当前位置： SCI文献检索 > Viruses-Basel期刊下所有文献 > In Vitro and In Vivo Antiviral Activity of Gingerenone A on Influenza A Virus Is Mediated by Targeting Janus Kinase 2.

In Vitro and In Vivo Antiviral Activity of Gingerenone A on Influenza A Virus Is Mediated by Targeting Janus Kinase 2.

Abstract：

:Janus kinase (JAK) inhibitors have been developed as novel immunomodulatory drugs and primarily used for treating rheumatoid arthritis and other inflammatory diseases. Recent studies have suggested that this category of anti-inflammatory drugs could be potentially useful for the control of inflammation "storms" in respiratory virus infections. In addition to their role in regulating immune cell functions, JAK1 and JAK2 have been recently identified as crucial cellular factors involved in influenza A virus (IAV) replication and could be potentially targeted for antiviral therapy. Gingerenone A (Gin A) is a compound derived from ginger roots and a dual inhibitor of JAK2 and p70 S6 kinase (S6K1). Our present study aimed to determine the antiviral activity of Gin A on influenza A virus (IAV) and to understand its mechanisms of action. Here, we reported that Gin A suppressed the replication of three IAV subtypes (H1N1, H5N1, H9N2) in four cell lines. IAV replication was also inhibited by Ruxolitinib (Rux), a JAK inhibitor, but not by PF-4708671, an S6K1 inhibitor. JAK2 overexpression enhanced H5N1 virus replication and attenuated Gin A-mediated antiviral activity. In vivo experiments revealed that Gin A treatment suppressed IAV replication in the lungs of H5N1 virus-infected mice, alleviated their body weight loss, and prolonged their survival. Our study suggests that Gin A restricts IAV replication by inhibiting JAK2 activity; Gin A could be potentially useful for the control of influenza virus infections.

journal_name

Viruses

journal_title

Viruses

authors

Wang J,Prinz RA,Liu X,Xu X

doi

10.3390/v12101141

subject

Has Abstract

pub_date

2020-10-08 00:00:00

issue

10

issn

1999-4915

pii

v12101141

journal_volume

12

pub_type

杂志文章

相关文献

Viruses-Basel文献大全
  • Expression of TIM-3 on Plasmacytoid Dendritic Cells as a Predictive Biomarker of Decline in HIV-1 RNA Level during ART.

    abstract：:Depletion and functional impairment of circulating plasmacytoid dendritic cells (pDCs) are characteristic attributes of HIV-1-infection. The mechanism of dysfunction of pDCs is unclear. Here, we studied the development of phenotype of pDCs in a cohort of HIV-1-infected individuals monitored before the initiation and d...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v10040154

    authors： Font-Haro A,Janovec V,Hofman T,Machala L,Jilich D,Melkova Z,Weber J,Trejbalova K,Hirsch I

    更新日期：2018-03-28 00:00:00

  • Ubiquitous Carbohydrate Binding Modules Decorate 936 Lactococcal Siphophage Virions.

    abstract：:With the availability of an increasing number of 3D structures of bacteriophage components, combined with powerful in silico predictive tools, it has become possible to decipher the structural assembly and functionality of phage adhesion devices. In the current study, we examined 113 members of the 936 group of lactoc...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v11070631

    authors： Hayes S,Mahony J,Vincentelli R,Ramond L,Nauta A,van Sinderen D,Cambillau C

    更新日期：2019-07-09 00:00:00

  • Base composition and translational selection are insufficient to explain codon usage bias in plant viruses.

    abstract：:Viral codon usage bias may be the product of a number of synergistic or antagonistic factors, including genomic nucleotide composition, translational selection, genomic architecture, and mutational or repair biases. Most studies of viral codon bias evaluate only the relative importance of genomic base composition and ...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v5010162

    authors： Cardinale DJ,DeRosa K,Duffy S

    更新日期：2013-01-15 00:00:00

  • Characteristics of Human OAS1 Isoform Proteins.

