Characterization of a Novel Megalocytivirus Isolated from European Chub (Squalius cephalus).

abstract：:Virus transmission is essential for spreading viral infections and is a highly coordinated process which occurs by cell-free transmission or cell-cell contact. The transmission of Bovine Foamy Virus (BFV) is highly cell-associated, with undetectable cell-free transmission. However, BFV particle budding can be induced ...

journal_title：Viruses

authors： Bao Q,Hipp M,Hugo A,Lei J,Liu Y,Kehl T,Hechler T,Löchelt M

更新日期：2015-11-11 00:00:00

abstract：:To assist the global eradication of peste des petits ruminants virus (PPRV), a molecular test for the rapid and reliable detection of PPRV was developed which additionally enables the detection of pathogens relevant for differential diagnostics. For this purpose, the necessary time frame of a magnetic bead-based nucle...

journal_title：Viruses

authors： Halecker S,Mettenleiter TC,Beer M,Hoffmann B

更新日期：2020-10-29 00:00:00

abstract：:Rotavirus (RV), a member of the Reoviridae family, causes infection in children and infants, with high morbidity and mortality. To be viable, the virus particle must package a set of eleven RNA segments. In order to understand the packaging mechanism, here, we co-synthesized sets of RNA segments in vitro in different ...

journal_title：Viruses

authors： Fajardo T,Sung PY,Celma CC,Roy P

更新日期：2017-06-29 00:00:00

abstract：:Via virome sequencing, six viruses were detected from Magnaporthe oryzae strains YC81-2, including one virus in the family Tombusviridae, one virus in the family Narnaviridae and four viruses in the family Botourmiaviridae. Since the RNA-dependent RNA polymerase (RdRp) of one botourmiavirus show the highest identity (...

journal_title：Viruses

authors： Liu Y,Zhang L,Esmael A,Duan J,Bian X,Jia J,Xie J,Cheng J,Fu Y,Jiang D,Lin Y

更新日期：2020-12-03 00:00:00

abstract：:Herpesviruses use a vesicle-mediated transfer of intranuclearly assembled nucleocapsids through the nuclear envelope (NE) for final maturation in the cytoplasm. The molecular basis for this novel vesicular nucleo-cytoplasmic transport is beginning to be elucidated in detail. The heterodimeric viral nuclear egress comp...

journal_title：Viruses

authors： Mettenleiter TC

更新日期：2016-09-27 00:00:00

abstract：:RNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade. Tissue distribution reveals that RNase L is highly expressed in t...

journal_title：Viruses

authors： Wei R,Chen G,Algehainy N,Zeng C,Liu C,Liu H,Liu W,Stacey D,Zhou A

更新日期：2020-01-07 00:00:00

abstract：:Cyclophilins are peptidyl-prolyl cis/trans isomerases important in the proper folding of certain proteins. Mounting evidence supports varied roles of cyclophilins, either positive or negative, in the life cycles of diverse viruses, but the nature and mechanisms of these roles are yet to be defined. The potential for c...

journal_title：Viruses

authors： Frausto SD,Lee E,Tang H

更新日期：2013-07-11 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. The 3' untranslated region (UTR) of this β-CoV contains essential cis-acting RNA elements for the viral genome transcription and replication. These elements include an equilibrium between an extended bulged s...

journal_title：Viruses

authors： Zhao J,Qiu J,Aryal S,Hackett JL,Wang J

更新日期：2020-12-21 00:00:00

abstract：:Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populatio...

journal_title：Viruses

authors： Mutsafi Y,Altan-Bonnet N

更新日期：2018-03-20 00:00:00

abstract：:Rabies is a highly fatal zoonotic disease which is primarily caused by rabies virus (RABV) although other members of the genus Lyssavirus can cause rabies as well. As yet, 14 serologically and genetically diverse lyssaviruses have been identified, mostly in bats. To assess the quality of rabies vaccines and immunoglob...

journal_title：Viruses

authors： Moeschler S,Locher S,Conzelmann KK,Krämer B,Zimmer G

更新日期：2016-09-16 00:00:00

abstract：:The Gammacoronavirus infectious bronchitis virus (IBV) causes a highly contagious and economically important respiratory disease in poultry. In the laboratory, most IBV strains are restricted to replication in ex vivo organ cultures or in ovo and do not replicate in cell culture, making the study of their basic virolo...

journal_title：Viruses

authors： Stevenson-Leggett P,Keep S,Bickerton E

更新日期：2020-09-29 00:00:00

abstract：:Currently, Brazil lives a triple arboviruses epidemic (DENV, ZIKV and CHIKV) making the differential diagnosis difficult for health professionals. Here, we aimed to investigate chikungunya cases and the possible occurrence of co-infections during the epidemic in Amapá (AP) that started in 2014 when the first autochtho...

