Abstract：
:Changes over time in HIV-1 subtype diversity within a population reflect changes in factors influencing the development of local epidemics. Here we report on the genetic diversity of 2364 reverse transcriptase sequences from people living with HIV-1 in New South Wales (NSW) notified between 2004 and 2018. These data represent >70% of all new HIV-1 notifications in the state over this period. Phylogenetic analysis was performed to identify subtype-specific transmission clusters. Subtype B and non-B infections differed across all demographics analysed (p < 0.001). We found a strong positive association for infections among females, individuals not born in Australia or reporting heterosexual transmission being of non-B origin. Further, we found an overall increase in non-B infections among men who have sex with men from 50 to 79% in the last 10 years. However, we also found differences between non-B subtypes; heterosexual transmission was positively associated with subtype C only. In addition, the majority of subtype B infections were associated with clusters, while the majority of non-B infections were singletons. However, we found seven non-B clusters (≥5 sequences) indicative of local ongoing transmission. In conclusion, we present how the HIV-1 epidemic has changed over time in NSW, becoming more heterogeneous with distinct subtype-specific demographic associations.
journal_name
Virusesjournal_title
Virusesauthors
Di Giallonardo F,Pinto AN,Keen P,Shaik A,Carrera A,Salem H,Selvey C,Nigro SJ,Fraser N,Price K,Holden J,Lee FJ,Dwyer DE,Bavinton BR,Grulich AE,Kelleher AD,On Behalf Of The Nsw Hiv Prevention Partnership Projectdoi
10.3390/v12121402subject
Has Abstractpub_date
2020-12-06 00:00:00issue
12issn
1999-4915pii
v12121402journal_volume
12pub_type
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