Abstract:
:Due to the emergence of non-endemic mosquito vectors and the recent outbreaks of mosquito-borne diseases, mosquito-borne pathogens are considered an increasing risk to public and animal health in Europe. To obtain a status quo regarding mosquito-borne viruses and their vectors in Germany, 97,648 mosquitoes collected from 2011 to 2016 throughout the country were screened for arboviruses. Mosquitoes were identified to species, pooled in groups of up to 50 individuals according to sampling location and date, and screened with different PCR assays for Flavi-, Alpha- and Orthobunyavirus RNA. Two pools tested positive for Usutu virus-RNA, two for Sindbis virus-RNA, and 24 for Batai virus-RNA. The pools consisted of Culex pipiens s.l., Culex modestus, Culex torrentium, Culiseta sp., Aedes vexans, Anopheles daciae, and Anopheles messeae mosquitoes and could be assigned to nine different collection sites, with seven of them located in northeastern Germany. Phylogenetic analyses of the viral RNA sequences showed relationships with strains of the viruses previously demonstrated in Germany. These findings confirm continuing mosquito-borne zoonotic arbovirus circulation even though only a rather small percentage of the screened samples tested positive. With respect to sampling sites and periods, virus circulation seems to be particularly intense in floodplains and after flooding events when mosquitoes develop in excessive numbers and where they have numerous avian hosts available to feed on.
journal_name
Virusesjournal_title
Virusesauthors
Scheuch DE,Schäfer M,Eiden M,Heym EC,Ziegler U,Walther D,Schmidt-Chanasit J,Keller M,Groschup MH,Kampen Hdoi
10.3390/v10070389subject
Has Abstractpub_date
2018-07-23 00:00:00issue
7issn
1999-4915pii
v10070389journal_volume
10pub_type
杂志文章相关文献
Viruses-Basel文献大全abstract::Timely implementation of antiviral treatment and other public health based responses are dependent on accurate and rapid diagnosis of the novel pandemic influenza A(H1N1) strain. In this study we developed a duplex real-time PCR (RT-PCR) (dFLU-TM) assay for the simultaneous detection of a broad range of influenza A su...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v1031204
更新日期:2009-12-01 00:00:00
abstract::Heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar) was first diagnosed in Norway in 1999. The disease is caused by Piscine orthoreovirus-1 (PRV-1). The virus is prevalent in farmed Atlantic salmon, but not always associated with disease. Phylogeny and sequence analyses of 31 PRV-1 ge...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11050465
更新日期:2019-05-22 00:00:00
abstract::Bacterial infections pose a challenge to human health and burden the health care system, especially with the spread of antibiotic-resistant populations. To provide effective treatment and improved prognosis, effective diagnostic methods are of great importance. Here we present phage-mediated molecular detection (PMMD)...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040435
更新日期:2020-04-11 00:00:00
abstract::Eukaryotic translation is a complex process composed of three main steps: initiation, elongation, and termination. During infections by RNA- and DNA-viruses, the eukaryotic translation machinery is used to assure optimal viral protein synthesis. Human immunodeficiency virus type I (HIV-1) uses several non-canonical pa...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v7010199
更新日期:2015-01-19 00:00:00
abstract::Enteroviruses, the most common human viral pathogens worldwide, have been associated with serous meningitis, encephalitis, syndrome of acute flaccid paralysis, myocarditis and the onset of diabetes type 1. In the future, the rapid identification of the etiological agent would allow to adjust the therapy promptly and t...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8010010
更新日期:2016-01-06 00:00:00
abstract::Type I interferon (IFN-I) is the first line of mammalian host defense against viral infection. To counteract this, the flaviviruses, like other viruses, have encoded a variety of antagonists, and use a multi-layered molecular defense strategy to establish their infections. Among the most potent antagonists is non-stru...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10120712
更新日期:2018-12-14 00:00:00
abstract::Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholesterolemia. Furthermore,...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v5051292
更新日期:2013-05-23 00:00:00
abstract::An effective vaccine is essential for controlling the spread of the SARS-CoV-2 virus. Here, we describe an influenza virus-based vaccine for SARS-CoV-2. We incorporated a membrane-anchored form of the SARS-CoV-2 spike receptor binding domain (RBD) in place of the neuraminidase (NA) coding sequence in an influenza viru...
