Challenges in mucosal HIV vaccine development: lessons from non-human primate models.

abstract：:Diagnostic electron microscopy for infectious diseases has the advantage that "everything" in the specimen can be observed, without a priori knowledge of the likely identity of the microorganisms present in the sample. The classical specimen preparation method used employs a droplet of sample, which allows particles t...

journal_title：Viruses

authors： Beniac DR,Siemens CG,Wright CJ,Booth TF

更新日期：2014-09-19 00:00:00

abstract：:Extracellular vesicles (EVs) play an important role in intercellular communication. They are naturally released from cells into the extracellular environment. Based on their biogenesis, release pathways, size, content, and function, EVs are classified into exosomes, microvesicles (MVs), and apoptotic bodies (ApoBDs). ...

journal_title：Viruses

authors： Alqatawni A,Sharma AL,Attilus B,Tyagi M,Daniel R

更新日期：2020-05-27 00:00:00

abstract：:The phenotype of HTLV-1-transformed CD4(+) T lymphocytes largely depends on defined viral effector molecules such as the viral oncoprotein Tax. In this review, we exemplify the expression pattern of characteristic lineage markers, costimulatory receptors and ligands of the tumor necrosis factor superfamily, cytokine r...

journal_title：Viruses

authors： Kress AK,Grassmann R,Fleckenstein B

更新日期：2011-08-01 00:00:00

abstract：:The hepatitis B virus (HBV) represents a worldwide public health problem; the virus is present in one third of the global population. However, this rate may in fact be higher due to occult hepatitis B virus infection (OBI). This condition is characterized by the presence of the viral genome in the liver of individuals...

journal_title：Viruses

authors： Morales-Romero J,Vargas G,García-Román R

更新日期：2014-04-08 00:00:00

abstract：:The bacteriophage lambda replication initiation protein P exhibits a toxic effect on its Escherichia coli (E. coli) host, likely due to the formation of a dead-end P-DnaB complex, sequestering the replicative DnaB helicase from further activity. Intracellular expression of P triggers SOS-independent cellular filamenta...

journal_title：Viruses

authors： Hayes S,Wang W,Rajamanickam K,Chu A,Banerjee A,Hayes C

更新日期：2016-06-22 00:00:00

abstract：:Janus kinase (JAK) inhibitors have been developed as novel immunomodulatory drugs and primarily used for treating rheumatoid arthritis and other inflammatory diseases. Recent studies have suggested that this category of anti-inflammatory drugs could be potentially useful for the control of inflammation "storms" in res...

journal_title：Viruses

authors： Wang J,Prinz RA,Liu X,Xu X

更新日期：2020-10-08 00:00:00

abstract：:Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populatio...

journal_title：Viruses

authors： Mutsafi Y,Altan-Bonnet N

更新日期：2018-03-20 00:00:00

abstract：:The orthopoxviruses (OPV) comprise several emerging viruses with great importance to human and veterinary medicine, including vaccinia virus (VACV), which causes outbreaks of bovine vaccinia (BV) in South America. Historically, VACV is the most comprehensively studied virus, however, its origin and natural hosts remai...

journal_title：Viruses

authors： Oliveira JS,Figueiredo PO,Costa GB,Assis FL,Drumond BP,da Fonseca FG,Nogueira ML,Kroon EG,Trindade GS

更新日期：2017-11-15 00:00:00

abstract：:About 70% of all Ewing sarcoma (EWS) patients are diagnosed under the age of 20 years. Over the last decades little progress has been made towards finding effective treatment approaches for primarily metastasized or refractory Ewing sarcoma in young patients. Here, in the context of the search for novel therapeutic op...

journal_title：Viruses

authors： Lacroix J,Kis Z,Josupeit R,Schlund F,Stroh-Dege A,Frank-Stöhr M,Leuchs B,Schlehofer JR,Rommelaere J,Dinsart C

更新日期：2018-06-03 00:00:00

abstract：:Tetherin (BST2/CD317/HM1.24) has emerged as a key host-cell ·defence molecule that acts by inhibiting the release and spread of diverse enveloped virions from infected cells. We analysed the biological features of canine tetherin and found it to be an unstable hydrophilic type I transmembrane protein with one transmem...

journal_title：Viruses

authors： Zheng Y,Hao X,Zheng Q,Lin X,Zhang X,Zeng W,Ding S,Zhou P,Li S

更新日期：2018-10-16 00:00:00

abstract：:Despite tremendous efforts over the course of many years, the quest for an effective HIV vaccine by the classical method of active immunization remains largely elusive. However, two recent studies in mice and macaques have now demonstrated a new strategy designated as Vectored ImmunoProphylaxis (VIP), which involves p...

