Integrase-Defective Lentiviral Vectors for Delivery of Monoclonal Antibodies against Influenza.

abstract：:The Iridoviridae family are large viruses (∼120-200 nm) that contain a linear double-stranded DNA genome. The genomic size of Iridoviridae family members range from 105,903 bases encoding 97 open reading frames (ORFs) for frog virus 3 to 212,482 bases encoding 211 ORFs for Chilo iridescent virus. The family Iridovirid...

journal_title：Viruses

authors： Eaton HE,Ring BA,Brunetti CR

更新日期：2010-07-01 00:00:00

abstract：:Small ruminant lentiviruses include members that infect sheep (ovine lentivirus [OvLV]; also known as ovine progressive pneumonia virus/maedi-visna virus) and goats (caprine arthritis encephalitis virus [CAEV]). Breed differences in seroprevalence and proviral concentration of OvLV had suggested a strong genetic compo...

journal_title：Viruses

authors： White SN,Knowles DP

更新日期：2013-06-14 00:00:00

abstract：:An outbreak of winter dysentery, complicated by severe respiratory syndrome, occurred in January 2020 in a high production dairy cow herd located in a hilly area of the Calabria region. Of the 52 animals belonging to the farm, 5 (9.6%) died with severe respiratory distress, death occurring 3-4 days after the appearanc...

journal_title：Viruses

authors： Amoroso MG,Lucifora G,Degli Uberti B,Serra F,De Luca G,Borriello G,De Domenico A,Brandi S,Cuomo MC,Bove F,Riccardi MG,Galiero G,Fusco G

更新日期：2020-11-19 00:00:00

abstract：:Aplastic anemia is a rare blood disease characterized by the destruction of the hematopoietic stem cells (HSC) in the bone marrow that, in the majority of cases, is caused by an autoimmune reaction. Patients with aplastic anemia are treated with immunosuppressive drugs and some of them, especially younger individuals ...

journal_title：Viruses

authors： Inoue H,Rai S,Tanaka H,Espinoza JL,Komori-Inoue M,Kakutani H,Minamoto S,Kumode T,Nakayama S,Taniguchi Y,Morita Y,Okuda T,Tatsumi Y,Ashida T,Matsumura I

更新日期：2020-04-08 00:00:00

abstract：:In rabies diagnosis, it is essential to count on a rapid test to give a quick response. The combined sensitivity and robustness of the TaqMan RT-PCR assays (qRT-PCR) have made these methods a valuable alternative for rabies virus (RABV) detection. We conducted a study to compare the applicability of two widely used qR...

journal_title：Viruses

authors： Caraballo DA,Lombardo MA,Becker P,Sabio MS,Lema C,Martínez LM,Beltrán FJ,Li Y,Cisterna DM

更新日期：2020-12-25 00:00:00

abstract：:Prymnesium parvum is a toxin-producing haptophyte that causes harmful algal blooms globally, leading to large-scale fish kills that have severe ecological and economic implications. For the model haptophyte, Emiliania huxleyi, it has been shown that large dsDNA viruses play an important role in regulating blooms and t...

journal_title：Viruses

authors： Wagstaff BA,Vladu IC,Barclay JE,Schroeder DC,Malin G,Field RA

更新日期：2017-03-09 00:00:00

abstract：:Commentary on Hare, S.; Gupta, S.S.; Valkov, E.; Engelman, A.; Cherepanov, P. Retroviral intasome assembly and inhibition of DNA strand transfer. Nature2010, 464, 232-236. ...

journal_title：Viruses

authors： Grandgenett D,Korolev S

更新日期：2010-05-01 00:00:00

abstract：:Endemic to West Africa and South America, mammalian arenaviruses can cross the species barrier from their natural rodent hosts to humans, resulting in illnesses ranging from mild flu-like syndromes to severe and fatal haemorrhagic zoonoses. The increased frequency of outbreaks and associated high fatality rates of the...

journal_title：Viruses

authors： Stott RJ,Strecker T,Foster TL

更新日期：2020-07-21 00:00:00

abstract：:The management of chronic hepatitis B virus (CHB) infection is an area of massive unmet clinical need worldwide. In spite of the development of powerful nucleoside/nucleotide analogue (NUC) drugs, and the widespread use of immune stimulators such as interferon-alpha (IFNα) or PEGylated interferon-alpha (PEG-IFNα), sub...

journal_title：Viruses

authors： Duraisamy GS,Bhosale D,Lipenská I,Huvarova I,Růžek D,Windisch MP,Miller AD