journal_title：Viruses

authors： de Souza TMA,Ribeiro ED,Corrêa VCE,Damasco PV,Santos CC,de Bruycker-Nogueira F,Chouin-Carneiro T,Faria NRDC,Nunes PCG,Heringer M,Lima MDRQ,Badolato-Corrêa J,Cipitelli MDC,Azeredo EL,Nogueira RMR,Dos Santos FB

更新日期：2018-11-12 00:00:00

abstract：:The cell response to virus infection and virus perturbation of that response is dynamic and is reflected by changes in cell susceptibility to infection. In this study, we evaluated the response of human epithelial cells to sequential infections with human respiratory syncytial virus strains A2 and B to determine if a ...

journal_title：Viruses

authors： Simeonov I,Gong X,Kim O,Poss M,Chiaromonte F,Fricks J

更新日期：2010-12-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) can infect a wide range of cell types, including cells of the adaptive and innate immunity but, normally, it completes a fully-permissive replication cycle only in epithelial or neural cells. Complex mechanisms controlling this delicate balance in immune cells and consequent restriction ...

journal_title：Viruses

authors： Marino-Merlo F,Papaianni E,Frezza C,Pedatella S,De Nisco M,Macchi B,Grelli S,Mastino A

更新日期：2019-05-10 00:00:00

abstract：:Since the emergence of NADC30-like porcine reproductive and respiratory syndrome virus (PRRSV) in China in 2013, PRRSVs have undergone rapid evolution. In this study, a novel variant of PRRSV strain (designated SCcd17) was successfully isolated from piglets with clinical signs in Sichuan Province in China in 2017, and...

journal_title：Viruses

authors： Zhou L,Kang R,Xie B,Tian Y,Wu X,Lv X,Yang X,Wang H

更新日期：2018-03-27 00:00:00

abstract：:HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of the nucleocapsid (NC) domain that interacts with nucleic acids, and p1 and p6, two unstructured regions, p6 containing the motifs to bind ALIX, the cellular ESCRT factor TSG101 and the viral protein Vpr. The processing of Ga...

journal_title：Viruses

authors： Mouhand A,Pasi M,Catala M,Zargarian L,Belfetmi A,Barraud P,Mauffret O,Tisné C

更新日期：2020-09-29 00:00:00

abstract：:Peptides derived from the C-terminal heptad repeat (CHR) region of HIV-1 gp41 is potent viral membrane fusion inhibitors, such as the first clinically approved peptide drug T20 and a group of newly-designed peptides. The resistance profiles of various HIV-1 fusion inhibitors were previously characterized, and the seco...

journal_title：Viruses

authors： Yu D,Su Y,Ding X,Zhu Y,Qin B,Chong H,Cui S,He Y

更新日期：2020-03-18 00:00:00

abstract：:With ongoing colony losses driven in part by the Varroa mite and the associated exacerbation of the virus load, there is an urgent need to protect honey bees (Apis mellifera) from fatal levels of virus infection and from the non-target effects of insecticides used in agricultural settings. A continuously replicating c...

journal_title：Viruses

authors： Guo Y,Goodman CL,Stanley DW,Bonning BC

更新日期：2020-02-20 00:00:00

abstract：:Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) systems are key immune mechanisms helping prokaryotic species fend off RNA and DNA viruses. CRISPR/Cas9 has broad applications in basic research and biotechnology and has been widely used across eukaryotic species for genome...

journal_title：Viruses

authors： Aman R,Mahas A,Butt H,Aljedaani F,Mahfouz M

更新日期：2018-12-19 00:00:00

abstract：:Different developmental stages of Artemia spp. (metanauplii, juveniles and adults) were bath-challenged with two isolates of the Lymphocystis disease virus (LCDV), namely, LCDV SA25 (belonging to the species Lymphocystis disease virus 3) and ATCC VR-342 (an unclassified member of the genus Lymphocystivirus). Viral qua...

journal_title：Viruses

authors： Valverde EJ,Labella AM,Borrego JJ,Castro D

更新日期：2019-06-01 00:00:00

abstract：:Interferon (IFN) regulatory factor 3 (IRF3) is the key transcription factor for the induction of IFN and antiviral genes. The absence of antiviral genes in IRF3 deficiency leads to susceptibility to a wide range of viral infections. Previously, we uncovered a function for nontranscriptional IRF3 (nt-IRF3), RLR (RIG-I-...

journal_title：Viruses

authors： Glanz A,Chawla K,Fabry S,Subramanian G,Garcia J,Jay B,Ciricillo J,Chakravarti R,Taylor RT,Chattopadhyay S

