Abstract：
:Human cytomegalovirus (HCMV), the largest human herpesvirus, infects a majority of the world's population. Like all herpesviruses, following primary productive infection, HCMV establishes a life-long latent infection, from which it can reactivate years later to produce new, infectious virus. Despite the presence of a massive and sustained anti-HCMV immune response, productively infected individuals can shed virus for extended periods of time, and once latent infection is established, it is never cleared from the host. It has been proposed that HCMV must therefore encode functions which help to evade immune mediated clearance during productive virus replication and latency. Molecular mimicry is a strategy used by many viruses to subvert and regulate anti-viral immunity and HCMV has hijacked/developed a range of functions that imitate host encoded immunomodulatory proteins. This review will focus on the HCMV encoded homologs of cellular cytokines/chemokines and their receptors, with an emphasis on how these virus encoded homologs may facilitate viral evasion of immune clearance.
journal_name
Virusesjournal_title
Virusesauthors
McSharry BP,Avdic S,Slobedman Bdoi
10.3390/v4112448subject
Has Abstractpub_date
2012-10-25 00:00:00pages
2448-70issue
11issn
1999-4915pii
v4112448journal_volume
4pub_type
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