Abstract：
:Measles virus (MeV) is a paramyxovirus that infects humans, principally children. Despite the existence of an effective and safe vaccine, the number of cases of measles has increased due to lack of vaccination coverage. The World Health Organization (WHO) reports that the number of cases worldwide multiplied fourfold between January and March 2019, to 112,000. Today, there is no treatment available for MeV. In recent years, it has been demonstrated that natural extracts (herbal or algal) with antiviral activity can also work as reducing agents that, in combination with nanotechnology, offer an innovative option to counteract viral infections. Here, we synthetized and evaluated the antiviral activity of gold nanoparticles using garlic extract (Allium sativa) as a reducing agent (AuNPs-As). These nanoparticles actively inhibited MeV replication in Vero cells at a 50% effective concentration (EC50) of 8.829 µg/mL, and the selectivity index (SI) obtained was 16.05. AuNPs-As likely inhibit viral infection by blocking viral particles directly, showing a potent virucidal effect. Gold nanoparticles may be useful as a promising strategy for treating and controlling the infection of MeV and other related enveloped viruses.
journal_name
Virusesjournal_title
Virusesauthors
Meléndez-Villanueva MA,Morán-Santibañez K,Martínez-Sanmiguel JJ,Rangel-López R,Garza-Navarro MA,Rodríguez-Padilla C,Zarate-Triviño DG,Trejo-Ávila LMdoi
10.3390/v11121111subject
Has Abstractpub_date
2019-11-30 00:00:00issue
12issn
1999-4915pii
v11121111journal_volume
11pub_type
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