Artemia spp., a Susceptible Host and Vector for Lymphocystis Disease Virus.

Abstract:

:Different developmental stages of Artemia spp. (metanauplii, juveniles and adults) were bath-challenged with two isolates of the Lymphocystis disease virus (LCDV), namely, LCDV SA25 (belonging to the species Lymphocystis disease virus 3) and ATCC VR-342 (an unclassified member of the genus Lymphocystivirus). Viral quantification and gene expression were analyzed by qPCR at different times post-inoculation (pi). In addition, infectious titres were determined at 8 dpi by integrated cell culture (ICC)-RT-PCR, an assay that detects viral mRNA in inoculated cell cultures. In LCDV-challenged Artemia, the viral load increased by 2-3 orders of magnitude (depending on developmental stage and viral isolate) during the first 8-12 dpi, with viral titres up to 2.3 × 102 Most Probable Number of Infectious Units (MPNIU)/mg. Viral transcripts were detected in the infected Artemia, relative expression values showed a similar temporal evolution in the different experimental groups. Moreover, gilthead seabream (Sparus aurata) fingerlings were challenged by feeding on LCDV-infected metanauplii. Although no Lymphocystis symptoms were observed in the fish, the number of viral DNA copies was significantly higher at the end of the experimental trial and major capsid protein (mcp) gene expression was consistently detected. The results obtained support that LCDV infects Artemia spp., establishing an asymptomatic productive infection at least under the experimental conditions tested, and that the infected metanauplii are a vector for LCDV transmission to gilthead seabream.

journal_name

Viruses

journal_title

Viruses

authors

Valverde EJ,Labella AM,Borrego JJ,Castro D

doi

10.3390/v11060506

subject

Has Abstract

pub_date

2019-06-01 00:00:00

issue

6

issn

1999-4915

pii

v11060506

journal_volume

11

pub_type

杂志文章
  • Antigenic Change in Human Influenza A(H2N2) Viruses Detected by Using Human Plasma from Aged and Younger Adult Individuals.

    abstract::Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using ferret antisera or mouse and human monoclonal antibodies. Here, we examined the antigenicity of human H2N2 viruses by using human plasma samples obtained from 50...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v11110978

    authors: Matsuzawa Y,Iwatsuki-Horimoto K,Nishimoto Y,Abe Y,Fukuyama S,Hamabata T,Okuda M,Go Y,Watanabe T,Imai M,Arai Y,Fouchier RAM,Yamayoshi S,Kawaoka Y

    更新日期:2019-10-23 00:00:00

  • Prevalence of antibodies against hantaviruses in serum and saliva of adults living or working on farms in Yorkshire, United Kingdom.

    abstract::Hantaviruses are an established cause of haemorrhagic fever with renal syndrome (HFRS) in Europe. Following a confirmed case of HFRS in the UK, in an individual residing on a farm in North Yorkshire and the Humber, a tidal estuary on the east coast of Northern England, and the subsequent isolation of a Seoul hantaviru...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v6020524

    authors: Jameson LJ,Newton A,Coole L,Newman EN,Carroll MW,Beeching NJ,Hewson R,Christley RM

    更新日期:2014-02-05 00:00:00

  • In Vitro Evolution of Bovine Foamy Virus Variants with Enhanced Cell-Free Virus Titers and Transmission.

    abstract::Virus transmission is essential for spreading viral infections and is a highly coordinated process which occurs by cell-free transmission or cell-cell contact. The transmission of Bovine Foamy Virus (BFV) is highly cell-associated, with undetectable cell-free transmission. However, BFV particle budding can be induced ...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v7112907

    authors: Bao Q,Hipp M,Hugo A,Lei J,Liu Y,Kehl T,Hechler T,Löchelt M

    更新日期:2015-11-11 00:00:00

  • Chicken eEF1α is a Critical Factor for the Polymerase Complex Activity of Very Virulent Infectious Bursal Disease Virus.

    abstract::Infectious bursal disease (IBD) is an immunosuppressive, highly contagious, and lethal disease of young chickens caused by IBD virus (IBDV). It results in huge economic loss to the poultry industry worldwide. Infection caused by very virulent IBDV (vvIBDV) strains results in high mortality in young chicken flocks. How...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v12020249

    authors: Yang B,Yan N,Liu A,Li Y,Chen Z,Gao L,Qi X,Gao Y,Liu C,Zhang Y,Cui H,Li K,Pan Q,Wang Y,Wang X

