Abstract:
:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), employs host-cell angiotensin-converting enzyme 2 (ACE2) for cell entry. Genetic analyses of ACE2 have identified several single-nucleotide polymorphisms (SNPs) specific to different human populations. Molecular dynamics simulations have indicated that several of these SNPs could affect interactions between SARS-CoV-2 and ACE2, thereby providing a partial explanation for the regional differences observed in SARS-CoV-2 infectivity and severity. However, the significance of population-specific ACE2 SNPs in SARS-CoV-2 infectivity is unknown, as no in vitro validation studies have been performed. Here, we analyzed the impact of eight SNPs found in specific populations on receptor binding and cell entry in vitro. Except for a SNP causing a nonsense mutation that reduced ACE2 expression, none of the selected SNPs markedly altered the interaction between ACE2 and the SARS-CoV-2 spike protein (SARS-2-S), which is responsible for receptor recognition and cell entry, or the efficiency of viral cell entry mediated by SARS-2-S. Our findings indicate that ACE2 polymorphisms have limited impact on the ACE2-dependent cell entry of SARS-CoV-2 and underscore the importance of future studies on the involvement of population-specific SNPs of other host genes in susceptibility toward SARS-CoV-2 infection.
journal_name
Virusesjournal_title
Virusesauthors
Hashizume M,Gonzalez G,Ono C,Takashima A,Iwasaki Mdoi
10.3390/v13010067subject
Has Abstractpub_date
2021-01-06 00:00:00issue
1issn
1999-4915pii
v13010067journal_volume
13pub_type
杂志文章相关文献
Viruses-Basel文献大全abstract::Extensive surveillance in bat populations in response to recent emerging diseases has revealed that this group of mammals acts as a reservoir for a large range of viruses. However, the oldest known association between a zoonotic virus and a bat is that between rabies virus and the vampire bat. Vampire bats are only fo...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v6051911
更新日期:2014-04-29 00:00:00
abstract::Mechanistic models are critical for our understanding of both within-host dynamics (i.e., pathogen replication and immune system processes) and among-host dynamics (i.e., transmission). Within-host models, however, are not often fit to experimental data, which can serve as a robust method of hypothesis testing and hyp...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11050396
更新日期:2019-04-27 00:00:00
abstract::Protoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9110323
更新日期:2017-10-31 00:00:00
abstract::Between January 2012 and March 2012, the infection rates of porcine epidemic diarrhea virus (PEDV) increased substantially in vaccinated swine herds in many porcine farms in Gansu Province, China. The spike (S) glycoprotein is an important determinant for PEDV biological properties. To determine the distribution profi...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v5081991
更新日期:2013-08-15 00:00:00
abstract::Gammaherpesviruses like Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) subvert the ubiquitin proteasome system for their own benefit in order to facilitate viral gene expression and replication. In particular, viral tegument proteins that share sequence homology to the formylglycineamide r...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9100308
更新日期:2017-10-21 00:00:00
abstract::One of the major obstacles that must be overcome in the design of effective lentiviral vaccines is the ability of lentiviruses to evolve in order to escape from neutralizing antibodies. The primary target for neutralizing antibodies is the highly variable viral envelope glycoprotein (Env), a glycoprotein that is essen...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v3101870
更新日期:2011-10-01 00:00:00
abstract::H1N1 swine influenza viruses (SIV) are prevalent in pigs globally, and occasionally emerge in humans, which raises concern about their pandemic threats. To stimulate hemagglutination (HA) of A/Swine/Guangdong/LM/2004 (H1N1) (SW/GD/04) antibody response, eukaryotic expression plasmid pCI-neo-HA was constructed and used...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v9080209
更新日期:2017-08-08 00:00:00
abstract::Nasopharyngeal cancer (NPC) is associated with Epstein Barr virus (EBV) infection. However different viral strains have been implicated in NPC worldwide. This study aimed to detect and characterize EBV in patients diagnosed with NPC in Ghana. A total of 55 patients diagnosed with NPC by CT scan and endoscopy were age-...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12070766
更新日期:2020-07-16 00:00:00
abstract::Koalas (Phascolarctos cinereus) are native Australian marsupials whose populations are in decline from a range of threats. Infectious diseases caused by the bacterium Chlamydia pecorum and other pathogens are of particular concern. We analysed 26 poly-A selected RNA-sequencing libraries from a data set designed to stu...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11030211
更新日期:2019-03-02 00:00:00
abstract::The Megalocytivirus genus includes three genotypes, red sea bream iridovirus (RSIV), infectious spleen and kidney necrosis virus (ISKNV), and turbot reddish body iridovirus (TRBIV), and has caused mass mortalities in various marine and freshwater fish species in East and Southeast Asia. Of the three genotypes, TRBIV-l...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12060681
更新日期:2020-06-24 00:00:00
abstract::Arthropod-borne flaviviruses are human pathogens of global medical importance, against which no effective small molecule-based antiviral therapy has currently been reported. Arbidol (umifenovir) is a broad-spectrum antiviral compound approved in Russia and China for prophylaxis and treatment of influenza. This compoun...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10040184
更新日期:2018-04-10 00:00:00
abstract::Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress toward...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11010074
更新日期:2019-01-17 00:00:00
abstract::Infectious retrovirus particles contain two copies of unspliced viral RNA that serve as the viral genome. Unspliced retroviral RNA is transcribed in the nucleus by the host RNA polymerase II and has three potential fates: (1) it can be spliced into subgenomic messenger RNAs (mRNAs) for the translation of viral protein...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v8090257
更新日期:2016-09-20 00:00:00
abstract::Live attenuated influenza vaccines (LAIV) have prevented morbidity and mortality associated with influenza viral infections for many years and represent the best therapeutic option to protect against influenza viral infections in humans. However, the development of LAIV has traditionally relied on empirical methods, s...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10100560
更新日期:2018-10-15 00:00:00
abstract::Over the past 15 years we have been investigating an alternative approach to treating HIV-1/AIDS, based on the creation of a disease-resistant immune system through transplantation of autologous, gene-modified (HIV-1-resistant) hematopoietic stem and progenitor cells (GM-HSPC). We propose that the expression of select...