journal_title:Viruses
pub_type: 评论,杂志文章
doi:10.3390/v12090987
更新日期:2020-09-05 00:00:00
abstract::Samples of two Ageratum conyzoides, one Sonchus oleraceus and one turnip (Brassica rapa var. rapa) exhibiting virus-like symptoms were collected from Pakistan and Nepal. Full-length begomovirus clones were obtained from the four plant samples and betasatellite clones from three of these. The begomovirus sequences were...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7020647
更新日期:2015-02-10 00:00:00
abstract::Dengue virus (DENV) infection is one of the most widespread mosquito-borne viral infections. Liver injury is commonly observed in severe DENV infection, and the present study aimed to examine the efficacy of crocetin treatment in an immunocompetent mouse model of DENV infection exhibiting liver injury. The efficacy of...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12080825
更新日期:2020-07-30 00:00:00
abstract::Chikungunya virus (CHIKV) has caused extensive outbreaks in several countries within the Americas, Asia, Oceanic/Pacific Islands, and Europe. In humans, CHIKV infections cause a debilitating disease with acute febrile illness and long-term polyarthralgia. Acute and chronic symptoms impose a major economic burden to he...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11040322
更新日期:2019-04-03 00:00:00
abstract::Bats are unique mammals, exhibit distinctive life history traits and have unique immunological approaches to suppression of viral diseases upon infection. High-throughput next-generation sequencing has been used in characterizing the virome of different bat species. The cave nectar bat, Eonycteris spelaea, has a broad...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11030250
更新日期:2019-03-12 00:00:00
abstract::The nervous system is the target for acute encephalitic viral infections, as well as a reservoir for persisting viruses. Intrathecal antibody (Ab) synthesis is well documented in humans afflicted by infections associated with neurological complications, as well as the demyelinating disease, multiple sclerosis. This re...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v5020732
更新日期:2013-02-15 00:00:00
abstract::Tospovirus is a tripartite negative stranded RNA virus and is considered as one of the most devastating plant viruses. Successful virus infection in plant requires many host factors. To date, very few host factors have been identified as important in Tospovirus infection in plants. We reported earlier that NSm protein...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10110647
更新日期:2018-11-17 00:00:00
abstract::We are currently facing a pandemic of COVID-19, caused by a spillover from an animal-originating coronavirus to humans occurring in the Wuhan region of China in December 2019. From China, the virus has spread to 188 countries and regions worldwide, reaching the Sahel region on March 2, 2020. Since whole genome sequenc...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111251
更新日期:2020-11-02 00:00:00
abstract::Next-generation sequencing (NGS) has opened up the possibility of detecting new viruses in unresolved diseases. Recently, astrovirus brain infections have been identified in neurologically diseased humans and animals by NGS, among them bovine astrovirus (BoAstV) CH13/NeuroS1, which has been found in brain tissues of c...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v9010012
更新日期:2017-01-18 00:00:00
abstract::Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress toward...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11010074
更新日期:2019-01-17 00:00:00
abstract::Commentary on Hare, S.; Gupta, S.S.; Valkov, E.; Engelman, A.; Cherepanov, P. Retroviral intasome assembly and inhibition of DNA strand transfer. Nature2010, 464, 232-236. ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v2051185
更新日期:2010-05-01 00:00:00
abstract::Half a century of research on membrane-containing phages has had a major impact on virology, providing new insights into virus diversity, evolution and ecological importance. The recent revolutionary technical advances in imaging, sequencing and lipid analysis have significantly boosted the depth and volume of knowled...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11010076
更新日期:2019-01-18 00:00:00
abstract::Mycoviruses infect a large number of diverse fungal species, but considering their prevalence, relatively few high-quality genome sequences have been determined. Many mycoviruses have linear double-stranded RNA genomes, which makes it technically challenging to ascertain their nucleotide sequence using conventional se...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010070
更新日期:2019-01-16 00:00:00
abstract::Hantaviruses are an established cause of haemorrhagic fever with renal syndrome (HFRS) in Europe. Following a confirmed case of HFRS in the UK, in an individual residing on a farm in North Yorkshire and the Humber, a tidal estuary on the east coast of Northern England, and the subsequent isolation of a Seoul hantaviru...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v6020524
更新日期:2014-02-05 00:00:00
abstract::The capsid domain (CA) of the lentiviral Gag polyproteins has two distinct roles during virion morphogenesis. As a domain of Gag, it mediates the Gag-Gag interactions that drive immature particle assembly, whereas as a mature protein, it self-assembles into the conical core of the mature virion. Lentiviral CA proteins...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11090816
更新日期:2019-09-04 00:00:00
abstract::The ability of the host to trigger apoptosis in infected cells is perhaps the most powerful tool by which viruses can be cleared from the host organism. To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and i...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4123831
更新日期:2012-12-18 00:00:00
abstract::West Nile virus (WNV) is an important emerging neurotropic virus, responsible for increasingly severe encephalitis outbreaks in humans and horses worldwide. However, the mechanism by which the virus gains entry to the brain (neuroinvasion) remains poorly understood. Hypotheses of hematogenous and transneural entry hav...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v6072796
更新日期:2014-07-18 00:00:00
abstract::Fruit trees, such as apricot trees, are constantly exposed to the attack of viruses. As they are propagated in a vegetative way, this risk is present not only in the field, where they remain for decades, but also during their propagation. Metagenomic diagnostic methods, based on next generation sequencing (NGS), offer...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10060318
更新日期:2018-06-11 00:00:00
abstract::We previously hypothesized that increased capillary permeability observed in both hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS) may be caused by hantavirus-specific cytotoxic T cells attacking endothelial cells presenting viral antigens on their surface based on clinical o...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v3071059
更新日期:2011-07-01 00:00:00
abstract::Simian hemorrhagic fever virus (SHFV) causes a fulminant and typically lethal viral hemorrhagic fever (VHF) in macaques (Cercopithecinae: Macaca spp.) but causes subclinical infections in patas monkeys (Cercopithecinae: Erythrocebus patas). This difference in disease course offers a unique opportunity to compare host ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010067
更新日期:2019-01-15 00:00:00
abstract::Since the emergence of NADC30-like porcine reproductive and respiratory syndrome virus (PRRSV) in China in 2013, PRRSVs have undergone rapid evolution. In this study, a novel variant of PRRSV strain (designated SCcd17) was successfully isolated from piglets with clinical signs in Sichuan Province in China in 2017, and...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10040151
更新日期:2018-03-27 00:00:00
abstract::Feline immunodeficiency virus (FIV) is widespread in feline populations and causes an AIDS-like illness in domestic cats. It is highly prevalent in several endangered feline species. In domestic cats FIV infection is a valuable small animal model for HIV infection. In recent years there has been sa significant increas...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v3112192
更新日期:2011-11-01 00:00:00
abstract::The two human oncogenic -herpesviruses, Epstein Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV), are prototypic pathogens that are controlled by T cell responses. Despite their ubiquitous distribution, persistent infections and transforming potential, most carriers' immune systems control them for li...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11121125
更新日期:2019-12-05 00:00:00