journal_title：Viruses

authors： Yang L,Wang P

更新日期：2014-01-27 00:00:00

abstract：:The mouse mammary tumor virus (MMTV) Pr77Gag polypeptide is an essential retroviral structural protein without which infectious viral particles cannot be formed. This process requires specific recognition and packaging of dimerized genomic RNA (gRNA) by Gag during virus assembly. Most of the previous work on retrovira...

journal_title：Viruses

authors： Chameettachal A,Pillai VN,Ali LM,Pitchai FNN,Ardah MT,Mustafa F,Marquet R,Rizvi TA

更新日期：2018-06-18 00:00:00

abstract：:Avian infectious bronchitis has caused huge economic losses in the poultry industry. Previous studies have reported that infectious bronchitis virus (IBV) infection can produce cytopathic effects (CPE) and apoptosis in some mammalian cells and primary cells. However, there is little research on IBV-induced immune cell...

journal_title：Viruses

authors： Han X,Tian Y,Guan R,Gao W,Yang X,Zhou L,Wang H

更新日期：2017-07-26 00:00:00

abstract：:Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses with global impact on the health of domestic cats. The two viruses differ in their potential to cause disease. FeLV is more pathogenic, and was long considered to be responsible for more clinical syndromes than any other agent in cat...

journal_title：Viruses

authors： Hartmann K

更新日期：2012-10-31 00:00:00

abstract：:Since deer were introduced into Australia in the mid-1800s, their wild populations have increased in size and distribution, posing a potential risk to the livestock industry, through their role in pathogen transmission cycles. In comparison to livestock, there are limited data on viral infections in all wildlife, incl...

journal_title：Viruses

authors： Huaman JL,Pacioni C,Forsyth DM,Pople A,Hampton JO,Carvalho TG,Helbig KJ

更新日期：2020-07-13 00:00:00

abstract：:In July 2018, a novel avian influenza virus (A/Mandarin duck/South Korea/KNU18-12/2018(H11N9)) was isolated from Mandarin ducks in South Korea. Phylogenetic and molecular analyses were conducted to characterize the genetic origins of the H11N9 strain. Phylogenetic analysis indicated that eight gene segments of strain ...

journal_title：Viruses

authors： Tuong HT,Nguyen NM,Sung HW,Park H,Yeo SJ

更新日期：2020-02-12 00:00:00

abstract：:Victoria and Yamagata lineages of influenza B viruses are globally circulating in seasonal epidemics. Madin-Darby canine kidney (MDCK) cells are permissive for viral isolation and vaccine manufacture. Nevertheless, the interplay between influenza B viruses and host microRNAs has not been investigated in this cell line...

journal_title：Viruses

authors： Saengchoowong S,Khongnomnan K,Poomipak W,Praianantathavorn K,Poovorawan Y,Zhang Q,Payungporn S

更新日期：2019-10-25 00:00:00

abstract：:Non-human primates (NHP) are the only animal model suitable to evaluate the protection efficacy of HIV-1 vaccines. It is important to understand how and when neutralizing antibodies (nAbs) with specificities similar to those of human broadly neutralizing antibodies (bnAbs) develop in NHPs. To address these questions, ...

journal_title：Viruses

authors： Gao N,Gai Y,Meng L,Wang C,Zhang X,Wang W,Qin C,Yu X,Gao F

更新日期：2020-01-31 00:00:00

abstract：:The recent emergence and rapid geographic expansion of Zika virus (ZIKV) poses a significant challenge for public health. Although historically causing only mild febrile illness, recent ZIKV outbreaks have been associated with more severe neurological complications, such as Guillain-Barré syndrome and fetal microcepha...

journal_title：Viruses

authors： Barnard TR,Rajah MM,Sagan SM

更新日期：2018-12-19 00:00:00

abstract：:The human cytomegalovirus (HCMV) replicates to high titers in primary human fibroblast cell cultures. A variety of primary human cells and some tumor-derived cell lines do also support permissive HCMV replication, yet at low levels. Cell lines established by transfection of the transforming functions of adenoviruses h...

journal_title：Viruses

authors： Krömmelbein N,Wiebusch L,Schiedner G,Büscher N,Sauer C,Florin L,Sehn E,Wolfrum U,Plachter B

更新日期：2016-02-02 00:00:00

abstract：:During infection, Citrus tristeza virus (CTV) produces a non-coding subgenomic RNA referred to as low-molecular-weight tristeza 1 (LMT1), which for a long time has been considered as a by-product of the complex CTV replication machinery. In this study, we investigated the role of LMT1 in the virus infection cycle usin...

