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HCV and oxidative stress in the liver.

Abstract：

:Hepatitis C virus (HCV) is the etiological agent accounting for chronic liver disease in approximately 2-3% of the population worldwide. HCV infection often leads to liver fibrosis and cirrhosis, various metabolic alterations including steatosis, insulin and interferon resistance or iron overload, and development of hepatocellular carcinoma or non-Hodgkin lymphoma. Multiple molecular mechanisms that trigger the emergence and development of each of these pathogenic processes have been identified so far. One of these involves marked induction of a reactive oxygen species (ROS) in infected cells leading to oxidative stress. To date, markers of oxidative stress were observed both in chronic hepatitis C patients and in various in vitro systems, including replicons or stable cell lines expressing viral proteins. The search for ROS sources in HCV-infected cells revealed several mechanisms of ROS production and thus a number of cellular proteins have become targets for future studies. Furthermore, during last several years it has been shown that HCV modifies antioxidant defense mechanisms. The aim of this review is to summarize the present state of art in the field and to try to predict directions for future studies.

journal_name

Viruses

journal_title

Viruses

authors

Ivanov AV,Bartosch B,Smirnova OA,Isaguliants MG,Kochetkov SN

doi

10.3390/v5020439

subject

Has Abstract

pub_date

2013-01-28 00:00:00

pages

439-69

issue

2

issn

1999-4915

pii

v5020439

journal_volume

5

pub_type

杂志文章,评审

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