The RNA Architecture of the SARS-CoV-2 3'-Untranslated Region.

abstract：:Peptides derived from the C-terminal heptad repeat (CHR) region of HIV-1 gp41 is potent viral membrane fusion inhibitors, such as the first clinically approved peptide drug T20 and a group of newly-designed peptides. The resistance profiles of various HIV-1 fusion inhibitors were previously characterized, and the seco...

journal_title：Viruses

authors： Yu D,Su Y,Ding X,Zhu Y,Qin B,Chong H,Cui S,He Y

更新日期：2020-03-18 00:00:00

abstract：:Global climate change-induced warming of the Artic seas is predicted to shift the phytoplankton community towards dominance of smaller-sized species due to global warming. Yet, little is known about their viral mortality agents despite the ecological importance of viruses regulating phytoplankton host dynamics and div...

journal_title：Viruses

authors： Maat DS,Biggs T,Evans C,van Bleijswijk JDL,van der Wel NN,Dutilh BE,Brussaard CPD

更新日期：2017-06-02 00:00:00

abstract：:Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of HTLV-associated disease and viral dynamics. A subset of 45 human T-...

journal_title：Viruses

authors： Usadi B,Bruhn R,Lin J,Lee TH,Blackburn E,Murphy EL

更新日期：2016-08-11 00:00:00

abstract：:A field study was undertaken to (i) measure the prevalence of feline leukaemia virus (FeLV) exposure and FeLV infection in a cross-section of healthy Australian pet cats; and (ii) investigate the outcomes following natural FeLV exposure in two Australian rescue facilities. Group 1 (n = 440) consisted of healthy client...

journal_title：Viruses

authors： Westman M,Norris J,Malik R,Hofmann-Lehmann R,Harvey A,McLuckie A,Perkins M,Schofield D,Marcus A,McDonald M,Ward M,Hall E,Sheehy P,Hosie M

更新日期：2019-05-31 00:00:00

abstract：:Arthropod-borne flaviviruses are human pathogens of global medical importance, against which no effective small molecule-based antiviral therapy has currently been reported. Arbidol (umifenovir) is a broad-spectrum antiviral compound approved in Russia and China for prophylaxis and treatment of influenza. This compoun...

journal_title：Viruses

authors： Haviernik J,Štefánik M,Fojtíková M,Kali S,Tordo N,Rudolf I,Hubálek Z,Eyer L,Ruzek D

更新日期：2018-04-10 00:00:00

abstract：:During infection, Citrus tristeza virus (CTV) produces a non-coding subgenomic RNA referred to as low-molecular-weight tristeza 1 (LMT1), which for a long time has been considered as a by-product of the complex CTV replication machinery. In this study, we investigated the role of LMT1 in the virus infection cycle usin...

journal_title：Viruses

authors： Kang SH,Sun YD,Atallah OO,Huguet-Tapia JC,Noble JD,Folimonova SY

更新日期：2019-05-14 00:00:00

abstract：:A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells by direct cellular contacts across a specialized structure, the virological synapse. This process was recently described through live cell imaging. Together with the accumulated knowledge on cellular and molecular structures involved ...

journal_title：Viruses

authors： Feldmann J,Schwartz O

更新日期：2010-08-01 00:00:00

abstract：:Influenza is a serious public health concern worldwide, as it causes significant morbidity and mortality. The emergence of drug-resistant viral strains requires new approaches for the treatment of influenza. In this study, Rubus coreanus seed (RCS) that is left over from the production of wine or juice was found to sh...

journal_title：Viruses

authors： Lee JH,Oh M,Seok JH,Kim S,Lee DB,Bae G,Bae HI,Bae SY,Hong YM,Kwon SO,Lee DH,Song CS,Mun JY,Chung MS,Kim KH

更新日期：2016-06-06 00:00:00

abstract：:Puumala virus (PUUV) is the agent of nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) in Europe. NE incidence presents a high spatial variation throughout France, while the geographical distribution of the wild reservoir of PUUV, the bank vole, is rather continuous. A missing pi...

journal_title：Viruses

authors： Castel G,Couteaudier M,Sauvage F,Pons JB,Murri S,Plyusnina A,Pontier D,Cosson JF,Plyusnin A,Marianneau P,Tordo N

更新日期：2015-10-22 00:00:00

abstract：:Exosomes are extracellular vesicles released upon fusion of multivesicular bodies(MVBs) with the cellular plasma membrane. They originate as intraluminal vesicles (ILVs) during the process of MVB formation. Exosomes were shown to contain selectively sorted functional proteins, lipids, and RNAs, mediating cell-to-cell ...

journal_title：Viruses

authors： Alenquer M,Amorim MJ

更新日期：2015-09-17 00:00:00

abstract：:To assist the global eradication of peste des petits ruminants virus (PPRV), a molecular test for the rapid and reliable detection of PPRV was developed which additionally enables the detection of pathogens relevant for differential diagnostics. For this purpose, the necessary time frame of a magnetic bead-based nucle...

