Abstract:
:Hantaviruses, members of the order Bunyavirales, family Hantaviridae, have a world-wide distribution and are responsible for greater than 150,000 cases of disease per year. The spectrum of disease associated with hantavirus infection include hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) also known as hantavirus cardiopulmonary syndrome (HCPS). There are currently no FDA-approved vaccines or treatments for these hantavirus diseases. This review provides a summary of the status of vaccine and antiviral treatment efforts including those tested in animal models or human clinical trials.
journal_name
Virusesjournal_title
Virusesauthors
Brocato RL,Hooper JWdoi
10.3390/v11070610subject
Has Abstractpub_date
2019-07-04 00:00:00issue
7issn
1999-4915pii
v11070610journal_volume
11pub_type
杂志文章,评审相关文献
Viruses-Basel文献大全abstract::The development of oncolytic viruses has led to an emerging new class of cancer therapeutics. Although the safety profile has been encouraging, the transition of oncolytic viruses to the clinical setting has been a slow process due to modifications. Therefore, a new generation of more potent oncolytic viruses needs to...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v8030072
更新日期:2016-03-07 00:00:00
abstract::Beyond acute infections, group B coxsackieviruses (CVB) are also reported to play a role in the development of chronic diseases, like type 1 diabetes. The viral pathogenesis mainly relies on the interplay between the viruses and innate immune response in genetically-susceptible individuals. We investigated the interac...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7112924
更新日期:2015-11-24 00:00:00
abstract::Commentary on Pais-Correia, A.M.; Sachse, M.; Guadagnini, S.; Robbiati, V.; Lasserre, R.; Gessain, A.; Gout, O.; Alcover, A.; Thoulouze, M.I. Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses. Nat. Med.2010, 16, 83-89. ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v2020601
更新日期:2010-02-01 00:00:00
abstract::Many blood-feeding arthropods are known vectors of viruses that are a source of unprecedented global health concern. Mosquitoes are an integral part of these arthropod vectors. Advancements in next-generation sequencing and bioinformatics has expanded our knowledge on the richness of viruses harbored by arthropods. In...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10010030
更新日期:2018-01-12 00:00:00
abstract::Sea star wasting disease (SSWD) is a condition that has affected asteroids for over 120 years, yet mechanistic understanding of this wasting etiology remains elusive. We investigated temporal virome variation in two Pisaster ochraceus specimens that wasted in the absence of external stimuli and two specimens that did ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111332
更新日期:2020-11-20 00:00:00
abstract::The members of the filoviruses are recognized as some of the most lethal viruses affecting human and non-human primates. The only two genera of the Filoviridae family, Marburg virus (MARV) and Ebola virus (EBOV), comprise the main etiologic agents of severe hemorrhagic fever outbreaks in central Africa, with case fata...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v2010262
更新日期:2010-01-01 00:00:00
abstract::Exosomes are membrane-enclosed vesicles actively released into the extracellular space, whose content reflect the physiological/pathological state of the cells they originate from. These vesicles participate in cell-to-cell communication and transfer of biologically active proteins, lipids, and RNAs. Their role in vir...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v7062770
更新日期:2015-06-19 00:00:00
abstract::The non-structural protein NSs of the Phenuiviridae family members appears to have a role in the host immunity escape. The stability of Toscana virus (TOSV) NSs protein was tested by a cycloheximide (CHX) chase approach on cells transfected with NSs deleted versions fused to a reporter gene. The presence of intrinsica...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12101153
更新日期:2020-10-12 00:00:00
abstract::Tospovirus is a tripartite negative stranded RNA virus and is considered as one of the most devastating plant viruses. Successful virus infection in plant requires many host factors. To date, very few host factors have been identified as important in Tospovirus infection in plants. We reported earlier that NSm protein...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10110647
更新日期:2018-11-17 00:00:00
abstract::Cotton leaf curl disease (CLCuD) is one of the most economically important diseases and is a constraint to cotton production in major producers, Pakistan and India. CLCuD is caused by monopartite plant viruses belonging to the family Geminiviridae (genus Begomovirus), in association with an essential, disease-specific...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9100280
更新日期:2017-09-29 00:00:00
abstract::Autophagy is an essential vacuolar process of the cell, leading to lysosomal degradation and recycling of proteins and organelles, which is extremely important in maintaining homeostasis. Multiple roles have been now associated with autophagy, in particular a pro-survival role in nutrient starvation or in stressful en...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9120372
更新日期:2017-12-04 00:00:00
abstract::The Vibrio cholerae biotype "El Tor" is responsible for all of the current epidemic and endemic cholera outbreaks worldwide. These outbreaks are clonal, and it is hypothesized that they originate from the coastal areas near the Bay of Bengal, where the lytic bacteriophage ICP1 (International Centre for Diarrhoeal Dise...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10060299
更新日期:2018-06-01 00:00:00
abstract::In rabies diagnosis, it is essential to count on a rapid test to give a quick response. The combined sensitivity and robustness of the TaqMan RT-PCR assays (qRT-PCR) have made these methods a valuable alternative for rabies virus (RABV) detection. We conducted a study to compare the applicability of two widely used qR...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010023
更新日期:2020-12-25 00:00:00
abstract::Kaposi's sarcoma associated-herpesvirus (KSHV, also known as human herpesvirus-8) is a gammaherpesvirus that establishes life-long infection in human B lymphocytes. KSHV infection is typically asymptomatic, but immunosuppression can predispose KSHV-infected individuals to primary effusion lymphoma (PEL); a malignancy ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12010012
