Preexisting Virus-Specific T Lymphocytes-Mediated Enhancement of Adenovirus Infections to Human Blood CD14+ Cells.

abstract：:Andes orthohantavirus (ANDV) is an important human pathogen causing hantavirus cardiopulmonary syndrome (HCPS) with a fatality rate of 30% in Chile. Around 60% of all cases have a severe clinical course, while the others have a mild clinical course. The main goal of this study was to understand if the genetic variatio...

journal_title：Viruses

authors： Ribeiro GE,Leon LE,Perez R,Cuiza A,Vial PA,Ferres M,Mertz GJ,Vial C

更新日期：2019-07-25 00:00:00

abstract：:Human respiratory syncytial virus (HRSV) is a major cause of pediatric infection and also causes disease in the elderly and those with underlying respiratory problems. There is no vaccine for HRSV and anti-viral therapeutics are not broadly applicable. To investigate the effect of HRSV biology in children, nasopharyng...

journal_title：Viruses

authors： Aljabr W,Armstrong S,Rickett NY,Pollakis G,Touzelet O,Cloutman-Green E,Matthews DA,Hiscox JA

更新日期：2019-10-10 00:00:00

abstract：:The two human oncogenic -herpesviruses, Epstein Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV), are prototypic pathogens that are controlled by T cell responses. Despite their ubiquitous distribution, persistent infections and transforming potential, most carriers' immune systems control them for li...

journal_title：Viruses

authors： Münz C

更新日期：2019-12-05 00:00:00

abstract：:Depletion and functional impairment of circulating plasmacytoid dendritic cells (pDCs) are characteristic attributes of HIV-1-infection. The mechanism of dysfunction of pDCs is unclear. Here, we studied the development of phenotype of pDCs in a cohort of HIV-1-infected individuals monitored before the initiation and d...

journal_title：Viruses

authors： Font-Haro A,Janovec V,Hofman T,Machala L,Jilich D,Melkova Z,Weber J,Trejbalova K,Hirsch I

更新日期：2018-03-28 00:00:00

abstract：:Since 2015, severe hydropericardium-hepatitis syndrome (HHS), caused by a highly pathogenic fowl adenovirus 4 (FAdV-4), emerged in China. In our previous study, the FAdV-4 has been identified as a novel genotype with a unique 1966-bp nucleotide deletion (1966Del) between open reading frame 42 and 43. In this study, th...

journal_title：Viruses

authors： Pan Q,Wang J,Gao Y,Cui H,Liu C,Qi X,Zhang Y,Wang Y,Wang X

更新日期：2018-09-13 00:00:00

abstract：:Seoul virus (SEOV) is a zoonotic orthohantavirus carried by black and brown rats, and can cause hemorrhagic fever with renal syndrome in humans. Human cases of SEOV virus infection have most recently been reported in the USA, United Kingdom, France and the Netherlands and were primarily associated with contact with pe...

journal_title：Viruses

authors： Maas M,van Heteren M,de Vries A,Kuiken T,Hoornweg T,Veldhuis Kroeze E,Rockx B

更新日期：2019-06-07 00:00:00

abstract：:Chikungunya virus (CHIKV) has caused extensive outbreaks in several countries within the Americas, Asia, Oceanic/Pacific Islands, and Europe. In humans, CHIKV infections cause a debilitating disease with acute febrile illness and long-term polyarthralgia. Acute and chronic symptoms impose a major economic burden to he...

journal_title：Viruses

authors： López-Camacho C,Kim YC,Blight J,Lazaro Moreli M,Montoya-Diaz E,Huiskonen JT,Kümmerer BM,Reyes-Sandoval A

更新日期：2019-04-03 00:00:00

abstract：:: African swine fever is a devastating hemorrhagic infectious disease, which affects domestic and wild swines (Susscrofa) of all breeds and ages, with a high lethality of up to 90-100% in naïve animals. The causative agent, African swine fever virus (ASFV), is a large and complex double-stranded DNA arbovirus which is...

journal_title：Viruses

authors： Montaner-Tarbes S,Pujol M,Jabbar T,Hawes P,Chapman D,Portillo HD,Fraile L,Sánchez-Cordón PJ,Dixon L,Montoya M

更新日期：2019-09-20 00:00:00

abstract：:Human noroviruses (HuNoVs) are a leading cause of acute gastroenteritis worldwide. HuNoV infections lead to substantial societal and economic burdens. There are currently no licensed vaccines or therapeutics for the prevention or treatment of HuNoVs. A lack of well-characterized in vitro and in vivo infection models h...

journal_title：Viruses

authors： Todd KV,Tripp RA

更新日期：2019-02-12 00:00:00

abstract：:Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A (H1N1) viruses in m...

journal_title：Viruses

authors： Warfield KL,Barnard DL,Enterlein SG,Smee DF,Khaliq M,Sampath A,Callahan MV,Ramstedt U,Day CW