    abstract：:The human OAS1 (hOAS1) gene produces multiple possible isoforms due to alternative splicing events and sequence variation among individuals, some of which affect splicing. The unique C-terminal sequences of the hOAS1 isoforms could differentially affect synthetase activity, protein stability, protein partner interacti...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v12020152

    authors： Di H,Elbahesh H,Brinton MA

    更新日期：2020-01-29 00:00:00

  • Vaccinia Virus Natural Infections in Brazil: The Good, the Bad, and the Ugly.

    abstract：:The orthopoxviruses (OPV) comprise several emerging viruses with great importance to human and veterinary medicine, including vaccinia virus (VACV), which causes outbreaks of bovine vaccinia (BV) in South America. Historically, VACV is the most comprehensively studied virus, however, its origin and natural hosts remai...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v9110340

    authors： Oliveira JS,Figueiredo PO,Costa GB,Assis FL,Drumond BP,da Fonseca FG,Nogueira ML,Kroon EG,Trindade GS

    更新日期：2017-11-15 00:00:00

  • Evaluation of the operator protection factors offered by positive pressure air suits against airborne microbiological challenge.

    abstract：:Laboratories throughout the world that perform work with Risk Group 4 Pathogens generally adopt one of two approaches within BSL-4 environments: either the use of positive pressure air-fed suits or using Class III microbiological safety cabinets and isolators for animal work. Within the UK at present, all laboratories...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v4081202

    authors： Steward JA,Lever MS

    更新日期：2012-08-01 00:00:00

  • miR-26a Inhibits Feline Herpesvirus 1 Replication by Targeting SOCS5 and Promoting Type I Interferon Signaling.

    abstract：:In response to viral infection, host cells activate various antiviral responses to inhibit virus replication. While feline herpesvirus 1 (FHV-1) manipulates the host early innate immune response in many different ways, the host could activate the antiviral response to counteract it through some unknown mechanisms. Mic...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v12010002

    authors： Zhang J,Li Z,Huang J,Yin H,Tian J,Qu L

    更新日期：2019-12-18 00:00:00

  • Identification of a Novel Recombinant Type 2 Porcine Reproductive and Respiratory Syndrome Virus in China.

    abstract：:Since the emergence of NADC30-like porcine reproductive and respiratory syndrome virus (PRRSV) in China in 2013, PRRSVs have undergone rapid evolution. In this study, a novel variant of PRRSV strain (designated SCcd17) was successfully isolated from piglets with clinical signs in Sichuan Province in China in 2017, and...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v10040151

    authors： Zhou L,Kang R,Xie B,Tian Y,Wu X,Lv X,Yang X,Wang H

    更新日期：2018-03-27 00:00:00

  • Merkel Cell Polyomavirus Large T Antigen Unique Domain Regulates Its Own Protein Stability and Cell Growth.

    abstract：:Merkel cell polyomavirus (MCV) is the only known human oncogenic virus in the polyomaviridae family and the etiological agent of most Merkel cell carcinomas (MCC). MCC is an aggressive and highly metastatic skin cancer with a propensity for recurrence and poor prognosis. Large tumor antigen (LT), is an essential oncop...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v12091043

    authors： Nwogu N,Ortiz LE,Kwun HJ

    更新日期：2020-09-18 00:00:00

  • Innovation in Newcastle Disease Virus Vectored Avian Influenza Vaccines.

    abstract：:Highly pathogenic avian influenza (HPAI) and Newcastle disease are economically important avian diseases worldwide. Effective vaccination is critical to control these diseases in poultry. Live attenuated Newcastle disease virus (NDV) vectored vaccines have been developed for bivalent vaccination against HPAI viruses a...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v11030300

    authors： Kim SH,Samal SK

    更新日期：2019-03-26 00:00:00

  • Phage Lytic Enzymes.

