Abstract：
:Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 µM of berberine, a reduction of 77.6% in the infectivity was observed; when emodin was used (40 µM), this reduction was approximately 83.3%. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution. We report here that berberine and emodin, two natural compounds, have strong virucidal effect in Zika virus.
journal_name
Virusesjournal_title
Virusesauthors
Batista MN,Braga ACS,Campos GRF,Souza MM,Matos RPA,Lopes TZ,Candido NM,Lima MLD,Machado FC,Andrade STQ,Bittar C,Nogueira ML,Carneiro BM,Mariutti RB,Arni RK,Calmon MF,Rahal Pdoi
10.3390/v11010049subject
Has Abstractpub_date
2019-01-11 00:00:00issue
1issn
1999-4915pii
v11010049journal_volume
11pub_type
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