Molecular modeling of prion transmission to humans.

abstract：:The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retroviral-induced disease....

journal_title：Viruses

authors： Pérès E,Bagdassarian E,This S,Villaudy J,Rigal D,Gazzolo L,Duc Dodon M

更新日期：2015-12-07 00:00:00

abstract：:Viruses protect their genomes by enclosing them into protein capsids that sometimes contain lipid bilayers that either reside above or below the protein layer. Controlled dissociation of virions provides important information on virion composition, interactions, and stoichiometry of virion components, as well as their...

journal_title：Viruses

authors： Eskelin K,Poranen MM

更新日期：2018-10-23 00:00:00

abstract：:Dendritic cells (DC) are major players in both innate and adaptive immune responses against influenza virus. These immune responses, as well as the important interface between the innate and adaptive systems, are orchestrated by specialized subsets of DC, including conventional steady-state DC, migratory DC and plasma...

journal_title：Viruses

authors： Summerfield A,McCullough KC

更新日期：2009-12-01 00:00:00

abstract：:Since deer were introduced into Australia in the mid-1800s, their wild populations have increased in size and distribution, posing a potential risk to the livestock industry, through their role in pathogen transmission cycles. In comparison to livestock, there are limited data on viral infections in all wildlife, incl...

journal_title：Viruses

authors： Huaman JL,Pacioni C,Forsyth DM,Pople A,Hampton JO,Carvalho TG,Helbig KJ

更新日期：2020-07-13 00:00:00

abstract：:Astroviruses (AstVs) cause disease in a wide variety of species. Porcine AstVs are highly genetically diverse and conventionally assigned to five genetic lineages (PoAstV1-5). Due to the increasing evidence that porcine astrovirus type 3 (PoAstV3) is a cause of encephalomyelitis in swine and to elucidate important eco...

journal_title：Viruses

authors： Rawal G,Ferreyra FM,Macedo NR,Bradner LK,Harmon KM,Allison G,Linhares DCL,Arruda BL

更新日期：2020-09-07 00:00:00

abstract：:The human cytomegalovirus (HCMV)-encoded cyclin-dependent kinase (CDK) ortholog pUL97 associates with human cyclin B1 and other types of cyclins. Here, the question was addressed whether cyclin interaction of pUL97 and additional viral proteins is detectable by mass spectrometry-based approaches. Proteomic data were v...

journal_title：Viruses

authors： Steingruber M,Kraut A,Socher E,Sticht H,Reichel A,Stamminger T,Amin B,Couté Y,Hutterer C,Marschall M

更新日期：2016-08-18 00:00:00

abstract：:In the last 20 years, molecular ecology approaches have proven to be extremely useful to identify and assess factors associated with viral emerging diseases, particularly in economically and socially important tropical crops such as maize (maize streak disease) and cassava (cassava mosaic disease). Molecular ecology a...

journal_title：Viruses

authors： Péréfarres F,Thierry M,Becker N,Lefeuvre P,Reynaud B,Delatte H,Lett JM

更新日期：2012-12-12 00:00:00

abstract：:Interferon (IFN) regulatory factor 3 (IRF3) is the key transcription factor for the induction of IFN and antiviral genes. The absence of antiviral genes in IRF3 deficiency leads to susceptibility to a wide range of viral infections. Previously, we uncovered a function for nontranscriptional IRF3 (nt-IRF3), RLR (RIG-I-...

journal_title：Viruses

authors： Glanz A,Chawla K,Fabry S,Subramanian G,Garcia J,Jay B,Ciricillo J,Chakravarti R,Taylor RT,Chattopadhyay S

更新日期：2020-04-14 00:00:00

abstract：:Victoria and Yamagata lineages of influenza B viruses are globally circulating in seasonal epidemics. Madin-Darby canine kidney (MDCK) cells are permissive for viral isolation and vaccine manufacture. Nevertheless, the interplay between influenza B viruses and host microRNAs has not been investigated in this cell line...

journal_title：Viruses

authors： Saengchoowong S,Khongnomnan K,Poomipak W,Praianantathavorn K,Poovorawan Y,Zhang Q,Payungporn S

更新日期：2019-10-25 00:00:00

abstract：:The use of the rabies vaccine for post-exposure prophylaxis started as early as 1885, revealing a safe and efficient tool to prevent human rabies cases. Preventive vaccination is the basis for the control of canine-mediated rabies, which has already been eliminated from extensive parts of the world, including Europe. ...

