Exosomes and Their Role in the Life Cycle and Pathogenesis of RNA Viruses.

abstract：:We studied whether cytosine phosphate-guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs). As a model, we used well-characterized CpG-recoded Zika virus vaccine candidates that p...

journal_title：Viruses

authors： Trus I,Berube N,Jiang P,Rak J,Gerdts V,Karniychuk U

更新日期：2020-05-25 00:00:00

abstract：:Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of s...

journal_title：Viruses

authors： Batista MN,Braga ACS,Campos GRF,Souza MM,Matos RPA,Lopes TZ,Candido NM,Lima MLD,Machado FC,Andrade STQ,Bittar C,Nogueira ML,Carneiro BM,Mariutti RB,Arni RK,Calmon MF,Rahal P

更新日期：2019-01-11 00:00:00

abstract：:Rotavirus causes severe gastroenteritis in children. Although vaccines are implemented, rotavirus-related diarrhea still claims ~200,000 lives annually worldwide, mainly in low-income settings, pointing to a need for improved vaccine tactics. To meet such a public health need, a P24-VP8* nanoparticle displaying the gl...

journal_title：Viruses

authors： Xia M,Huang P,Jiang X,Tan M

更新日期：2021-01-06 00:00:00

abstract：:We previously characterized a carbohydrate binding protein, Gp047, derived from lytic Campylobacter phage NCTC 12673, as a promising diagnostic tool for the identification of Campylobacter jejuni and Campylobacter coli. We also demonstrated that this protein binds specifically to acetamidino-modified pseudaminic acid ...

journal_title：Viruses

authors： Javed MA,Sacher JC,van Alphen LB,Patry RT,Szymanski CM

更新日期：2015-12-16 00:00:00

abstract：:Coronaviruses are enveloped RNA viruses capable of causing respiratory, enteric, or systemic diseases in a variety of mammalian hosts that vary in clinical severity from subclinical to fatal. The host range and tissue tropism are largely determined by the coronaviral spike protein, which initiates cellular infection b...

journal_title：Viruses

authors： Haake C,Cook S,Pusterla N,Murphy B

更新日期：2020-09-13 00:00:00

abstract：:Zika virus recently re-emerged and caused global outbreaks mainly in Central Africa, Southeast Asia, the Pacific Islands and in Central and South America. Even though there is a declining trend, the virus continues to spread throughout different geographical regions of the world. Since its re-emergence in 2015, massiv...

journal_title：Viruses

authors： Alves MP,Vielle NJ,Thiel V,Pfaender S

更新日期：2018-10-30 00:00:00

abstract：:Bacteriophage (phage) therapy is a promising alternative to antibiotics for the treatment of bacterial pathogens, including Clostridiumdifficile. However, as for many species, in C. difficile the physical interactions between phages and bacterial cells have not been studied in detail. The initial interaction, known as...

journal_title：Viruses

authors： Thanki AM,Taylor-Joyce G,Dowah A,Nale JY,Malik D,Clokie MRJ

更新日期：2018-08-06 00:00:00

abstract：:Small Ruminant Lentiviruses (SRLVs) are widespread in many countries and cause economically relevant, slow, and persistent diseases in sheep and goats. Monitoring the genetic diversity of SRLVs is useful to improve the diagnostic tools used in the eradication programs. In this study, SRLVs detected in Spanish Assaf sh...

journal_title：Viruses

authors： Gayo E,Cuteri V,Polledo L,Rossi G,García Marín JF,Preziuso S

更新日期：2018-06-09 00:00:00

abstract：:Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using ferret antisera or mouse and human monoclonal antibodies. Here, we examined the antigenicity of human H2N2 viruses by using human plasma samples obtained from 50...

journal_title：Viruses

authors： Matsuzawa Y,Iwatsuki-Horimoto K,Nishimoto Y,Abe Y,Fukuyama S,Hamabata T,Okuda M,Go Y,Watanabe T,Imai M,Arai Y,Fouchier RAM,Yamayoshi S,Kawaoka Y

更新日期：2019-10-23 00:00:00

abstract：:Bovine viral diarrhea virus (BVDV) is an important pathogen belonging to the Pestivirus genus, Flaviviridae family, which comprises viral species that causes an economic impact in animal production. Cattle are the natural host of BVDV and the main source of infection for pigs and other animal species. Due to its antig...

journal_title：Viruses

authors： de Oliveira LG,Mechler-Dreibi ML,Almeida HMS,Gatto IRH

更新日期：2020-05-31 00:00:00

abstract：:Influenza A viruses (IAV) have been a major public health threat worldwide, and options for antiviral therapy become increasingly limited with the emergence of drug-resisting virus strains. New and effective anti-IAV drugs, especially for highly pathogenic influenza, with different modes of action, are urgently needed...

