Abstract：
:The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This review focuses on different aspects of the adaptive immune responses as determinants of the different outcomes of HCV infection, clearance or persistent infection, and outlines current concepts of HCV evasion strategies. Unravelling these important mechanisms of virus-host interaction will contribute to the development of novel strategies to prevent and control HCV infection.
journal_name
Virusesjournal_title
Virusesauthors
Zeisel MB,Fafi-Kremer S,Robinet E,Habersetzer F,Baumert TF,Stoll-Keller Fdoi
10.3390/v1020276subject
Has Abstractpub_date
2009-09-01 00:00:00pages
276-97issue
2issn
1999-4915pii
v1020276journal_volume
1pub_type
杂志文章相关文献
Viruses-Basel文献大全abstract：:Progression of HIV infection is variable among individuals, and definition disease progression biomarkers is still needed. Here, we aimed to categorize the predictive potential of several variables using feature selection methods and decision trees. A total of seventy-five treatment-naïve subjects were enrolled during...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10010034
更新日期：2018-01-13 00:00:00
abstract：:Cellular receptor-mediated signaling pathways play critical roles during the initial immune response to Human Cytomegalovirus (HCMV) infection. However, the involvement of type-I transmembrane glycoprotein CD147/EMMPRIN (extracellular matrix metalloproteinase inducer) in the antiviral response to HCMV infection is sti...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v9120365
更新日期：2017-12-01 00:00:00
abstract：:Bats are unique mammals, exhibit distinctive life history traits and have unique immunological approaches to suppression of viral diseases upon infection. High-throughput next-generation sequencing has been used in characterizing the virome of different bat species. The cave nectar bat, Eonycteris spelaea, has a broad...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11030250
更新日期：2019-03-12 00:00:00
abstract：:Unlike other human herpesviruses, human herpesvirus 6A and 6B (HHV-6A/B) infection can lead to integration of the viral genome in human chromosomes. When integration occurs in germinal cells, the integrated HHV-6A/B genome can be transmitted to 50% of descendants. Such individuals, carrying one copy of the HHV-6A/B ge...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v9070160
更新日期：2017-06-26 00:00:00
abstract：:Protoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic ...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v9110323
更新日期：2017-10-31 00:00:00
abstract：:Human respiratory syncytial virus (HRSV) is a major cause of pediatric infection and also causes disease in the elderly and those with underlying respiratory problems. There is no vaccine for HRSV and anti-viral therapeutics are not broadly applicable. To investigate the effect of HRSV biology in children, nasopharyng...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11100926
更新日期：2019-10-10 00:00:00
abstract：:Different developmental stages of Artemia spp. (metanauplii, juveniles and adults) were bath-challenged with two isolates of the Lymphocystis disease virus (LCDV), namely, LCDV SA25 (belonging to the species Lymphocystis disease virus 3) and ATCC VR-342 (an unclassified member of the genus Lymphocystivirus). Viral qua...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11060506
更新日期：2019-06-01 00:00:00
abstract：:African swine fever (ASF) has become the major threat for the global swine industry. Furthermore, the epidemiological situation of African swine fever virus (ASFV) in some endemic regions of Sub-Saharan Africa is worse than ever, with multiple virus strains and genotypes currently circulating in a given area. Despite ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12121474
更新日期：2020-12-21 00:00:00
abstract：:P4 is a mobile genetic element (MGE) that can exist as a plasmid or integrated into its Escherichia coli host genome, but becomes packaged into phage particles by a helper bacteriophage, such as P2. P4 is the original example of what we have termed "molecular piracy", the process by which one MGE usurps the life cycle...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12090953
更新日期：2020-08-27 00:00:00
abstract：:Bacteriophage (phage) therapy is a promising alternative to antibiotics for the treatment of bacterial pathogens, including Clostridiumdifficile. However, as for many species, in C. difficile the physical interactions between phages and bacterial cells have not been studied in detail. The initial interaction, known as...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10080411
更新日期：2018-08-06 00:00:00
abstract：:Measles virus (MeV) is a paramyxovirus that infects humans, principally children. Despite the existence of an effective and safe vaccine, the number of cases of measles has increased due to lack of vaccination coverage. The World Health Organization (WHO) reports that the number of cases worldwide multiplied fourfold ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11121111
更新日期：2019-11-30 00:00:00
abstract：:A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells by direct cellular contacts across a specialized structure, the virological synapse. This process was recently described through live cell imaging. Together with the accumulated knowledge on cellular and molecular structures involved ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v2081666
更新日期：2010-08-01 00:00:00
abstract：:Exosomes are membrane-enclosed vesicles actively released into the extracellular space, whose content reflect the physiological/pathological state of the cells they originate from. These vesicles participate in cell-to-cell communication and transfer of biologically active proteins, lipids, and RNAs. Their role in vir...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v7062770
更新日期：2015-06-19 00:00:00
abstract：:A number of characteristics including lack of virulence and the ability to grow to high titers, have made bovine adenovirus-3 (BAdV-3) a vector of choice for further development as a vaccine-delivery vehicle for cattle. Despite the importance of blood leukocytes, including dendritic cells (DC), in the induction of pro...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12121431
更新日期：2020-12-12 00:00:00