journal_title：Viruses

authors： Echevarría JE,Banyard AC,McElhinney LM,Fooks AR

更新日期：2019-09-24 00:00:00

abstract：:Viral codon usage bias may be the product of a number of synergistic or antagonistic factors, including genomic nucleotide composition, translational selection, genomic architecture, and mutational or repair biases. Most studies of viral codon bias evaluate only the relative importance of genomic base composition and ...

journal_title：Viruses

authors： Cardinale DJ,DeRosa K,Duffy S

更新日期：2013-01-15 00:00:00

abstract：:Nipah virus (NiV) is an emerging zoonotic virus that is transmitted by bats to humans and to pigs, causing severe respiratory disease and often fatal encephalitis. Antibodies directed against the NiV-glycoprotein (G) protein are known to play a major role in clearing NiV infection and in providing vaccine-induced prot...

journal_title：Viruses

authors： Kalodimou G,Veit S,Jany S,Kalinke U,Broder CC,Sutter G,Volz A

更新日期：2019-12-24 00:00:00

abstract：:Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbr...

journal_title：Viruses

authors： Kanda T,Sasaki R,Masuzaki R,Matsumoto N,Ogawa M,Moriyama M

更新日期：2020-05-12 00:00:00

abstract：:Zika virus (ZIKV) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and Guillain⁻Barré syndrome in adults. Efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating ZI...

journal_title：Viruses

authors： Siddharthan V,Miao J,Van Wettere AJ,Li R,Wu H,Sullivan E,Jiao J,Hooper JW,Safronetz D,Morrey JD,Julander JG,Wang Z

更新日期：2019-01-22 00:00:00

abstract：:Zika virus (ZIKV) is a vertically and sexually transmissible virus resulting in severe congenital malformation. The goal of this study was to develop an ovine model of ZIKV infection. Between 28-35 days gestation (DG), four pregnant animals were infected with two doses of 6 × 106 PFU of ZIKV; four control animals rece...

journal_title：Viruses

authors： Schwarz ER,Pozor MA,Pu R,Barr KL,Beachboard SE,MacLachlan NJ,Prakoso D,Long MT

更新日期：2019-08-29 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) infection strongly modulates the host's immune response. The RNA silencing pathway is an intracellular innate response to viral infections. However, it is unknown whether PRRSV interacts with cellular RNA silencing to facilitate the viral infection. Here, we ...

journal_title：Viruses

authors： Chen J,Shi X,Zhang X,Wang L,Luo J,Xing G,Deng R,Yang H,Li J,Wang A,Zhang G

更新日期：2015-10-23 00:00:00

abstract：:Tetraspanins are integral transmembrane proteins organized in microdomains displaying specific and direct interactions with other tetraspanins and molecular partners. Among them, CD81 has been implicated in a variety of physiological and pathological processes. CD81 also plays a crucial role in pathogen entry into hos...

journal_title：Viruses

authors： Zona L,Tawar RG,Zeisel MB,Xiao F,Schuster C,Lupberger J,Baumert TF

更新日期：2014-02-18 00:00:00

abstract：:Ebola virus is the causative agent of Ebola virus disease in humans. The lethality of Ebola virus infection is about 50%, supporting the urgent need to develop anti-Ebola drugs. Glycoprotein (GP) is the only surface protein of the Ebola virus, which is functionally critical for the virus to attach and enter the host c...

journal_title：Viruses

authors： Cui Q,Cheng H,Xiong R,Zhang G,Du R,Anantpadma M,Davey RA,Rong L

更新日期：2018-11-30 00:00:00

abstract：:Rabies is a highly fatal zoonotic disease which is primarily caused by rabies virus (RABV) although other members of the genus Lyssavirus can cause rabies as well. As yet, 14 serologically and genetically diverse lyssaviruses have been identified, mostly in bats. To assess the quality of rabies vaccines and immunoglob...

journal_title：Viruses

authors： Moeschler S,Locher S,Conzelmann KK,Krämer B,Zimmer G

更新日期：2016-09-16 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy-tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs by transfer of a c...

journal_title：Viruses

authors： Carpentier A,Barez PY,Hamaidia M,Gazon H,de Brogniez A,Perike S,Gillet N,Willems L

更新日期：2015-07-07 00:00:00

abstract：:While bats are increasingly recognized as a source of coronavirus epidemics, the diversity and emergence potential of bat coronaviruses remains to be fully understood. Among 1779 bat samples collected in China, diverse coronaviruses were detected in 32 samples from five different bat species by RT-PCR. Two novel alpha...

