Perturbation of Human T-Cell Leukemia Virus Type 1 Particle Morphology by Differential Gag Co-Packaging.

abstract：:Our previous studies have demonstrated that haploid AAV vectors made from capsids of two different serotypes induced high transduction and prevented serotype-specific antibody binding. In this study, we explored the transduction efficiency of several haploid viruses, which were made from the VP1/VP2 of one serotype an...

journal_title：Viruses

authors： Chai Z,Zhang X,Dobbins AL,Frost EA,Samulski RJ,Li C

更新日期：2019-12-09 00:00:00

abstract：:The outbreak of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China has been brought to global attention and declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Scientific advancements since the pandemic of severe acute respiratory syndrome (SARS)...

journal_title：Viruses

authors： Jin Y,Yang H,Ji W,Wu W,Chen S,Zhang W,Duan G

更新日期：2020-03-27 00:00:00

abstract：:Pestiviruses, which include economically important animal pathogens such as bovine viral diarrhea virus and classical swine fever virus, possess three envelope glycoproteins, namely Erns, E1, and E2. This article discusses the structures and functions of these glycoproteins and their effects on viral pathogenicity in ...

journal_title：Viruses

authors： Wang FI,Deng MC,Huang YL,Chang CY

更新日期：2015-06-29 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hooved animals that poses a constant burden on farmers in endemic regions and threatens the livestock industries in disease-free countries. Despite the increased number of publicly available whole genome sequences, FMDV data are biased by...

journal_title：Viruses

authors： Lasecka-Dykes L,Wright CF,Di Nardo A,Logan G,Mioulet V,Jackson T,Tuthill TJ,Knowles NJ,King DP

更新日期：2018-04-13 00:00:00

abstract：:Phylodynamic inference is a pivotal tool in understanding transmission dynamics of viral outbreaks. These analyses are strongly guided by the input of an epidemiological model as well as sequence data that must contain sufficient intersequence variability in order to be informative. These criteria, however, may not be...

journal_title：Viruses

authors： Lam A,Duchene S

更新日期：2021-01-08 00:00:00

abstract：:Influenza A virus is a successful parasite and requires host factors to complete its life cycle. Prop5 is an antisense oligonucleotide, targeting programmed cell death protein 5 (PDCD5). In this study, we tested the antiviral activity of prop5 against mouse-adapted A/FM/1/47 strain of influenza A virus in a mouse mode...

journal_title：Viruses

authors： Li K,Zhou Z,Wang YO,Liu J,Zhao HB,Yang J,Wang SQ

更新日期：2014-02-06 00:00:00

abstract：:Positive-strand RNA (+RNA) viruses are an important group of human and animal pathogens that have significant global health and economic impacts. Notable members include West Nile virus, Dengue virus, Chikungunya, Severe acute respiratory syndrome (SARS) Coronavirus and enteroviruses of the Picornaviridae family.Unfor...

journal_title：Viruses

authors： Reid CR,Airo AM,Hobman TC

更新日期：2015-08-06 00:00:00

abstract：:With the inclusion of new members, understanding about evolutionary mechanisms and processes by which members of the proposed order, Megavirales, have evolved has become a key area of interest. The central role of gene acquisition has been shown in previous studies. However, the major drawback in gene acquisition stud...

journal_title：Viruses

authors： Jain S,Panda A,Colson P,Raoult D,Pontarotti P

更新日期：2017-04-07 00:00:00

abstract：:Double-stranded DNA viruses package their genomes into pre-assembled protein procapsids. This process is driven by macromolecular motors that transiently assemble at a unique vertex of the procapsid and utilize homomeric ring ATPases to couple genome encapsidation to ATP hydrolysis. Here, we describe the biochemical a...

journal_title：Viruses

authors： Reyes-Aldrete E,Dill EA,Bussetta C,Szymanski MR,Diemer G,Maindola P,White MA,Bujalowski WM,Choi KH,Morais MC

更新日期：2020-12-23 00:00:00

abstract：:Delivering rapid protection against infectious agents to non-immune populations is a formidable public health challenge. Although passive immunotherapy is a fast and effective method of protection, large-scale production and administration of monoclonal antibodies (mAbs) is expensive and unpractical. Viral vector-medi...

journal_title：Viruses

authors： Michelini Z,Minkoff JM,Yang J,Negri D,Cara A,Hanson BJ,Salvatore M

更新日期：2020-12-17 00:00:00

abstract：:Although most hepatitis E virus (HEV) infections are asymptomatic, some can be severe, causing fulminant hepatitis and extra-hepatic manifestations, including neurological and kidney injuries. Chronic HEV infections may also occur in immunocompromised patients. This review describes how our understanding of the pathog...