journal_title：Viruses

authors： Halecker S,Mettenleiter TC,Beer M,Hoffmann B

更新日期：2020-10-29 00:00:00

abstract：:Microvirin (MVN) is one of the human immunodeficiency virus (HIV-1) entry inhibitor lectins, which consists of two structural domains sharing 35% sequence identity and contrary to many other antiviral lectins, it exists as a monomer. In this study, we engineered an MVN variant, LUMS1, consisting of two domains with 10...

journal_title：Viruses

authors： Shahid M,Qadir A,Yang J,Ahmad I,Zahid H,Mirza S,Windisch MP,Shahzad-Ul-Hussan S

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:Duck plague virus (DPV) can induce apoptosis in duck embryo fibroblasts (DEFs) and in infected ducks, but the molecular mechanism of DPV-induced apoptosis remains unknown. METHODS:We first used qRT-PCR and a Caspase-Glo assay to determine whether the caspase protein family plays an important role in DPV-ind...

journal_title：Viruses

authors： Zhao C,Wang M,Cheng A,Yang Q,Wu Y,Jia R,Zhu D,Chen S,Liu M,Zhao X,Zhang S,Liu Y,Yu Y,Zhang L,Tian B,Rehman MU,Pan L,Chen X

更新日期：2019-02-24 00:00:00

abstract：:Seoul virus (SEOV) is a zoonotic orthohantavirus carried by black and brown rats, and can cause hemorrhagic fever with renal syndrome in humans. Human cases of SEOV virus infection have most recently been reported in the USA, United Kingdom, France and the Netherlands and were primarily associated with contact with pe...

journal_title：Viruses

authors： Maas M,van Heteren M,de Vries A,Kuiken T,Hoornweg T,Veldhuis Kroeze E,Rockx B

更新日期：2019-06-07 00:00:00

abstract：:Because of its ecological characteristics, the Caxiuanã National Forest (FLONA) is a potential area of arbovirus circulation. The present study aimed to investigate the occurrence of arbovirus transmission cycles at FLONA de Caxiuanã. Five field trips were performed to capture mosquitoes and sylvatic vertebrates. For ...

journal_title：Viruses

authors： Araújo PA,Freitas MO,Chiang JO,Silva FA,Chagas LL,Casseb SM,Silva SP,Nunes-Neto JP,Rosa-Júnior JW,Nascimento BS,Hernández LA,Paz TB,Barros LL,Silva EP,Azevedo RS,Martins LC,Ferreira MS,Vasconcelos PF

更新日期：2019-08-22 00:00:00

abstract：:Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne infectious disease, therefore, the information on the whole genome of the SFTS virus (SFTSV) is still limited. This study demonstrates a nearly whole genome of the SFTSV identified in Osaka in 2017 and 2018 by next-generation sequencing (NGS). Th...

journal_title：Viruses

authors： Ikemori R,Aoyama I,Sasaki T,Takabayashi H,Morisada K,Kinoshita M,Ikuta K,Yumisashi T,Motomura K

更新日期：2021-01-25 00:00:00

abstract：:The impact of topical applications of deltamethrin and ivermectin to cattle on Culicoides spp. landing and blood-feeding was studied in this work using sticky traps mounted on Friesian heifers' backs. There was no effect of the insecticides on total numbers of Culicoides trapped or the proportion engorged. Deltamethri...

journal_title：Viruses

authors： Murchie AK,Thompson GM,Clawson S,Brown A,Gordon AW,Jess S

更新日期：2019-08-08 00:00:00

abstract：:Dengue virus (DENV) infection is one of the most widespread mosquito-borne viral infections. Liver injury is commonly observed in severe DENV infection, and the present study aimed to examine the efficacy of crocetin treatment in an immunocompetent mouse model of DENV infection exhibiting liver injury. The efficacy of...

journal_title：Viruses

authors： Sreekanth GP,Chuncharunee A,Yenchitsomanus PT,Limjindaporn T

更新日期：2020-07-30 00:00:00

abstract：:Staphylococcus aureus is a common and often virulent pathogen in humans. This bacterium is widespread, being present on the skin and in the nose of healthy people. Staphylococcus aureus can cause infections with severe outcomes ranging from pustules to sepsis and death. The introduction of antibiotics led to a general...

journal_title：Viruses

authors： Kaźmierczak Z,Górski A,Dąbrowska K

更新日期：2014-07-01 00:00:00

abstract：:Astroviral infection is considered to be one of the causes of mammalian diarrheal diseases. It has been shown that astrovirus infections cause varying degrees of diarrhea in turkeys and mice. However, the pathogenesis of porcine astrovirus is unknown. In this study, the virulence of a cytopathic porcine astrovirus (PA...

