当前位置： SCI文献检索 > Viruses-Basel期刊下所有文献 > Dendritic Cells in HIV/SIV Prophylactic and Therapeutic Vaccination.

Dendritic Cells in HIV/SIV Prophylactic and Therapeutic Vaccination.

Abstract：

:Dendritic cells (DCs) are involved in human and simian immunodeficiency virus (HIV and SIV) pathogenesis but also play a critical role in orchestrating innate and adaptive vaccine-specific immune responses. Effective HIV/SIV vaccines require strong antigen-specific CD4 T cell responses, cytotoxic activity of CD8 T cells, and neutralizing/non-neutralizing antibody production at mucosal and systemic sites. To develop a protective HIV/SIV vaccine, vaccine regimens including DCs themselves, protein, DNA, mRNA, virus vectors, and various combinations have been evaluated in different animal and human models. Recent studies have shown that DCs enhanced prophylactic HIV/SIV vaccine efficacy by producing pro-inflammatory cytokines, improving T cell responses, and recruiting effector cells to target tissues. DCs are also targets for therapeutic HIV/SIV vaccines due to their ability to reverse latency, present antigen, and augment T and B cell immunity. Here, we review the complex interactions of DCs over the course of HIV/SIV prophylactic and therapeutic immunizations, providing new insights into development of advanced DC-targeted HIV/SIV vaccines.

journal_name

Viruses

journal_title

Viruses

authors

Ko EJ,Robert-Guroff M

doi

10.3390/v12010024

subject

Has Abstract

pub_date

2019-12-24 00:00:00

issue

1

issn

1999-4915

pii

v12010024

journal_volume

12

pub_type

杂志文章,评审

相关文献

Viruses-Basel文献大全
  • Diverse Morphology and Structural Features of Old and New World Hantaviruses.

    abstract：:To further understanding of the structure and morphology of the Orthohantavirus, family Hantaviridae, we have employed cryo-electron microscopy (cryo-EM) for three New World hantaviruses: Andes (ANDV), Sin Nombre (SNV), and Black Creek Canal (BCCV). Building upon our prior cryo-EM and cryo-tomography study of the Old ...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v11090862

    authors： Parvate A,Williams EP,Taylor MK,Chu YK,Lanman J,Saphire EO,Jonsson CB

    更新日期：2019-09-16 00:00:00

  • NCBI's Virus Discovery Codeathon: Building "FIVE" -The Federated Index of Viral Experiments API Index.

    abstract：:Viruses represent important test cases for data federation due to their genome size and the rapid increase in sequence data in publicly available databases. However, some consequences of previously decentralized (unfederated) data are lack of consensus or comparisons between feature annotations. Unifying or displaying...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v12121424

    authors： Martí-Carreras J,Gener AR,Miller SD,Brito AF,Camacho CE,Connor R,Deboutte W,Glickman C,Kristensen DM,Meyer WK,Modha S,Norris AL,Saha S,Belford AK,Biederstedt E,Brister JR,Buchmann JP,Cooley NP,Edwards RA,Javkar K,

    更新日期：2020-12-10 00:00:00

  • Host-Virus Interaction: How Host Cells Defend against Influenza A Virus Infection.

    abstract：:Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and activated to restrict v...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v12040376

    authors： Zhang Y,Xu Z,Cao Y

    更新日期：2020-03-29 00:00:00

  • Distinct Contributions of Autophagy Receptors in Measles Virus Replication.

    abstract：:Autophagy is a potent cell autonomous defense mechanism that engages the lysosomal pathway to fight intracellular pathogens. Several autophagy receptors can recognize invading pathogens in order to target them towards autophagy for their degradation after the fusion of pathogen-containing autophagosomes with lysosomes...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v9050123

    authors： Petkova DS,Verlhac P,Rozières A,Baguet J,Claviere M,Kretz-Remy C,Mahieux R,Viret C,Faure M