journal_title：Viruses

authors： Lau SKP,Wong ACP,Zhang L,Luk HKH,Kwok JSL,Ahmed SS,Cai JP,Zhao PSH,Teng JLL,Tsui SKW,Yuen KY,Woo PCY

更新日期：2019-05-07 00:00:00

abstract：:To further understanding of the structure and morphology of the Orthohantavirus, family Hantaviridae, we have employed cryo-electron microscopy (cryo-EM) for three New World hantaviruses: Andes (ANDV), Sin Nombre (SNV), and Black Creek Canal (BCCV). Building upon our prior cryo-EM and cryo-tomography study of the Old ...

journal_title：Viruses

authors： Parvate A,Williams EP,Taylor MK,Chu YK,Lanman J,Saphire EO,Jonsson CB

更新日期：2019-09-16 00:00:00

abstract：:Human adenovirus type 4 (HAdV-E4), which is intriguingly limited to military populations, causes acute respiratory disease with demonstrated morbidity and mortality implications. This respiratory pathogen contains genome identity with chimpanzee adenoviruses, indicating zoonotic origins. A signature of these "old" HAd...

journal_title：Viruses

authors： Zhang J,Kang J,Dehghan S,Sridhar S,Lau SKP,Ou J,Woo PCY,Zhang Q,Seto D

更新日期：2019-01-31 00:00:00

abstract：:In recent decades, chikungunya virus (CHIKV) has become geographically widespread. In 2004, the CHIKV East/Central/South African (ECSA) genotype moved from Africa to Indian ocean islands and India followed by a large epidemic in Southeast Asia. In 2013, the CHIKV Asian genotype drove an outbreak in the Americas. Since...

journal_title：Viruses

authors： Phadungsombat J,Imad H,Rahman M,Nakayama EE,Kludkleeb S,Ponam T,Rahim R,Hasan A,Poltep K,Yamanaka A,Matsee W,Piyaphanee W,Phumratanaprapin W,Shioda T

更新日期：2020-11-17 00:00:00

abstract：:Viral lysis is a main mortality factor for bacteria in deep-sea sediments, leading to changing microbial community structures and the release of cellular components to the environment. Nature and fate of these compounds and the role of viruses for microbial diversity is largely unknown. We investigated the effect of v...

journal_title：Viruses

authors： Heinrichs ME,Tebbe DA,Wemheuer B,Niggemann J,Engelen B

更新日期：2020-08-22 00:00:00

abstract：:Since the human immunodeficiency virus (HIV) was discovered as the etiological agent of acquired immunodeficiency syndrome (AIDS), it has encouraged much research into antiviral compounds. The reverse transcriptase (RT) of HIV has been a main target for antiviral drugs. However, all drugs developed so far inhibit the ...

journal_title：Viruses

authors： Beilhartz GL,Götte M

更新日期：2010-04-01 00:00:00

abstract：:Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A (H1N1) viruses in m...

journal_title：Viruses

authors： Warfield KL,Barnard DL,Enterlein SG,Smee DF,Khaliq M,Sampath A,Callahan MV,Ramstedt U,Day CW

更新日期：2016-03-07 00:00:00

abstract：:Lassa mammarenavirus (LASV) is the etiologic agent of Lassa fever. In endemic regions in West Africa, LASV genetic diversity tends to cluster by geographic area. Seven LASV lineages are recognized, but the role of viral genetic determinants on disease presentation in humans is uncertain. We investigated the geographic...

journal_title：Viruses

authors： Forni D,Sironi M

更新日期：2020-04-13 00:00:00

abstract：:Many geometric forms are found in nature, some of them adhering to mathematical laws or amazing aesthetic rules. One of the best-known examples in microbiology is the icosahedral shape of certain viruses with 20 triangular facets and 12 edges. What is less known, however, is that a complementary object displaying 12 f...

journal_title：Viruses

authors： Besson S,Vragniau C,Vassal-Stermann E,Dagher MC,Fender P

更新日期：2020-07-02 00:00:00

abstract：:Cyclophilins are peptidyl-prolyl cis/trans isomerases important in the proper folding of certain proteins. Mounting evidence supports varied roles of cyclophilins, either positive or negative, in the life cycles of diverse viruses, but the nature and mechanisms of these roles are yet to be defined. The potential for c...

journal_title：Viruses

authors： Frausto SD,Lee E,Tang H

更新日期：2013-07-11 00:00:00