更新日期：2016-03-07 00:00:00

abstract：:Herpesviridae comprise a large family of enveloped DNA viruses all of whom employ orthologs of the same three glycoproteins, gB, gH and gL. Additionally, herpesviruses often employ accessory proteins to bind receptors and/or bind the heterodimer gH/gL or even to determine cell tropism. Sorting out how these proteins f...

journal_title：Viruses

authors： Eisenberg RJ,Atanasiu D,Cairns TM,Gallagher JR,Krummenacher C,Cohen GH

更新日期：2012-05-01 00:00:00

abstract：:Several human monoclonal antibodies (hmAbs) and antibody fragments, including the best characterized in terms of structure-function b12 and Fab X5, exhibit relatively potent and broad HIV-1 neutralizing activity. However, the elicitation of b12 or b12-like antibodies in vivo by vaccine immunogens based on the HIV-1 en...

journal_title：Viruses

authors： Xiao X,Chen W,Feng Y,Dimitrov DS

更新日期：2009-12-01 00:00:00

abstract：:Vaccination is the most effective means to prevent influenza virus infection, although current approaches are associated with suboptimal efficacy. Here, we generated virus-like particles (VLPs) composed of the hemagglutinin (HA), neuraminidase (NA) and matrix protein (M1) of A/Changchun/01/2009 (H1N1) with or without ...

journal_title：Viruses

authors： Ji X,Ren Z,Xu N,Meng L,Yu Z,Feng N,Sang X,Li S,Li Y,Wang T,Zhao Y,Wang H,Zheng X,Jin H,Li N,Yang S,Cao J,Liu W,Gao Y,Xia X

更新日期：2016-04-21 00:00:00

abstract：:The DNA damage response (DDR) is a complex signalling network activated when DNA is altered by intrinsic or extrinsic agents. DDR plays important roles in genome stability and cell cycle regulation, as well as in tumour transformation. Viruses have evolved successful life cycle strategies in order to ensure a chronic ...

journal_title：Viruses

authors： Bordignon V,Di Domenico EG,Trento E,D'Agosto G,Cavallo I,Pontone M,Pimpinelli F,Mariani L,Ensoli F

更新日期：2017-12-19 00:00:00

abstract：:HIV-1 is a global health crisis that has infected more than 37 million people. Latent reservoirs throughout the body are a major hurdle when it comes to eradicating the virus. In our previous study, we found that exosomes, a type of extracellular vesicle (EV), from uninfected cells activate the transcription of HIV-1 ...

journal_title：Viruses

authors： Barclay RA,Mensah GA,Cowen M,DeMarino C,Kim Y,Pinto DO,Erickson J,Kashanchi F

更新日期：2020-06-19 00:00:00

abstract：:The bacteriophage lambda replication initiation protein P exhibits a toxic effect on its Escherichia coli (E. coli) host, likely due to the formation of a dead-end P-DnaB complex, sequestering the replicative DnaB helicase from further activity. Intracellular expression of P triggers SOS-independent cellular filamenta...

journal_title：Viruses

authors： Hayes S,Wang W,Rajamanickam K,Chu A,Banerjee A,Hayes C

更新日期：2016-06-22 00:00:00

abstract：:In rabies diagnosis, it is essential to count on a rapid test to give a quick response. The combined sensitivity and robustness of the TaqMan RT-PCR assays (qRT-PCR) have made these methods a valuable alternative for rabies virus (RABV) detection. We conducted a study to compare the applicability of two widely used qR...

journal_title：Viruses

authors： Caraballo DA,Lombardo MA,Becker P,Sabio MS,Lema C,Martínez LM,Beltrán FJ,Li Y,Cisterna DM

更新日期：2020-12-25 00:00:00

abstract：:The phenotype of HTLV-1-transformed CD4(+) T lymphocytes largely depends on defined viral effector molecules such as the viral oncoprotein Tax. In this review, we exemplify the expression pattern of characteristic lineage markers, costimulatory receptors and ligands of the tumor necrosis factor superfamily, cytokine r...

journal_title：Viruses

authors： Kress AK,Grassmann R,Fleckenstein B

更新日期：2011-08-01 00:00:00

abstract：:The mosquito antiviral response has mainly been studied in the context of arthropod-borne virus (arbovirus) infection in female mosquitoes. However, in nature, both female and male mosquitoes are frequently infected with insect-specific viruses (ISVs). ISVs are capable of infecting the reproductive organs of both sexe...

journal_title：Viruses

authors： Frangeul L,Blanc H,Saleh MC,Suzuki Y

更新日期：2020-04-21 00:00:00

abstract：:The degree of antigenic drift in swine influenza A viruses (swIAV) has historically been regarded as minimal compared to that of human influenza A virus strains. However, as surveillance activities on swIAV have increased, more isolates have been characterized, revealing a high level of genetic and antigenic differenc...

