A3R Phage and Staphylococcus aureus Lysate Do Not Induce Neutrophil Degranulation.

abstract：:Abstract: Since 2007, highly pathogenic clade 2.3.2 H5N1 avian influenza A (A(H5N1)) viruses have evolved to clade 2.3.2.1a, b, and c; currently only 2.3.2.1c A(H5N1) viruses circulate in wild birds and poultry. During antigenic evolution, clade 2.3.2.1a and c A(H5N1) viruses acquired both S144N and V223I mutations ar...

journal_title：Viruses

authors： An SH,Lee CY,Hong SM,Song CS,Kim JH,Kwon HJ

更新日期：2019-10-09 00:00:00

abstract：:Knowledge of the antibody-mediated immune response to SARS-CoV-2 is crucial to understand virus immunogenicity, establish seroprevalence, and determine whether subjects or recovered patients are at risk for infection/reinfection and would therefore benefit from vaccination. Here, we describe a novel and simple cell-EL...

journal_title：Viruses

authors： Zarletti G,Tiberi M,De Molfetta V,Bossù M,Toppi E,Bossù P,Scapigliati G

更新日期：2020-11-08 00:00:00

abstract：:The South African national treatment programme includes nucleoside reverse transcriptase inhibitors (NRTIs) in both first and second line highly active antiretroviral therapy regimens. Mutations in the RNase H domain have been associated with resistance to NRTIs but primarily in HIV-1 subtype B studies. Here, we inves...

journal_title：Viruses

authors： Ngcapu S,Theys K,Libin P,Marconi VC,Sunpath H,Ndung'u T,Gordon ML

更新日期：2017-11-08 00:00:00

abstract：:The hydrophobic pocket in the HIV-1 gp41 N-terminal heptad repeat (NHR) domain plays an important role in viral fusion and entry into the host cell, and serves as an attractive target for development of HIV-1 fusion/entry inhibitors. The peptide anti-HIV drug targeting gp41 NHR, T-20 (generic name: enfuvirtide; brand ...

journal_title：Viruses

authors： Yu F,Lu L,Du L,Zhu X,Debnath AK,Jiang S

更新日期：2013-01-11 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hooved animals that poses a constant burden on farmers in endemic regions and threatens the livestock industries in disease-free countries. Despite the increased number of publicly available whole genome sequences, FMDV data are biased by...

journal_title：Viruses

authors： Lasecka-Dykes L,Wright CF,Di Nardo A,Logan G,Mioulet V,Jackson T,Tuthill TJ,Knowles NJ,King DP

更新日期：2018-04-13 00:00:00

abstract：:Rapid and sensitive detection of prions is important in managing prion diseases. The real-time quaking-induced conversion (RT-QuIC) assay for prion seeding activity has been applied to many prion diseases and provides for specific antemortem diagnostic testing. We evaluated RT-QuIC's long-term consistency and varied m...

journal_title：Viruses

authors： Orrú CD,Hughson AG,Groveman BR,Campbell KJ,Anson KJ,Manca M,Kraus A,Caughey B

更新日期：2016-05-23 00:00:00

abstract：:Astroviruses (AstVs) cause disease in a wide variety of species. Porcine AstVs are highly genetically diverse and conventionally assigned to five genetic lineages (PoAstV1-5). Due to the increasing evidence that porcine astrovirus type 3 (PoAstV3) is a cause of encephalomyelitis in swine and to elucidate important eco...

journal_title：Viruses

authors： Rawal G,Ferreyra FM,Macedo NR,Bradner LK,Harmon KM,Allison G,Linhares DCL,Arruda BL

更新日期：2020-09-07 00:00:00

abstract：:Canine parvovirus (CPV-2) is the causative agent of haemorrhagic gastroenteritis in canids. Three antigenic variants-CPV-2a, CPV-2b and CPV-2c-have been described, which are determined by variations at residue 426 of the VP2 capsid protein. In Colombia, the CPV-2a and CPV-2b antigenic variants have previously been rep...

journal_title：Viruses

authors： Giraldo-Ramirez S,Rendon-Marin S,Ruiz-Saenz J

更新日期：2020-04-30 00:00:00

abstract：:The cell response to virus infection and virus perturbation of that response is dynamic and is reflected by changes in cell susceptibility to infection. In this study, we evaluated the response of human epithelial cells to sequential infections with human respiratory syncytial virus strains A2 and B to determine if a ...