abstract：:Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of HTLV-associated disease and viral dynamics. A subset of 45 human T-...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v8080221
更新日期：2016-08-11 00:00:00
abstract：:The Middle East respiratory syndrome coronavirus (MERS-CoV) was first isolated in 2012, and circulated worldwide with high mortality. The continual outbreaks of MERS-CoV highlight the importance of developing antiviral therapeutics. Here, we rationally designed a novel fusion inhibitor named MERS-five-helix bundle (ME...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v9090255
更新日期：2017-09-14 00:00:00
abstract：:The successful control of HBV infection requires an efficient expansion of distinct elements of the adaptive immune system (B cells, helper and cytotoxic T cells) that, due to the hepatotropic nature of HBV, need to operate in the liver parenchyma. In this respect, we will discuss broad features of HBV immunity in pat...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v1020091
更新日期：2009-09-01 00:00:00
abstract：:Duck Tembusu virus (DTMUV) is a recently emerging pathogenic flavivirus that has resulted in a huge economic loss in the duck industry. However, no vaccine is currently available to control this pathogen. Consequently, a practical strategy to construct a vaccine against this pathogen should be determined. In this stud...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v6062428
更新日期：2014-06-20 00:00:00
abstract：:Crimean-Congo hemorrhagic fever virus is one the most important and wide spread tick-borne viruses. Very little is known about the transmission from the tick and the early aspects of pathogenesis. Here, we generate human cutaneous antigen presenting cells-dermal dendritic cells and Langerhans cells-from umbilical cord...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10070381
更新日期：2018-07-20 00:00:00
abstract：:Infectious bursal disease (IBD) is an immunosuppressive, highly contagious, and lethal disease of young chickens caused by IBD virus (IBDV). It results in huge economic loss to the poultry industry worldwide. Infection caused by very virulent IBDV (vvIBDV) strains results in high mortality in young chicken flocks. How...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12020249
更新日期：2020-02-23 00:00:00
abstract：:We previously hypothesized that increased capillary permeability observed in both hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS) may be caused by hantavirus-specific cytotoxic T cells attacking endothelial cells presenting viral antigens on their surface based on clinical o...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v3071059
更新日期：2011-07-01 00:00:00
abstract：:Bovine rotavirus A (RVA), a major causative pathogen of diarrhea in dairy and Japanese beef calves, has led to severe economic losses in numerous countries. A dual genotyping system based on genomic segments encoding VP7 (G genotype) and VP4 (P genotype), comprising the outer layer of the virion, has been used to unde...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12121386
更新日期：2020-12-03 00:00:00
abstract：:A myriad of factors favor the emergence and re-emergence of arthropod-borne viruses (arboviruses), including migration, climate change, intensified livestock production, an increasing volume of international trade and transportation, and changes to ecosystems (e.g., deforestation and loss of biodiversity). Consequentl...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v3060629
更新日期：2011-06-01 00:00:00
abstract：:Viruses protect their genomes by enclosing them into protein capsids that sometimes contain lipid bilayers that either reside above or below the protein layer. Controlled dissociation of virions provides important information on virion composition, interactions, and stoichiometry of virion components, as well as their...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10110579
更新日期：2018-10-23 00:00:00
abstract：:Peptide-displayed phage libraries are billion-clone collections of diverse chimeric bacteriophage particles, decorated by genetically fused peptides built from a random combination of natural amino acids. Studying the molecular evolution of peptide-displayed libraries in mammalian model systems, using in vivo phage di...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11110988
更新日期：2019-10-26 00:00:00
abstract：:The M112-113 gene is the first early gene of the murine cytomegalovirus (MCMV), and its expression is activated by the immediate-early 3 (IE3) protein during MCMV infection in permissive cells. At its 5' terminus, a 10-bp motif, upstream of the TATA box of the M112-113 gene, was identified to bind to IE3, and it is ne...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12090954
更新日期：2020-08-28 00:00:00
abstract：:Phage lytic enzymes are enzymes produced by bacterial viruses, either as part of their virion to facilitate bacterial infection through local peptidoglycan degradation, or as soluble proteins to induce massive cell lysis at the end of the lytic replication cycle [...]. ...
journal_title：Viruses
pub_type： 社论
doi：10.3390/v11020113
更新日期：2019-01-29 00:00:00
abstract：:Lactococcus lactis is one of the most important bacteria in dairy fermentations, being used in the production of cheese and buttermilk. The processes are vulnerable to phage attacks, and undefined mixtures of lactococcal strains are often used to reduce the risk of bacteriophage caused fermentation failure. Other prev...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11050443
更新日期：2019-05-16 00:00:00
abstract：:Endemic to West Africa and South America, mammalian arenaviruses can cross the species barrier from their natural rodent hosts to humans, resulting in illnesses ranging from mild flu-like syndromes to severe and fatal haemorrhagic zoonoses. The increased frequency of outbreaks and associated high fatality rates of the...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12070784
更新日期：2020-07-21 00:00:00
abstract：:African swine fever is a highly lethal hemorrhagic fever of Suidae, threatening pig production globally. Suidae can be infected by different ways like ingestion of contaminated feed, direct contact with infected animals or fomites, and biting by infected soft tick bites. As already described, European soft ticks (Orni...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12030300
更新日期：2020-03-11 00:00:00