journal_title：Viruses

authors： Fang Q,Wang C,Liu H,Wu Q,Liang S,Cen M,Dong Q,Wei Y,Chen Y,Ouyang K,Wei Z,Huang W

更新日期：2019-12-13 00:00:00

abstract：:This is the first record of a fish nidovirus isolated from a consignment of goldfish at the United Kingdom (UK) border. The full-length viral genome was 25,985 nt, sharing a 97.9% nucleotide identity with the Chinook salmon bafinivirus (CSBV) NIDO with two deletions of 537 and 480 nt on the ORF Ia protein. To assess t...

journal_title：Viruses

authors： Cano I,Stone D,Savage J,Wood G,Mulhearn B,Gray J,Stinton N,Ross S,Bonar M,Taylor NGH,Bateman KS,Feist SW

更新日期：2020-05-25 00:00:00

abstract：:The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This review focuses on differ...

journal_title：Viruses

authors： Zeisel MB,Fafi-Kremer S,Robinet E,Habersetzer F,Baumert TF,Stoll-Keller F

更新日期：2009-09-01 00:00:00

abstract：:Circoviruses infect a variety of animal species and have small (~1.8-2.2 kb) circular single-stranded DNA genomes. Recently a penguin circovirus (PenCV) was identified associated with an Adélie Penguin (Pygoscelis adeliae) with feather disorder and in the cloacal swabs of three asymptomatic Adélie Penguins at Cape Cro...

journal_title：Viruses

authors： Levy H,Fiddaman SR,Djurhuus A,Black CE,Kraberger S,Smith AL,Hart T,Varsani A

更新日期：2020-08-06 00:00:00

abstract：:Extracellular vesicles (EVs) play an important role in intercellular communication. They are naturally released from cells into the extracellular environment. Based on their biogenesis, release pathways, size, content, and function, EVs are classified into exosomes, microvesicles (MVs), and apoptotic bodies (ApoBDs). ...

journal_title：Viruses

authors： Alqatawni A,Sharma AL,Attilus B,Tyagi M,Daniel R

更新日期：2020-05-27 00:00:00

abstract：:SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated viral infection are important for studying immunity. Because SARS-CoV-2 is a biosafety-level-3 virus, one way to simplify such assays is ...

journal_title：Viruses

authors： Crawford KHD,Eguia R,Dingens AS,Loes AN,Malone KD,Wolf CR,Chu HY,Tortorici MA,Veesler D,Murphy M,Pettie D,King NP,Balazs AB,Bloom JD

更新日期：2020-05-06 00:00:00

abstract：:Autophagy is a potent cell autonomous defense mechanism that engages the lysosomal pathway to fight intracellular pathogens. Several autophagy receptors can recognize invading pathogens in order to target them towards autophagy for their degradation after the fusion of pathogen-containing autophagosomes with lysosomes...

journal_title：Viruses

authors： Petkova DS,Verlhac P,Rozières A,Baguet J,Claviere M,Kretz-Remy C,Mahieux R,Viret C,Faure M

更新日期：2017-05-22 00:00:00

abstract：:Peptide-displayed phage libraries are billion-clone collections of diverse chimeric bacteriophage particles, decorated by genetically fused peptides built from a random combination of natural amino acids. Studying the molecular evolution of peptide-displayed libraries in mammalian model systems, using in vivo phage di...

journal_title：Viruses

authors： Gillespie JW,Yang L,De Plano LM,Stackhouse MA,Petrenko VA

更新日期：2019-10-26 00:00:00

abstract：:HIV-1 causes a chronic infection in humans that is characterized by high plasma viremia, progressive loss of CD4+ T lymphocytes, and severe immunodeficiency resulting in opportunistic disease and AIDS. Viral persistence is mediated in part by the ability of the Nef protein to down-regulate HLA molecules on the infecte...

journal_title：Viruses

authors： Mwimanzi P,Markle TJ,Ueno T,Brockman MA

更新日期：2012-09-01 00:00:00

abstract：:Virus-induced inflammation plays a critical role in determining the clinical outcome of an acute respiratory virus infection. We have shown previously that the administration of immunobiotic Lactobacillus plantarum (Lp) directly to the respiratory tract prevents lethal inflammatory responses to subsequent infection wi...

journal_title：Viruses

authors： Mai E,Percopo CM,Limkar AR,Sek AC,Ma M,Rosenberg HF

更新日期：2020-12-22 00:00:00

abstract：:Human parechovirus (HPeV), particularly type 3 (HPeV3), is an important cause of sepsis-/meningitis-like illness in young infants. Laboratory records identified a total of ten HPeV-positive cases in Southeastern Australia between January and July 2019. The HPeV present in these cases were typed by Sanger sequencing of...

journal_title：Viruses

authors： Chamings A,Liew KC,Reid E,Athan E,Raditsis A,Vuillermin P,Yoga Y,Caly L,Druce J,Alexandersen S

更新日期：2019-10-03 00:00:00