Novel Mutations Evading Avian Immunity around the Receptor Binding Site of the Clade 2.3.2.1c Hemagglutinin Gene Reduce Viral Thermostability and Mammalian Pathogenicity.

abstract：:The strong association between Varroa destructor, deformed wing virus (DWV), and high overwintering colony losses (OCL) of honey bees is well established. Three DWV master variants (DWV-A, -B, and -C) have been described, and their role in colony mortality remains an open question. Therefore, the aim of this study is ...

journal_title：Viruses

authors： Kevill JL,de Souza FS,Sharples C,Oliver R,Schroeder DC,Martin SJ

更新日期：2019-05-09 00:00:00

abstract：:The Flaviviridae family comprises a number of human pathogens, which, although sharing structural and functional features, cause diseases with very different outcomes. This can be explained by the plurality of functions exerted by the few proteins coded by viral genomes, with some of these functions shared among membe...

journal_title：Viruses

authors： Zeidler JD,Fernandes-Siqueira LO,Barbosa GM,Da Poian AT

更新日期：2017-03-13 00:00:00

abstract：:Lassa virus (LASV) and Mopeia virus (MOPV) are two closely related Old-World mammarenaviruses. LASV causes severe hemorrhagic fever with high mortality in humans, whereas no case of MOPV infection has been reported. Comparing MOPV and LASV is a powerful strategy to unravel pathogenic mechanisms that occur during the c...

journal_title：Viruses

authors： Baillet N,Krieger S,Journeaux A,Caro V,Tangy F,Vidalain PO,Baize S

更新日期：2019-03-23 00:00:00

abstract：:Circoviruses infect a variety of animal species and have small (~1.8-2.2 kb) circular single-stranded DNA genomes. Recently a penguin circovirus (PenCV) was identified associated with an Adélie Penguin (Pygoscelis adeliae) with feather disorder and in the cloacal swabs of three asymptomatic Adélie Penguins at Cape Cro...

journal_title：Viruses

authors： Levy H,Fiddaman SR,Djurhuus A,Black CE,Kraberger S,Smith AL,Hart T,Varsani A

更新日期：2020-08-06 00:00:00

abstract：:Oropouche fever is an emerging zoonotic disease caused by Oropouche virus (OROV), an arthropod transmitted Orthobunyavirus circulating in South and Central America. During the last 60 years, more than 30 epidemics and over half a million clinical cases attributed to OROV infection have been reported in Brazil, Peru, P...

journal_title：Viruses

authors： Sakkas H,Bozidis P,Franks A,Papadopoulou C

更新日期：2018-04-04 00:00:00

abstract：:The neutrophil extracellular trap (ET) is a eukaryotic host defense machinery that operates by capturing and concentrating pathogens in a filamentous network manufactured by neutrophils and made of DNA, histones, and many other components. Respiratory virus-induced ETs are involved in tissue damage and impairment of t...

journal_title：Viruses

authors： Real-Hohn A,Zhu R,Ganjian H,Ibrahim N,Hinterdorfer P,Kowalski H,Blaas D

更新日期：2020-07-04 00:00:00

abstract：:Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV), an infectious coronavirus first reported in 2012, has a mortality rate greater than 35%. Therapeutic antibodies are key tools for preventing and treating MERS-CoV infection, but to date no such agents have been approved for treatment of this virus. Nanobo...

journal_title：Viruses

authors： He L,Tai W,Li J,Chen Y,Gao Y,Li J,Sun S,Zhou Y,Du L,Zhao G

更新日期：2019-02-19 00:00:00

abstract：:Nasopharyngeal cancer (NPC) is associated with Epstein Barr virus (EBV) infection. However different viral strains have been implicated in NPC worldwide. This study aimed to detect and characterize EBV in patients diagnosed with NPC in Ghana. A total of 55 patients diagnosed with NPC by CT scan and endoscopy were age-...

journal_title：Viruses

authors： Ayee R,Ofori MEO,Tagoe EA,Languon S,Searyoh K,Armooh L,Bilson-Amoah E,Baidoo K,Kitcher E,Wright E,Quaye O

更新日期：2020-07-16 00:00:00

abstract：:Retroviruses integrate a reverse transcribed double stranded DNA copy of their viral genome into the chromosomal DNA of cells they infect. Occasionally, exogenous retroviruses infect germ cells and when this happens a profound shift in the virus host dynamic occurs. Retroviruses maintained as hereditable viral genetic...

journal_title：Viruses

authors： Liu M,Eiden MV

更新日期：2011-06-01 00:00:00

abstract：:Usutu virus (USUV) is a neurotropic flavivirus closely related to West Nile virus (WNV). Its enzootic cycle mainly involves mosquitoes and birds. Human infection can occur with occasional, but sometimes severe, neurological complications. Since its emergence and spread in Europe over the last two decades, USUV has bee...