    更新日期:2020-02-23 00:00:00

  • Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala.

    abstract::Koalas (Phascolarctos cinereus) are native Australian marsupials whose populations are in decline from a range of threats. Infectious diseases caused by the bacterium Chlamydia pecorum and other pathogens are of particular concern. We analysed 26 poly-A selected RNA-sequencing libraries from a data set designed to stu...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v11030211

    authors: Harvey E,Madden D,Polkinghorne A,Holmes EC

    更新日期:2019-03-02 00:00:00

  • Clinical aspects of feline retroviruses: a review.

    abstract::Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses with global impact on the health of domestic cats. The two viruses differ in their potential to cause disease. FeLV is more pathogenic, and was long considered to be responsible for more clinical syndromes than any other agent in cat...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v4112684

    authors: Hartmann K

    更新日期:2012-10-31 00:00:00

  • The role of RNA interference (RNAi) in arbovirus-vector interactions.

    abstract::RNA interference (RNAi) was shown over 18 years ago to be a mechanism by which arbovirus replication and transmission could be controlled in arthropod vectors. During the intervening period, research on RNAi has defined many of the components and mechanisms of this antiviral pathway in arthropods, yet a number of unex...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v7020820

    authors: Blair CD,Olson KE

    更新日期:2015-02-17 00:00:00

  • The International Virus Bioinformatics Meeting 2020.

    abstract::The International Virus Bioinformatics Meeting 2020 was originally planned to take place in Bern, Switzerland, in March 2020. However, the COVID-19 pandemic put a spoke in the wheel of almost all conferences to be held in 2020. After moving the conference to 8-9 October 2020, we got hit by the second wave and finally ...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v12121398

    authors: Hufsky F,Beerenwinkel N,Meyer IM,Roux S,Cook GM,Kinsella CM,Lamkiewicz K,Marquet M,Nieuwenhuijse DF,Olendraite I,Paraskevopoulou S,Young F,Dijkman R,Ibrahim B,Kelly J,Le Mercier P,Marz M,Ramette A,Thiel V

    更新日期:2020-12-06 00:00:00

  • The Interactions between HBV and the Innate Immunity of Hepatocytes.

    abstract::Hepatitis B virus (HBV) infection affects ~350 million people and poses a major public health problem worldwide. HBV is a major cause of cirrhosis and hepatocellular carcinoma. Fewer than 5% of HBV-infected adults (but up to 90% of HBV-infected infants and children) develop chronic HBV infection as indicated by contin...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v12030285

    authors: Megahed FAK,Zhou X,Sun P

    更新日期:2020-03-05 00:00:00

  • Antiviral Agents: Discovery to Resistance.

    abstract::In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [...]. ...

    journal_title:Viruses

    pub_type: 社论

    doi:10.3390/v12040406

    authors: Adamson CS

    更新日期:2020-04-07 00:00:00

  • Ginkgolic Acid Inhibits Herpes Simplex Virus Type 1 Skin Infection and Prevents Zosteriform Spread in Mice.

    abstract::Herpes simplex virus type 1 (HSV-1) causes a lifelong latent infection with an estimated global prevalence of 66%. Primary and recurrent HSV infections are characterized by a tingling sensation, followed by an eruption of vesicles, which can cause painful erosions. Commonly used antiviral drugs against HSV infection a...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v13010086

    authors: Bhutta MS,Shechter O,Gallo ES,Martin SD,Jones E,Doncel GF,Borenstein R

    更新日期:2021-01-09 00:00:00

  • Two Different Strains of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) in North and South Osaka by Phylogenetic Analysis of Evolutionary Lineage: Evidence for Independent SFTSV Transmission.

    abstract::Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne infectious disease, therefore, the information on the whole genome of the SFTS virus (SFTSV) is still limited. This study demonstrates a nearly whole genome of the SFTSV identified in Osaka in 2017 and 2018 by next-generation sequencing (NGS). Th...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v13020177

    authors: Ikemori R,Aoyama I,Sasaki T,Takabayashi H,Morisada K,Kinoshita M,Ikuta K,Yumisashi T,Motomura K

    更新日期:2021-01-25 00:00:00

  • An Emerging Human Parechovirus Type 5 Causing Sepsis-Like Illness in Infants in Australia.

