Abstract：
:The Pneumoviridae family includes human metapneumovirus (HMPV) and human orthopneumovirus, which is also known as a respiratory syncytial virus (HRSV). These are large enveloped, negative single-strand RNA viruses. HMPV and HRSV are the human members, which commonly infect children. HMPV, which was discovered in 2001, infects most children until the age of five, which causes an influenza-like illness. The interaction of this virus with immune cells is poorly understood. In this study, we show that HMPV evades natural killer (NK) cell attack by downregulating stress-induced ligands for the activating receptor NKG2D including: Major histocompatibility complex (MHC) class I polypeptide-related sequences A and B (MICA, MICB), UL16 binding proteins ULBP2, and ULBP3, but not ULBP1. Mechanistically, we show that the viral protein G is involved in the downregulation of ULBP2 and that the viral protein M2.2 is required for MICA and MICB downregulation. These findings emphasize the importance of NK cells, in general, and NKG2D, in particular, in controlling HMPV infection, which opens new avenues for treating HMPV.
journal_name
Virusesjournal_title
Virusesauthors
Diab M,Schmiedel D,Seidel E,Bacharach E,Mandelboim Odoi
10.3390/v12070781subject
Has Abstractpub_date
2020-07-20 00:00:00issue
7issn
1999-4915pii
v12070781journal_volume
12pub_type
杂志文章相关文献
Viruses-Basel文献大全abstract：:A wide gap exists between the rapid acceptance of genetically modified (GM) crops for cultivation by farmers in many countries and in the global markets for food and feed, and the often-limited acceptance by consumers. This review contrasts the advances of practical applications of agricultural biotechnology with the ...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v7082819
更新日期：2015-07-30 00:00:00
abstract：:Bovine viral diarrhea virus (BVDV) is an important pathogen belonging to the Pestivirus genus, Flaviviridae family, which comprises viral species that causes an economic impact in animal production. Cattle are the natural host of BVDV and the main source of infection for pigs and other animal species. Due to its antig...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12060600
更新日期：2020-05-31 00:00:00
abstract：:RNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade. Tissue distribution reveals that RNase L is highly expressed in t...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12010073
更新日期：2020-01-07 00:00:00
abstract：:Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A (H1N1) viruses in m...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v8030071
更新日期：2016-03-07 00:00:00
abstract：:Peste des Petits Ruminants (PPR) is a highly infectious disease caused by a virus of the Morbillivirus genus. The current PPR eradication effort relies mainly on the implementation of massive vaccination campaigns. One of the most widely used PPR vaccines is the Nigeria 75/1 strain obtained after attenuation by 75 ser...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11080724
更新日期：2019-08-07 00:00:00
abstract：:The porcine epidemic diarrhea virus (PEDV) poses a great threat to the global swine industries and the unreliable protection induced by the currently available vaccines remains a major challenge. We previously generated a genogroup 2b (G2b) PEDV Taiwan Pintung 52 (PEDVPT) strain, PEDVPT-P96, and determined its promisi...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10100543
更新日期：2018-10-04 00:00:00
abstract：:While bats are increasingly recognized as a source of coronavirus epidemics, the diversity and emergence potential of bat coronaviruses remains to be fully understood. Among 1779 bat samples collected in China, diverse coronaviruses were detected in 32 samples from five different bat species by RT-PCR. Two novel alpha...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11050423
更新日期：2019-05-07 00:00:00
abstract：:To further understanding of the structure and morphology of the Orthohantavirus, family Hantaviridae, we have employed cryo-electron microscopy (cryo-EM) for three New World hantaviruses: Andes (ANDV), Sin Nombre (SNV), and Black Creek Canal (BCCV). Building upon our prior cryo-EM and cryo-tomography study of the Old ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11090862
更新日期：2019-09-16 00:00:00
abstract：:Internal ribosome entry is a key mechanism for viral protein synthesis in a subset of RNA viruses. Cricket paralysis virus (CrPV), a member of Dicistroviridae, has a positive-sense single strand RNA genome that contains two internal ribosome entry sites (IRES), a 5'untranslated region (5'UTR) and intergenic region (IG...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v8010025
更新日期：2016-01-19 00:00:00
