Abstract：
:Lifelong persistent infection by herpesviruses depends on the balance between host immune responses and viral immune evasion. CD4 T cells responding to antigens presented on major histocompatibility complex class II (MHC-II) molecules are known to play an important role in controlling herpesvirus infections. Here we review, with emphasis on human herpesvirus infections, the strategies evolved to evade CD4 T cell immunity. These viruses target multiple points on the MHC class II antigen presentation pathway. The mechanisms include: suppression of CIITA to inhibit the synthesis of MHC class II molecules, diversion or degradation of HLA-DR molecules during membrane transport, and direct targeting of the invariant chain chaperone of HLA-DR.
journal_name
Virusesjournal_title
Virusesauthors
Zuo J,Rowe Mdoi
10.3390/v4081335subject
Has Abstractpub_date
2012-08-01 00:00:00pages
1335-53issue
8issn
1999-4915pii
v4081335journal_volume
4pub_type
杂志文章,评审相关文献
Viruses-Basel文献大全abstract：:The Protoparvovirus (PtPV) genus of the Parvoviridae family of viruses includes important animal pathogens and reference molecular models for the entire family. Some virus members of the PtPV genus have arisen as promising tools to treat tumoral processes, as they exhibit marked oncotropism and oncolytic activities wh...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v9110313
更新日期：2017-10-26 00:00:00
abstract：:An outbreak of winter dysentery, complicated by severe respiratory syndrome, occurred in January 2020 in a high production dairy cow herd located in a hilly area of the Calabria region. Of the 52 animals belonging to the farm, 5 (9.6%) died with severe respiratory distress, death occurring 3-4 days after the appearanc...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12111331
更新日期：2020-11-19 00:00:00
abstract：:Dendritic cells (DC) are major players in both innate and adaptive immune responses against influenza virus. These immune responses, as well as the important interface between the innate and adaptive systems, are orchestrated by specialized subsets of DC, including conventional steady-state DC, migratory DC and plasma...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v1031022
更新日期：2009-12-01 00:00:00
abstract：:Global climate change-induced warming of the Artic seas is predicted to shift the phytoplankton community towards dominance of smaller-sized species due to global warming. Yet, little is known about their viral mortality agents despite the ecological importance of viruses regulating phytoplankton host dynamics and div...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v9060134
更新日期：2017-06-02 00:00:00
abstract：:With the availability of an increasing number of 3D structures of bacteriophage components, combined with powerful in silico predictive tools, it has become possible to decipher the structural assembly and functionality of phage adhesion devices. In the current study, we examined 113 members of the 936 group of lactoc...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11070631
更新日期：2019-07-09 00:00:00
abstract：:Exosomes are extracellular vesicles released upon fusion of multivesicular bodies(MVBs) with the cellular plasma membrane. They originate as intraluminal vesicles (ILVs) during the process of MVB formation. Exosomes were shown to contain selectively sorted functional proteins, lipids, and RNAs, mediating cell-to-cell ...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v7092862
更新日期：2015-09-17 00:00:00
abstract：:Viroids are small non-capsidated non-coding RNA replicons that utilize host factors for efficient propagation and spread through the entire plant. They can incite specific disease symptoms in susceptible plants. To better understand viroid-plant interactions, we employed microarray analysis to observe the changes of g...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10050257
更新日期：2018-05-15 00:00:00
abstract：:The phenotype of HTLV-1-transformed CD4(+) T lymphocytes largely depends on defined viral effector molecules such as the viral oncoprotein Tax. In this review, we exemplify the expression pattern of characteristic lineage markers, costimulatory receptors and ligands of the tumor necrosis factor superfamily, cytokine r...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v3081439
更新日期：2011-08-01 00:00:00
abstract：:Parrot bornaviruses (PaBVs) are the causative agents of proventricular dilatation disease (PDD), a chronic and often fatal neurologic disorder in Psittaciformes. The disease is widely distributed in private parrot collections and threatens breeding populations of endangered species. Thus, immunoprophylaxis strategies ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11121130
更新日期：2019-12-06 00:00:00
abstract：:Monkeypox is a smallpox-like illness that can be accompanied by a range of significant medical complications. To date there are no standard or optimized guidelines for the clinical management of monkeypox (MPX) patients, particularly in low-resource settings. Consequently, patients can experience protracted illness an...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v9120380
更新日期：2017-12-12 00:00:00
abstract：:The human cytomegalovirus (HCMV)-encoded cyclin-dependent kinase (CDK) ortholog pUL97 associates with human cyclin B1 and other types of cyclins. Here, the question was addressed whether cyclin interaction of pUL97 and additional viral proteins is detectable by mass spectrometry-based approaches. Proteomic data were v...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v8080219
更新日期：2016-08-18 00:00:00
abstract：:The assembly of a hexameric lattice of retroviral immature particles requires the involvement of cell factors such as proteins and small molecules. A small, negatively charged polyanionic molecule, myo-inositol hexaphosphate (IP6), was identified to stimulate the assembly of immature particles of HIV-1 and other lenti...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v13010129
更新日期：2021-01-18 00:00:00
abstract：:It is increasingly clear that DNA viruses exploit cellular epigenetic processes to control their life cycles during infection. This review will address epigenetic regulation in members of the polyomaviruses, adenoviruses, human papillomaviruses, hepatitis B, and herpes viruses. For each type of virus, what is known ab...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v9110346