更新日期：2020-09-07 00:00:00

abstract：:Human cytomegalovirus (HCMV) encodes a number of viral proteins with homology to cellular G protein-coupled receptors (GPCRs). These viral GPCRs, including US27, US28, UL33, and UL78, have been ascribed numerous functions during infection, including activating diverse cellular pathways, binding to immunomodulatory che...

journal_title：Viruses

authors： Noriega VM,Gardner TJ,Redmann V,Bongers G,Lira SA,Tortorella D

更新日期：2014-03-12 00:00:00

abstract：:Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC func...

journal_title：Viruses

authors： Guise AJ,Budayeva HG,Diner BA,Cristea IM

更新日期：2013-06-27 00:00:00

abstract：:Heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar) was first diagnosed in Norway in 1999. The disease is caused by Piscine orthoreovirus-1 (PRV-1). The virus is prevalent in farmed Atlantic salmon, but not always associated with disease. Phylogeny and sequence analyses of 31 PRV-1 ge...

journal_title：Viruses

authors： Dhamotharan K,Tengs T,Wessel Ø,Braaen S,Nyman IB,Hansen EF,Christiansen DH,Dahle MK,Rimstad E,Markussen T

更新日期：2019-05-22 00:00:00

abstract：:While 25 compounds have been formally licensed for the treatment of HIV infection (AIDS), only seven licensed products are currently available for the treatment of chronic hepatitis B virus (HBV) infection: interferon-α, pegylated interferon-α, lamivudine, adefovir (dipivoxil), entecavir, telbivudine and tenofovir (di...

journal_title：Viruses

authors： De Clercq E,Férir G,Kaptein S,Neyts J

更新日期：2010-06-01 00:00:00

abstract：:Kaposi's sarcoma associated herpesvirus (KSHV), like other human herpes viruses, establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic phases. The latent phase is characterized by the persistence of viral episomes in a highly ordered chromatin structure and with the expression of ...

journal_title：Viruses

authors： Uppal T,Banerjee S,Sun Z,Verma SC,Robertson ES

更新日期：2014-12-11 00:00:00

abstract：:Infectious retrovirus particles contain two copies of unspliced viral RNA that serve as the viral genome. Unspliced retroviral RNA is transcribed in the nucleus by the host RNA polymerase II and has three potential fates: (1) it can be spliced into subgenomic messenger RNAs (mRNAs) for the translation of viral protein...

journal_title：Viruses

authors： Kaddis Maldonado RJ,Parent LJ

更新日期：2016-09-20 00:00:00

abstract：:Extensive surveillance in bat populations in response to recent emerging diseases has revealed that this group of mammals acts as a reservoir for a large range of viruses. However, the oldest known association between a zoonotic virus and a bat is that between rabies virus and the vampire bat. Vampire bats are only fo...

journal_title：Viruses

authors： Johnson N,Aréchiga-Ceballos N,Aguilar-Setien A

更新日期：2014-04-29 00:00:00

abstract：:Cervical cancer is the fourth most frequently occurring cancer in women around the world and can affect them during their reproductive years. Since the development of the Papanicolaou (Pap) test, screening has been essential in identifying cervical cancer at a treatable stage. With the identification of the human papi...

journal_title：Viruses

authors： Chrysostomou AC,Stylianou DC,Constantinidou A,Kostrikis LG

更新日期：2018-12-19 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) causes a highly contagious disease with catastrophic economic impact for affected countries. BHK21 suspension cells are preferred for the industrial production of FMDV vaccine antigen, but not all virus strains can be successfully propagated in these cells. Serotype Asia-1 is often ...

journal_title：Viruses

authors： Dill V,Hoffmann B,Zimmer A,Beer M,Eschbaumer M

更新日期：2017-08-18 00:00:00

abstract：:The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retroviral-induced disease....

journal_title：Viruses

authors： Pérès E,Bagdassarian E,This S,Villaudy J,Rigal D,Gazzolo L,Duc Dodon M

更新日期：2015-12-07 00:00:00

abstract：:Zika virus (ZIKV) is an emerging mosquito-borne pathogen associated with microcephaly and other congenital abnormalities in newborns as well as neurologic complications in adults. The explosive transmission of the virus in the last ten years put it in the limelight and improved our understanding of its biology and pat...

journal_title：Viruses

authors： Botwina P,Obłoza M,Szczepański A,Szczubiałka K,Nowakowska M,Pyrć K

更新日期：2020-08-23 00:00:00

abstract：:Type-I interferons (IFN-I) play an important role in the innate immune response to several retroviruses. They seem to be effective in controlling the in vivo infection, though many of the clinical signs of retroviral infection may be due to their continual presence which over-stimulates the immune system and activates...