    abstract::Human parechovirus (HPeV), particularly type 3 (HPeV3), is an important cause of sepsis-/meningitis-like illness in young infants. Laboratory records identified a total of ten HPeV-positive cases in Southeastern Australia between January and July 2019. The HPeV present in these cases were typed by Sanger sequencing of...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v11100913

    authors: Chamings A,Liew KC,Reid E,Athan E,Raditsis A,Vuillermin P,Yoga Y,Caly L,Druce J,Alexandersen S

    更新日期:2019-10-03 00:00:00

  • 3D Analysis of HCMV Induced-Nuclear Membrane Structures by FIB/SEM Tomography: Insight into an Unprecedented Membrane Morphology.

    abstract::We show that focused ion beam/scanning electron microscopy (FIB/SEM) tomography is an excellent method to analyze the three-dimensional structure of a fibroblast nucleus infected with human cytomegalovirus (HCMV). We found that the previously described infoldings of the inner nuclear membrane, which are unique among i...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v7112900

    authors: Villinger C,Neusser G,Kranz C,Walther P,Mertens T

    更新日期:2015-11-04 00:00:00

  • CD8 and CD4 T cells in west nile virus immunity and pathogenesis.

    abstract::CD4 and CD8 T lymphocytes are adaptive immune cells that play a key role in the immune response to pathogens. They have been extensively studied in a variety of model systems and the mechanisms by which they function are well described. However, the responses by these cell types vary widely from pathogen to pathogen. ...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v5102573

    authors: Netland J,Bevan MJ

    更新日期:2013-10-22 00:00:00

  • Differential Zika Virus Infection of Testicular Cell Lines.

    abstract:BACKGROUND:Zika virus is a mosquito-borne flavivirus responsible for recent outbreaks of epidemic proportions in Latin America. Sexual transmission of the virus has been reported in 13 countries and may be an important route of infection. Sexual transmission of ZIKV has mostly been male-to-female, and persistence of vi...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v11010042

    authors: Mlera L,Bloom ME

    更新日期:2019-01-09 00:00:00

  • Metagenomic Virome Analysis of Culex Mosquitoes from Kenya and China.

    abstract::Many blood-feeding arthropods are known vectors of viruses that are a source of unprecedented global health concern. Mosquitoes are an integral part of these arthropod vectors. Advancements in next-generation sequencing and bioinformatics has expanded our knowledge on the richness of viruses harbored by arthropods. In...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v10010030

    authors: Atoni E,Wang Y,Karungu S,Waruhiu C,Zohaib A,Obanda V,Agwanda B,Mutua M,Xia H,Yuan Z

    更新日期:2018-01-12 00:00:00

  • Evasion of the interferon-mediated antiviral response by filoviruses.

    abstract::The members of the filoviruses are recognized as some of the most lethal viruses affecting human and non-human primates. The only two genera of the Filoviridae family, Marburg virus (MARV) and Ebola virus (EBOV), comprise the main etiologic agents of severe hemorrhagic fever outbreaks in central Africa, with case fata...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v2010262

    authors: Cárdenas WB

    更新日期:2010-01-01 00:00:00

  • Oropouche Fever: A Review.

    abstract::Oropouche fever is an emerging zoonotic disease caused by Oropouche virus (OROV), an arthropod transmitted Orthobunyavirus circulating in South and Central America. During the last 60 years, more than 30 epidemics and over half a million clinical cases attributed to OROV infection have been reported in Brazil, Peru, P...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v10040175

    authors: Sakkas H,Bozidis P,Franks A,Papadopoulou C

    更新日期:2018-04-04 00:00:00

  • Unprecedented Diversity of Lactococcal Group 936 Bacteriophages Revealed by Amplicon Sequencing of the Portal Protein Gene.

    abstract::Lactococcus lactis is one of the most important bacteria in dairy fermentations, being used in the production of cheese and buttermilk. The processes are vulnerable to phage attacks, and undefined mixtures of lactococcal strains are often used to reduce the risk of bacteriophage caused fermentation failure. Other prev...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v11050443

    authors: Frantzen CA,Holo H

    更新日期:2019-05-16 00:00:00

  • Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection.

    abstract::The progressive loss of immunological memory during aging correlates with a reduced proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that this phenotype is recapitulated during chronic viral infection. The antigenic volume imposed by persistent and latent viruses exposes the immune ...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v9100289

    authors: Bellon M,Nicot C

    更新日期:2017-10-05 00:00:00

  • Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells.

    abstract::Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-ΔSH) enhanced the secretion of type I interfer...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v10060278

    authors: Bao X,Kolli D,Esham D,Velayutham TS,Casola A

    更新日期:2018-05-23 00:00:00

  • Caging the beast: TRIM5α binding to the HIV-1 core.