更新日期：2017-11-17 00:00:00
abstract：:In rabies diagnosis, it is essential to count on a rapid test to give a quick response. The combined sensitivity and robustness of the TaqMan RT-PCR assays (qRT-PCR) have made these methods a valuable alternative for rabies virus (RABV) detection. We conducted a study to compare the applicability of two widely used qR...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v13010023
更新日期：2020-12-25 00:00:00
abstract：:Viroids are small, non-coding, circular RNA molecules that infect plants. Different hypotheses for their evolutionary origin have been put forward, such as an early emergence in a precellular RNA World or several de novo independent evolutionary origins in plants. Here, we discuss the plausibility of de novo emergence...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11050425
更新日期：2019-05-09 00:00:00
abstract：:Oropouche fever is an emerging zoonotic disease caused by Oropouche virus (OROV), an arthropod transmitted Orthobunyavirus circulating in South and Central America. During the last 60 years, more than 30 epidemics and over half a million clinical cases attributed to OROV infection have been reported in Brazil, Peru, P...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v10040175
更新日期：2018-04-04 00:00:00
abstract：:Noroviruses are a leading cause of gastroenteritis worldwide. Although infections in healthy individuals are self-resolving, immunocompromised individuals are at risk for chronic disease and severe complications. Chronic norovirus infections in immunocompromised hosts are often characterized by long-term virus sheddin...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12060619
更新日期：2020-06-05 00:00:00
abstract：:Half a century of research on membrane-containing phages has had a major impact on virology, providing new insights into virus diversity, evolution and ecological importance. The recent revolutionary technical advances in imaging, sequencing and lipid analysis have significantly boosted the depth and volume of knowled...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v11010076
更新日期：2019-01-18 00:00:00
abstract：:We previously hypothesized that increased capillary permeability observed in both hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS) may be caused by hantavirus-specific cytotoxic T cells attacking endothelial cells presenting viral antigens on their surface based on clinical o...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v3071059
更新日期：2011-07-01 00:00:00
abstract：:The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This review focuses on differ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v1020276
更新日期：2009-09-01 00:00:00
abstract：:Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and animal diseases must comply with regulatory requirements as they pertain to environmental risk asses...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v9110318
更新日期：2017-10-29 00:00:00
abstract：:Bovine viral diarrhea virus (BVDV) is an important pathogen belonging to the Pestivirus genus, Flaviviridae family, which comprises viral species that causes an economic impact in animal production. Cattle are the natural host of BVDV and the main source of infection for pigs and other animal species. Due to its antig...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12060600
更新日期：2020-05-31 00:00:00
abstract：:Rotavirus causes severe gastroenteritis in children. Although vaccines are implemented, rotavirus-related diarrhea still claims ~200,000 lives annually worldwide, mainly in low-income settings, pointing to a need for improved vaccine tactics. To meet such a public health need, a P24-VP8* nanoparticle displaying the gl...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v13010072
更新日期：2021-01-06 00:00:00
abstract：:Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and maintenance of genomic information in both cells and a variety of viral pathogens. While the process of dNTP biosynthesis by cellular enzymes, such as ribonucleotide reductase (RNR) and thymidine kinase (TK), has been extensively inves...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12040382
更新日期：2020-03-31 00:00:00
abstract：:Mycoviruses appear to be widespread in Fusarium species worldwide. The aim of this work was to identify mycoviral infections in Fusarium spp., isolated from maize and sorghum grown in Argentina, and to estimate their potential effects on the pathogenicity and toxigenesis of the host fungus towards maize. Mycoviruses w...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12101161
更新日期：2020-10-14 00:00:00
abstract：:HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of the nucleocapsid (NC) domain that interacts with nucleic acids, and p1 and p6, two unstructured regions, p6 containing the motifs to bind ALIX, the cellular ESCRT factor TSG101 and the viral protein Vpr. The processing of Ga...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12101109
更新日期：2020-09-29 00:00:00
abstract：:Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A (H1N1) viruses in m...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v8030071
更新日期：2016-03-07 00:00:00
abstract：:Hepatitis B surface antigen (HBsAg) promotes persistent hepatitis B virus (HBV) infection. It primarily corresponds to small (S) envelope protein secreted as subviral particles. We previously found that genotype D clones expressed less S protein than genotype A clones but showed higher extracellular/intracellular rati...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12090967
更新日期：2020-09-01 00:00:00
abstract：:Evidence that Hepatitis D virus (HDV) genotype is involved in HDV infection pathogenesis is increasing. Indeed, HDV genotypes have been shown to be linked to different outcomes in terms of liver fibrosis and treatment response. Herein, we show that the promising HDVdb genotyping tool available online can lead to wrong...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12101066
更新日期：2020-09-23 00:00:00
abstract：:Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hooved animals that poses a constant burden on farmers in endemic regions and threatens the livestock industries in disease-free countries. Despite the increased number of publicly available whole genome sequences, FMDV data are biased by...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10040192
更新日期：2018-04-13 00:00:00