journal_title:Viruses
pub_type: 临床试验,杂志文章
doi:10.3390/v5112898
更新日期:2013-11-22 00:00:00
abstract::Viruses represent important test cases for data federation due to their genome size and the rapid increase in sequence data in publicly available databases. However, some consequences of previously decentralized (unfederated) data are lack of consensus or comparisons between feature annotations. Unifying or displaying...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121424
更新日期:2020-12-10 00:00:00
abstract::Viral codon usage bias may be the product of a number of synergistic or antagonistic factors, including genomic nucleotide composition, translational selection, genomic architecture, and mutational or repair biases. Most studies of viral codon bias evaluate only the relative importance of genomic base composition and ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v5010162
更新日期:2013-01-15 00:00:00
abstract::Rotavirus causes severe gastroenteritis in children. Although vaccines are implemented, rotavirus-related diarrhea still claims ~200,000 lives annually worldwide, mainly in low-income settings, pointing to a need for improved vaccine tactics. To meet such a public health need, a P24-VP8* nanoparticle displaying the gl...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010072
更新日期:2021-01-06 00:00:00
abstract::Factors controlling the community composition of marine heterotrophic prokaryotes include organic-C, mineral nutrients, predation, and viral lysis. Two mesocosm experiments, performed at an Arctic location and bottom-up manipulated with organic-C, had very different results in community composition for both prokaryote...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v9090238
更新日期:2017-08-23 00:00:00
abstract::Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy-tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs by transfer of a c...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v7072793
更新日期:2015-07-07 00:00:00
abstract::The immune-suppressive effects of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) on T cells have been observed via multiple in vitro and in vivo models. However, the precise mechanism that causes these effects is still undefined. In this study, we investigated whether n-3 PUFAs regulated T cell receptor (TCR) and p...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12060639
更新日期:2020-06-12 00:00:00
abstract::Poxviruses are important pathogens of man and numerous domestic and wild animal species. Cross species (including zoonotic) poxvirus infections can have drastic consequences for the recipient host. Bats are a diverse order of mammals known to carry lethal viral zoonoses such as Rabies, Hendra, Nipah, and SARS. Consequ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v6041564
更新日期:2014-04-03 00:00:00
abstract::Interferon (IFN) regulatory factor 3 (IRF3) is the key transcription factor for the induction of IFN and antiviral genes. The absence of antiviral genes in IRF3 deficiency leads to susceptibility to a wide range of viral infections. Previously, we uncovered a function for nontranscriptional IRF3 (nt-IRF3), RLR (RIG-I-...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040442
更新日期:2020-04-14 00:00:00
abstract::Human herpesvirus-6A and B (HHV-6A, HHV-6B) have recently defined endogenous genomes, resulting from integration into the germline: chromosomally-integrated "CiHHV-6A/B". These affect approximately 1.0% of human populations, giving potential for virus gene expression in every cell. We previously showed that CiHHV-6A w...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8010019
更新日期:2016-01-15 00:00:00
abstract::An equine parvovirus-hepatitis (EqPV-H) has been recently identified in association with equine serum hepatitis, also known as Theiler's disease. This disease was first described by Arnold Theiler in 1918 and is often observed after applications with blood products in equines. So far, the virus has only been described...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11050461
更新日期:2019-05-21 00:00:00
abstract::A Pseudorabies virus (PRV) variant has emerged in China since 2011 that is not protected by commercial vaccines, and has not been well studied. The PRV genome is large and difficult to manipulate, but it is feasible to use clustered, regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology. However, id...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8040090
更新日期:2016-03-29 00:00:00
abstract::Foodborne illnesses remain a major cause of hospitalization and death worldwide despite many advances in food sanitation techniques and pathogen surveillance. Traditional antimicrobial methods, such as pasteurization, high pressure processing, irradiation, and chemical disinfectants are capable of reducing microbial p...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10040205
更新日期:2018-04-19 00:00:00
abstract::Preclinical infection model systems are extremely valuable tools to aid in our understanding of Human Papillomavirus (HPV) biology, disease progression, prevention, and treatments. In this context, rodent papillomaviruses and their respective infection models are useful tools but remain underutilized resources in the ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9120362
更新日期:2017-11-27 00:00:00
abstract::Type I interferon (IFN-I) is the first line of mammalian host defense against viral infection. To counteract this, the flaviviruses, like other viruses, have encoded a variety of antagonists, and use a multi-layered molecular defense strategy to establish their infections. Among the most potent antagonists is non-stru...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10120712
更新日期:2018-12-14 00:00:00
abstract::Feline immunodeficiency virus (FIV) is widespread in feline populations and causes an AIDS-like illness in domestic cats. It is highly prevalent in several endangered feline species. In domestic cats FIV infection is a valuable small animal model for HIV infection. In recent years there has been sa significant increas...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v3112192
更新日期:2011-11-01 00:00:00