Abstract:
:Preclinical infection model systems are extremely valuable tools to aid in our understanding of Human Papillomavirus (HPV) biology, disease progression, prevention, and treatments. In this context, rodent papillomaviruses and their respective infection models are useful tools but remain underutilized resources in the field of papillomavirus biology. Two rodent papillomaviruses, MnPV1, which infects the Mastomys species of multimammate rats, and MmuPV1, which infects laboratory mice, are currently the most studied rodent PVs. Both of these viruses cause malignancy in the skin and can provide attractive infection models to study the lesser understood cutaneous papillomaviruses that have been frequently associated with HPV-related skin cancers. Of these, MmuPV1 is the first reported rodent papillomavirus that can naturally infect the laboratory strain of mice. MmuPV1 is an attractive model virus to study papillomavirus pathogenesis because of the ubiquitous availability of lab mice and the fact that this mouse species is genetically modifiable. In this review, we have summarized the knowledge we have gained about PV biology from the study of rodent papillomaviruses and point out the remaining gaps that can provide new research opportunities.
journal_name
Virusesjournal_title
Virusesauthors
Uberoi A,Lambert PFdoi
10.3390/v9120362subject
Has Abstractpub_date
2017-11-27 00:00:00issue
12issn
1999-4915pii
v9120362journal_volume
9pub_type
杂志文章,评审相关文献
Viruses-Basel文献大全abstract::The Spounavirinae viruses are ubiquitous in nature and have an obligatory virulent lifestyle. They infect Firmicutes, a bacterial phylum containing an array of environmental non-pathogenic and pathogenic organisms. To expand the knowledge of this viral subfamily, new strains were isolated and investigated in this stud...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v9060146
更新日期:2017-06-12 00:00:00
abstract::Virus transmission is essential for spreading viral infections and is a highly coordinated process which occurs by cell-free transmission or cell-cell contact. The transmission of Bovine Foamy Virus (BFV) is highly cell-associated, with undetectable cell-free transmission. However, BFV particle budding can be induced ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7112907
更新日期:2015-11-11 00:00:00
abstract::Bacterial biofilm prevention and eradication are common treatment problems, hence there is a need for advanced and precise experimental methods for its monitoring. Bacterial resistance to antibiotics has resulted in an interest in using a natural bacterial enemy-bacteriophages. In this study, we present the applicatio...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040407
更新日期:2020-04-07 00:00:00
abstract::Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and animal diseases must comply with regulatory requirements as they pertain to environmental risk asses...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9110318
更新日期:2017-10-29 00:00:00
abstract::Timely implementation of antiviral treatment and other public health based responses are dependent on accurate and rapid diagnosis of the novel pandemic influenza A(H1N1) strain. In this study we developed a duplex real-time PCR (RT-PCR) (dFLU-TM) assay for the simultaneous detection of a broad range of influenza A su...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v1031204
更新日期:2009-12-01 00:00:00
abstract::HIV continues to spread among vulnerable heterosexual (HET), Men-having-Sex with Men (MSM) and intravenous drug user (IDU) populations, influenced by a complex array of biological, behavioral and societal factors. Phylogenetics analyses of large sequence datasets from national drug resistance testing programs reveal t...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10010010
更新日期:2017-12-28 00:00:00
abstract::Despite worldwide efforts to understand the transmission dynamics of Zika virus (ZIKV), scanty evaluation has been made on the vector competence of Aedes aegypti fed directly on viremic human and non-human primates (NHPs). We blood-fed Ae. aegypti from two districts in Rio de Janeiro on six ZIKV infected pregnant rhes...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121345
更新日期:2020-11-24 00:00:00
abstract::Marek's disease virus (MDV) is a member of alphaherpesviruses associated with Marek's disease, a highly contagious neoplastic disease in chickens. Complete sequencing of the viral genome and recombineering techniques using infectious bacterial artificial chromosome (BAC) clones of Marek's disease virus genome have ide...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10060279
