Abstract：
:The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retroviral-induced disease. This review will focus on the recent advances in the generation of immunodeficient and human hemato-lymphoid system mice with a particular emphasis on the development of mouse models for HTLV-1-mediated pathogenesis, their present limitations and the challenges yet to be addressed.
journal_name
Virusesjournal_title
Virusesauthors
Pérès E,Bagdassarian E,This S,Villaudy J,Rigal D,Gazzolo L,Duc Dodon Mdoi
10.3390/v7122944subject
Has Abstractpub_date
2015-12-07 00:00:00pages
6371-86issue
12issn
1999-4915pii
v7122944journal_volume
7pub_type
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