Marine Viruses: Key Players in Marine Ecosystems.

abstract：:Nef proteins from all primate Lentiviruses, including the simian immunodeficiency virus of chimpanzees (SIVcpz), increase viral progeny infectivity. However, the function of Nef involved with the increase in viral infectivity is still not completely understood. Nonetheless, until now, studies investigating the functio...

journal_title：Viruses

authors： Sabino Cunha M,Lima Sampaio T,Peterlin BM,Jesus da Costa L

更新日期：2016-07-07 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and animal diseases must comply with regulatory requirements as they pertain to environmental risk asses...

journal_title：Viruses

authors： Okeke MI,Okoli AS,Diaz D,Offor C,Oludotun TG,Tryland M,Bøhn T,Moens U

更新日期：2017-10-29 00:00:00

abstract：:Despite tremendous efforts over the course of many years, the quest for an effective HIV vaccine by the classical method of active immunization remains largely elusive. However, two recent studies in mice and macaques have now demonstrated a new strategy designated as Vectored ImmunoProphylaxis (VIP), which involves p...

journal_title：Viruses

authors： Yang L,Wang P

更新日期：2014-01-27 00:00:00

abstract：:Using different prion strains, such as the variant Creutzfeldt-Jakob disease agent and the atypical bovine spongiform encephalopathy agents, and using transgenic mice expressing human or bovine prion protein, we assessed the reliability of protein misfolding cyclic amplification (PMCA) to model interspecies and geneti...

journal_title：Viruses

authors： Levavasseur E,Privat N,Martin JC,Simoneau S,Baron T,Flan B,Torres JM,Haïk S

更新日期：2014-10-02 00:00:00

abstract：:Abstract: Since 2007, highly pathogenic clade 2.3.2 H5N1 avian influenza A (A(H5N1)) viruses have evolved to clade 2.3.2.1a, b, and c; currently only 2.3.2.1c A(H5N1) viruses circulate in wild birds and poultry. During antigenic evolution, clade 2.3.2.1a and c A(H5N1) viruses acquired both S144N and V223I mutations ar...

journal_title：Viruses

authors： An SH,Lee CY,Hong SM,Song CS,Kim JH,Kwon HJ

更新日期：2019-10-09 00:00:00

abstract：:Retroviruses integrate a reverse transcribed double stranded DNA copy of their viral genome into the chromosomal DNA of cells they infect. Occasionally, exogenous retroviruses infect germ cells and when this happens a profound shift in the virus host dynamic occurs. Retroviruses maintained as hereditable viral genetic...

journal_title：Viruses

authors： Liu M,Eiden MV

更新日期：2011-06-01 00:00:00

abstract：:Although polyethylene glycol (PEG) application is the most widely used method in removing nonstructural proteins (NSPs) for foot-and-mouth disease (FMD) vaccine production, some NSPs remaining in the antigen could elicit antibodies against these proteins after repeated vaccinations in livestock. Therefore, the purpose...

journal_title：Viruses

authors： Park SY,Lee JM,Kim AY,Park SH,Kim JS,Kim H,Park JW,Park JH,Ko YJ,Park CK

更新日期：2020-12-07 00:00:00

abstract：:Several viral infections of swine are responsible for major economic losses and represent a threat to the swine industry worldwide. New tools are needed to prevent and control endemic, emerging, and re-emerging viral diseases. Dendritic cells (DC) play a central role in linking the innate and adaptive arms of the immu...

journal_title：Viruses

authors： Franzoni G,Graham SP,Dei Giudici S,Oggiano A

更新日期：2019-05-16 00:00:00

abstract：:Kaposi's sarcoma associated-herpesvirus (KSHV, also known as human herpesvirus-8) is a gammaherpesvirus that establishes life-long infection in human B lymphocytes. KSHV infection is typically asymptomatic, but immunosuppression can predispose KSHV-infected individuals to primary effusion lymphoma (PEL); a malignancy ...

journal_title：Viruses

authors： Pringle ES,Wertman J,Melong N,Coombs AJ,Young AL,O'Leary D,Veinotte C,Robinson CA,Ha MN,Dellaire G,Druley TE,McCormick C,Berman JN

更新日期：2019-12-20 00:00:00

abstract：:Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholesterolemia. Furthermore,...

journal_title：Viruses

authors： Felmlee DJ,Hafirassou ML,Lefevre M,Baumert TF,Schuster C

更新日期：2013-05-23 00:00:00

abstract：:Since the emergence of NADC30-like porcine reproductive and respiratory syndrome virus (PRRSV) in China in 2013, PRRSVs have undergone rapid evolution. In this study, a novel variant of PRRSV strain (designated SCcd17) was successfully isolated from piglets with clinical signs in Sichuan Province in China in 2017, and...

