Cell surface markers in HTLV-1 pathogenesis.


:The phenotype of HTLV-1-transformed CD4(+) T lymphocytes largely depends on defined viral effector molecules such as the viral oncoprotein Tax. In this review, we exemplify the expression pattern of characteristic lineage markers, costimulatory receptors and ligands of the tumor necrosis factor superfamily, cytokine receptors, and adhesion molecules on HTLV-1-transformed cells. These molecules may provide survival signals for the transformed cells. Expression of characteristic surface markers might therefore contribute to persistence of HTLV-1-transformed lymphocytes and to the development of HTLV-1-associated disease.






Kress AK,Grassmann R,Fleckenstein B




Has Abstract


2011-08-01 00:00:00












  • Antigenic Change in Human Influenza A(H2N2) Viruses Detected by Using Human Plasma from Aged and Younger Adult Individuals.

    abstract::Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using ferret antisera or mouse and human monoclonal antibodies. Here, we examined the antigenicity of human H2N2 viruses by using human plasma samples obtained from 50...


    pub_type: 杂志文章


    authors: Matsuzawa Y,Iwatsuki-Horimoto K,Nishimoto Y,Abe Y,Fukuyama S,Hamabata T,Okuda M,Go Y,Watanabe T,Imai M,Arai Y,Fouchier RAM,Yamayoshi S,Kawaoka Y

    更新日期:2019-10-23 00:00:00

  • Human leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from natural sequence variants?

    abstract::HIV-1 causes a chronic infection in humans that is characterized by high plasma viremia, progressive loss of CD4+ T lymphocytes, and severe immunodeficiency resulting in opportunistic disease and AIDS. Viral persistence is mediated in part by the ability of the Nef protein to down-regulate HLA molecules on the infecte...


    pub_type: 杂志文章,评审


    authors: Mwimanzi P,Markle TJ,Ueno T,Brockman MA

    更新日期:2012-09-01 00:00:00

  • Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques.

    abstract::Despite worldwide efforts to understand the transmission dynamics of Zika virus (ZIKV), scanty evaluation has been made on the vector competence of Aedes aegypti fed directly on viremic human and non-human primates (NHPs). We blood-fed Ae. aegypti from two districts in Rio de Janeiro on six ZIKV infected pregnant rhes...


    pub_type: 杂志文章


    authors: Fernandes RS,David MR,De Abreu FVS,Ferreira-de-Brito A,Gardinali NR,Lima SMB,Andrade MCR,Kugelmeier T,Oliveira JM,Pinto MA,Lourenço-de-Oliveira R

    更新日期:2020-11-24 00:00:00

  • Integrase-Defective Lentiviral Vectors for Delivery of Monoclonal Antibodies against Influenza.

    abstract::Delivering rapid protection against infectious agents to non-immune populations is a formidable public health challenge. Although passive immunotherapy is a fast and effective method of protection, large-scale production and administration of monoclonal antibodies (mAbs) is expensive and unpractical. Viral vector-medi...


    pub_type: 杂志文章


    authors: Michelini Z,Minkoff JM,Yang J,Negri D,Cara A,Hanson BJ,Salvatore M

    更新日期:2020-12-17 00:00:00

  • Ageratum enation virus-a begomovirus of weeds with the potential to infect crops.

    abstract::Samples of two Ageratum conyzoides, one Sonchus oleraceus and one turnip (Brassica rapa var. rapa) exhibiting virus-like symptoms were collected from Pakistan and Nepal. Full-length begomovirus clones were obtained from the four plant samples and betasatellite clones from three of these. The begomovirus sequences were...


    pub_type: 杂志文章


    authors: Tahir M,Amin I,Haider MS,Mansoor S,Briddon RW

    更新日期:2015-02-10 00:00:00

  • A hypothesis for bacteriophage DNA packaging motors.