journal_title：Viruses

authors： Ye M,Liao Y,Wu L,Qi W,Choudhry N,Liu Y,Chen W,Song G,Chen J

更新日期：2020-02-18 00:00:00

abstract：:Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress toward...

journal_title：Viruses

authors： Schindewolf C,Menachery VD

更新日期：2019-01-17 00:00:00

abstract：:We determined the earliest full-length HIV-1 gag gene sequences in 110 patients with HIV-1, including 20 hemophiliacs (HPs) and 90 local controls (LCs). The gag gene from stored sera was amplified using RT-PCR, and was subjected to direct sequencing. Phylogenetic analysis indicated that 94 and 16 sequences belonged to...

journal_title：Viruses

authors： Cho YK,Kim JE,Foley BT

更新日期：2019-06-11 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and animal diseases must comply with regulatory requirements as they pertain to environmental risk asses...

journal_title：Viruses

authors： Okeke MI,Okoli AS,Diaz D,Offor C,Oludotun TG,Tryland M,Bøhn T,Moens U

更新日期：2017-10-29 00:00:00

abstract：:Lymphoma is one of the most common malignancies in domestic cats. The lymphomagenic potential of Felis catus gammaherpesvirus 1 (FcaGHV1), a common infection in domestic cats, is unknown. In other species, including humans, cellular transformation by gammaherpesviruses is typically mediated by viral genes expressed du...

journal_title：Viruses

authors： Aghazadeh M,Shi M,Pesavento PA,Durham AC,Polley T,Donahoe SL,Troyer RM,Barrs VR,Holmes EC,Beatty JA

更新日期：2018-08-30 00:00:00

abstract：:Geminiviruses are important plant pathogens that affect crops around the world. In some geminivirus-host interactions, infected plants show recovery, a phenomenon characterized by symptom disappearance in newly emerging leaves. In pepper-Pepper golden mosaic virus (PepGMV) interaction, the host recovery process involv...

journal_title：Viruses

authors： Rodríguez-Gandarilla MG,Rodríguez-Negrete EA,Rivera-Bustamante RF

更新日期：2020-03-05 00:00:00

abstract：:For the past two decades, norovirus pandemic variants have emerged every 3⁻5 years, and dominate until they are replaced by alternate strains. However, this scenario changed in 2016 with the co-circulation of six prevalent viruses, three of which possessed the pandemic GII.4 Sydney 2012 capsid. An increased number of ...

journal_title：Viruses

authors： Lun JH,Hewitt J,Yan GJH,Enosi Tuipulotu D,Rawlinson WD,White PA

更新日期：2018-10-09 00:00:00

abstract：:Insectivorous bats are speculated to be ancestral hosts of Middle-East respiratory syndrome (MERS) coronavirus (CoV). MERS-CoV causes disease in humans with thirty-five percent fatality, and has evolved proteins that counteract human antiviral responses. Since bats experimentally infected with MERS-CoV do not develop ...

journal_title：Viruses

authors： Banerjee A,Falzarano D,Rapin N,Lew J,Misra V

更新日期：2019-02-13 00:00:00

abstract：:The family Totiviridae currently contains five genera Totivirus, Victorivirus, Leishmavirus, Trichomonasvirus, and Giardiavirus. Members in this family generally have a set of two-open reading frame (ORF) elements in their genome with the 5'-proximal ORF (ORF1) encoding a capsid protein (CP) and the 3'-proximal one (O...

journal_title：Viruses

authors： Jamal A,Sato Y,Shahi S,Shamsi W,Kondo H,Suzuki N

更新日期：2019-06-25 00:00:00

abstract：:Hepatitis B virus (HBV) persistence is at the basis of HBV reactivation as a consequence of chemotherapy and immunosuppressive treatments. The identification of early viral replication indicators and markers of effective HBV immunological control would be useful in monitoring patients who are at risk of potential vira...

journal_title：Viruses

authors： Svicher V,Salpini R,Malagnino V,Piermatteo L,Alkhatib M,Cerva C,Sarmati L

更新日期：2019-08-25 00:00:00

abstract：:HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of the nucleocapsid (NC) domain that interacts with nucleic acids, and p1 and p6, two unstructured regions, p6 containing the motifs to bind ALIX, the cellular ESCRT factor TSG101 and the viral protein Vpr. The processing of Ga...