    更新日期：2017-05-22 00:00:00

  • Nucleocapsid Structure of Negative Strand RNA Virus.

    abstract：:Negative strand RNA viruses (NSVs) include many important human pathogens, such as influenza virus, Ebola virus, and rabies virus. One of the unique characteristics that NSVs share is the assembly of the nucleocapsid and its role in viral RNA synthesis. In NSVs, the single strand RNA genome is encapsidated in the line...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v12080835

    authors： Luo M,Terrell JR,Mcmanus SA

    更新日期：2020-07-30 00:00:00

  • Role of Dendritic Cells in Exposing Latent HIV-1 for the Kill.

    abstract：:The development of effective yet nontoxic strategies to target the latent human immunodeficiency virus-1 (HIV-1) reservoir in antiretroviral therapy (ART)-suppressed individuals poses a critical barrier to a functional cure. The 'kick and kill' approach to HIV eradication entails proviral reactivation during ART, coup...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v12010037

    authors： Kristoff J,Rinaldo CR,Mailliard RB

    更新日期：2019-12-28 00:00:00

  • New Viruses from the Ectoparasite Mite Varroa destructor Infesting Apis mellifera and Apis cerana.

    abstract：:Varroa destructor is an ectoparasitic mite of Asian or Eastern honeybees Apis cerana(A. cerana) which has become a serious threat to European subspecies of Western honeybees Apis mellifera (A. mellifera) within the last century. V.destructor and its vectored honeybee viruses became serious threats for colony survival....

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v11020094

    authors： Levin S,Sela N,Erez T,Nestel D,Pettis J,Neumann P,Chejanovsky N

    更新日期：2019-01-24 00:00:00

  • PCR Detection and Phylogenetic Analysis of Megalocytivirus Isolates in Farmed Giant Sea Perch Lates calcarifer in Southern Taiwan.

    abstract：:The Megalocytivirus genus includes three genotypes, red sea bream iridovirus (RSIV), infectious spleen and kidney necrosis virus (ISKNV), and turbot reddish body iridovirus (TRBIV), and has caused mass mortalities in various marine and freshwater fish species in East and Southeast Asia. Of the three genotypes, TRBIV-l...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v12060681

    authors： Tsai JM,Huang SL,Yang CD

    更新日期：2020-06-24 00:00:00

  • Clinical Characterization of Host Response to Simian Hemorrhagic Fever Virus Infection in Permissive and Refractory Hosts: A Model for Determining Mechanisms of VHF Pathogenesis.

    abstract：:Simian hemorrhagic fever virus (SHFV) causes a fulminant and typically lethal viral hemorrhagic fever (VHF) in macaques (Cercopithecinae: Macaca spp.) but causes subclinical infections in patas monkeys (Cercopithecinae: Erythrocebus patas). This difference in disease course offers a unique opportunity to compare host ...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v11010067

    authors： Cornish JP,Moore IN,Perry DL,Lara A,Minai M,Promeneur D,Hagen KR,Virtaneva K,Paneru M,Buechler CR,O'Connor DH,Bailey AL,Cooper K,Mazur S,Bernbaum JG,Pettitt J,Jahrling PB,Kuhn JH,Johnson RF

    更新日期：2019-01-15 00:00:00

  • Exploratory Spatial Analysis of in vitro Respiratory Syncytial Virus Co-infections.

    abstract：:The cell response to virus infection and virus perturbation of that response is dynamic and is reflected by changes in cell susceptibility to infection. In this study, we evaluated the response of human epithelial cells to sequential infections with human respiratory syncytial virus strains A2 and B to determine if a ...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v2122782

    authors： Simeonov I,Gong X,Kim O,Poss M,Chiaromonte F,Fricks J

    更新日期：2010-12-01 00:00:00

  • Interactions of Human Dermal Dendritic Cells and Langerhans Cells Treated with Hyalomma Tick Saliva with Crimean-Congo Hemorrhagic Fever Virus.