journal_title：Viruses

authors： Zhou L,Kang R,Xie B,Tian Y,Wu X,Lv X,Yang X,Wang H

更新日期：2018-03-27 00:00:00

abstract：:Human herpesvirus-6A and B (HHV-6A, HHV-6B) have recently defined endogenous genomes, resulting from integration into the germline: chromosomally-integrated "CiHHV-6A/B". These affect approximately 1.0% of human populations, giving potential for virus gene expression in every cell. We previously showed that CiHHV-6A w...

journal_title：Viruses

authors： Tweedy J,Spyrou MA,Pearson M,Lassner D,Kuhl U,Gompels UA

更新日期：2016-01-15 00:00:00

abstract：:Old world hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) upon zoonotic transmission to humans. In Europe, the Puumala virus (PUUV) is the main causative agent of HFRS. Tula virus (TULV) is also widely distributed in Europe, but there is little knowledge about the pathogenicity of TULV for humans, as r...

journal_title：Viruses

authors： Bourquain D,Bodenstein C,Schürer S,Schaade L

更新日期：2019-09-14 00:00:00

abstract：:Viral codon usage bias may be the product of a number of synergistic or antagonistic factors, including genomic nucleotide composition, translational selection, genomic architecture, and mutational or repair biases. Most studies of viral codon bias evaluate only the relative importance of genomic base composition and ...

journal_title：Viruses

authors： Cardinale DJ,DeRosa K,Duffy S

更新日期：2013-01-15 00:00:00

abstract：:Interferon-inducible transmembrane proteins (IFITM1/2/3) have been reported to suppress the entry of a wide range of viruses. However, their antiviral functional residues and specific mechanisms are still unclear. Here, we firstly resolved the topology of IFITM1 on the plasma membrane where N-terminus points into the ...

journal_title：Viruses

authors： Sun F,Xia Z,Han Y,Gao M,Wang L,Wu Y,Sabatier JM,Miao L,Cao Z

更新日期：2020-03-08 00:00:00

abstract：:Viroids are small pathogenic circular single-stranded RNAs, present in two complementary sequences, named plus and minus, in infected plant cells. A high degree of complementarities between different regions of the RNAs allows them to adopt complex structures. Since viroids are naked non-coding RNAs, interactions with...

journal_title：Viruses

authors： Delan-Forino C,Deforges J,Benard L,Sargueil B,Maurel MC,Torchet C

更新日期：2014-01-29 00:00:00

abstract：:Herpesviridae comprise a large family of enveloped DNA viruses all of whom employ orthologs of the same three glycoproteins, gB, gH and gL. Additionally, herpesviruses often employ accessory proteins to bind receptors and/or bind the heterodimer gH/gL or even to determine cell tropism. Sorting out how these proteins f...

journal_title：Viruses

authors： Eisenberg RJ,Atanasiu D,Cairns TM,Gallagher JR,Krummenacher C,Cohen GH

更新日期：2012-05-01 00:00:00

abstract：:The honey bee queen is the central hub of a colony to produce eggs and release pheromones to maintain social cohesion. Among many environmental stresses, viruses are a major concern to compromise the queen's health and reproductive vigor. Viruses have evolved numerous strategies to infect queens either via vertical tr...

journal_title：Viruses

authors： Amiri E,Strand MK,Tarpy DR,Rueppell O

更新日期：2020-03-17 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects almost everyone in the world in many ways. We previously predicted antivirals (atazanavir, remdesivir and lopinavir/ritonavir) and non-antiviral drugs (tiotropium and rapamycin) that may inhi...

journal_title：Viruses

authors： Kang K,Kim HH,Choi Y

更新日期：2020-07-20 00:00:00

abstract：:Several human monoclonal antibodies (hmAbs) and antibody fragments, including the best characterized in terms of structure-function b12 and Fab X5, exhibit relatively potent and broad HIV-1 neutralizing activity. However, the elicitation of b12 or b12-like antibodies in vivo by vaccine immunogens based on the HIV-1 en...

journal_title：Viruses

authors： Xiao X,Chen W,Feng Y,Dimitrov DS

更新日期：2009-12-01 00:00:00

abstract：:Fruit trees, such as apricot trees, are constantly exposed to the attack of viruses. As they are propagated in a vegetative way, this risk is present not only in the field, where they remain for decades, but also during their propagation. Metagenomic diagnostic methods, based on next generation sequencing (NGS), offer...