journal_title：Viruses

authors： Lhomme S,Marion O,Abravanel F,Chapuy-Regaud S,Kamar N,Izopet J

更新日期：2016-08-05 00:00:00

abstract：:Feline immunodeficiency virus (FIV) is widespread in feline populations and causes an AIDS-like illness in domestic cats. It is highly prevalent in several endangered feline species. In domestic cats FIV infection is a valuable small animal model for HIV infection. In recent years there has been sa significant increas...

journal_title：Viruses

authors： Kenyon JC,Lever AM

更新日期：2011-11-01 00:00:00

abstract：:Micro RNAs (miRNAs) are a class of small non-coding single-stranded RNA, which play an important role in modulating host-Influenza A virus (IAV) crosstalk. The interplay between influenza and miRNA interaction is defined by a plethora of complex mechanisms, which are not fully understood yet. Here, we demonstrate that...

journal_title：Viruses

authors： Sharma S,Chatterjee A,Kumar P,Lal S,Kondabagil K

更新日期：2020-04-15 00:00:00

abstract：:Rapid and sensitive detection of prions is important in managing prion diseases. The real-time quaking-induced conversion (RT-QuIC) assay for prion seeding activity has been applied to many prion diseases and provides for specific antemortem diagnostic testing. We evaluated RT-QuIC's long-term consistency and varied m...

journal_title：Viruses

authors： Orrú CD,Hughson AG,Groveman BR,Campbell KJ,Anson KJ,Manca M,Kraus A,Caughey B

更新日期：2016-05-23 00:00:00

abstract：:Rotavirus causes severe gastroenteritis in children. Although vaccines are implemented, rotavirus-related diarrhea still claims ~200,000 lives annually worldwide, mainly in low-income settings, pointing to a need for improved vaccine tactics. To meet such a public health need, a P24-VP8* nanoparticle displaying the gl...

journal_title：Viruses

authors： Xia M,Huang P,Jiang X,Tan M

更新日期：2021-01-06 00:00:00

abstract：:Lactococcus lactis is one of the most important bacteria in dairy fermentations, being used in the production of cheese and buttermilk. The processes are vulnerable to phage attacks, and undefined mixtures of lactococcal strains are often used to reduce the risk of bacteriophage caused fermentation failure. Other prev...

journal_title：Viruses

authors： Frantzen CA,Holo H

更新日期：2019-05-16 00:00:00

abstract：:The whole world is currently facing an unseen enemy, called coronavirus disease 2019 (COVID-19), which is causing a global pandemic. This disease is caused by a novel single-stranded enveloped RNA virus, known as the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Although huge efforts are being made to ...

journal_title：Viruses

authors： Hassan STS

更新日期：2020-04-23 00:00:00

abstract：:We are currently facing a pandemic of COVID-19, caused by a spillover from an animal-originating coronavirus to humans occurring in the Wuhan region of China in December 2019. From China, the virus has spread to 188 countries and regions worldwide, reaching the Sahel region on March 2, 2020. Since whole genome sequenc...

journal_title：Viruses

authors： Kouriba B,Dürr A,Rehn A,Sangaré AK,Traoré BY,Bestehorn-Willmann MS,Ouedraogo J,Heitzer A,Sogodogo E,Maiga A,Walter MC,Zimmermann F,Wölfel R,Antwerpen MH

更新日期：2020-11-02 00:00:00

abstract：:The development of high-throughput technologies allows for evaluating gene expression at the whole-genome level. Together with proteomic and metabolomic studies, these analyses have resulted in the identification of plant genes whose function or expression is altered as a consequence of pathogen attacks. Members of th...

journal_title：Viruses

authors： Czosnek H,Eybishtz A,Sade D,Gorovits R,Sobol I,Bejarano E,Rosas-Díaz T,Lozano-Durán R

更新日期：2013-03-22 00:00:00

abstract：:A metagenomic study was performed on 498 female and 40 male Aedes albopictus mosquitos collected in August and September 2019 in Ticino, a region in southern Switzerland, to address the question regarding the risk of the local transmission of zoonotic viruses. A total of 13 viruses from seven different virus families ...