    abstract：:Crimean-Congo hemorrhagic fever virus is one the most important and wide spread tick-borne viruses. Very little is known about the transmission from the tick and the early aspects of pathogenesis. Here, we generate human cutaneous antigen presenting cells-dermal dendritic cells and Langerhans cells-from umbilical cord...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v10070381

    authors： Rodriguez SE,McAuley AJ,Gargili A,Bente DA

    更新日期：2018-07-20 00:00:00

  • Cell-Free and Cell-Based Approaches to Explore the Roles of Host Membranes and Lipids in the Formation of Viral Replication Compartment Induced by Tombusviruses.

    abstract：:Plant positive strand RNA viruses are intracellular infectious agents that take advantage of cellular lipids and membranes to support replication and protect viral RNA from degradation by host antiviral responses. In this review, we discuss how Tomato bushy stunt virus (TBSV) co-opts lipid transfer proteins and modula...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v8030068

    authors： Nagy PD,Pogany J,Xu K

    更新日期：2016-03-03 00:00:00

  • Phaeoviral Infections Are Present in Macrocystis, Ecklonia and Undaria (Laminariales) and Are Influenced by Wave Exposure in Ectocarpales.

    abstract：:Two sister orders of the brown macroalgae (class Phaeophyceae), the morphologically complex Laminariales (commonly referred to as kelp) and the morphologically simple Ectocarpales are natural hosts for the dsDNA phaeoviruses (family Phycodnaviridae) that persist as proviruses in the genomes of their hosts. We have pre...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v10080410

    authors： McKeown DA,Schroeder JL,Stevens K,Peters AF,Sáez CA,Park J,Rothman MD,Bolton JJ,Brown MT,Schroeder DC

    更新日期：2018-08-05 00:00:00

  • A Novel and Divergent Gyrovirus with Unusual Genomic Features Detected in Wild Passerine Birds from a Remote Rainforest in French Guiana.

    abstract：:Sequence-independent amplification techniques have become important tools for virus discovery, metagenomics, and exploration of viral diversity at the global scale, especially in remote areas. Here, we describe the detection and genetic characterization of a novel gyrovirus, named GyV11, present in cloacal, oral, and ...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v11121148

    authors： Truchado DA,Diaz-Piqueras JM,Gomez-Lucia E,Doménech A,Milá B,Pérez-Tris J,Schmidt-Chanasit J,Cadar D,Benítez L

    更新日期：2019-12-11 00:00:00

  • Molecular characterization and phylogenetic analysis of new variants of the porcine epidemic diarrhea virus in Gansu, China in 2012.

    abstract：:Between January 2012 and March 2012, the infection rates of porcine epidemic diarrhea virus (PEDV) increased substantially in vaccinated swine herds in many porcine farms in Gansu Province, China. The spike (S) glycoprotein is an important determinant for PEDV biological properties. To determine the distribution profi...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v5081991

    authors： Tian Y,Yu Z,Cheng K,Liu Y,Huang J,Xin Y,Li Y,Fan S,Wang T,Huang G,Feng N,Yang Z,Yang S,Gao Y,Xia X

    更新日期：2013-08-15 00:00:00

  • MERS-CoV: Understanding the Latest Human Coronavirus Threat.

    abstract：:Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness. The 60-year-old man died as a result of renal and respiratory failure after admission to a hospital in Jeddah, Saudi A...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v10020093

    authors： Chafekar A,Fielding BC

    更新日期：2018-02-24 00:00:00

  • Phylogenetic, Evolutionary and Structural Analysis of Canine Parvovirus (CPV-2) Antigenic Variants Circulating in Colombia.