    abstract：:Phage lytic enzymes are enzymes produced by bacterial viruses, either as part of their virion to facilitate bacterial infection through local peptidoglycan degradation, or as soluble proteins to induce massive cell lysis at the end of the lytic replication cycle [...]. ...

    journal_title：Viruses

    pub_type： 社论

    doi：10.3390/v11020113

    authors： Briers Y

    更新日期：2019-01-29 00:00:00

  • Brockman, M.A., et al., Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants? Viruses 2012, 4, 1711-1730.

    abstract：:In the original manuscript, the text in figure 1 is illegible. Furthermore, there is an unnecessary carriage return (page 1716, ~line 18) "crystallographic ... methods". ...

    journal_title：Viruses

    pub_type： 杂志文章,已发布勘误

    doi：10.3390/v4102014

    authors： Mwimanzi P,Markle TJ,Ueno T,Brockman MA

    更新日期：2012-10-05 00:00:00

  • The Serological Prevalence of Rabies Virus-Neutralizing Antibodies in the Bat Population on the Caribbean Island of Trinidad.

    abstract：:: Rabies virus (RABV) is the only lyssavirus known to be present within the Caribbean. The island of Trinidad, is richly diverse in chiropteran fauna and endemic for bat-transmitted rabies with low RABV isolation rates observed in this population. We aimed to determine the seroprevalence of rabies virus neutralizing a...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v12020178

    authors： Seetahal JFR,Greenberg L,Satheshkumar PS,Sanchez-Vazquez MJ,Legall G,Singh S,Ramkissoon V,Schountz T,Munster V,Oura CAL,Carrington CVF

    更新日期：2020-02-05 00:00:00

  • Field Evaluation of Deltamethrin and Ivermectin Applications to Cattle on Culicoides Host-Alighting, Blood-Feeding, and Emergence.

    abstract：:The impact of topical applications of deltamethrin and ivermectin to cattle on Culicoides spp. landing and blood-feeding was studied in this work using sticky traps mounted on Friesian heifers' backs. There was no effect of the insecticides on total numbers of Culicoides trapped or the proportion engorged. Deltamethri...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v11080731

    authors： Murchie AK,Thompson GM,Clawson S,Brown A,Gordon AW,Jess S

    更新日期：2019-08-08 00:00:00

  • Phylogenomic Analysis of Global Isolates of Canid Alphaherpesvirus 1.

    abstract：:Canid alphaherpesvirus 1 (CHV-1) is a widespread pathogen of dogs with multiple associated clinical signs. There has been limited prior investigation into the genomics and phylogeny of this virus using whole viral genome analysis. Fifteen CHV-1 isolates were collected from animals with ocular disease based in the USA....

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v12121421

    authors： Lewin AC,Coghill LM,Mironovich M,Liu CC,Carter RT,Ledbetter EC

    更新日期：2020-12-10 00:00:00

  • In Vitro Synthesized RNA Generated from cDNA Clones of Both Genomic Components of Cucurbit yellow stunting disorder virus Replicates in Cucumber Protoplasts.

    abstract：:Cucurbit yellow stunting disorder virus (CYSDV), a bipartite whitefly-transmitted virus, constitutes a major threat to commercial cucurbit production worldwide. Here, construction of full-length CYSDV RNA1 and RNA2 cDNA clones allowed the in vitro synthesis of RNA transcripts able to replicate in cucumber protoplasts....