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    pub_type: 杂志文章


    authors: Serwer P

    更新日期:2010-09-01 00:00:00

  • Development of Antibodies with Broad Neutralization Specificities against HIV-1 after Long Term SHIV Infection in Macaques.

    abstract::Non-human primates (NHP) are the only animal model suitable to evaluate the protection efficacy of HIV-1 vaccines. It is important to understand how and when neutralizing antibodies (nAbs) with specificities similar to those of human broadly neutralizing antibodies (bnAbs) develop in NHPs. To address these questions, ...


    pub_type: 杂志文章


    authors: Gao N,Gai Y,Meng L,Wang C,Zhang X,Wang W,Qin C,Yu X,Gao F

    更新日期:2020-01-31 00:00:00

  • Emaravirus: a novel genus of multipartite, negative strand RNA plant viruses.

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    pub_type: 杂志文章,评审


    authors: Mielke-Ehret N,Mühlbach HP

    更新日期:2012-09-01 00:00:00

  • Enteric Viral Co-Infections: Pathogenesis and Perspective.

    abstract::Enteric viral co-infections, infections involving more than one virus, have been reported for a diverse group of etiological agents, including rotavirus, norovirus, astrovirus, adenovirus, and enteroviruses. These pathogens are causative agents for acute gastroenteritis and diarrheal disease in immunocompetent and imm...


    pub_type: 杂志文章,评审


    authors: Makimaa H,Ingle H,Baldridge MT

    更新日期:2020-08-18 00:00:00

  • Protoparvovirus Interactions with the Cellular DNA Damage Response.

    abstract::Protoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic ...


    pub_type: 杂志文章,评审


    authors: Majumder K,Etingov I,Pintel DJ

    更新日期:2017-10-31 00:00:00

  • Interplay between the Hepatitis B Virus and Innate Immunity: From an Understanding to the Development of Therapeutic Concepts.

    abstract::The hepatitis B virus (HBV) infects hepatocytes, which are the main cell type composing a human liver. However, the liver is enriched with immune cells, particularly innate cells (e.g., myeloid cells, natural killer and natural killer T-cells (NK/NKT), dendritic cells (DCs)), in resting condition. Hence, the study of ...


    pub_type: 杂志文章,评审


    authors: Faure-Dupuy S,Lucifora J,Durantel D

    更新日期:2017-04-28 00:00:00

  • Gammaherpesviral Tegument Proteins, PML-Nuclear Bodies and the Ubiquitin-Proteasome System.

    abstract::Gammaherpesviruses like Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) subvert the ubiquitin proteasome system for their own benefit in order to facilitate viral gene expression and replication. In particular, viral tegument proteins that share sequence homology to the formylglycineamide r...


    pub_type: 杂志文章,评审


    authors: Full F,Hahn AS,Großkopf AK,Ensser A

    更新日期:2017-10-21 00:00:00

  • Artificial Intelligence-Assisted Loop Mediated Isothermal Amplification (AI-LAMP) for Rapid Detection of SARS-CoV-2.

    abstract::Until vaccines and effective therapeutics become available, the practical solution to transit safely out of the current coronavirus disease 19 (CoVID-19) lockdown may include the implementation of an effective testing, tracing and tracking system. However, this requires a reliable and clinically validated diagnostic p...


    pub_type: 杂志文章


    authors: Rohaim MA,Clayton E,Sahin I,Vilela J,Khalifa ME,Al-Natour MQ,Bayoumi M,Poirier AC,Branavan M,Tharmakulasingam M,Chaudhry NS,Sodi R,Brown A,Burkhart P,Hacking W,Botham J,Boyce J,Wilkinson H,Williams C,Whittingham-Dow

    更新日期:2020-09-01 00:00:00

  • Synthesis and Translation of Viral mRNA in Reovirus-Infected Cells: Progress and Remaining Questions.

