Caging the beast: TRIM5α binding to the HIV-1 core.


:The potent HIV-1 inhibitor TRIM5α blocks HIV-1 infection by accelerating the uncoating of HIV-1. TRIM5α is known to form higher-order self-association complexes that contribute to the avidity of TRIM5α for the HIV-1 capsid, and are essential to inhibit infection; these higher-order self-association complexes are dependent upon an intact B-box 2 domain. Even though the ability to form higher-order self-association complexes resembles the clathrin triskelion that forms a protein array, or cage, around the endocytic vesicle, evidence for the ability of TRIM5α to assemble a similar type of structure surrounding the HIV-1 core has been lacking. Recent work by Ganser-Pornillos, Chandrasekaran and colleagues has now demonstrated the ability of the restriction factor TRIM5α to "cage" or "net" the HIV-1 core by forming an hexagonal array on the surface of the viral capsid. This hexagonal array is strikingly similar in design to the array formed by the clathrin triskelion on the surface of the clathrin-coated endocytic vesicle. This remarkable finding represents an important advance on our understanding of the restriction factor TRIM5α, and suggests that TRIM5α cages the HIV-1 core in order to terminate infection. The present note discusses the implications of this discovery.






Diaz-Griffero F




Has Abstract


2011-05-01 00:00:00












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    authors: Siddharthan V,Miao J,Van Wettere AJ,Li R,Wu H,Sullivan E,Jiao J,Hooper JW,Safronetz D,Morrey JD,Julander JG,Wang Z

    更新日期:2019-01-22 00:00:00

  • Diversity and Evolution of Viral Pathogen Community in Cave Nectar Bats (Eonycteris spelaea).

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    pub_type: 杂志文章


    authors: Mendenhall IH,Wen DLH,Jayakumar J,Gunalan V,Wang L,Mauer-Stroh S,Su YCF,Smith GJD

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  • Successive Passage In Vitro Led to Lower Virulence and Higher Titer of A Variant Porcine Epidemic Diarrhea Virus.

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    authors: Zhao P,Wang S,Chen Z,Yu J,Tang R,Qiu W,Zhao L,Liu Y,Guo X,He H,Xu G,Li J,Wu J

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  • Effects of a Covert Infection with Phthorimaea operculella granulovirus in Insect Populations of Phthorimaea operculella.

    abstract::Virus infections of insects can easily stay undetected, neither showing typical signs of a disease, nor being lethal. Such a stable and most of the time covert infection with Phthorimaea operculella granulovirus (PhopGV) was detected in a Phthorimaea operculella laboratory colony, which originated from Italy (Phop-IT)...


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    authors: Larem A,Ben Tiba S,Fritsch E,Undorf-Spahn K,Wennmann JT,Jehle JA

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  • The molecular biology of feline immunodeficiency virus (FIV).

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    pub_type: 杂志文章,评审


    authors: Kenyon JC,Lever AM

    更新日期:2011-11-01 00:00:00

  • Achimota Pararubulavirus 3: A New Bat-Derived Paramyxovirus of the Genus Pararubulavirus.

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  • The genomic diversity and phylogenetic relationship in the family iridoviridae.

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    authors: Eaton HE,Ring BA,Brunetti CR

    更新日期:2010-07-01 00:00:00

  • Rotavirus Genomic RNA Complex Forms via Specific RNA-RNA Interactions: Disruption of RNA Complex Inhibits Virus Infectivity.

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    authors: Fajardo T,Sung PY,Celma CC,Roy P

    更新日期:2017-06-29 00:00:00

  • Expression Level of Small Envelope Protein in Addition to Sequence Divergence inside Its Major Hydrophilic Region Contributes to More Efficient Surface Antigen Secretion by Hepatitis B Virus Subgenotype D2 than Subgenotype A2.

    abstract::Hepatitis B surface antigen (HBsAg) promotes persistent hepatitis B virus (HBV) infection. It primarily corresponds to small (S) envelope protein secreted as subviral particles. We previously found that genotype D clones expressed less S protein than genotype A clones but showed higher extracellular/intracellular rati...


    pub_type: 杂志文章


    authors: Wang Q,Fu S,Zhang J,Yuan Q,Li J,Xia N,Wen YM,Wang Y,Tong S

    更新日期:2020-09-01 00:00:00

  • Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis.

    abstract::Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a dearth of published evidence supporting the higher virulence of MAR...


    pub_type: 杂志文章


    authors: Blair PW,Keshtkar-Jahromi M,Psoter KJ,Reisler RB,Warren TK,Johnston SC,Goff AJ,Downey LG,Bavari S,Cardile AP

    更新日期:2018-11-21 00:00:00

  • Ubiquitous Carbohydrate Binding Modules Decorate 936 Lactococcal Siphophage Virions.