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v8060170

    authors： Owen CA,Moukarzel R,Huang X,Kassem MA,Eliasco E,Aranda MA,Coutts RH,Livieratos IC

    更新日期：2016-06-14 00:00:00

  • Variability and Global Distribution of Subgenotypes of Bovine Viral Diarrhea Virus.

    abstract：:Bovine viral diarrhea virus (BVDV) is a globally-distributed agent responsible for numerous clinical syndromes that lead to major economic losses. Two species, BVDV-1 and BVDV-2, discriminated on the basis of genetic and antigenic differences, are classified in the genus Pestivirus within the Flaviviridae family and d...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v9060128

    authors： Yeşilbağ K,Alpay G,Becher P

    更新日期：2017-05-26 00:00:00

  • Viral Encephalitis of Unknown Cause: Current Perspective and Recent Advances.

    abstract：:Viral encephalitis causes acute inflammation of the brain parenchyma and is a significant cause of human morbidity and mortality. Although Herpes Simplex encephalitis is the most frequent known cause of fatal sporadic encephalitis in humans, an increasingly wide range of viruses and other microbial pathogens are impli...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v9060138

    authors： Kennedy PGE,Quan PL,Lipkin WI

    更新日期：2017-06-06 00:00:00

  • Detection of Usutu, Sindbis, and Batai Viruses in Mosquitoes (Diptera: Culicidae) Collected in Germany, 2011⁻2016.

    abstract：:Due to the emergence of non-endemic mosquito vectors and the recent outbreaks of mosquito-borne diseases, mosquito-borne pathogens are considered an increasing risk to public and animal health in Europe. To obtain a status quo regarding mosquito-borne viruses and their vectors in Germany, 97,648 mosquitoes collected f...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v10070389

    authors： Scheuch DE,Schäfer M,Eiden M,Heym EC,Ziegler U,Walther D,Schmidt-Chanasit J,Keller M,Groschup MH,Kampen H

    更新日期：2018-07-23 00:00:00

  • Cell-Free and Cell-Based Approaches to Explore the Roles of Host Membranes and Lipids in the Formation of Viral Replication Compartment Induced by Tombusviruses.

    abstract：:Plant positive strand RNA viruses are intracellular infectious agents that take advantage of cellular lipids and membranes to support replication and protect viral RNA from degradation by host antiviral responses. In this review, we discuss how Tomato bushy stunt virus (TBSV) co-opts lipid transfer proteins and modula...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v8030068

    authors： Nagy PD,Pogany J,Xu K

    更新日期：2016-03-03 00:00:00

  • A Divergent Hepatitis D-Like Agent in Birds.

    abstract：:Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures tha...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v10120720

    authors： Wille M,Netter HJ,Littlejohn M,Yuen L,Shi M,Eden JS,Klaassen M,Holmes EC,Hurt AC

    更新日期：2018-12-17 00:00:00

  • Beet Necrotic Yellow Vein Virus Noncoding RNA Production Depends on a 5'→3' Xrn Exoribonuclease Activity.

    abstract：:The RNA3 species of the beet necrotic yellow vein virus (BNYVV), a multipartite positive-stranded RNA phytovirus, contains the 'core' nucleotide sequence required for its systemic movement in Beta macrocarpa. Within this 'core' sequence resides a conserved "coremin" motif of 20 nucleotides that is absolutely essential...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v10030137

    authors： Flobinus A,Chevigny N,Charley PA,Seissler T,Klein E,Bleykasten-Grosshans C,Ratti C,Bouzoubaa S,Wilusz J,Gilmer D

    更新日期：2018-03-19 00:00:00

  • Effects of a Covert Infection with Phthorimaea operculella granulovirus in Insect Populations of Phthorimaea operculella.

    abstract：:Virus infections of insects can easily stay undetected, neither showing typical signs of a disease, nor being lethal. Such a stable and most of the time covert infection with Phthorimaea operculella granulovirus (PhopGV) was detected in a Phthorimaea operculella laboratory colony, which originated from Italy (Phop-IT)...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v11040337

    authors： Larem A,Ben Tiba S,Fritsch E,Undorf-Spahn K,Wennmann JT,Jehle JA

    更新日期：2019-04-09 00:00:00

  • Orchestrating the Selection and Packaging of Genomic RNA by Retroviruses: An Ensemble of Viral and Host Factors.