更新日期：2020-04-14 00:00:00

abstract：:Usutu virus (USUV) is a neurotropic flavivirus closely related to West Nile virus (WNV). Its enzootic cycle mainly involves mosquitoes and birds. Human infection can occur with occasional, but sometimes severe, neurological complications. Since its emergence and spread in Europe over the last two decades, USUV has bee...

journal_title：Viruses

authors： Benzarti E,Rivas J,Sarlet M,Franssen M,Desmecht D,Schmidt-Chanasit J,Savini G,Lorusso A,Van Laere AS,Garigliany MM

更新日期：2020-01-31 00:00:00

abstract：:Various methods exist to detect an astrovirus infection. Current methods include electron microscopy (EM), cell culture, immunoassays, polymerase chain reaction (PCR) and various other molecular approaches that can be applied in the context of diagnostic or in surveillance studies. With the advent of metagenomics, nov...

journal_title：Viruses

authors： Pérot P,Lecuit M,Eloit M

更新日期：2017-01-12 00:00:00

abstract：:Streptococcus thermophilus is considered one of the most important species for the dairy industry. Due to their diffusion in dairy environments, bacteriophages can represent a threat to this widely used bacterial species. Despite the presence of a CRISPR-Cas system in the S. thermophilus genome, some lysogenic strains...

journal_title：Viruses

authors： da Silva Duarte V,Giaretta S,Campanaro S,Treu L,Armani A,Tarrah A,Oliveira de Paula S,Giacomini A,Corich V

更新日期：2018-12-22 00:00:00

abstract：:Because of its ecological characteristics, the Caxiuanã National Forest (FLONA) is a potential area of arbovirus circulation. The present study aimed to investigate the occurrence of arbovirus transmission cycles at FLONA de Caxiuanã. Five field trips were performed to capture mosquitoes and sylvatic vertebrates. For ...

journal_title：Viruses

authors： Araújo PA,Freitas MO,Chiang JO,Silva FA,Chagas LL,Casseb SM,Silva SP,Nunes-Neto JP,Rosa-Júnior JW,Nascimento BS,Hernández LA,Paz TB,Barros LL,Silva EP,Azevedo RS,Martins LC,Ferreira MS,Vasconcelos PF

更新日期：2019-08-22 00:00:00

abstract：:The human cytomegalovirus (HCMV) replicates to high titers in primary human fibroblast cell cultures. A variety of primary human cells and some tumor-derived cell lines do also support permissive HCMV replication, yet at low levels. Cell lines established by transfection of the transforming functions of adenoviruses h...

journal_title：Viruses

authors： Krömmelbein N,Wiebusch L,Schiedner G,Büscher N,Sauer C,Florin L,Sehn E,Wolfrum U,Plachter B

更新日期：2016-02-02 00:00:00

abstract：:Puumala virus (PUUV) is the agent of nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) in Europe. NE incidence presents a high spatial variation throughout France, while the geographical distribution of the wild reservoir of PUUV, the bank vole, is rather continuous. A missing pi...

journal_title：Viruses

authors： Castel G,Couteaudier M,Sauvage F,Pons JB,Murri S,Plyusnina A,Pontier D,Cosson JF,Plyusnin A,Marianneau P,Tordo N

更新日期：2015-10-22 00:00:00

abstract：:Influenza A viruses (IAV) have been a major public health threat worldwide, and options for antiviral therapy become increasingly limited with the emergence of drug-resisting virus strains. New and effective anti-IAV drugs, especially for highly pathogenic influenza, with different modes of action, are urgently needed...

journal_title：Viruses

authors： Ye M,Liao Y,Wu L,Qi W,Choudhry N,Liu Y,Chen W,Song G,Chen J

更新日期：2020-02-18 00:00:00

abstract：:Bluetongue (BT) is an arthropod-borne viral disease of ruminants with serious trade and socio-economic implications. Although the disease has been reported in a number of countries in sub-Saharan Africa, there is currently no information on circulating serotypes and disease distribution in Zambia. Following surveillan...

journal_title：Viruses

authors： Chambaro HM,Sasaki M,Simulundu E,Silwamba I,Sinkala Y,Gonzalez G,Squarre D,Fandamu P,Lubaba CH,Munyeme M,Maseko A,Chimvwele C,Mataa L,Mooya LE,Mukubesa AN,Harima H,Samui KL,Munang'andu HM,Simuunza M,Nalubamba KS,Q

更新日期：2020-08-31 00:00:00

abstract：:The human cytomegalovirus (HCMV) terminase complex is part of DNA-packaging machinery that delivers a unit-length genome into a procapsid. Sequence comparison of herpesvirus homologs allowed us to identify a potential LATLNDIERFL and zinc finger pattern in N-terminal part of pUL56. Recombinant viruses were generated w...

journal_title：Viruses

authors： Ligat G,Couvreux A,Cazal R,Alain S,Hantz S

更新日期：2019-11-26 00:00:00