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    pub_type: 杂志文章,评审


    authors: Lemay G

    更新日期:2018-11-27 00:00:00

  • Role of Herpes Simplex Envelope Glycoprotein B and Toll-Like Receptor 2 in Ocular Inflammation: An ex vivo Organotypic Rabbit Corneal Model.

    abstract::It has been recently reported, using in vitro studies, that the herpes simplex virus 1 (HSV-1) encoded envelope glycoprotein B (gB1) interacts with cell surface toll-like receptor 2 (TLR2) and induces the secretion of interleukin-8 (IL8), a representative marker of inflammatory cytokine activation. The purpose of this...


    pub_type: 杂志文章


    authors: Marino A,Pergolizzi S,Cimino F,Lauriano ER,Speciale A,D'Angelo V,Sicurella M,Argnani R,Manservigi R,Marconi P

    更新日期:2019-09-04 00:00:00

  • Herpesviruses placating the unwilling host: manipulation of the MHC class II antigen presentation pathway.

    abstract::Lifelong persistent infection by herpesviruses depends on the balance between host immune responses and viral immune evasion. CD4 T cells responding to antigens presented on major histocompatibility complex class II (MHC-II) molecules are known to play an important role in controlling herpesvirus infections. Here we r...


    pub_type: 杂志文章,评审


    authors: Zuo J,Rowe M

    更新日期:2012-08-01 00:00:00

  • Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease.

    abstract::Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholesterolemia. Furthermore,...


    pub_type: 杂志文章,评审


    authors: Felmlee DJ,Hafirassou ML,Lefevre M,Baumert TF,Schuster C

    更新日期:2013-05-23 00:00:00

  • Interaction of a Densovirus with Glycans of the Peritrophic Matrix Mediates Oral Infection of the Lepidopteran Pest Spodoptera frugiperda.

    abstract::The success of oral infection by viruses depends on their capacity to overcome the gut epithelial barrier of their host to crossing over apical, mucous extracellular matrices. As orally transmitted viruses, densoviruses, are also challenged by the complexity of the insect gut barriers, more specifically by the chitino...


    pub_type: 杂志文章


    authors: Pigeyre L,Schatz M,Ravallec M,Gasmi L,Nègre N,Clouet C,Seveno M,El Koulali K,Decourcelle M,Guerardel Y,Cot D,Dupressoir T,Gosselin-Grenet AS,Ogliastro M

    更新日期:2019-09-17 00:00:00

  • Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs.

    abstract::Finding a cure for HIV is challenging because the virus is able to integrate itself into the host cell genome and establish a silent state, called latency, allowing it to evade antiviral drugs and the immune system. Various "shock and kill" strategies are being explored in attempts to eliminate latent HIV reservoirs. ...


    pub_type: 杂志文章,评审


    authors: Kuang XT,Brockman MA

    更新日期:2018-11-30 00:00:00

  • A Quest of Great Importance-Developing a Broad Spectrum Escherichia coli Phage Collection.

    abstract::Shigella ssp. and enterotoxigenic Escherichiacoli are the most common etiological agents of diarrheal diseases in malnourished children under five years of age in developing countries. The ever-growing issue of antibiotic resistance and the potential negative impact of antibiotic use on infant commensal microbiota are...


    pub_type: 杂志文章


    authors: Kaczorowska J,Casey E,Neve H,Franz CMAP,Noben JP,Lugli GA,Ventura M,Sinderen DV,Mahony J

    更新日期:2019-09-26 00:00:00

  • Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects.

    abstract::Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of HTLV-associated disease and viral dynamics. A subset of 45 human T-...


    pub_type: 杂志文章


    authors: Usadi B,Bruhn R,Lin J,Lee TH,Blackburn E,Murphy EL

    更新日期:2016-08-11 00:00:00

  • Genetic Susceptibility to Human Norovirus Infection: An Update.

    abstract::Noroviruses are the most common etiological agent of acute gastroenteritis worldwide. Despite their high infectivity, a subpopulation of individuals is resistant to infection and disease. This susceptibility is norovirus genotype-dependent and is largely mediated by the presence or absence of human histo-blood group a...


    pub_type: 杂志文章,评审


    authors: Nordgren J,Svensson L

    更新日期:2019-03-06 00:00:00

  • Effect of type-I interferon on retroviruses.

