Abstract：
:Developments of genome amplification techniques have rapidly expanded the family of human polyomaviruses (PyV). Following infection early in life, PyV persist in their hosts and are generally of no clinical consequence. High-level replication of PyV can occur in patients under immunosuppressive or immunomodulatory therapy and causes severe clinical entities, such as progressive multifocal leukoencephalopathy, polyomavirus-associated nephropathy or Merkel cell carcinoma. The characterization of known and newly-discovered human PyV, their relationship to human health, and the mechanisms underlying pathogenesis remain to be elucidated. Here, we summarize the most widely-used in vitro and in vivo models to study the PyV-host interaction, pathogenesis and anti-viral drug screening. We discuss the strengths and limitations of the different models and the lessons learned.
journal_name
Virusesjournal_title
Virusesauthors
Barth H,Solis M,Kack-Kack W,Soulier E,Velay A,Fafi-Kremer Sdoi
10.3390/v8100292subject
Has Abstractpub_date
2016-10-22 00:00:00issue
10issn
1999-4915pii
v8100292journal_volume
8pub_type
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