更新日期:2018-05-24 00:00:00
abstract::We show that focused ion beam/scanning electron microscopy (FIB/SEM) tomography is an excellent method to analyze the three-dimensional structure of a fibroblast nucleus infected with human cytomegalovirus (HCMV). We found that the previously described infoldings of the inner nuclear membrane, which are unique among i...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7112900
更新日期:2015-11-04 00:00:00
abstract::It is increasingly clear that DNA viruses exploit cellular epigenetic processes to control their life cycles during infection. This review will address epigenetic regulation in members of the polyomaviruses, adenoviruses, human papillomaviruses, hepatitis B, and herpes viruses. For each type of virus, what is known ab...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9110346
更新日期:2017-11-17 00:00:00
abstract::We use a Species Distribution Modeling (SDM) approach along with Geographic Information Systems (GIS) techniques to examine the potential distribution of hantavirus pulmonary syndrome (HPS) caused by Andes virus (ANDV) in southern Argentina and, more precisely, define and estimate the area with the highest infection p...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v6010201
更新日期:2014-01-14 00:00:00
abstract::Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hooved animals that poses a constant burden on farmers in endemic regions and threatens the livestock industries in disease-free countries. Despite the increased number of publicly available whole genome sequences, FMDV data are biased by...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10040192
更新日期:2018-04-13 00:00:00
abstract::Tetherin (BST2/CD317/HM1.24) has emerged as a key host-cell ·defence molecule that acts by inhibiting the release and spread of diverse enveloped virions from infected cells. We analysed the biological features of canine tetherin and found it to be an unstable hydrophilic type I transmembrane protein with one transmem...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10100565
更新日期:2018-10-16 00:00:00
abstract::The immune-suppressive effects of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) on T cells have been observed via multiple in vitro and in vivo models. However, the precise mechanism that causes these effects is still undefined. In this study, we investigated whether n-3 PUFAs regulated T cell receptor (TCR) and p...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12060639
更新日期:2020-06-12 00:00:00
abstract::The use of integrase inhibitors (INI) is increasing in antiretroviral therapies (ART) and INI are not all equal regarding genetic barrier to resistance. The aim of this manuscript was to review main in vivo and in vitro knowledge about two particular integrase resistance-associated mutations: R263K and E157Q. The R263...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10010041
更新日期:2018-01-18 00:00:00
abstract::Hantaviruses are an established cause of haemorrhagic fever with renal syndrome (HFRS) in Europe. Following a confirmed case of HFRS in the UK, in an individual residing on a farm in North Yorkshire and the Humber, a tidal estuary on the east coast of Northern England, and the subsequent isolation of a Seoul hantaviru...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v6020524
更新日期:2014-02-05 00:00:00
abstract::Human adenovirus type 4 (HAdV-E4), which is intriguingly limited to military populations, causes acute respiratory disease with demonstrated morbidity and mortality implications. This respiratory pathogen contains genome identity with chimpanzee adenoviruses, indicating zoonotic origins. A signature of these "old" HAd...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020129
更新日期:2019-01-31 00:00:00
abstract::Bats provide important ecosystem services as pollinators, seed dispersers, and/or insect controllers, but they have also been found harboring different viruses with zoonotic potential. Virome studies in bats distributed in Asia, Africa, Europe, and North America have increased dramatically over the past decade, wherea...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040422
更新日期:2020-04-09 00:00:00
abstract::Mechanistic models are critical for our understanding of both within-host dynamics (i.e., pathogen replication and immune system processes) and among-host dynamics (i.e., transmission). Within-host models, however, are not often fit to experimental data, which can serve as a robust method of hypothesis testing and hyp...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11050396
