Abstract：
:Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-ΔSH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.
journal_name
Virusesjournal_title
Virusesauthors
Bao X,Kolli D,Esham D,Velayutham TS,Casola Adoi
10.3390/v10060278subject
Has Abstractpub_date
2018-05-23 00:00:00issue
6issn
1999-4915pii
v10060278journal_volume
10pub_type
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