journal_title：Viruses

authors： Simeonov I,Gong X,Kim O,Poss M,Chiaromonte F,Fricks J

更新日期：2010-12-01 00:00:00

abstract：:The smaller tea tortrix, Adoxophyes honmai (Lepidoptera: Tortricidae), is an economically important pest of tea in Japan. Previous work showed that a fast-killing nucleopolyhedrovirus (NPV) isolated from A. orana (AdorNPV) and a slow-killing NPV isolated from A. honmai (AdhoNPV) are both infectious to A. honmai larvae...

journal_title：Viruses

authors： Takahashi M,Nakai M,Saito Y,Sato Y,Ishijima C,Kunimi Y

更新日期：2015-03-18 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and animal diseases must comply with regulatory requirements as they pertain to environmental risk asses...

journal_title：Viruses

authors： Okeke MI,Okoli AS,Diaz D,Offor C,Oludotun TG,Tryland M,Bøhn T,Moens U

更新日期：2017-10-29 00:00:00

abstract：:Although the concept of high-level containment care (HLCC or 'biocontainment'), dates back to 1969, the 2014-2016 outbreak of Ebola virus disease (EVD) brought with it a renewed emphasis on the use of specialized HLCC units in the care of patients with EVD. Employment of these units in the United States and Western Eu...

journal_title：Viruses

authors： Cieslak TJ,Herstein JJ,Kortepeter MG,Hewlett AL

更新日期：2019-08-22 00:00:00

abstract：:Tetherin is an interferon-induced, intrinsic cellular response factor that blocks release of numerous viruses, including Ebola virus, from infected cells. As with many viruses targeted by host factors, Ebola virus employs a tetherin antagonist, the viral glycoprotein (EboGP), to counteract restriction and promote viru...

journal_title：Viruses

authors： Vande Burgt NH,Kaletsky RL,Bates P

更新日期：2015-10-26 00:00:00

abstract：:Lactococcus lactis is one of the most important bacteria in dairy fermentations, being used in the production of cheese and buttermilk. The processes are vulnerable to phage attacks, and undefined mixtures of lactococcal strains are often used to reduce the risk of bacteriophage caused fermentation failure. Other prev...

journal_title：Viruses

authors： Frantzen CA,Holo H

更新日期：2019-05-16 00:00:00

abstract：:Tetraspanins are integral transmembrane proteins organized in microdomains displaying specific and direct interactions with other tetraspanins and molecular partners. Among them, CD81 has been implicated in a variety of physiological and pathological processes. CD81 also plays a crucial role in pathogen entry into hos...

journal_title：Viruses

authors： Zona L,Tawar RG,Zeisel MB,Xiao F,Schuster C,Lupberger J,Baumert TF

更新日期：2014-02-18 00:00:00

abstract：:Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) systems are key immune mechanisms helping prokaryotic species fend off RNA and DNA viruses. CRISPR/Cas9 has broad applications in basic research and biotechnology and has been widely used across eukaryotic species for genome...

journal_title：Viruses

authors： Aman R,Mahas A,Butt H,Aljedaani F,Mahfouz M

更新日期：2018-12-19 00:00:00

abstract：:The potent HIV-1 inhibitor TRIM5α blocks HIV-1 infection by accelerating the uncoating of HIV-1. TRIM5α is known to form higher-order self-association complexes that contribute to the avidity of TRIM5α for the HIV-1 capsid, and are essential to inhibit infection; these higher-order self-association complexes are depen...

journal_title：Viruses

authors： Diaz-Griffero F

更新日期：2011-05-01 00:00:00

abstract：:In rabies diagnosis, it is essential to count on a rapid test to give a quick response. The combined sensitivity and robustness of the TaqMan RT-PCR assays (qRT-PCR) have made these methods a valuable alternative for rabies virus (RABV) detection. We conducted a study to compare the applicability of two widely used qR...

journal_title：Viruses

authors： Caraballo DA,Lombardo MA,Becker P,Sabio MS,Lema C,Martínez LM,Beltrán FJ,Li Y,Cisterna DM

更新日期：2020-12-25 00:00:00

abstract：:Countries rely on good diagnostic tests and appropriate testing schemes to fight against economically important small ruminant lentivirus (SRLV) infections. We undertook an extensive comparative analysis of seven commercially available serological tests and one in-house real-time PCR (qPCR) detecting genotype A and B ...

journal_title：Viruses

authors： Michiels R,Van Mael E,Quinet C,Adjadj NR,Cay AB,De Regge N

更新日期：2018-12-08 00:00:00

abstract：:Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV), an infectious coronavirus first reported in 2012, has a mortality rate greater than 35%. Therapeutic antibodies are key tools for preventing and treating MERS-CoV infection, but to date no such agents have been approved for treatment of this virus. Nanobo...