更新日期:2019-04-27 00:00:00
abstract::The Protoparvovirus (PtPV) genus of the Parvoviridae family of viruses includes important animal pathogens and reference molecular models for the entire family. Some virus members of the PtPV genus have arisen as promising tools to treat tumoral processes, as they exhibit marked oncotropism and oncolytic activities wh...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9110313
更新日期:2017-10-26 00:00:00
abstract::Three dsRNAs, in sizes of approximately 2.5⁻5 kbp, were detected in the plant pathogenic fungus Nigrospora oryzae strain CS-7.5-4. Genomic analysis showed that the 5.0 kb dsRNA was a victorivirus named as Nigrospora oryzae victorivirus 2 (NoRV2). The genome of NoRV2 was 5166 bp in length containing two overlapping ope...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010083
更新日期:2019-01-19 00:00:00
abstract::Most cases of hemorrhagic fever with renal syndrome (HFRS) in Europe are caused by the Puumala hantavirus (PUUV). Typical features of the disease are increased vascular permeability, acute kidney injury (AKI), and thrombocytopenia. YKL-40 is an inflammatory glycoprotein involved in various forms of acute and chronic i...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11090767
更新日期:2019-08-21 00:00:00
abstract::Baboons are susceptible to natural Ebola virus (EBOV) infection and share 96% genetic homology with humans. Despite these characteristics, baboons have rarely been utilized as experimental models of human EBOV infection to evaluate the efficacy of prophylactics and therapeutics in the United States. This review will s...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4102400
更新日期:2012-10-23 00:00:00
abstract::The Human immunodeficiency virus-1 (HIV-1) accessory protein Vpu modulates numerous proteins, including the host proteins CD4 and BST-2/tetherin. Vpu interacts with the Skp, Cullin, F-Box (SCF) ubiquitin ligase through interactions with the F-Box protein βTrCP (1 and/or 2). This interaction is dependent on phosphoryla...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10100573
更新日期:2018-10-19 00:00:00
abstract::The begomoviruses (BGVs) are plant pathogens that evolved in the Old World during the Cretaceous and arrived to the New World (NW) in the Cenozoic era. A subgroup of NW BGVs, the "Squash leaf curl virus (SLCV) lineage" (S-Lin), includes viruses with unique characteristics. To get clues on the evolutionary origin of th...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11070644
更新日期:2019-07-13 00:00:00
abstract::Autophagy is an essential vacuolar process of the cell, leading to lysosomal degradation and recycling of proteins and organelles, which is extremely important in maintaining homeostasis. Multiple roles have been now associated with autophagy, in particular a pro-survival role in nutrient starvation or in stressful en...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9120372
更新日期:2017-12-04 00:00:00
abstract::The extension of virology beyond its traditional medical, veterinary, or agricultural applications, now called environmental virology, has shown that viruses are both the most numerous and diverse biological entities on Earth. In particular, virus isolations from unicellular eukaryotic hosts (heterotrophic and photosy...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12101130
更新日期:2020-10-06 00:00:00
abstract::Rabies is a viral infection that targets the nervous system, specifically neurons. The clinical manifestations of the disease are dramatic and their outcome fatal; paradoxically, conventional histopathological descriptions reveal only subtle changes in the affected nervous tissue. Some researchers have considered that...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10030112
更新日期:2018-03-06 00:00:00
abstract::The mosquito antiviral response has mainly been studied in the context of arthropod-borne virus (arbovirus) infection in female mosquitoes. However, in nature, both female and male mosquitoes are frequently infected with insect-specific viruses (ISVs). ISVs are capable of infecting the reproductive organs of both sexe...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040468
更新日期:2020-04-21 00:00:00
abstract::The Pneumoviridae family includes human metapneumovirus (HMPV) and human orthopneumovirus, which is also known as a respiratory syncytial virus (HRSV). These are large enveloped, negative single-strand RNA viruses. HMPV and HRSV are the human members, which commonly infect children. HMPV, which was discovered in 2001,...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12070781
更新日期:2020-07-20 00:00:00