    abstract：:Canine parvovirus (CPV-2) is the causative agent of haemorrhagic gastroenteritis in canids. Three antigenic variants-CPV-2a, CPV-2b and CPV-2c-have been described, which are determined by variations at residue 426 of the VP2 capsid protein. In Colombia, the CPV-2a and CPV-2b antigenic variants have previously been rep...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v12050500

    authors： Giraldo-Ramirez S,Rendon-Marin S,Ruiz-Saenz J

    更新日期：2020-04-30 00:00:00

  • Interaction of a Densovirus with Glycans of the Peritrophic Matrix Mediates Oral Infection of the Lepidopteran Pest Spodoptera frugiperda.

    abstract：:The success of oral infection by viruses depends on their capacity to overcome the gut epithelial barrier of their host to crossing over apical, mucous extracellular matrices. As orally transmitted viruses, densoviruses, are also challenged by the complexity of the insect gut barriers, more specifically by the chitino...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v11090870

    authors： Pigeyre L,Schatz M,Ravallec M,Gasmi L,Nègre N,Clouet C,Seveno M,El Koulali K,Decourcelle M,Guerardel Y,Cot D,Dupressoir T,Gosselin-Grenet AS,Ogliastro M

    更新日期：2019-09-17 00:00:00

  • Challenges in mucosal HIV vaccine development: lessons from non-human primate models.

    abstract：:An efficacious HIV vaccine is urgently needed to curb the AIDS pandemic. The modest protection elicited in the phase III clinical vaccine trial in Thailand provided hope that this goal might be achieved. However, new approaches are necessary for further advances. As HIV is transmitted primarily across mucosal surfaces...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v6083129

    authors： Tuero I,Robert-Guroff M

    更新日期：2014-08-15 00:00:00

  • Canine Influenza Virus is Mildly Restricted by Canine Tetherin Protein.

    abstract：:Tetherin (BST2/CD317/HM1.24) has emerged as a key host-cell ·defence molecule that acts by inhibiting the release and spread of diverse enveloped virions from infected cells. We analysed the biological features of canine tetherin and found it to be an unstable hydrophilic type I transmembrane protein with one transmem...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v10100565

    authors： Zheng Y,Hao X,Zheng Q,Lin X,Zhang X,Zeng W,Ding S,Zhou P,Li S

    更新日期：2018-10-16 00:00:00

  • Experimental Infection of Pregnant Female Sheep with Zika Virus During Early Gestation.

    abstract：:Zika virus (ZIKV) is a vertically and sexually transmissible virus resulting in severe congenital malformation. The goal of this study was to develop an ovine model of ZIKV infection. Between 28-35 days gestation (DG), four pregnant animals were infected with two doses of 6 × 106 PFU of ZIKV; four control animals rece...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v11090795

    authors： Schwarz ER,Pozor MA,Pu R,Barr KL,Beachboard SE,MacLachlan NJ,Prakoso D,Long MT

    更新日期：2019-08-29 00:00:00

  • A3R Phage and Staphylococcus aureus Lysate Do Not Induce Neutrophil Degranulation.

    abstract：:The objective of this study was to evaluate the effects of A3R phage and Staphylococcus aureus lysate obtained after phage infection on neutrophil degranulation. The exocytosis of primary and secondary granules from neutrophils was investigated in vitro in whole blood specimens by flow cytometry based on the expressio...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v9020036

    authors： Borysowski J,Międzybrodzki R,Wierzbicki P,Kłosowska D,Korczak-Kowalska G,Weber-Dąbrowska B,Górski A

    更新日期：2017-02-21 00:00:00

  • Artemia spp., a Susceptible Host and Vector for Lymphocystis Disease Virus.

    abstract：:Different developmental stages of Artemia spp. (metanauplii, juveniles and adults) were bath-challenged with two isolates of the Lymphocystis disease virus (LCDV), namely, LCDV SA25 (belonging to the species Lymphocystis disease virus 3) and ATCC VR-342 (an unclassified member of the genus Lymphocystivirus). Viral qua...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v11060506

    authors： Valverde EJ,Labella AM,Borrego JJ,Castro D

    更新日期：2019-06-01 00:00:00

  • Evolution of Attenuation and Risk of Reversal in Peste des Petits Ruminants Vaccine Strain Nigeria 75/1.