journal_title：Viruses

authors： Kang SH,Sun YD,Atallah OO,Huguet-Tapia JC,Noble JD,Folimonova SY

更新日期：2019-05-14 00:00:00

abstract：:The management of chronic hepatitis B virus (CHB) infection is an area of massive unmet clinical need worldwide. In spite of the development of powerful nucleoside/nucleotide analogue (NUC) drugs, and the widespread use of immune stimulators such as interferon-alpha (IFNα) or PEGylated interferon-alpha (PEG-IFNα), sub...

journal_title：Viruses

authors： Duraisamy GS,Bhosale D,Lipenská I,Huvarova I,Růžek D,Windisch MP,Miller AD

更新日期：2020-09-07 00:00:00

abstract：:Bovine viral diarrhea virus (BVDV) is a globally-distributed agent responsible for numerous clinical syndromes that lead to major economic losses. Two species, BVDV-1 and BVDV-2, discriminated on the basis of genetic and antigenic differences, are classified in the genus Pestivirus within the Flaviviridae family and d...

journal_title：Viruses

authors： Yeşilbağ K,Alpay G,Becher P

更新日期：2017-05-26 00:00:00

abstract：:On average, there are 3-5 million severe cases of influenza virus infections globally each year. Seasonal influenza vaccines provide limited protection against divergent influenza strains. Therefore, the development of a universal influenza vaccine is a top priority for the NIH. Here, we report a comprehensive summary...

journal_title：Viruses

authors： Corder BN,Bullard BL,Poland GA,Weaver EA

更新日期：2020-10-20 00:00:00

abstract：:Between January 2012 and March 2012, the infection rates of porcine epidemic diarrhea virus (PEDV) increased substantially in vaccinated swine herds in many porcine farms in Gansu Province, China. The spike (S) glycoprotein is an important determinant for PEDV biological properties. To determine the distribution profi...

journal_title：Viruses

authors： Tian Y,Yu Z,Cheng K,Liu Y,Huang J,Xin Y,Li Y,Fan S,Wang T,Huang G,Feng N,Yang Z,Yang S,Gao Y,Xia X

更新日期：2013-08-15 00:00:00

abstract：:Knowledge of the antibody-mediated immune response to SARS-CoV-2 is crucial to understand virus immunogenicity, establish seroprevalence, and determine whether subjects or recovered patients are at risk for infection/reinfection and would therefore benefit from vaccination. Here, we describe a novel and simple cell-EL...

journal_title：Viruses

authors： Zarletti G,Tiberi M,De Molfetta V,Bossù M,Toppi E,Bossù P,Scapigliati G

更新日期：2020-11-08 00:00:00

abstract：:Via virome sequencing, six viruses were detected from Magnaporthe oryzae strains YC81-2, including one virus in the family Tombusviridae, one virus in the family Narnaviridae and four viruses in the family Botourmiaviridae. Since the RNA-dependent RNA polymerase (RdRp) of one botourmiavirus show the highest identity (...

journal_title：Viruses

authors： Liu Y,Zhang L,Esmael A,Duan J,Bian X,Jia J,Xie J,Cheng J,Fu Y,Jiang D,Lin Y

更新日期：2020-12-03 00:00:00

abstract：:Andrias davidianus ranavirus (ADRV) is an emerging viral pathogen that causes severe systemic hemorrhagic disease in Chinese giant salamanders. There is an urgent need for developing an effective vaccine against this fatal disease. In this study, DNA vaccines containing the ADRV 2L gene (pcDNA-2L) and the 58L gene (pc...

journal_title：Viruses

authors： Chen ZY,Li T,Gao XC,Wang CF,Zhang QY

更新日期：2018-01-24 00:00:00

abstract：:West Nile virus (WNV) is an important emerging neurotropic virus, responsible for increasingly severe encephalitis outbreaks in humans and horses worldwide. However, the mechanism by which the virus gains entry to the brain (neuroinvasion) remains poorly understood. Hypotheses of hematogenous and transneural entry hav...

journal_title：Viruses

authors： Suen WW,Prow NA,Hall RA,Bielefeldt-Ohmann H

更新日期：2014-07-18 00:00:00

abstract：:Small Ruminant Lentiviruses (SRLVs) are widespread in many countries and cause economically relevant, slow, and persistent diseases in sheep and goats. Monitoring the genetic diversity of SRLVs is useful to improve the diagnostic tools used in the eradication programs. In this study, SRLVs detected in Spanish Assaf sh...

journal_title：Viruses

authors： Gayo E,Cuteri V,Polledo L,Rossi G,García Marín JF,Preziuso S

更新日期：2018-06-09 00:00:00