Cell surface markers in HTLV-1 pathogenesis.

Abstract:

:The phenotype of HTLV-1-transformed CD4(+) T lymphocytes largely depends on defined viral effector molecules such as the viral oncoprotein Tax. In this review, we exemplify the expression pattern of characteristic lineage markers, costimulatory receptors and ligands of the tumor necrosis factor superfamily, cytokine receptors, and adhesion molecules on HTLV-1-transformed cells. These molecules may provide survival signals for the transformed cells. Expression of characteristic surface markers might therefore contribute to persistence of HTLV-1-transformed lymphocytes and to the development of HTLV-1-associated disease.

journal_name

Viruses

journal_title

Viruses

authors

Kress AK,Grassmann R,Fleckenstein B

doi

10.3390/v3081439

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

1439-59

issue

8

issn

1999-4915

pii

v3081439

journal_volume

3

pub_type

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