Abstract：
:The ability of the host to trigger apoptosis in infected cells is perhaps the most powerful tool by which viruses can be cleared from the host organism. To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and intrinsic apoptosis. In this manuscript, we review the current literature regarding how HPV-infected cells avoid apoptosis and the molecular mechanisms involved in these events. In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. Many of the current efforts regarding anti-cancer drug development are focused on directing tumor cells to undergo apoptosis. However, the ability of HPV-infected cells to resist apoptotic signals renders such therapies ineffective. Possible mechanisms for overcoming the resistance of HPV-infected tumor cells to anticancer drugs will be discussed.
journal_name
Virusesjournal_title
Virusesauthors
Yuan CH,Filippova M,Duerksen-Hughes Pdoi
10.3390/v4123831subject
Has Abstractpub_date
2012-12-18 00:00:00pages
3831-50issue
12issn
1999-4915pii
v4123831journal_volume
4pub_type
杂志文章,评审相关文献
Viruses-Basel文献大全abstract：:In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [...]. ...
journal_title：Viruses
pub_type： 社论
doi：10.3390/v12040406
更新日期：2020-04-07 00:00:00
abstract：:Begomoviruses are one of the major groups of plant viruses with an important economic impact on crop production in tropical and subtropical regions. The global spread of its polyphagous vector, the whitefly Bemisia tabaci, has contributed to the emergence and diversification of species within this genus. In this study...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11040327
更新日期：2019-04-04 00:00:00
abstract：:During flavivirus infection, some viral proteins move to the nucleus and cellular components are relocated from the nucleus to the cytoplasm. Thus, the integrity of the main regulator of the nuclear-cytoplasmic transport, the nuclear pore complex (NPC), was evaluated during infection with dengue virus (DENV) and Zika ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12060583
更新日期：2020-05-26 00:00:00
abstract：:At the end of my doctoral studies, in 1988, I published a review article on the major steps of transcription and translation during the mammalian reovirus multiplication cycle, a topic that still fascinates me 30 years later. It is in the nature of scientific research to generate further questioning as new knowledge e...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v10120671
更新日期：2018-11-27 00:00:00
abstract：:During the last 25 years, swine vesicular disease (SVD) has occurred in Italy mostly sub-clinically. Therefore, regular testing of fecal samples from suspected holdings and high turnover premises was fundamental to identifying virus circulation and to achieve SVD eradication. In this study, we evaluated diagnostic per...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12111336
更新日期：2020-11-20 00:00:00
abstract：:Live attenuated influenza vaccines (LAIV) have prevented morbidity and mortality associated with influenza viral infections for many years and represent the best therapeutic option to protect against influenza viral infections in humans. However, the development of LAIV has traditionally relied on empirical methods, s...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v10100560
更新日期：2018-10-15 00:00:00
abstract：:Despite tremendous efforts over the course of many years, the quest for an effective HIV vaccine by the classical method of active immunization remains largely elusive. However, two recent studies in mice and macaques have now demonstrated a new strategy designated as Vectored ImmunoProphylaxis (VIP), which involves p...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v6020428
更新日期：2014-01-27 00:00:00
abstract：:Due to the emergence of non-endemic mosquito vectors and the recent outbreaks of mosquito-borne diseases, mosquito-borne pathogens are considered an increasing risk to public and animal health in Europe. To obtain a status quo regarding mosquito-borne viruses and their vectors in Germany, 97,648 mosquitoes collected f...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10070389
更新日期：2018-07-23 00:00:00
abstract：:Hepatitis C is a major global health burden with an estimated 160 million infected individuals worldwide. This long-term disease evolves slowly, often leading to chronicity and potentially to liver failure. There is no anti-HCV vaccine, and, until recently, the only treatment available, based on pegylated interferon a...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v4102197
更新日期：2012-10-17 00:00:00
abstract：:In response to viral infection, host cells activate various antiviral responses to inhibit virus replication. While feline herpesvirus 1 (FHV-1) manipulates the host early innate immune response in many different ways, the host could activate the antiviral response to counteract it through some unknown mechanisms. Mic...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12010002
更新日期：2019-12-18 00:00:00
abstract：:Human respiratory syncytial virus (HRSV) is a major cause of pediatric infection and also causes disease in the elderly and those with underlying respiratory problems. There is no vaccine for HRSV and anti-viral therapeutics are not broadly applicable. To investigate the effect of HRSV biology in children, nasopharyng...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11100926
更新日期：2019-10-10 00:00:00
abstract：:The progressive loss of immunological memory during aging correlates with a reduced proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that this phenotype is recapitulated during chronic viral infection. The antigenic volume imposed by persistent and latent viruses exposes the immune ...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v9100289
更新日期：2017-10-05 00:00:00
abstract：:As more cases of COVID-19 are studied and treated worldwide, it had become apparent that the lethal and most severe cases of pneumonia are due to an out-of-control inflammatory response to the SARS-CoV-2 virus. I explored the putative causes of this specific feature through a detailed genomic comparison with the close...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12060646
更新日期：2020-06-15 00:00:00
abstract：:Hematopoietic stem cell transplantation from anti-cytomegalovirus immunoglobulin G (anti-CMV-IgG) positive donors facilitated immunological recovery post-transplant, which may indicate that chronic CMV infection has an effect on the immune system. This can be seen in the recipients after reconstitution with donor lymp...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v7031391