journal_title：Viruses

authors： Baráth D,Jaksa-Czotter N,Molnár J,Varga T,Balássy J,Szabó LK,Kirilla Z,Tusnády GE,Preininger É,Várallyay É

更新日期：2018-06-11 00:00:00

abstract：:Human adenovirus type 4 (HAdV-E4), which is intriguingly limited to military populations, causes acute respiratory disease with demonstrated morbidity and mortality implications. This respiratory pathogen contains genome identity with chimpanzee adenoviruses, indicating zoonotic origins. A signature of these "old" HAd...

journal_title：Viruses

authors： Zhang J,Kang J,Dehghan S,Sridhar S,Lau SKP,Ou J,Woo PCY,Zhang Q,Seto D

更新日期：2019-01-31 00:00:00

abstract：:Influenza virus infections can lead to viral pneumonia and acute respiratory distress syndrome in severe cases, causing significant morbidity and mortality and posing a great threat to human health. Because of the diversity of influenza virus strains and drug resistance to the current direct antiviral agents, there ha...

journal_title：Viruses

authors： Zhang L,Chen J,Ke C,Zhang H,Zhang S,Tang W,Liu C,Liu G,Chen S,Hu A,Sun W,Xiao Y,Liu M,Chen X

更新日期：2020-05-18 00:00:00

abstract：:Pestiviruses, which include economically important animal pathogens such as bovine viral diarrhea virus and classical swine fever virus, possess three envelope glycoproteins, namely Erns, E1, and E2. This article discusses the structures and functions of these glycoproteins and their effects on viral pathogenicity in ...

journal_title：Viruses

authors： Wang FI,Deng MC,Huang YL,Chang CY

更新日期：2015-06-29 00:00:00

abstract：:Many blood-feeding arthropods are known vectors of viruses that are a source of unprecedented global health concern. Mosquitoes are an integral part of these arthropod vectors. Advancements in next-generation sequencing and bioinformatics has expanded our knowledge on the richness of viruses harbored by arthropods. In...

journal_title：Viruses

authors： Atoni E,Wang Y,Karungu S,Waruhiu C,Zohaib A,Obanda V,Agwanda B,Mutua M,Xia H,Yuan Z

更新日期：2018-01-12 00:00:00

abstract：:The two human oncogenic -herpesviruses, Epstein Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV), are prototypic pathogens that are controlled by T cell responses. Despite their ubiquitous distribution, persistent infections and transforming potential, most carriers' immune systems control them for li...

journal_title：Viruses

authors： Münz C

更新日期：2019-12-05 00:00:00

abstract：:Finding a cure for HIV is challenging because the virus is able to integrate itself into the host cell genome and establish a silent state, called latency, allowing it to evade antiviral drugs and the immune system. Various "shock and kill" strategies are being explored in attempts to eliminate latent HIV reservoirs. ...

journal_title：Viruses

authors： Kuang XT,Brockman MA

更新日期：2018-11-30 00:00:00

abstract：:Aplastic anemia is a rare blood disease characterized by the destruction of the hematopoietic stem cells (HSC) in the bone marrow that, in the majority of cases, is caused by an autoimmune reaction. Patients with aplastic anemia are treated with immunosuppressive drugs and some of them, especially younger individuals ...

journal_title：Viruses

authors： Inoue H,Rai S,Tanaka H,Espinoza JL,Komori-Inoue M,Kakutani H,Minamoto S,Kumode T,Nakayama S,Taniguchi Y,Morita Y,Okuda T,Tatsumi Y,Ashida T,Matsumura I

更新日期：2020-04-08 00:00:00

abstract：:Foodborne illnesses remain a major cause of hospitalization and death worldwide despite many advances in food sanitation techniques and pathogen surveillance. Traditional antimicrobial methods, such as pasteurization, high pressure processing, irradiation, and chemical disinfectants are capable of reducing microbial p...

journal_title：Viruses

authors： Moye ZD,Woolston J,Sulakvelidze A

更新日期：2018-04-19 00:00:00

abstract：:As countries with endemic canine rabies progress towards elimination by 2030, it will become necessary to employ techniques to help plan, monitor, and confirm canine rabies elimination. Sequencing can provide critical information to inform control and vaccination strategies by identifying genetically distinct virus va...

journal_title：Viruses

authors： Gigante CM,Yale G,Condori RE,Costa NC,Long NV,Minh PQ,Chuong VD,Tho ND,Thanh NT,Thin NX,Hanh NTH,Wambura G,Ade F,Mito O,Chuchu V,Muturi M,Mwatondo A,Hampson K,Thumbi SM,Thomae BG,de Paz VH,Meneses S,Munyua P,

更新日期：2020-11-04 00:00:00