Abstract:
:Koalas (Phascolarctos cinereus) are native Australian marsupials whose populations are in decline from a range of threats. Infectious diseases caused by the bacterium Chlamydia pecorum and other pathogens are of particular concern. We analysed 26 poly-A selected RNA-sequencing libraries from a data set designed to study the immune response of koalas to ocular chlamydial infection. Using virus discovery techniques, we identified the coding-complete genome sequence of a novel picorna-like virus, denoted Burpengary virus, that was most common in south-east Queensland. Notably, abundance measurements of the virus across all 26 libraries revealed an inverse relationship between abundance and ocular disease in koalas, suggesting that the co-infection of Burpengary virus and Chlamydia pecorum is inhibited.
journal_name
Virusesjournal_title
Virusesauthors
Harvey E,Madden D,Polkinghorne A,Holmes ECdoi
10.3390/v11030211subject
Has Abstractpub_date
2019-03-02 00:00:00issue
3issn
1999-4915pii
v11030211journal_volume
11pub_type
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