journal_title：Viruses

authors： He L,Tai W,Li J,Chen Y,Gao Y,Li J,Sun S,Zhou Y,Du L,Zhao G

更新日期：2019-02-19 00:00:00

abstract：:The most highly expressed protein during the productive phase of the human papillomavirus (HPV) life cycle is E1^E4. Its full role during infection remains to be established. HPV E1^E4 is expressed during both the early and late stages of the virus life cycle and contributes to viral genome amplification. In an attemp...

journal_title：Viruses

authors： Biryukov J,Myers JC,McLaughlin-Drubin ME,Griffin HM,Milici J,Doorbar J,Meyers C

更新日期：2017-12-19 00:00:00

abstract：:The development of high-throughput technologies allows for evaluating gene expression at the whole-genome level. Together with proteomic and metabolomic studies, these analyses have resulted in the identification of plant genes whose function or expression is altered as a consequence of pathogen attacks. Members of th...

journal_title：Viruses

authors： Czosnek H,Eybishtz A,Sade D,Gorovits R,Sobol I,Bejarano E,Rosas-Díaz T,Lozano-Durán R

更新日期：2013-03-22 00:00:00

abstract：:Nervous necrosis virus (NNV) can infect many species of fish and has an 80-100% mortality rate. NNV capsid protein (NNVCP) is the only structural protein of NNV, but there are few studies on the protein-protein interaction between NNVCP and the host cell. To investigate NNV morphogenesis, native NNV capsid protein (NN...

journal_title：Viruses

authors： Huang PY,Hsiao HC,Wang SW,Lo SF,Lu MW,Chen LL

更新日期：2020-09-04 00:00:00

abstract：:African swine fever (ASF) is a devastating disease in pigs, with no vaccines for control. The genetic manipulation of African swine fever virus (ASFV) is often tedious and time consuming. Here, we describe a method to manipulate the virus genome to produce gene deletion viruses in a much-reduced time. This method comb...

journal_title：Viruses

authors： Rathakrishnan A,Moffat K,Reis AL,Dixon LK

更新日期：2020-06-05 00:00:00

abstract：:Human endogenous retroviruses (ERVs) represent 8% of the total human genome. Although the majority of these ancient proviral sequences have only retained non-coding long terminal repeats (LTRs), a number of "endogenized" retroviral genes encode functional proteins. Previous studies have underlined the implication of t...

journal_title：Viruses

authors： Lokossou AG,Toudic C,Barbeau B

更新日期：2014-11-24 00:00:00

abstract：:Global climate change-induced warming of the Artic seas is predicted to shift the phytoplankton community towards dominance of smaller-sized species due to global warming. Yet, little is known about their viral mortality agents despite the ecological importance of viruses regulating phytoplankton host dynamics and div...

journal_title：Viruses

authors： Maat DS,Biggs T,Evans C,van Bleijswijk JDL,van der Wel NN,Dutilh BE,Brussaard CPD

更新日期：2017-06-02 00:00:00

abstract：:Negative strand RNA viruses (NSVs) include many important human pathogens, such as influenza virus, Ebola virus, and rabies virus. One of the unique characteristics that NSVs share is the assembly of the nucleocapsid and its role in viral RNA synthesis. In NSVs, the single strand RNA genome is encapsidated in the line...

journal_title：Viruses

authors： Luo M,Terrell JR,Mcmanus SA

更新日期：2020-07-30 00:00:00

abstract：:Food security is currently a global socio-political pressure point that is exacerbated by the everincreasing world population[...]. ...

journal_title：Viruses

authors： Mahony J,Casey E,van Sinderen D

更新日期：2020-02-13 00:00:00

abstract：:Hepatitis B virus (HBV) persistence is at the basis of HBV reactivation as a consequence of chemotherapy and immunosuppressive treatments. The identification of early viral replication indicators and markers of effective HBV immunological control would be useful in monitoring patients who are at risk of potential vira...

journal_title：Viruses

authors： Svicher V,Salpini R,Malagnino V,Piermatteo L,Alkhatib M,Cerva C,Sarmati L

更新日期：2019-08-25 00:00:00

abstract：:At the end of my doctoral studies, in 1988, I published a review article on the major steps of transcription and translation during the mammalian reovirus multiplication cycle, a topic that still fascinates me 30 years later. It is in the nature of scientific research to generate further questioning as new knowledge e...

journal_title：Viruses

authors： Lemay G

更新日期：2018-11-27 00:00:00