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Host Cell Restriction Factors that Limit Influenza A Infection.

Abstract：

:Viral infection of different cell types induces a unique spectrum of host defence genes, including interferon-stimulated genes (ISGs) and genes encoding other proteins with antiviral potential. Although hundreds of ISGs have been described, the vast majority have not been functionally characterised. Cellular proteins with putative antiviral activity (hereafter referred to as "restriction factors") can target various steps in the virus life-cycle. In the context of influenza virus infection, restriction factors have been described that target virus entry, genomic replication, translation and virus release. Genome wide analyses, in combination with ectopic overexpression and/or gene silencing studies, have accelerated the identification of restriction factors that are active against influenza and other viruses, as well as providing important insights regarding mechanisms of antiviral activity. Herein, we review current knowledge regarding restriction factors that mediate anti-influenza virus activity and consider the viral countermeasures that are known to limit their impact. Moreover, we consider the strengths and limitations of experimental approaches to study restriction factors, discrepancies between in vitro and in vivo studies, and the potential to exploit restriction factors to limit disease caused by influenza and other respiratory viruses.

journal_name

Viruses

journal_title

Viruses

authors

Villalón-Letelier F,Brooks AG,Saunders PM,Londrigan SL,Reading PC

doi

10.3390/v9120376

subject

Has Abstract

pub_date

2017-12-07 00:00:00

issue

12

issn

1999-4915

pii

v9120376

journal_volume

9

pub_type

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