journal_title：Viruses

authors： Ryt-Hansen P,Pedersen AG,Larsen I,Kristensen CS,Krog JS,Wacheck S,Larsen LE

更新日期：2020-02-23 00:00:00

abstract：:The South African national treatment programme includes nucleoside reverse transcriptase inhibitors (NRTIs) in both first and second line highly active antiretroviral therapy regimens. Mutations in the RNase H domain have been associated with resistance to NRTIs but primarily in HIV-1 subtype B studies. Here, we inves...

journal_title：Viruses

authors： Ngcapu S,Theys K,Libin P,Marconi VC,Sunpath H,Ndung'u T,Gordon ML

更新日期：2017-11-08 00:00:00

abstract：:The Pneumoviridae family includes human metapneumovirus (HMPV) and human orthopneumovirus, which is also known as a respiratory syncytial virus (HRSV). These are large enveloped, negative single-strand RNA viruses. HMPV and HRSV are the human members, which commonly infect children. HMPV, which was discovered in 2001,...

journal_title：Viruses

authors： Diab M,Schmiedel D,Seidel E,Bacharach E,Mandelboim O

更新日期：2020-07-20 00:00:00

abstract：:Despite tremendous efforts over the course of many years, the quest for an effective HIV vaccine by the classical method of active immunization remains largely elusive. However, two recent studies in mice and macaques have now demonstrated a new strategy designated as Vectored ImmunoProphylaxis (VIP), which involves p...

journal_title：Viruses

authors： Yang L,Wang P

更新日期：2014-01-27 00:00:00

abstract：:The management of chronic hepatitis B virus (CHB) infection is an area of massive unmet clinical need worldwide. In spite of the development of powerful nucleoside/nucleotide analogue (NUC) drugs, and the widespread use of immune stimulators such as interferon-alpha (IFNα) or PEGylated interferon-alpha (PEG-IFNα), sub...

journal_title：Viruses

authors： Duraisamy GS,Bhosale D,Lipenská I,Huvarova I,Růžek D,Windisch MP,Miller AD

更新日期：2020-09-07 00:00:00

abstract：:Viruses were recognized as the causative agents of fish diseases, such as infectious pancreatic necrosis and Oregon sockeye disease, in the early 1960s [1], and have since been shown to be responsible for diseases in all marine life from bacteria to protists, mollusks, crustaceans, fish and mammals [2].[...]. ...

journal_title：Viruses

authors： Middelboe M,Brussaard CPD

更新日期：2017-10-18 00:00:00

abstract：:Human coronaviruses (HCoVs) cause mild to severe respiratory diseases. Six types of HCoVs have been discovered, the most recent one termed the Middle East respiratory syndrome coronavirus (MERS-CoV). The aim of this study is to monitor the circulation of HCoV types in the population during 2015⁻2016 in Israel. HCoVs w...

journal_title：Viruses

authors： Friedman N,Alter H,Hindiyeh M,Mendelson E,Shemer Avni Y,Mandelboim M

更新日期：2018-09-21 00:00:00

abstract：:In the original manuscript, the text in figure 1 is illegible. Furthermore, there is an unnecessary carriage return (page 1716, ~line 18) "crystallographic ... methods". ...

journal_title：Viruses

authors： Mwimanzi P,Markle TJ,Ueno T,Brockman MA

更新日期：2012-10-05 00:00:00

abstract：:Pestiviruses, which include economically important animal pathogens such as bovine viral diarrhea virus and classical swine fever virus, possess three envelope glycoproteins, namely Erns, E1, and E2. This article discusses the structures and functions of these glycoproteins and their effects on viral pathogenicity in ...

journal_title：Viruses

authors： Wang FI,Deng MC,Huang YL,Chang CY

更新日期：2015-06-29 00:00:00

abstract：:Sequence-independent amplification techniques have become important tools for virus discovery, metagenomics, and exploration of viral diversity at the global scale, especially in remote areas. Here, we describe the detection and genetic characterization of a novel gyrovirus, named GyV11, present in cloacal, oral, and ...

journal_title：Viruses

authors： Truchado DA,Diaz-Piqueras JM,Gomez-Lucia E,Doménech A,Milá B,Pérez-Tris J,Schmidt-Chanasit J,Cadar D,Benítez L

更新日期：2019-12-11 00:00:00

abstract：:With the inclusion of new members, understanding about evolutionary mechanisms and processes by which members of the proposed order, Megavirales, have evolved has become a key area of interest. The central role of gene acquisition has been shown in previous studies. However, the major drawback in gene acquisition stud...

journal_title：Viruses

authors： Jain S,Panda A,Colson P,Raoult D,Pontarotti P

更新日期：2017-04-07 00:00:00