Abstract:
:Virus transmission is essential for spreading viral infections and is a highly coordinated process which occurs by cell-free transmission or cell-cell contact. The transmission of Bovine Foamy Virus (BFV) is highly cell-associated, with undetectable cell-free transmission. However, BFV particle budding can be induced by overexpression of wild-type (wt) BFV Gag and Env or artificial retargeting of Gag to the plasma membrane via myristoylation membrane targeting signals, closely resembling observations in other foamy viruses. Thus, the particle release machinery of wt BFV appears to be an excellent model system to study viral adaption to cell-free transmission by in vitro selection and evolution. Using selection for BFV variants with high cell-free infectivity in bovine and non-bovine cells, infectivity dramatically increased from almost no infectious units to about 105-106 FFU (fluorescent focus forming units)/mL in both cell types. Importantly, the selected BFV variants with high titer (HT) cell-free infectivity could still transmit via cell-cell contacts and were neutralized by serum from naturally infected cows. These selected HT-BFV variants will shed light into virus transmission and potential routes of intervention in the spread of viral infections. It will also allow the improvement or development of new promising approaches for antiretroviral therapies.
journal_name
Virusesjournal_title
Virusesauthors
Bao Q,Hipp M,Hugo A,Lei J,Liu Y,Kehl T,Hechler T,Löchelt Mdoi
10.3390/v7112907subject
Has Abstractpub_date
2015-11-11 00:00:00pages
5855-74issue
11issn
1999-4915pii
v7112907journal_volume
7pub_type
杂志文章相关文献
Viruses-Basel文献大全abstract::A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells by direct cellular contacts across a specialized structure, the virological synapse. This process was recently described through live cell imaging. Together with the accumulated knowledge on cellular and molecular structures involved ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v2081666
更新日期:2010-08-01 00:00:00
abstract::Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using ferret antisera or mouse and human monoclonal antibodies. Here, we examined the antigenicity of human H2N2 viruses by using human plasma samples obtained from 50...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11110978
更新日期:2019-10-23 00:00:00
abstract::Although there have been many epidemiological reports of the inter-country transmission of measles, systematic analysis of the global transmission dynamics of the measles virus (MV) is limited. In this study, we applied phylogeographic analysis to characterize the global transmission dynamics of the MV using large-sca...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v9040082
更新日期:2017-04-16 00:00:00
abstract::Merkel cell polyomavirus (MCV) is the only known human oncogenic virus in the polyomaviridae family and the etiological agent of most Merkel cell carcinomas (MCC). MCC is an aggressive and highly metastatic skin cancer with a propensity for recurrence and poor prognosis. Large tumor antigen (LT), is an essential oncop...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12091043
更新日期:2020-09-18 00:00:00
abstract::Multi-drug resistance is increasing at alarming rates. The efficacy of phage therapy, treating bacterial infections with bacteriophages alone or in combination with traditional antibiotics, has been demonstrated in emergency cases in the United States and in other countries, however remains to be approved for wide-spr...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10040188
更新日期:2018-04-10 00:00:00
abstract::Janus kinase (JAK) inhibitors have been developed as novel immunomodulatory drugs and primarily used for treating rheumatoid arthritis and other inflammatory diseases. Recent studies have suggested that this category of anti-inflammatory drugs could be potentially useful for the control of inflammation "storms" in res...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12101141
更新日期:2020-10-08 00:00:00
abstract::An equine parvovirus-hepatitis (EqPV-H) has been recently identified in association with equine serum hepatitis, also known as Theiler's disease. This disease was first described by Arnold Theiler in 1918 and is often observed after applications with blood products in equines. So far, the virus has only been described...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11050461
更新日期:2019-05-21 00:00:00
abstract::This is the first record of a fish nidovirus isolated from a consignment of goldfish at the United Kingdom (UK) border. The full-length viral genome was 25,985 nt, sharing a 97.9% nucleotide identity with the Chinook salmon bafinivirus (CSBV) NIDO with two deletions of 537 and 480 nt on the ORF Ia protein. To assess t...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12050578
更新日期:2020-05-25 00:00:00
abstract::A myriad of factors favor the emergence and re-emergence of arthropod-borne viruses (arboviruses), including migration, climate change, intensified livestock production, an increasing volume of international trade and transportation, and changes to ecosystems (e.g., deforestation and loss of biodiversity). Consequentl...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v3060629
更新日期:2011-06-01 00:00:00
abstract::Extensive surveillance in bat populations in response to recent emerging diseases has revealed that this group of mammals acts as a reservoir for a large range of viruses. However, the oldest known association between a zoonotic virus and a bat is that between rabies virus and the vampire bat. Vampire bats are only fo...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v6051911
更新日期:2014-04-29 00:00:00
abstract::MicroRNAs (miRNAs) are non-coding but functional RNA molecules of 21-25 nucleotides in length. MiRNAs play significant regulatory roles in diverse plant biological processes. In order to decipher the relationship between nbe-miR1919c-5p and the accumulations of tobacco curly shoot virus (TbCSV) and its betasatellite (...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040392
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Zika virus is a mosquito-borne flavivirus responsible for recent outbreaks of epidemic proportions in Latin America. Sexual transmission of the virus has been reported in 13 countries and may be an important route of infection. Sexual transmission of ZIKV has mostly been male-to-female, and persistence of vi...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010042
更新日期:2019-01-09 00:00:00
abstract::Several human monoclonal antibodies (hmAbs) and antibody fragments, including the best characterized in terms of structure-function b12 and Fab X5, exhibit relatively potent and broad HIV-1 neutralizing activity. However, the elicitation of b12 or b12-like antibodies in vivo by vaccine immunogens based on the HIV-1 en...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v1030802