    abstract：:Infectious retrovirus particles contain two copies of unspliced viral RNA that serve as the viral genome. Unspliced retroviral RNA is transcribed in the nucleus by the host RNA polymerase II and has three potential fates: (1) it can be spliced into subgenomic messenger RNAs (mRNAs) for the translation of viral protein...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v8090257

    authors： Kaddis Maldonado RJ,Parent LJ

    更新日期：2016-09-20 00:00:00

  • Human cytomegalovirus encoded homologs of cytokines, chemokines and their receptors: roles in immunomodulation.

    abstract：:Human cytomegalovirus (HCMV), the largest human herpesvirus, infects a majority of the world's population. Like all herpesviruses, following primary productive infection, HCMV establishes a life-long latent infection, from which it can reactivate years later to produce new, infectious virus. Despite the presence of a ...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v4112448

    authors： McSharry BP,Avdic S,Slobedman B

    更新日期：2012-10-25 00:00:00

  • A Truncated Nef Peptide from SIVcpz Inhibits the Production of HIV-1 Infectious Progeny.

    abstract：:Nef proteins from all primate Lentiviruses, including the simian immunodeficiency virus of chimpanzees (SIVcpz), increase viral progeny infectivity. However, the function of Nef involved with the increase in viral infectivity is still not completely understood. Nonetheless, until now, studies investigating the functio...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v8070189

    authors： Sabino Cunha M,Lima Sampaio T,Peterlin BM,Jesus da Costa L

    更新日期：2016-07-07 00:00:00

  • A Decrease in Temperature and Humidity Precedes Human Rhinovirus Infections in a Cold Climate.

    abstract：:Both temperature and humidity may independently or jointly contribute to the risk of human rhinovirus (HRV) infections, either through altered survival and spread of viruses in the environment or due to changes in host susceptibility. This study examined the relationship between short-term variations in temperature an...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v8090244

    authors： Ikäheimo TM,Jaakkola K,Jokelainen J,Saukkoriipi A,Roivainen M,Juvonen R,Vainio O,Jaakkola JJ

    更新日期：2016-09-02 00:00:00

  • Bovine Adenovirus-3 Tropism for Bovine Leukocyte Sub-Populations.

    abstract：:A number of characteristics including lack of virulence and the ability to grow to high titers, have made bovine adenovirus-3 (BAdV-3) a vector of choice for further development as a vaccine-delivery vehicle for cattle. Despite the importance of blood leukocytes, including dendritic cells (DC), in the induction of pro...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v12121431

    authors： Khosa S,Araya MB,Griebel P,Arsic N,Tikoo SK

    更新日期：2020-12-12 00:00:00

  • Maturation Pathways of Cross-Reactive HIV-1 Neutralizing Antibodies.

    abstract：:Several human monoclonal antibodies (hmAbs) and antibody fragments, including the best characterized in terms of structure-function b12 and Fab X5, exhibit relatively potent and broad HIV-1 neutralizing activity. However, the elicitation of b12 or b12-like antibodies in vivo by vaccine immunogens based on the HIV-1 en...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v1030802

    authors： Xiao X,Chen W,Feng Y,Dimitrov DS

    更新日期：2009-12-01 00:00:00

  • Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques.

    abstract：:Despite worldwide efforts to understand the transmission dynamics of Zika virus (ZIKV), scanty evaluation has been made on the vector competence of Aedes aegypti fed directly on viremic human and non-human primates (NHPs). We blood-fed Ae. aegypti from two districts in Rio de Janeiro on six ZIKV infected pregnant rhes...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v12121345

    authors： Fernandes RS,David MR,De Abreu FVS,Ferreira-de-Brito A,Gardinali NR,Lima SMB,Andrade MCR,Kugelmeier T,Oliveira JM,Pinto MA,Lourenço-de-Oliveira R

    更新日期：2020-11-24 00:00:00