    abstract::Type-I interferons (IFN-I) play an important role in the innate immune response to several retroviruses. They seem to be effective in controlling the in vivo infection, though many of the clinical signs of retroviral infection may be due to their continual presence which over-stimulates the immune system and activates...


    pub_type: 杂志文章


    authors: Gómez-Lucía E,Collado VM,Miró G,Doménech A

    更新日期:2009-12-01 00:00:00

  • Shedding Light on the Effect of Natural Anti-Herpesvirus Alkaloids on SARS-CoV-2: A Treatment Option for COVID-19.

    abstract::The whole world is currently facing an unseen enemy, called coronavirus disease 2019 (COVID-19), which is causing a global pandemic. This disease is caused by a novel single-stranded enveloped RNA virus, known as the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Although huge efforts are being made to ...


    pub_type: 社论


    authors: Hassan STS

    更新日期:2020-04-23 00:00:00

  • Experimental Infection of Pregnant Female Sheep with Zika Virus During Early Gestation.

    abstract::Zika virus (ZIKV) is a vertically and sexually transmissible virus resulting in severe congenital malformation. The goal of this study was to develop an ovine model of ZIKV infection. Between 28-35 days gestation (DG), four pregnant animals were infected with two doses of 6 × 106 PFU of ZIKV; four control animals rece...


    pub_type: 杂志文章


    authors: Schwarz ER,Pozor MA,Pu R,Barr KL,Beachboard SE,MacLachlan NJ,Prakoso D,Long MT

    更新日期:2019-08-29 00:00:00

  • Oligopeptide m13 phage display in pathogen research.

    abstract::Phage display has become an established, widely used method for selection of peptides, antibodies or alternative scaffolds. The use of phage display for the selection of antigens from genomic or cDNA libraries of pathogens which is an alternative to the classical way of identifying immunogenic proteins is not well-kno...


    pub_type: 杂志文章,评审


    authors: Kügler J,Zantow J,Meyer T,Hust M

    更新日期:2013-10-16 00:00:00

  • Evaluation of the operator protection factors offered by positive pressure air suits against airborne microbiological challenge.

    abstract::Laboratories throughout the world that perform work with Risk Group 4 Pathogens generally adopt one of two approaches within BSL-4 environments: either the use of positive pressure air-fed suits or using Class III microbiological safety cabinets and isolators for animal work. Within the UK at present, all laboratories...


    pub_type: 杂志文章


    authors: Steward JA,Lever MS

    更新日期:2012-08-01 00:00:00

  • Origin and Spread of the Dengue Virus Type 1, Genotype V in Senegal, 2015-2019.

    abstract::Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades. Dengue is caused by genetically distinct serotypes, DENV-1-4. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and M...


    pub_type: 杂志文章


    authors: Dieng I,Cunha M,Diagne MM,Sembène PM,Zanotto PMA,Faye O,Faye O,Sall AA

    更新日期:2021-01-04 00:00:00

  • "FastCheckFLI PPR-like"-A Molecular Tool for the Fast Genome Detection of PPRV and Differential Diagnostic Pathogens.

    abstract::To assist the global eradication of peste des petits ruminants virus (PPRV), a molecular test for the rapid and reliable detection of PPRV was developed which additionally enables the detection of pathogens relevant for differential diagnostics. For this purpose, the necessary time frame of a magnetic bead-based nucle...


    pub_type: 杂志文章


    authors: Halecker S,Mettenleiter TC,Beer M,Hoffmann B

    更新日期:2020-10-29 00:00:00

  • The role of interferon antagonist, non-structural proteins in the pathogenesis and emergence of arboviruses.

    abstract::A myriad of factors favor the emergence and re-emergence of arthropod-borne viruses (arboviruses), including migration, climate change, intensified livestock production, an increasing volume of international trade and transportation, and changes to ecosystems (e.g., deforestation and loss of biodiversity). Consequentl...


    pub_type: 杂志文章,评审


    authors: Hollidge BS,Weiss SR,Soldan SS

    更新日期:2011-06-01 00:00:00