更新日期:2009-12-01 00:00:00
abstract::We describe herein, limitations on research at biosafety level 4 (BSL-4) containment laboratories, with regard to biosecurity regulations, safety considerations, research space limitations, and physical constraints in executing experimental procedures. These limitations can severely impact the number of collaborations...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4123932
更新日期:2012-12-01 00:00:00
abstract::The extension of virology beyond its traditional medical, veterinary, or agricultural applications, now called environmental virology, has shown that viruses are both the most numerous and diverse biological entities on Earth. In particular, virus isolations from unicellular eukaryotic hosts (heterotrophic and photosy...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12101130
更新日期:2020-10-06 00:00:00
abstract::Canine parvovirus (CPV-2) is the causative agent of haemorrhagic gastroenteritis in canids. Three antigenic variants-CPV-2a, CPV-2b and CPV-2c-have been described, which are determined by variations at residue 426 of the VP2 capsid protein. In Colombia, the CPV-2a and CPV-2b antigenic variants have previously been rep...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12050500
更新日期:2020-04-30 00:00:00
abstract::Since deer were introduced into Australia in the mid-1800s, their wild populations have increased in size and distribution, posing a potential risk to the livestock industry, through their role in pathogen transmission cycles. In comparison to livestock, there are limited data on viral infections in all wildlife, incl...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12070752
更新日期:2020-07-13 00:00:00
abstract::Old world hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) upon zoonotic transmission to humans. In Europe, the Puumala virus (PUUV) is the main causative agent of HFRS. Tula virus (TULV) is also widely distributed in Europe, but there is little knowledge about the pathogenicity of TULV for humans, as r...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11090855
更新日期:2019-09-14 00:00:00
abstract::Low pathogenic avian influenza (LPAI) H7N9 viruses have recently evolved to gain a polybasic cleavage site in the hemagglutinin (HA) protein, resulting in variants with increased lethality in poultry that meet the criteria for highly pathogenic avian influenza (HPAI) viruses. Both LPAI and HPAI variants can cause seve...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12010065
更新日期:2020-01-05 00:00:00
abstract::Influenza A viruses (IAVs) harbor a segmented RNA genome that is organized into eight distinct viral ribonucleoprotein (vRNP) complexes. Although a segmented genome may be a major advantage to adapt to new host environments, it comes at the cost of a highly sophisticated genome packaging mechanism. Newly synthesized v...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v8060165
更新日期:2016-06-17 00:00:00
abstract::Hepatitis C virus (HCV) is the etiological agent accounting for chronic liver disease in approximately 2-3% of the population worldwide. HCV infection often leads to liver fibrosis and cirrhosis, various metabolic alterations including steatosis, insulin and interferon resistance or iron overload, and development of h...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v5020439
更新日期:2013-01-28 00:00:00
abstract::Global climate change-induced warming of the Artic seas is predicted to shift the phytoplankton community towards dominance of smaller-sized species due to global warming. Yet, little is known about their viral mortality agents despite the ecological importance of viruses regulating phytoplankton host dynamics and div...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v9060134
更新日期:2017-06-02 00:00:00
abstract::Zika virus (ZIKV) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and Guillain⁻Barré syndrome in adults. Efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating ZI...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020092
更新日期:2019-01-22 00:00:00
abstract::Retroviruses integrate a reverse transcribed double stranded DNA copy of their viral genome into the chromosomal DNA of cells they infect. Occasionally, exogenous retroviruses infect germ cells and when this happens a profound shift in the virus host dynamic occurs. Retroviruses maintained as hereditable viral genetic...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v3060901
更新日期:2011-06-01 00:00:00
abstract::The virion proteins of Kaposi sarcoma-associated herpesvirus (KSHV) were initially characterized in 2005 in two separate studies that combined the detection of 24 viral proteins and a few cellular components via LC-MS/MS or MALDI-TOF. Despite considerable advances in the sensitivity and specificity of mass spectrometr...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121382
更新日期:2020-12-02 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has a curative potential for many hematologic malignancies and blood diseases. However, the success of allo-HSCT is limited by graft-versus-host disease (GVHD), an immunological syndrome that involves inflammation and tissue damage mediated by donor lympho...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v8030085
更新日期:2016-03-22 00:00:00
abstract::Finding a cure for HIV is challenging because the virus is able to integrate itself into the host cell genome and establish a silent state, called latency, allowing it to evade antiviral drugs and the immune system. Various "shock and kill" strategies are being explored in attempts to eliminate latent HIV reservoirs. ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10120677
更新日期:2018-11-30 00:00:00
abstract::The APOBEC3 family of proteins in mammals consists of cellular cytosine deaminases and well-known restriction factors against retroviruses, including lentiviruses. APOBEC3 genes are highly amplified and diversified in mammals, suggesting that their evolution and diversification have been driven by conflicts with ancie...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v13010124
更新日期:2021-01-17 00:00:00
abstract::Porcine reproductive and respiratory syndrome virus (PRRSV) infection strongly modulates the host's immune response. The RNA silencing pathway is an intracellular innate response to viral infections. However, it is unknown whether PRRSV interacts with cellular RNA silencing to facilitate the viral infection. Here, we ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7102893
更新日期:2015-10-23 00:00:00
abstract::The International Virus Bioinformatics Meeting 2020 was originally planned to take place in Bern, Switzerland, in March 2020. However, the COVID-19 pandemic put a spoke in the wheel of almost all conferences to be held in 2020. After moving the conference to 8-9 October 2020, we got hit by the second wave and finally ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121398
更新日期:2020-12-06 00:00:00