Abstract：
:Photodynamic inactivation (PDI) has been used to inactivate microorganisms through the use of photosensitizers. The inactivation of mammalian viruses and bacteriophages by photosensitization has been applied with success since the first decades of the last century. Due to the fact that mammalian viruses are known to pose a threat to public health and that bacteriophages are frequently used as models of mammalian viruses, it is important to know and understand the mechanisms and photodynamic procedures involved in their photoinactivation. The aim of this review is to (i) summarize the main approaches developed until now for the photodynamic inactivation of bacteriophages and mammalian viruses and, (ii) discuss and compare the present state of the art of mammalian viruses PDI with phage photoinactivation, with special focus on the most relevant mechanisms, molecular targets and factors affecting the viral inactivation process.
journal_name
Virusesjournal_title
Virusesauthors
Costa L,Faustino MA,Neves MG,Cunha A,Almeida Adoi
10.3390/v4071034subject
Has Abstractpub_date
2012-07-01 00:00:00pages
1034-74issue
7issn
1999-4915pii
v4071034journal_volume
4pub_type
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