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Protoparvovirus Interactions with the Cellular DNA Damage Response.

Abstract：

:Protoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic cell cycle block that features the inactivation of ATR-kinase mediated signaling, proteasome-targeted degradation of p21, and inhibition of cyclin B1 expression. This review explores how protoparvoviruses, and specifically MVM, co-opt the common mechanisms regulating the DDR and cell cycle progression in order to prepare the host nuclear environment for productive infection.

journal_name

Viruses

journal_title

Viruses

authors

Majumder K,Etingov I,Pintel DJ

doi

10.3390/v9110323

subject

Has Abstract

pub_date

2017-10-31 00:00:00

issue

11

issn

1999-4915

pii

v9110323

journal_volume

9

pub_type

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