更新日期：2015-03-23 00:00:00
abstract：:Countries rely on good diagnostic tests and appropriate testing schemes to fight against economically important small ruminant lentivirus (SRLV) infections. We undertook an extensive comparative analysis of seven commercially available serological tests and one in-house real-time PCR (qPCR) detecting genotype A and B ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10120696
更新日期：2018-12-08 00:00:00
abstract：:The extension of virology beyond its traditional medical, veterinary, or agricultural applications, now called environmental virology, has shown that viruses are both the most numerous and diverse biological entities on Earth. In particular, virus isolations from unicellular eukaryotic hosts (heterotrophic and photosy...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12101130
更新日期：2020-10-06 00:00:00
abstract：:The human respiratory syncytial virus (hRSV) and human Metapneumovirus (hMPV) are two of the leading etiological agents of acute lower respiratory tract infections, which constitute the main cause of mortality in infants. However, there are currently approved vaccines for neither hRSV nor hMPV. Moreover, despite the s...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12060637
更新日期：2020-06-12 00:00:00
abstract：:The chikungunya virus (CHIKV) is an emerging pathogen with widespread distribution in regions of Africa, India, and Asia that threatens to spread into temperate climates with the introduction of its major vector, Aedes albopictus. CHIKV causes a disease frequently misdiagnosed as dengue fever, with potentially life-th...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v8060163
更新日期：2016-06-10 00:00:00
abstract：:The APOBEC3 family of proteins in mammals consists of cellular cytosine deaminases and well-known restriction factors against retroviruses, including lentiviruses. APOBEC3 genes are highly amplified and diversified in mammals, suggesting that their evolution and diversification have been driven by conflicts with ancie...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v13010124
更新日期：2021-01-17 00:00:00
abstract：:In July 2018, a novel avian influenza virus (A/Mandarin duck/South Korea/KNU18-12/2018(H11N9)) was isolated from Mandarin ducks in South Korea. Phylogenetic and molecular analyses were conducted to characterize the genetic origins of the H11N9 strain. Phylogenetic analysis indicated that eight gene segments of strain ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12020203
更新日期：2020-02-12 00:00:00
abstract：:Zika virus (ZIKV) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and Guillain⁻Barré syndrome in adults. Efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating ZI...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11020092
更新日期：2019-01-22 00:00:00
abstract：:BST-2 or tetherin is a host cell restriction factor that prevents the budding of enveloped viruses at the cell surface, thus impairing the viral spread. Several countermeasures to evade this antiviral factor have been positively selected in retroviruses: the human immunodeficiency virus type 2 (HIV-2) relies on the en...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v8100285
更新日期：2016-10-14 00:00:00
abstract：:Phage display has become an established, widely used method for selection of peptides, antibodies or alternative scaffolds. The use of phage display for the selection of antigens from genomic or cDNA libraries of pathogens which is an alternative to the classical way of identifying immunogenic proteins is not well-kno...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v5102531
更新日期：2013-10-16 00:00:00
abstract：:We studied whether cytosine phosphate-guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs). As a model, we used well-characterized CpG-recoded Zika virus vaccine candidates that p...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12050579
更新日期：2020-05-25 00:00:00
abstract：:The cell response to virus infection and virus perturbation of that response is dynamic and is reflected by changes in cell susceptibility to infection. In this study, we evaluated the response of human epithelial cells to sequential infections with human respiratory syncytial virus strains A2 and B to determine if a ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v2122782
更新日期：2010-12-01 00:00:00
abstract：:Autophagy is an essential vacuolar process of the cell, leading to lysosomal degradation and recycling of proteins and organelles, which is extremely important in maintaining homeostasis. Multiple roles have been now associated with autophagy, in particular a pro-survival role in nutrient starvation or in stressful en...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v9120372
更新日期：2017-12-04 00:00:00
abstract：:Varroa destructor is an ectoparasitic mite of Asian or Eastern honeybees Apis cerana(A. cerana) which has become a serious threat to European subspecies of Western honeybees Apis mellifera (A. mellifera) within the last century. V.destructor and its vectored honeybee viruses became serious threats for colony survival....
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11020094
更新日期：2019-01-24 00:00:00
abstract：:A novel virus from moribund European chub (Squalius cephalus) was isolated on epithelioma papulosum cyprini (EPC) cells. Transmission electron microscopic examination revealed abundant non-enveloped, hexagonal virus particles in the cytoplasm of infected EPC cells consistent with an iridovirus. Illumina MiSeq sequence...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11050440
更新日期：2019-05-15 00:00:00
abstract：:The family Totiviridae currently contains five genera Totivirus, Victorivirus, Leishmavirus, Trichomonasvirus, and Giardiavirus. Members in this family generally have a set of two-open reading frame (ORF) elements in their genome with the 5'-proximal ORF (ORF1) encoding a capsid protein (CP) and the 3'-proximal one (O...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11060577
更新日期：2019-06-25 00:00:00
abstract：:The Flaviviridae family comprises a number of human pathogens, which, although sharing structural and functional features, cause diseases with very different outcomes. This can be explained by the plurality of functions exerted by the few proteins coded by viral genomes, with some of these functions shared among membe...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v9030042
更新日期：2017-03-13 00:00:00
