019-02-09 00:00:00

abstract：:The Flaviviridae family comprises a number of human pathogens, which, although sharing structural and functional features, cause diseases with very different outcomes. This can be explained by the plurality of functions exerted by the few proteins coded by viral genomes, with some of these functions shared among membe...

journal_title：Viruses

authors： Zeidler JD,Fernandes-Siqueira LO,Barbosa GM,Da Poian AT

更新日期：2017-03-13 00:00:00

abstract：:The Human immunodeficiency virus-1 (HIV-1) accessory protein Vpu modulates numerous proteins, including the host proteins CD4 and BST-2/tetherin. Vpu interacts with the Skp, Cullin, F-Box (SCF) ubiquitin ligase through interactions with the F-Box protein βTrCP (1 and/or 2). This interaction is dependent on phosphoryla...

journal_title：Viruses

authors： Song YE,Cyburt D,Lucas TM,Gregory DA,Lyddon TD,Johnson MC

更新日期：2018-10-19 00:00:00

abstract：:Changes over time in HIV-1 subtype diversity within a population reflect changes in factors influencing the development of local epidemics. Here we report on the genetic diversity of 2364 reverse transcriptase sequences from people living with HIV-1 in New South Wales (NSW) notified between 2004 and 2018. These data r...

journal_title：Viruses

authors： Di Giallonardo F,Pinto AN,Keen P,Shaik A,Carrera A,Salem H,Selvey C,Nigro SJ,Fraser N,Price K,Holden J,Lee FJ,Dwyer DE,Bavinton BR,Grulich AE,Kelleher AD,On Behalf Of The Nsw Hiv Prevention Partnership Project

更新日期：2020-12-06 00:00:00

abstract：:: Rabies virus (RABV) is the only lyssavirus known to be present within the Caribbean. The island of Trinidad, is richly diverse in chiropteran fauna and endemic for bat-transmitted rabies with low RABV isolation rates observed in this population. We aimed to determine the seroprevalence of rabies virus neutralizing a...

journal_title：Viruses

authors： Seetahal JFR,Greenberg L,Satheshkumar PS,Sanchez-Vazquez MJ,Legall G,Singh S,Ramkissoon V,Schountz T,Munster V,Oura CAL,Carrington CVF

更新日期：2020-02-05 00:00:00

abstract：:Influenza is a serious public health concern worldwide, as it causes significant morbidity and mortality. The emergence of drug-resistant viral strains requires new approaches for the treatment of influenza. In this study, Rubus coreanus seed (RCS) that is left over from the production of wine or juice was found to sh...

journal_title：Viruses

authors： Lee JH,Oh M,Seok JH,Kim S,Lee DB,Bae G,Bae HI,Bae SY,Hong YM,Kwon SO,Lee DH,Song CS,Mun JY,Chung MS,Kim KH

更新日期：2016-06-06 00:00:00

abstract：:Kaposi's sarcoma associated herpesvirus (KSHV), like other human herpes viruses, establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic phases. The latent phase is characterized by the persistence of viral episomes in a highly ordered chromatin structure and with the expression of ...

journal_title：Viruses

authors： Uppal T,Banerjee S,Sun Z,Verma SC,Robertson ES

更新日期：2014-12-11 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and animal diseases must comply with regulatory requirements as they pertain to environmental risk asses...

journal_title：Viruses

authors： Okeke MI,Okoli AS,Diaz D,Offor C,Oludotun TG,Tryland M,Bøhn T,Moens U

更新日期：2017-10-29 00:00:00

abstract：:Measles virus (MeV) is a paramyxovirus that infects humans, principally children. Despite the existence of an effective and safe vaccine, the number of cases of measles has increased due to lack of vaccination coverage. The World Health Organization (WHO) reports that the number of cases worldwide multiplied fourfold ...

journal_title：Viruses

authors： Meléndez-Villanueva MA,Morán-Santibañez K,Martínez-Sanmiguel JJ,Rangel-López R,Garza-Navarro MA,Rodríguez-Padilla C,Zarate-Triviño DG,Trejo-Ávila LM

更新日期：2019-11-30 00:00:00

abstract：:Viruses protect their genomes by enclosing them into protein capsids that sometimes contain lipid bilayers that either reside above or below the protein layer. Controlled dissociation of virions provides important information on virion composition, interactions, and stoichiometry of virion components, as well as their...

journal_title：Viruses

authors： Eskelin K,Poranen MM

更新日期：2018-10-23 00:00:00

abstract：:The smaller tea tortrix, Adoxophyes honmai (Lepidoptera: Tortricidae), is an economically important pest of tea in Japan. Previous work showed that a fast-killing nucleopolyhedrovirus (NPV) isolated from A. orana (AdorNPV) and a slow-killing NPV isolated from A. honmai (AdhoNPV) are both infectious to A. honmai larvae...

journal_title：Viruses

authors： Takahashi M,Nakai M,Saito Y,Sato Y,Ishijima C,Kunimi Y

更新日期：2015-03-18 00:00:00

abstract：:Insectivorous bats are speculated to be ancestral hosts of Middle-East respiratory syndrome (MERS) coronavirus (CoV). MERS-CoV causes disease in humans with thirty-five percent fatality, and has evolved proteins that counteract human antiviral responses. Since bats experimentally infected with MERS-CoV do not develop ...

journal_title：Viruses

authors： Banerjee A,Falzarano D,Rapin N,Lew J,Misra V

更新日期：2019-02-13 00:00:00