    abstract：:Peste des Petits Ruminants (PPR) is a highly infectious disease caused by a virus of the Morbillivirus genus. The current PPR eradication effort relies mainly on the implementation of massive vaccination campaigns. One of the most widely used PPR vaccines is the Nigeria 75/1 strain obtained after attenuation by 75 ser...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v11080724

    authors： Eloiflin RJ,Boyer M,Kwiatek O,Guendouz S,Loire E,Servan de Almeida R,Libeau G,Bataille A

    更新日期：2019-08-07 00:00:00

  • Contemporary Zika Virus Isolates Induce More dsRNA and Produce More Negative-Strand Intermediate in Human Astrocytoma Cells.

    abstract：:The recent emergence and rapid geographic expansion of Zika virus (ZIKV) poses a significant challenge for public health. Although historically causing only mild febrile illness, recent ZIKV outbreaks have been associated with more severe neurological complications, such as Guillain-Barré syndrome and fetal microcepha...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v10120728

    authors： Barnard TR,Rajah MM,Sagan SM

    更新日期：2018-12-19 00:00:00

  • Bovine Adenovirus-3 Tropism for Bovine Leukocyte Sub-Populations.

    abstract：:A number of characteristics including lack of virulence and the ability to grow to high titers, have made bovine adenovirus-3 (BAdV-3) a vector of choice for further development as a vaccine-delivery vehicle for cattle. Despite the importance of blood leukocytes, including dendritic cells (DC), in the induction of pro...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v12121431

    authors： Khosa S,Araya MB,Griebel P,Arsic N,Tikoo SK

    更新日期：2020-12-12 00:00:00

  • Cervical Cancer Screening Programs in Europe: The Transition Towards HPV Vaccination and Population-Based HPV Testing.

    abstract：:Cervical cancer is the fourth most frequently occurring cancer in women around the world and can affect them during their reproductive years. Since the development of the Papanicolaou (Pap) test, screening has been essential in identifying cervical cancer at a treatable stage. With the identification of the human papi...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v10120729

    authors： Chrysostomou AC,Stylianou DC,Constantinidou A,Kostrikis LG

    更新日期：2018-12-19 00:00:00

  • In Vitro and In Vivo Antiviral Activity of Gingerenone A on Influenza A Virus Is Mediated by Targeting Janus Kinase 2.

    abstract：:Janus kinase (JAK) inhibitors have been developed as novel immunomodulatory drugs and primarily used for treating rheumatoid arthritis and other inflammatory diseases. Recent studies have suggested that this category of anti-inflammatory drugs could be potentially useful for the control of inflammation "storms" in res...

    journal_title：Viruses

    pub_type： 杂志文章

    doi：10.3390/v12101141

    authors： Wang J,Prinz RA,Liu X,Xu X

    更新日期：2020-10-08 00:00:00

  • Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection.

    abstract：:The progressive loss of immunological memory during aging correlates with a reduced proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that this phenotype is recapitulated during chronic viral infection. The antigenic volume imposed by persistent and latent viruses exposes the immune ...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v9100289

    authors： Bellon M,Nicot C

    更新日期：2017-10-05 00:00:00

  • Exosomes and Their Role in the Life Cycle and Pathogenesis of RNA Viruses.

    abstract：:Exosomes are membrane-enclosed vesicles actively released into the extracellular space, whose content reflect the physiological/pathological state of the cells they originate from. These vesicles participate in cell-to-cell communication and transfer of biologically active proteins, lipids, and RNAs. Their role in vir...

    journal_title：Viruses

    pub_type： 杂志文章,评审

    doi：10.3390/v7062770

    authors： Chahar HS,Bao X,Casola A

    更新日期：2015-06-19 00:00:00