Abstract：
:Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research laboratory animal, as well as current benefits and challenges of this model. Availability of immunological reagents is addressed. Salient features of EVD in hamsters, including relevant pathology and coagulation parameters, are compared directly with the mouse, guinea pig and nonhuman primate models.
journal_name
Virusesjournal_title
Virusesauthors
Wahl-Jensen V,Bollinger L,Safronetz D,de Kok-Mercado F,Scott DP,Ebihara Hdoi
10.3390/v4123754subject
Has Abstractpub_date
2012-12-14 00:00:00pages
3754-84issue
12issn
1999-4915pii
v4123754journal_volume
4pub_type
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