journal_title：Viruses

authors： Gómez-Lucía E,Collado VM,Miró G,Doménech A

更新日期：2009-12-01 00:00:00

abstract：:Most cases of hemorrhagic fever with renal syndrome (HFRS) in Europe are caused by the Puumala hantavirus (PUUV). Typical features of the disease are increased vascular permeability, acute kidney injury (AKI), and thrombocytopenia. YKL-40 is an inflammatory glycoprotein involved in various forms of acute and chronic i...

journal_title：Viruses

authors： Outinen TK,Mantula P,Jaatinen P,Hämäläinen M,Moilanen E,Vaheri A,Huhtala H,Mäkelä S,Mustonen J

更新日期：2019-08-21 00:00:00

abstract：:Antigen-specific T lymphocytes play a critical role in controlling viral infections. However, we report here that preexisting virus-specific T cell responses also contribute to promoting adenovirus (Ad) infection. Previously, we found that CD14+ monocytes from Ad-seropositive individuals exhibited an increased suscept...

journal_title：Viruses

authors： Feng F,Zhao J,Li P,Li R,Chen L,Sun C

更新日期：2019-02-13 00:00:00

abstract：:The Protoparvovirus (PtPV) genus of the Parvoviridae family of viruses includes important animal pathogens and reference molecular models for the entire family. Some virus members of the PtPV genus have arisen as promising tools to treat tumoral processes, as they exhibit marked oncotropism and oncolytic activities wh...

journal_title：Viruses

authors： Ros C,Bayat N,Wolfisberg R,Almendral JM

更新日期：2017-10-26 00:00:00

abstract：:Foamy viruses (FVs) are globally prevalent retroviruses that establish apparently apathogenic lifelong infections. Feline FV (FFV) has been isolated from domestic cats with concurrent diseases, including urinary syndromes. We experimentally infected five cats with FFV to study viral kinetics and tropism, peripheral bl...

journal_title：Viruses

authors： Ledesma-Feliciano C,Troyer RM,Zheng X,Miller C,Cianciolo R,Bordicchia M,Dannemiller N,Gagne R,Beatty J,Quimby J,Löchelt M,VandeWoude S

更新日期：2019-07-19 00:00:00

abstract：:The human cytomegalovirus (HCMV) terminase complex is part of DNA-packaging machinery that delivers a unit-length genome into a procapsid. Sequence comparison of herpesvirus homologs allowed us to identify a potential LATLNDIERFL and zinc finger pattern in N-terminal part of pUL56. Recombinant viruses were generated w...

journal_title：Viruses

authors： Ligat G,Couvreux A,Cazal R,Alain S,Hantz S

更新日期：2019-11-26 00:00:00

abstract：:Microvirin (MVN) is one of the human immunodeficiency virus (HIV-1) entry inhibitor lectins, which consists of two structural domains sharing 35% sequence identity and contrary to many other antiviral lectins, it exists as a monomer. In this study, we engineered an MVN variant, LUMS1, consisting of two domains with 10...

journal_title：Viruses

authors： Shahid M,Qadir A,Yang J,Ahmad I,Zahid H,Mirza S,Windisch MP,Shahzad-Ul-Hussan S

更新日期：2020-02-11 00:00:00

abstract：:The two human oncogenic -herpesviruses, Epstein Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV), are prototypic pathogens that are controlled by T cell responses. Despite their ubiquitous distribution, persistent infections and transforming potential, most carriers' immune systems control them for li...

journal_title：Viruses

authors： Münz C

更新日期：2019-12-05 00:00:00

abstract：:Staphylococcus aureus is a common and often virulent pathogen in humans. This bacterium is widespread, being present on the skin and in the nose of healthy people. Staphylococcus aureus can cause infections with severe outcomes ranging from pustules to sepsis and death. The introduction of antibiotics led to a general...

journal_title：Viruses

authors： Kaźmierczak Z,Górski A,Dąbrowska K

更新日期：2014-07-01 00:00:00

abstract：:Bombyx mori nuclear polyhedrosis virus (BmNPV) is an important pathogen of silkworms. Despite extensive studies in recent decades, the interaction between BmNPV and host cells is still not clearly understood. Autophagy is an intrinsic innate immune mechanism and it controls infection autonomously in virus-infected cel...

journal_title：Viruses

authors： Wang,Xiao Q,Zhou XL,Zhu Y,Dong ZQ,Chen P,Pan MH,Lu C

更新日期：2017-12-30 00:00:00