更新日期:2019-12-20 00:00:00
abstract::The use of the rabies vaccine for post-exposure prophylaxis started as early as 1885, revealing a safe and efficient tool to prevent human rabies cases. Preventive vaccination is the basis for the control of canine-mediated rabies, which has already been eliminated from extensive parts of the world, including Europe. ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11100892
更新日期:2019-09-24 00:00:00
abstract::HIV-1 is a global health crisis that has infected more than 37 million people. Latent reservoirs throughout the body are a major hurdle when it comes to eradicating the virus. In our previous study, we found that exosomes, a type of extracellular vesicle (EV), from uninfected cells activate the transcription of HIV-1 ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12060665
更新日期:2020-06-19 00:00:00
abstract::The morbillivirus genus comprises major human and animal pathogens, including the highly contagious measles virus. Morbilliviruses feature single stranded negative sense RNA genomes that are wrapped by a plasma membrane-derived lipid envelope. Genomes are encapsidated by the viral nucleocapsid protein forming ribonucl...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v8090251
更新日期:2016-09-10 00:00:00
abstract::Filovirus serological diagnosis and epidemiological investigations are hampered due to the unavailability of validated immunoassays. Diagnostic performance of three indirect enzyme-linked immunosorbent assays (I-ELISA) was evaluated for the detection of IgG antibody to Ebola virus (EBOV) in human sera. One I-ELISA was...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11080678
更新日期:2019-07-24 00:00:00
abstract::Because of its ecological characteristics, the Caxiuanã National Forest (FLONA) is a potential area of arbovirus circulation. The present study aimed to investigate the occurrence of arbovirus transmission cycles at FLONA de Caxiuanã. Five field trips were performed to capture mosquitoes and sylvatic vertebrates. For ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11090774
更新日期:2019-08-22 00:00:00
abstract::Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades. Dengue is caused by genetically distinct serotypes, DENV-1-4. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and M...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010057
更新日期:2021-01-04 00:00:00
abstract::While bats are increasingly recognized as a source of coronavirus epidemics, the diversity and emergence potential of bat coronaviruses remains to be fully understood. Among 1779 bat samples collected in China, diverse coronaviruses were detected in 32 samples from five different bat species by RT-PCR. Two novel alpha...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11050423
更新日期:2019-05-07 00:00:00
abstract::Bats are an important source of viral zoonoses, including paramyxoviruses. The paramyxoviral Pararubulavirus genus contains viruses mostly derived from bats that are common, diverse, distributed throughout the Old World, and known to be zoonotic. Here, we describe a new member of the genus Achimota pararubulavirus 3 (...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111236
更新日期:2020-10-30 00:00:00
abstract::Next-generation sequencing (NGS) has opened up the possibility of detecting new viruses in unresolved diseases. Recently, astrovirus brain infections have been identified in neurologically diseased humans and animals by NGS, among them bovine astrovirus (BoAstV) CH13/NeuroS1, which has been found in brain tissues of c...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v9010012
更新日期:2017-01-18 00:00:00
abstract::During flavivirus infection, some viral proteins move to the nucleus and cellular components are relocated from the nucleus to the cytoplasm. Thus, the integrity of the main regulator of the nuclear-cytoplasmic transport, the nuclear pore complex (NPC), was evaluated during infection with dengue virus (DENV) and Zika ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12060583
更新日期:2020-05-26 00:00:00
abstract::Varroa destructor is an ectoparasitic mite of Asian or Eastern honeybees Apis cerana(A. cerana) which has become a serious threat to European subspecies of Western honeybees Apis mellifera (A. mellifera) within the last century. V.destructor and its vectored honeybee viruses became serious threats for colony survival....
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020094
更新日期:2019-01-24 00:00:00
abstract::Porcine circovirus type 2 (PCV2) is the etiological agent of porcine circovirus diseases and porcine circovirus-associated diseases (PCVDs/PCVADs). However, the pathogenesis of PCV2 is not fully understood. We previously found that 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is negatively associated with P...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11060544
更新日期:2019-06-11 00:00:00
abstract::The Iridoviridae family are large viruses (∼120-200 nm) that contain a linear double-stranded DNA genome. The genomic size of Iridoviridae family members range from 105,903 bases encoding 97 open reading frames (ORFs) for frog virus 3 to 212,482 bases encoding 211 ORFs for Chilo iridescent virus. The family Iridovirid...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v2071458
更新日期:2010-07-01 00:00:00
abstract::Hepatitis C Virus (HCV) remains an important public health threat with approximately 170 million carriers worldwide who are at risk of developing hepatitis C-associated end-stage liver diseases. Despite improvement of HCV treatment using the novel direct-acting antivirals (DAAs) targeting viral replication, there is a...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10120669
更新日期:2018-11-27 00:00:00
abstract::The Bunyaviridae is the largest family of RNA viruses, with over 350 members worldwide. Several of these viruses cause severe diseases in livestock and humans. With an increasing number and frequency of outbreaks, bunyaviruses represent a growing threat to public health and agricultural productivity globally. Yet, the...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v8050143
更新日期:2016-05-24 00:00:00
abstract::Coronaviruses are enveloped RNA viruses capable of causing respiratory, enteric, or systemic diseases in a variety of mammalian hosts that vary in clinical severity from subclinical to fatal. The host range and tissue tropism are largely determined by the coronaviral spike protein, which initiates cellular infection b...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12091023
更新日期:2020-09-13 00:00:00