journal_title：Viruses

authors： Benzarti E,Rivas J,Sarlet M,Franssen M,Desmecht D,Schmidt-Chanasit J,Savini G,Lorusso A,Van Laere AS,Garigliany MM

更新日期：2020-01-31 00:00:00

abstract：:SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated viral infection are important for studying immunity. Because SARS-CoV-2 is a biosafety-level-3 virus, one way to simplify such assays is ...

journal_title：Viruses

authors： Crawford KHD,Eguia R,Dingens AS,Loes AN,Malone KD,Wolf CR,Chu HY,Tortorici MA,Veesler D,Murphy M,Pettie D,King NP,Balazs AB,Bloom JD

更新日期：2020-05-06 00:00:00

abstract：:Virus-induced inflammation plays a critical role in determining the clinical outcome of an acute respiratory virus infection. We have shown previously that the administration of immunobiotic Lactobacillus plantarum (Lp) directly to the respiratory tract prevents lethal inflammatory responses to subsequent infection wi...

journal_title：Viruses

authors： Mai E,Percopo CM,Limkar AR,Sek AC,Ma M,Rosenberg HF

更新日期：2020-12-22 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is an important cancer-causing human retrovirus that has infected approximately 15 million individuals worldwide. Many aspects of HTLV-1 replication, including virus particle structure and assembly, are poorly understood. Group-specific antigen (Gag) proteins labeled at the ...

journal_title：Viruses

authors： Maldonado JO,Angert I,Cao S,Berk S,Zhang W,Mueller JD,Mansky LM

更新日期：2017-07-19 00:00:00

abstract：:During the epizootic of highly pathogenic avian influenza (HPAI) H5N8 virus in Europe in 2016-2017, HPAI viruses of subtype H5N5 were also isolated. However, the detection of H5N5 viruses was limited compared to H5N8. In this study, we show that the genetic constellation of a newly isolated H5N5 virus is different fro...

journal_title：Viruses

authors： Bergervoet SA,Ho CKY,Heutink R,Bossers A,Beerens N

更新日期：2019-05-31 00:00:00

abstract：:Puumala virus (PUUV) is the agent of nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) in Europe. NE incidence presents a high spatial variation throughout France, while the geographical distribution of the wild reservoir of PUUV, the bank vole, is rather continuous. A missing pi...

journal_title：Viruses

authors： Castel G,Couteaudier M,Sauvage F,Pons JB,Murri S,Plyusnina A,Pontier D,Cosson JF,Plyusnin A,Marianneau P,Tordo N

更新日期：2015-10-22 00:00:00

abstract：:Viroids are small, non-coding, circular RNA molecules that infect plants. Different hypotheses for their evolutionary origin have been put forward, such as an early emergence in a precellular RNA World or several de novo independent evolutionary origins in plants. Here, we discuss the plausibility of de novo emergence...

journal_title：Viruses

authors： Catalán P,Elena SF,Cuesta JA,Manrubia S

更新日期：2019-05-09 00:00:00

abstract：:Cotton leaf curl disease (CLCuD) is one of the most economically important diseases and is a constraint to cotton production in major producers, Pakistan and India. CLCuD is caused by monopartite plant viruses belonging to the family Geminiviridae (genus Begomovirus), in association with an essential, disease-specific...

journal_title：Viruses

authors： Zubair M,Zaidi SS,Shakir S,Amin I,Mansoor S

更新日期：2017-09-29 00:00:00

abstract：:: African swine fever is a devastating hemorrhagic infectious disease, which affects domestic and wild swines (Susscrofa) of all breeds and ages, with a high lethality of up to 90-100% in naïve animals. The causative agent, African swine fever virus (ASFV), is a large and complex double-stranded DNA arbovirus which is...

journal_title：Viruses

authors： Montaner-Tarbes S,Pujol M,Jabbar T,Hawes P,Chapman D,Portillo HD,Fraile L,Sánchez-Cordón PJ,Dixon L,Montoya M

更新日期：2019-09-20 00:00:00

abstract：:Via virome sequencing, six viruses were detected from Magnaporthe oryzae strains YC81-2, including one virus in the family Tombusviridae, one virus in the family Narnaviridae and four viruses in the family Botourmiaviridae. Since the RNA-dependent RNA polymerase (RdRp) of one botourmiavirus show the highest identity (...

journal_title：Viruses

authors： Liu Y,Zhang L,Esmael A,Duan J,Bian X,Jia J,Xie J,Cheng J,Fu Y,Jiang D,Lin Y