    abstract::The potent HIV-1 inhibitor TRIM5α blocks HIV-1 infection by accelerating the uncoating of HIV-1. TRIM5α is known to form higher-order self-association complexes that contribute to the avidity of TRIM5α for the HIV-1 capsid, and are essential to inhibit infection; these higher-order self-association complexes are depen...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v3050423

    authors: Diaz-Griffero F

    更新日期:2011-05-01 00:00:00

  • The cyclin-dependent kinase ortholog pUL97 of human cytomegalovirus interacts with cyclins.

    abstract::The human cytomegalovirus (HCMV)-encoded protein kinase, pUL97, is considered a cyclin-dependent kinase (CDK) ortholog, due to shared structural and functional characteristics. The primary mechanism of CDK activation is binding to corresponding cyclins, including cyclin T1, which is the usual regulatory cofactor of CD...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v5123213

    authors: Graf L,Webel R,Wagner S,Hamilton ST,Rawlinson WD,Sticht H,Marschall M

    更新日期:2013-12-18 00:00:00

  • Evolution of Attenuation and Risk of Reversal in Peste des Petits Ruminants Vaccine Strain Nigeria 75/1.

    abstract::Peste des Petits Ruminants (PPR) is a highly infectious disease caused by a virus of the Morbillivirus genus. The current PPR eradication effort relies mainly on the implementation of massive vaccination campaigns. One of the most widely used PPR vaccines is the Nigeria 75/1 strain obtained after attenuation by 75 ser...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v11080724

    authors: Eloiflin RJ,Boyer M,Kwiatek O,Guendouz S,Loire E,Servan de Almeida R,Libeau G,Bataille A

    更新日期:2019-08-07 00:00:00

  • Biological invasions of geminiviruses: case study of TYLCV and Bemisia tabaci in Reunion Island.

    abstract::In the last 20 years, molecular ecology approaches have proven to be extremely useful to identify and assess factors associated with viral emerging diseases, particularly in economically and socially important tropical crops such as maize (maize streak disease) and cassava (cassava mosaic disease). Molecular ecology a...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v4123665

    authors: Péréfarres F,Thierry M,Becker N,Lefeuvre P,Reynaud B,Delatte H,Lett JM

    更新日期:2012-12-12 00:00:00

  • Field efficacy and transmission of fast- and slow-killing nucleopolyhedroviruses that are infectious to Adoxophyes honmai (Lepidoptera: Tortricidae).

    abstract::The smaller tea tortrix, Adoxophyes honmai (Lepidoptera: Tortricidae), is an economically important pest of tea in Japan. Previous work showed that a fast-killing nucleopolyhedrovirus (NPV) isolated from A. orana (AdorNPV) and a slow-killing NPV isolated from A. honmai (AdhoNPV) are both infectious to A. honmai larvae...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v7031271

    authors: Takahashi M,Nakai M,Saito Y,Sato Y,Ishijima C,Kunimi Y

    更新日期:2015-03-18 00:00:00

  • Expression, delivery and function of insecticidal proteins expressed by recombinant baculoviruses.

    abstract::Since the development of methods for inserting and expressing genes in baculoviruses, a line of research has focused on developing recombinant baculoviruses that express insecticidal peptides and proteins. These recombinant viruses have been engineered with the goal of improving their pesticidal potential by shortenin...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v7010422

    authors: Kroemer JA,Bonning BC,Harrison RL

    更新日期:2015-01-21 00:00:00

  • Human Polyclonal Antibodies Produced from Transchromosomal Bovine Provides Prophylactic and Therapeutic Protections Against Zika Virus Infection in STAT2 KO Syrian Hamsters.

    abstract::Zika virus (ZIKV) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and Guillain⁻Barré syndrome in adults. Efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating ZI...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v11020092

    authors: Siddharthan V,Miao J,Van Wettere AJ,Li R,Wu H,Sullivan E,Jiao J,Hooper JW,Safronetz D,Morrey JD,Julander JG,Wang Z

    更新日期:2019-01-22 00:00:00

  • Adaptive immunity to hepatitis C virus.

    abstract::The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This review focuses on differ...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v1020276

    authors: Zeisel MB,Fafi-Kremer S,Robinet E,Habersetzer F,Baumert TF,Stoll-Keller F

    更新日期:2009-09-01 00:00:00