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    pub_type: 杂志文章


    authors: Hayes S,Mahony J,Vincentelli R,Ramond L,Nauta A,van Sinderen D,Cambillau C

    更新日期:2019-07-09 00:00:00

  • NF-κB-Dependent Production of ROS and Restriction of HSV-1 Infection in U937 Monocytic Cells.

    abstract::Herpes simplex virus 1 (HSV-1) can infect a wide range of cell types, including cells of the adaptive and innate immunity but, normally, it completes a fully-permissive replication cycle only in epithelial or neural cells. Complex mechanisms controlling this delicate balance in immune cells and consequent restriction ...


    pub_type: 杂志文章


    authors: Marino-Merlo F,Papaianni E,Frezza C,Pedatella S,De Nisco M,Macchi B,Grelli S,Mastino A

    更新日期:2019-05-10 00:00:00

  • Emaravirus: a novel genus of multipartite, negative strand RNA plant viruses.

    abstract::Ringspot symptoms in European mountain ash (Sorbus aucuparia L.), fig mosaic, rose rosette, raspberry leaf blotch, pigeonpea sterility mosaic (Cajanus cajan) and High Plains disease of maize and wheat were found to be associated with viruses that share several characteristics. They all have single-stranded multipartit...


    pub_type: 杂志文章,评审


    authors: Mielke-Ehret N,Mühlbach HP

    更新日期:2012-09-01 00:00:00

  • HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B.

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    pub_type: 杂志文章,评审


    authors: Collin V,Flamand L

    更新日期:2017-06-26 00:00:00

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    authors: Aksnes I,Markussen T,Braaen S,Rimstad E

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    pub_type: 杂志文章,评审


    authors: Haake C,Cook S,Pusterla N,Murphy B

    更新日期:2020-09-13 00:00:00

  • Serum-Derived Extracellular Vesicles from African Swine Fever Virus-Infected Pigs Selectively Recruit Viral and Porcine Proteins.

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    pub_type: 杂志文章


    authors: Montaner-Tarbes S,Pujol M,Jabbar T,Hawes P,Chapman D,Portillo HD,Fraile L,Sánchez-Cordón PJ,Dixon L,Montoya M

    更新日期:2019-09-20 00:00:00

  • Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes.

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    pub_type: 杂志文章


    authors: Rodriguez M,Lapierre J,Ojha CR,Estrada-Bueno H,Dever SM,Gewirtz DA,Kashanchi F,El-Hage N

    更新日期:2017-07-28 00:00:00

  • Half a Century of Research on Membrane-Containing Bacteriophages: Bringing New Concepts to Modern Virology.

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    pub_type: 杂志文章,评审


    authors: Mäntynen S,Sundberg LR,Oksanen HM,Poranen MM

    更新日期:2019-01-18 00:00:00

  • Genetic Diversity of the Noncoding Control Region of the Novel Human Polyomaviruses.

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    pub_type: 杂志文章,评审


    authors: Moens U,Prezioso C,Pietropaolo V

    更新日期:2020-12-07 00:00:00

  • Discovering host genes involved in the infection by the Tomato Yellow Leaf Curl Virus complex and in the establishment of resistance to the virus using Tobacco Rattle Virus-based post transcriptional gene silencing.

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    pub_type: 杂志文章,评审


    authors: Czosnek H,Eybishtz A,Sade D,Gorovits R,Sobol I,Bejarano E,Rosas-Díaz T,Lozano-Durán R

    更新日期:2013-03-22 00:00:00

  • Isolation and Characterization of a Double Stranded DNA Megavirus Infecting the Toxin-Producing Haptophyte Prymnesium parvum.

