Purinergic Receptors: Elucidating the Role of these Immune Mediators in HIV-1 Fusion.

abstract：:Fruit trees, such as apricot trees, are constantly exposed to the attack of viruses. As they are propagated in a vegetative way, this risk is present not only in the field, where they remain for decades, but also during their propagation. Metagenomic diagnostic methods, based on next generation sequencing (NGS), offer...

journal_title：Viruses

authors： Baráth D,Jaksa-Czotter N,Molnár J,Varga T,Balássy J,Szabó LK,Kirilla Z,Tusnády GE,Preininger É,Várallyay É

更新日期：2018-06-11 00:00:00

abstract：:RNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade. Tissue distribution reveals that RNase L is highly expressed in t...

journal_title：Viruses

authors： Wei R,Chen G,Algehainy N,Zeng C,Liu C,Liu H,Liu W,Stacey D,Zhou A

更新日期：2020-01-07 00:00:00

abstract：:MicroRNAs (miRNAs) are non-coding but functional RNA molecules of 21-25 nucleotides in length. MiRNAs play significant regulatory roles in diverse plant biological processes. In order to decipher the relationship between nbe-miR1919c-5p and the accumulations of tobacco curly shoot virus (TbCSV) and its betasatellite (...

journal_title：Viruses

authors： Du J,Wu R,Liu Z,Sun M,Ghanem H,Li M,Wu G,Qing L

更新日期：2020-04-01 00:00:00

abstract：:Bovine lactoferrin (bLf) is an iron-binding glycoprotein folded in two symmetric globular lobes (N- and C-lobes) with potent antimicrobial and immunomodulatory activities. Recently, we have shown that bLf, and in particular its C-lobe, interacts with influenza A virus hemagglutinin and prevents infection by different ...

journal_title：Viruses

authors： Superti F,Agamennone M,Pietrantoni A,Ammendolia MG

更新日期：2019-01-11 00:00:00

abstract：:West Nile virus (WNV) is a member of the genus Flavivirus in the family Flaviviridae. Flaviviruses replicate in the cytoplasm of infected cells and modify the host cell environment. Although much has been learned about virion structure and virion-endosomal membrane fusion, the cell receptor(s) used have not been defin...

journal_title：Viruses

authors： Brinton MA

更新日期：2013-12-27 00:00:00

abstract：:Over the past 15 years we have been investigating an alternative approach to treating HIV-1/AIDS, based on the creation of a disease-resistant immune system through transplantation of autologous, gene-modified (HIV-1-resistant) hematopoietic stem and progenitor cells (GM-HSPC). We propose that the expression of select...

journal_title：Viruses

authors： DiGiusto DL,Stan R,Krishnan A,Li H,Rossi JJ,Zaia JA

更新日期：2013-11-22 00:00:00

abstract：:Kaposi's sarcoma associated-herpesvirus (KSHV, also known as human herpesvirus-8) is a gammaherpesvirus that establishes life-long infection in human B lymphocytes. KSHV infection is typically asymptomatic, but immunosuppression can predispose KSHV-infected individuals to primary effusion lymphoma (PEL); a malignancy ...

journal_title：Viruses

authors： Pringle ES,Wertman J,Melong N,Coombs AJ,Young AL,O'Leary D,Veinotte C,Robinson CA,Ha MN,Dellaire G,Druley TE,McCormick C,Berman JN

更新日期：2019-12-20 00:00:00

abstract：:Usutu virus (USUV) is a neurotropic flavivirus closely related to West Nile virus (WNV). Its enzootic cycle mainly involves mosquitoes and birds. Human infection can occur with occasional, but sometimes severe, neurological complications. Since its emergence and spread in Europe over the last two decades, USUV has bee...

journal_title：Viruses

authors： Benzarti E,Rivas J,Sarlet M,Franssen M,Desmecht D,Schmidt-Chanasit J,Savini G,Lorusso A,Van Laere AS,Garigliany MM

更新日期：2020-01-31 00:00:00

abstract：:Pteropine orthoreovirus (PRV; Reoviridae: Spinareovirinae) is an emerging bat-borne zoonotic virus that causes influenza-like illness (ILI). PRV has thus far been found only in Australia and Asia, where diverse old-world fruit bats (Pteropodidae) serve as hosts. In this study, we report the discovery of PRV in Africa,...

journal_title：Viruses

authors： Bennett AJ,Goldberg TL

更新日期：2020-07-09 00:00:00

abstract：:Phylodynamic inference is a pivotal tool in understanding transmission dynamics of viral outbreaks. These analyses are strongly guided by the input of an epidemiological model as well as sequence data that must contain sufficient intersequence variability in order to be informative. These criteria, however, may not be...