journal_title：Viruses

authors： Kubacki J,Flacio E,Qi W,Guidi V,Tonolla M,Fraefel C

更新日期：2020-08-24 00:00:00

abstract：:In July 2018, a novel avian influenza virus (A/Mandarin duck/South Korea/KNU18-12/2018(H11N9)) was isolated from Mandarin ducks in South Korea. Phylogenetic and molecular analyses were conducted to characterize the genetic origins of the H11N9 strain. Phylogenetic analysis indicated that eight gene segments of strain ...

journal_title：Viruses

authors： Tuong HT,Nguyen NM,Sung HW,Park H,Yeo SJ

更新日期：2020-02-12 00:00:00

abstract：:Cervical cancer is the fourth most frequently occurring cancer in women around the world and can affect them during their reproductive years. Since the development of the Papanicolaou (Pap) test, screening has been essential in identifying cervical cancer at a treatable stage. With the identification of the human papi...

journal_title：Viruses

authors： Chrysostomou AC,Stylianou DC,Constantinidou A,Kostrikis LG

更新日期：2018-12-19 00:00:00

abstract：:Viroids are small pathogenic circular single-stranded RNAs, present in two complementary sequences, named plus and minus, in infected plant cells. A high degree of complementarities between different regions of the RNAs allows them to adopt complex structures. Since viroids are naked non-coding RNAs, interactions with...

journal_title：Viruses

authors： Delan-Forino C,Deforges J,Benard L,Sargueil B,Maurel MC,Torchet C

更新日期：2014-01-29 00:00:00

abstract：:Bombyx mori bidensovirus (BmBDV) is a single-stranded DNA (ssDNA) virus from the genus Bidensovirus of the Bidnaviridae family, which, thus far, solely infects insects. It has a unique genome that contains bipartite DNA molecules (VD1 and VD2). In this study, we explored the detailed transcription mapping of the compl...

journal_title：Viruses

authors： Li R,Chang P,Lü P,Hu Z,Chen K,Yao Q,Yu Q

更新日期：2019-04-03 00:00:00

abstract：:Flaviviruses are enveloped arthropod-borne viruses with a single-stranded, positive-sense RNA genome that can cause serious illness in humans and animals. The 11 kb 5' capped RNA genome consists of a single open reading frame (ORF), and is flanked by 5' and 3' untranslated regions (UTR). The ORF is a polyprotein that ...

journal_title：Viruses

authors： Ng WC,Soto-Acosta R,Bradrick SS,Garcia-Blanco MA,Ooi EE

更新日期：2017-06-06 00:00:00

abstract：:RNA virus invasion induces a cytosolic RIG-I-like receptor (RLR) signaling pathway by promoting assembly of the Mitochondrial antiviral-signaling protein (MAVS) signalosome and triggers the rapid production of type I interferons (IFNs) and proinflammatory cytokines. During this process, the pivotal kinase TANK binding...

journal_title：Viruses

authors： He TS,Xie T,Li J,Yang YX,Li C,Wang W,Cao L,Rao H,Ju C,Xu LG

更新日期：2019-02-15 00:00:00

abstract：:Canine parvovirus (CPV-2) is the causative agent of haemorrhagic gastroenteritis in canids. Three antigenic variants-CPV-2a, CPV-2b and CPV-2c-have been described, which are determined by variations at residue 426 of the VP2 capsid protein. In Colombia, the CPV-2a and CPV-2b antigenic variants have previously been rep...

journal_title：Viruses

authors： Giraldo-Ramirez S,Rendon-Marin S,Ruiz-Saenz J

更新日期：2020-04-30 00:00:00

abstract：:Glycoprotein B (gB) plays an important role in alphaherpesvirus cellular entry and acts in concert with gD and the gH/gL complex. To evaluate whether functional differences exist between gB1 and gB4, the corresponding genes were exchanged between the two viruses. The gB4-containing-EHV-1 (EHV-1_gB4) recombinant virus ...

journal_title：Viruses

authors： Spiesschaert B,Osterrieder N,Azab W

更新日期：2015-02-03 00:00:00

abstract：:Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research l...

journal_title：Viruses

authors： Wahl-Jensen V,Bollinger L,Safronetz D,de Kok-Mercado F,Scott DP,Ebihara H

更新日期：2012-12-14 00:00:00

abstract：:Viroids are small non-capsidated non-coding RNA replicons that utilize host factors for efficient propagation and spread through the entire plant. They can incite specific disease symptoms in susceptible plants. To better understand viroid-plant interactions, we employed microarray analysis to observe the changes of g...

journal_title：Viruses

authors： Więsyk A,Iwanicka-Nowicka R,Fogtman A,Zagórski-Ostoja W,Góra-Sochacka A

更新日期：2018-05-15 00:00:00