更新日期：2020-12-03 00:00:00

abstract：:It is difficult to observe the molecular choreography between viruses and host cell components, as they exist on a spatial scale beyond the reach of conventional microscopy. However, novel super-resolution microscopy techniques have cast aside technical limitations to reveal a nanoscale view of virus replication and c...

journal_title：Viruses

authors： Grove J

更新日期：2014-03-19 00:00:00

abstract：:A wide gap exists between the rapid acceptance of genetically modified (GM) crops for cultivation by farmers in many countries and in the global markets for food and feed, and the often-limited acceptance by consumers. This review contrasts the advances of practical applications of agricultural biotechnology with the ...

journal_title：Viruses

authors： Lucht JM

更新日期：2015-07-30 00:00:00

abstract：:The successful control of HBV infection requires an efficient expansion of distinct elements of the adaptive immune system (B cells, helper and cytotoxic T cells) that, due to the hepatotropic nature of HBV, need to operate in the liver parenchyma. In this respect, we will discuss broad features of HBV immunity in pat...

journal_title：Viruses

authors： Bertoletti A,Tan AT,Gehring AJ

更新日期：2009-09-01 00:00:00

abstract：:Many blood-feeding arthropods are known vectors of viruses that are a source of unprecedented global health concern. Mosquitoes are an integral part of these arthropod vectors. Advancements in next-generation sequencing and bioinformatics has expanded our knowledge on the richness of viruses harbored by arthropods. In...

journal_title：Viruses

authors： Atoni E,Wang Y,Karungu S,Waruhiu C,Zohaib A,Obanda V,Agwanda B,Mutua M,Xia H,Yuan Z

更新日期：2018-01-12 00:00:00

abstract：:A field study was undertaken to (i) measure the prevalence of feline leukaemia virus (FeLV) exposure and FeLV infection in a cross-section of healthy Australian pet cats; and (ii) investigate the outcomes following natural FeLV exposure in two Australian rescue facilities. Group 1 (n = 440) consisted of healthy client...

journal_title：Viruses

authors： Westman M,Norris J,Malik R,Hofmann-Lehmann R,Harvey A,McLuckie A,Perkins M,Schofield D,Marcus A,McDonald M,Ward M,Hall E,Sheehy P,Hosie M

更新日期：2019-05-31 00:00:00

abstract：:Hantaviruses are an established cause of haemorrhagic fever with renal syndrome (HFRS) in Europe. Following a confirmed case of HFRS in the UK, in an individual residing on a farm in North Yorkshire and the Humber, a tidal estuary on the east coast of Northern England, and the subsequent isolation of a Seoul hantaviru...

journal_title：Viruses

authors： Jameson LJ,Newton A,Coole L,Newman EN,Carroll MW,Beeching NJ,Hewson R,Christley RM

更新日期：2014-02-05 00:00:00

abstract：:Severe fever with thrombocytopenia syndrome (SFTS), a tick-borne infectious disease, is difficult to differentiate from other common febrile diseases. Clinically distinctive features and climate variates associated with tick growth can be useful predictors for SFTS. This retrospective study (2013-2019) demonstrated th...

journal_title：Viruses

authors： Kim M,Heo ST,Oh H,Oh S,Lee KH,Yoo JR

更新日期：2020-12-23 00:00:00

abstract：:At the end of 2019, a new disease appeared and spread all over the world, the COVID-19, produced by the coronavirus SARS-CoV-2. As a consequence of this worldwide health crisis, the scientific community began to redirect their knowledge and resources to fight against it. Here we summarize the recent research on viruse...

journal_title：Viruses

authors： Fernandez-Garcia L,Pacios O,González-Bardanca M,Blasco L,Bleriot I,Ambroa A,López M,Bou G,Tomás M

更新日期：2020-10-16 00:00:00

abstract：:Although there have been many epidemiological reports of the inter-country transmission of measles, systematic analysis of the global transmission dynamics of the measles virus (MV) is limited. In this study, we applied phylogeographic analysis to characterize the global transmission dynamics of the MV using large-sca...

journal_title：Viruses

authors： Furuse Y,Oshitani H

更新日期：2017-04-16 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy-tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs by transfer of a c...

journal_title：Viruses

authors： Carpentier A,Barez PY,Hamaidia M,Gazon H,de Brogniez A,Perike S,Gillet N,Willems L

更新日期：2015-07-07 00:00:00

abstract：:The hypothesis is presented that bacteriophage DNA packaging motors have a cycle comprised of bind/release thermal ratcheting with release-associated DNA pushing via ATP-dependent protein folding. The proposed protein folding occurs in crystallographically observed peptide segments that project into an axial channel o...

journal_title：Viruses

authors： Serwer P

更新日期：2010-09-01 00:00:00