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Overview of the Nucleic-Acid Binding Properties of the HIV-1 Nucleocapsid Protein in Its Different Maturation States.

Abstract：

:HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of the nucleocapsid (NC) domain that interacts with nucleic acids, and p1 and p6, two unstructured regions, p6 containing the motifs to bind ALIX, the cellular ESCRT factor TSG101 and the viral protein Vpr. The processing of Gag by the viral protease subsequently liberates NCp15 (NC-p1-p6), NCp9 (NC-p1) and NCp7, NCp7 displaying the optimal chaperone activity of nucleic acids. This review focuses on the nucleic acid binding properties of the NC domain in the different maturation states during the HIV-1 viral cycle.

journal_name

Viruses

journal_title

Viruses

authors

Mouhand A,Pasi M,Catala M,Zargarian L,Belfetmi A,Barraud P,Mauffret O,Tisné C

doi

10.3390/v12101109

subject

Has Abstract

pub_date

2020-09-29 00:00:00

issue

10

issn

1999-4915

pii

v12101109

journal_volume

12

pub_type

杂志文章,评审

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