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    pub_type: 杂志文章


    authors: Wagstaff BA,Vladu IC,Barclay JE,Schroeder DC,Malin G,Field RA

    更新日期:2017-03-09 00:00:00

  • Genetic Characterization and Phylogenetic Analysis of Small Ruminant Lentiviruses Detected in Spanish Assaf Sheep with Different Mammary Lesions.

    abstract::Small Ruminant Lentiviruses (SRLVs) are widespread in many countries and cause economically relevant, slow, and persistent diseases in sheep and goats. Monitoring the genetic diversity of SRLVs is useful to improve the diagnostic tools used in the eradication programs. In this study, SRLVs detected in Spanish Assaf sh...


    pub_type: 杂志文章


    authors: Gayo E,Cuteri V,Polledo L,Rossi G,García Marín JF,Preziuso S

    更新日期:2018-06-09 00:00:00

  • n-3 Polyunsaturated Fatty Acids Impede the TCR Mobility and the TCR-pMHC Interaction of Anti-Viral CD8+ T Cells.

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    pub_type: 杂志文章


    authors: Lim Y,Kim S,Kim S,Kim DI,Kang KW,Hong SH,Lee SM,Koh HR,Seo YJ

    更新日期:2020-06-12 00:00:00

  • Overexpression of MAP2 and NF-H Associated with Dendritic Pathology in the Spinal Cord of Mice Infected with Rabies Virus.

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    pub_type: 杂志文章


    authors: Monroy-Gómez J,Santamaría G,Torres-Fernández O

    更新日期:2018-03-06 00:00:00

  • The RNA Architecture of the SARS-CoV-2 3'-Untranslated Region.

    abstract::Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. The 3' untranslated region (UTR) of this β-CoV contains essential cis-acting RNA elements for the viral genome transcription and replication. These elements include an equilibrium between an extended bulged s...


    pub_type: 杂志文章


    authors: Zhao J,Qiu J,Aryal S,Hackett JL,Wang J

    更新日期:2020-12-21 00:00:00

  • A Putative Role of de-Mono-ADP-Ribosylation of STAT1 by the SARS-CoV-2 Nsp3 Protein in the Cytokine Storm Syndrome of COVID-19.

    abstract::As more cases of COVID-19 are studied and treated worldwide, it had become apparent that the lethal and most severe cases of pneumonia are due to an out-of-control inflammatory response to the SARS-CoV-2 virus. I explored the putative causes of this specific feature through a detailed genomic comparison with the close...


    pub_type: 杂志文章


    authors: Claverie JM

    更新日期:2020-06-15 00:00:00

  • Phosphorylation of Single Stranded RNA Virus Proteins and Potential for Novel Therapeutic Strategies.

    abstract::Post translational modification of proteins is a critical requirement that regulates function. Among the diverse kinds of protein post translational modifications, phosphorylation plays essential roles in protein folding, protein:protein interactions, signal transduction, intracellular localization, transcription regu...


    pub_type: 杂志文章,评审


    authors: Keck F,Ataey P,Amaya M,Bailey C,Narayanan A

    更新日期:2015-10-12 00:00:00

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    abstract::Flaviviruses are enveloped arthropod-borne viruses with a single-stranded, positive-sense RNA genome that can cause serious illness in humans and animals. The 11 kb 5' capped RNA genome consists of a single open reading frame (ORF), and is flanked by 5' and 3' untranslated regions (UTR). The ORF is a polyprotein that ...


    pub_type: 杂志文章,评审


    authors: Ng WC,Soto-Acosta R,Bradrick SS,Garcia-Blanco MA,Ooi EE

    更新日期:2017-06-06 00:00:00

  • Innate Immune Components that Regulate the Pathogenesis and Resolution of hRSV and hMPV Infections.

    abstract::The human respiratory syncytial virus (hRSV) and human Metapneumovirus (hMPV) are two of the leading etiological agents of acute lower respiratory tract infections, which constitute the main cause of mortality in infants. However, there are currently approved vaccines for neither hRSV nor hMPV. Moreover, despite the s...


    pub_type: 杂志文章,评审


    authors: Andrade CA,Pacheco GA,Gálvez NMS,Soto JA,Bueno SM,Kalergis AM

    更新日期:2020-06-12 00:00:00