journal_title：Viruses

authors： Lam A,Duchene S

更新日期：2021-01-08 00:00:00

abstract：:Zika virus (ZIKV) infection during pregnancy leads to severe congenital Zika syndrome, which includes microcephaly and other neurological malformations. No therapeutic agents have, so far, been approved for the treatment of ZIKV infection in humans; as such, there is a need for a continuous effort to develop effective...

journal_title：Viruses

authors： Gao Y,Tai W,Wang N,Li X,Jiang S,Debnath AK,Du L,Chen S

更新日期：2019-11-02 00:00:00

abstract：:It has been recently reported, using in vitro studies, that the herpes simplex virus 1 (HSV-1) encoded envelope glycoprotein B (gB1) interacts with cell surface toll-like receptor 2 (TLR2) and induces the secretion of interleukin-8 (IL8), a representative marker of inflammatory cytokine activation. The purpose of this...

journal_title：Viruses

authors： Marino A,Pergolizzi S,Cimino F,Lauriano ER,Speciale A,D'Angelo V,Sicurella M,Argnani R,Manservigi R,Marconi P

更新日期：2019-09-04 00:00:00

abstract：:Neuraminidase inhibitors (NAIs) are vital in managing seasonal and pandemic influenza infections. NAI susceptibilities of virus isolates (n = 5540) collected during the 2008-2009 influenza season were assessed in the chemiluminescent neuraminidase inhibition (NI) assay. Box-and-whisker plot analyses of log-transformed...

journal_title：Viruses

authors： Okomo-Adhiambo M,Sleeman K,Ballenger K,Nguyen HT,Mishin VP,Sheu TG,Smagala J,Li Y,Klimov AI,Gubareva LV

更新日期：2010-10-01 00:00:00

abstract：:Porcine endogenous retroviruses (PERVs) are integrated in the genome of pigs and are transmitted like cellular genes from parents to the offspring. Whereas PERV-A and PERV-B are present in all pigs, PERV-C was found to be in many, but not all pigs. When PERV-C is present, recombination with PERV-A may happen and the P...

journal_title：Viruses

authors： Krüger L,Stillfried M,Prinz C,Schröder V,Neubert LK,Denner J

更新日期：2020-04-08 00:00:00

abstract：:There is an epidemic of obesity starting about 1980 in both developed and undeveloped countries definitely associated with multiple etiologies. About 670 million people worldwide are obese. The incidence of obesity has increased in all age groups, including children. Obesity causes numerous diseases and the interactio...

journal_title：Viruses

authors： Ponterio E,Gnessi L

更新日期：2015-07-08 00:00:00

abstract：:The cell response to virus infection and virus perturbation of that response is dynamic and is reflected by changes in cell susceptibility to infection. In this study, we evaluated the response of human epithelial cells to sequential infections with human respiratory syncytial virus strains A2 and B to determine if a ...

journal_title：Viruses

authors： Simeonov I,Gong X,Kim O,Poss M,Chiaromonte F,Fricks J

更新日期：2010-12-01 00:00:00

abstract：:Dendritic cells (DCs) are involved in human and simian immunodeficiency virus (HIV and SIV) pathogenesis but also play a critical role in orchestrating innate and adaptive vaccine-specific immune responses. Effective HIV/SIV vaccines require strong antigen-specific CD4 T cell responses, cytotoxic activity of CD8 T cel...

journal_title：Viruses

authors： Ko EJ,Robert-Guroff M

更新日期：2019-12-24 00:00:00

abstract：:Lymphoma is one of the most common malignancies in domestic cats. The lymphomagenic potential of Felis catus gammaherpesvirus 1 (FcaGHV1), a common infection in domestic cats, is unknown. In other species, including humans, cellular transformation by gammaherpesviruses is typically mediated by viral genes expressed du...

journal_title：Viruses

authors： Aghazadeh M,Shi M,Pesavento PA,Durham AC,Polley T,Donahoe SL,Troyer RM,Barrs VR,Holmes EC,Beatty JA

更新日期：2018-08-30 00:00:00

abstract：:Small ruminant lentiviruses include members that infect sheep (ovine lentivirus [OvLV]; also known as ovine progressive pneumonia virus/maedi-visna virus) and goats (caprine arthritis encephalitis virus [CAEV]). Breed differences in seroprevalence and proviral concentration of OvLV had suggested a strong genetic compo...

journal_title：Viruses

authors： White SN,Knowles DP

更新日期：2013-06-14 00:00:00

abstract：:Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-ΔSH) enhanced the secretion of type I interfer...

journal_title：Viruses

authors： Bao X,Kolli D,Esham D,Velayutham TS,Casola A

更新日期：2018-05-23 00:00:00

abstract：:Tumor-targeted immunomodulation using oncolytic viral vectors is currently being investigated as a promising strategy in cancer therapy. In a previous study, we showed that a measles virus Schwarz vaccine strain (MeVac) vector encoding an interleukin-12 fusion protein (FmIL-12) is an effective immunotherapy in the MC3...