journal_title：Viruses

authors： Mouhand A,Pasi M,Catala M,Zargarian L,Belfetmi A,Barraud P,Mauffret O,Tisné C

更新日期：2020-09-29 00:00:00

abstract：:Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) are poorly understood autoimmune liver diseases. Immunosuppression is used to treat AIH and ursodeoxycholic acid is used to slow the progression of PBC. Nevertheless, a proportion of patients with both disorders progress to liver failure. Following liver t...

journal_title：Viruses

authors： Wasilenko ST,Montano-Loza AJ,Mason AL

更新日期：2013-01-24 00:00:00

abstract：:Two sister orders of the brown macroalgae (class Phaeophyceae), the morphologically complex Laminariales (commonly referred to as kelp) and the morphologically simple Ectocarpales are natural hosts for the dsDNA phaeoviruses (family Phycodnaviridae) that persist as proviruses in the genomes of their hosts. We have pre...

journal_title：Viruses

authors： McKeown DA,Schroeder JL,Stevens K,Peters AF,Sáez CA,Park J,Rothman MD,Bolton JJ,Brown MT,Schroeder DC

更新日期：2018-08-05 00:00:00

abstract：:Extracellular vesicles (EVs) play an important role in intercellular communication. They are naturally released from cells into the extracellular environment. Based on their biogenesis, release pathways, size, content, and function, EVs are classified into exosomes, microvesicles (MVs), and apoptotic bodies (ApoBDs). ...

journal_title：Viruses

authors： Alqatawni A,Sharma AL,Attilus B,Tyagi M,Daniel R

更新日期：2020-05-27 00:00:00

abstract：:The human cytomegalovirus (HCMV)-encoded protein kinase, pUL97, is considered a cyclin-dependent kinase (CDK) ortholog, due to shared structural and functional characteristics. The primary mechanism of CDK activation is binding to corresponding cyclins, including cyclin T1, which is the usual regulatory cofactor of CD...

journal_title：Viruses

authors： Graf L,Webel R,Wagner S,Hamilton ST,Rawlinson WD,Sticht H,Marschall M

更新日期：2013-12-18 00:00:00

abstract：:During the early stages of human papillomavirus (HPV) infections, the innate immune system creates a pro-inflammatory microenvironment by recruiting innate immune cells to eliminate the infected cells, initiating an effective acquired immune response. However, HPV exhibits a wide range of strategies for evading immune...

journal_title：Viruses

authors： Amador-Molina A,Hernández-Valencia JF,Lamoyi E,Contreras-Paredes A,Lizano M

更新日期：2013-10-28 00:00:00

abstract：:A Pseudorabies virus (PRV) variant has emerged in China since 2011 that is not protected by commercial vaccines, and has not been well studied. The PRV genome is large and difficult to manipulate, but it is feasible to use clustered, regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology. However, id...

journal_title：Viruses

authors： Tang YD,Liu JT,Fang QQ,Wang TY,Sun MX,An TQ,Tian ZJ,Cai XH

更新日期：2016-03-29 00:00:00

abstract：:Andes orthohantavirus (ANDV) is an important human pathogen causing hantavirus cardiopulmonary syndrome (HCPS) with a fatality rate of 30% in Chile. Around 60% of all cases have a severe clinical course, while the others have a mild clinical course. The main goal of this study was to understand if the genetic variatio...

journal_title：Viruses

authors： Ribeiro GE,Leon LE,Perez R,Cuiza A,Vial PA,Ferres M,Mertz GJ,Vial C

更新日期：2019-07-25 00:00:00

abstract：:African swine fever (ASF) has become the major threat for the global swine industry. Furthermore, the epidemiological situation of African swine fever virus (ASFV) in some endemic regions of Sub-Saharan Africa is worse than ever, with multiple virus strains and genotypes currently circulating in a given area. Despite ...

journal_title：Viruses

authors： Lopez E,van Heerden J,Bosch-Camós L,Accensi F,Navas MJ,López-Monteagudo P,Argilaguet J,Gallardo C,Pina-Pedrero S,Salas ML,Salt J,Rodriguez F

更新日期：2020-12-21 00:00:00

abstract：:Crimean-Congo hemorrhagic fever virus is one the most important and wide spread tick-borne viruses. Very little is known about the transmission from the tick and the early aspects of pathogenesis. Here, we generate human cutaneous antigen presenting cells-dermal dendritic cells and Langerhans cells-from umbilical cord...

journal_title：Viruses

authors： Rodriguez SE,McAuley AJ,Gargili A,Bente DA

更新日期：2018-07-20 00:00:00