journal_title：Viruses

authors： Backhaus PS,Veinalde R,Hartmann L,Dunder JE,Jeworowski LM,Albert J,Hoyler B,Poth T,Jäger D,Ungerechts G,Engeland CE

更新日期：2019-10-03 00:00:00

abstract：:Ebola virus is the causative agent of Ebola virus disease in humans. The lethality of Ebola virus infection is about 50%, supporting the urgent need to develop anti-Ebola drugs. Glycoprotein (GP) is the only surface protein of the Ebola virus, which is functionally critical for the virus to attach and enter the host c...

journal_title：Viruses

authors： Cui Q,Cheng H,Xiong R,Zhang G,Du R,Anantpadma M,Davey RA,Rong L

更新日期：2018-11-30 00:00:00

abstract：:Porcine circovirus type 2 (PCV2) is the etiological agent of porcine circovirus diseases and porcine circovirus-associated diseases (PCVDs/PCVADs). However, the pathogenesis of PCV2 is not fully understood. We previously found that 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is negatively associated with P...

journal_title：Viruses

authors： Ouyang T,Niu G,Zhang Y,Liu X,Zhang X,Zhang S,Geng Y,Pang D,Ouyang H,Ren L

更新日期：2019-06-11 00:00:00

abstract：:Because of its ecological characteristics, the Caxiuanã National Forest (FLONA) is a potential area of arbovirus circulation. The present study aimed to investigate the occurrence of arbovirus transmission cycles at FLONA de Caxiuanã. Five field trips were performed to capture mosquitoes and sylvatic vertebrates. For ...

journal_title：Viruses

authors： Araújo PA,Freitas MO,Chiang JO,Silva FA,Chagas LL,Casseb SM,Silva SP,Nunes-Neto JP,Rosa-Júnior JW,Nascimento BS,Hernández LA,Paz TB,Barros LL,Silva EP,Azevedo RS,Martins LC,Ferreira MS,Vasconcelos PF

更新日期：2019-08-22 00:00:00

abstract：:Chikungunya virus (CHIKV) has caused extensive outbreaks in several countries within the Americas, Asia, Oceanic/Pacific Islands, and Europe. In humans, CHIKV infections cause a debilitating disease with acute febrile illness and long-term polyarthralgia. Acute and chronic symptoms impose a major economic burden to he...

journal_title：Viruses

authors： López-Camacho C,Kim YC,Blight J,Lazaro Moreli M,Montoya-Diaz E,Huiskonen JT,Kümmerer BM,Reyes-Sandoval A

更新日期：2019-04-03 00:00:00

abstract：:Developments of genome amplification techniques have rapidly expanded the family of human polyomaviruses (PyV). Following infection early in life, PyV persist in their hosts and are generally of no clinical consequence. High-level replication of PyV can occur in patients under immunosuppressive or immunomodulatory the...

journal_title：Viruses

authors： Barth H,Solis M,Kack-Kack W,Soulier E,Velay A,Fafi-Kremer S

更新日期：2016-10-22 00:00:00

abstract：:One of the major obstacles that must be overcome in the design of effective lentiviral vaccines is the ability of lentiviruses to evolve in order to escape from neutralizing antibodies. The primary target for neutralizing antibodies is the highly variable viral envelope glycoprotein (Env), a glycoprotein that is essen...

journal_title：Viruses

authors： Hosie MJ,Pajek D,Samman A,Willett BJ

更新日期：2011-10-01 00:00:00

abstract：:Different developmental stages of Artemia spp. (metanauplii, juveniles and adults) were bath-challenged with two isolates of the Lymphocystis disease virus (LCDV), namely, LCDV SA25 (belonging to the species Lymphocystis disease virus 3) and ATCC VR-342 (an unclassified member of the genus Lymphocystivirus). Viral qua...

journal_title：Viruses

authors： Valverde EJ,Labella AM,Borrego JJ,Castro D

更新日期：2019-06-01 00:00:00

abstract：:The levels of vascular endothelial growth factor-A (VEGF) were estimated in 102 serum samples from 63 hospitalized Greek patients with hemorrhagic fever with renal syndrome (HFRS) caused by Dobrava/Belgrade virus. Significantly higher VEGF levels were seen in the severe when compared with non-severe cases (mean values...

journal_title：Viruses

authors： Tsergouli K,Papa A

更新日期：2013-12-10 00:00:00

abstract：:Since the development of methods for inserting and expressing genes in baculoviruses, a line of research has focused on developing recombinant baculoviruses that express insecticidal peptides and proteins. These recombinant viruses have been engineered with the goal of improving their pesticidal potential by shortenin...

journal_title：Viruses

authors： Kroemer JA,Bonning BC,Harrison RL

更新日期：2015-01-21 00:00:00