abstract：:Viral codon usage bias may be the product of a number of synergistic or antagonistic factors, including genomic nucleotide composition, translational selection, genomic architecture, and mutational or repair biases. Most studies of viral codon bias evaluate only the relative importance of genomic base composition and ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v5010162
更新日期：2013-01-15 00:00:00
abstract：:HIV continues to spread among vulnerable heterosexual (HET), Men-having-Sex with Men (MSM) and intravenous drug user (IDU) populations, influenced by a complex array of biological, behavioral and societal factors. Phylogenetics analyses of large sequence datasets from national drug resistance testing programs reveal t...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v10010010
更新日期：2017-12-28 00:00:00
abstract：:Influenza A virus is a successful parasite and requires host factors to complete its life cycle. Prop5 is an antisense oligonucleotide, targeting programmed cell death protein 5 (PDCD5). In this study, we tested the antiviral activity of prop5 against mouse-adapted A/FM/1/47 strain of influenza A virus in a mouse mode...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v6020573
更新日期：2014-02-06 00:00:00
abstract：:Different lines of evidence support an association between Epstein-Barr virus (EBV) and gastric cancer (GC). The main understood risk factor to develop GC is infection by Helicobacter pylori (H. pylori), which triggers a local inflammatory response critical for progression from gastritis to GC. The role of EBV in earl...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v6010301
更新日期：2014-01-20 00:00:00
abstract：:Enteroviruses, the most common human viral pathogens worldwide, have been associated with serous meningitis, encephalitis, syndrome of acute flaccid paralysis, myocarditis and the onset of diabetes type 1. In the future, the rapid identification of the etiological agent would allow to adjust the therapy promptly and t...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v8010010
更新日期：2016-01-06 00:00:00
abstract：:The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retroviral-induced disease....
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v7122944
更新日期：2015-12-07 00:00:00
abstract：:A metagenomic study was performed on 498 female and 40 male Aedes albopictus mosquitos collected in August and September 2019 in Ticino, a region in southern Switzerland, to address the question regarding the risk of the local transmission of zoonotic viruses. A total of 13 viruses from seven different virus families ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12090929
更新日期：2020-08-24 00:00:00
abstract：:We developed an innovative strategy to induce a cytotoxic T cell (CTL) immune response against protein antigens of choice. It relies on the production of exosomes, i.e., nanovesicles spontaneously released by all cell types. We engineered the upload of huge amounts of protein antigens upon fusion with an anchoring pro...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v7031079
更新日期：2015-03-09 00:00:00
abstract：:RNA interference (RNAi) was shown over 18 years ago to be a mechanism by which arbovirus replication and transmission could be controlled in arthropod vectors. During the intervening period, research on RNAi has defined many of the components and mechanisms of this antiviral pathway in arthropods, yet a number of unex...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v7020820
更新日期：2015-02-17 00:00:00
abstract：:Porcine circovirus 2 (PCV2) is the etiological agent that causes porcine circovirus diseases and porcine circovirus-associated diseases (PCVD/PCVAD), which are present in every major swine-producing country in the world. PCV2 infections may downregulate the host immune system and enhance the infection and replication ...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v11020185
更新日期：2019-02-21 00:00:00
abstract：:A Chikungunya virus (CHIKV) outbreak in Italy in 2007 spread to include the islands of the Caribbean and most of the Americas and still circulates in Europe and Africa. Florida being close in distance to the Caribbean islands experienced a CHIKV outbreak in 2014 and continues to have a few travel-related cases each ye...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12080823
更新日期：2020-07-29 00:00:00
abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has a curative potential for many hematologic malignancies and blood diseases. However, the success of allo-HSCT is limited by graft-versus-host disease (GVHD), an immunological syndrome that involves inflammation and tissue damage mediated by donor lympho...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v8030085
更新日期：2016-03-22 00:00:00
abstract：:Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses with global impact on the health of domestic cats. The two viruses differ in their potential to cause disease. FeLV is more pathogenic, and was long considered to be responsible for more clinical syndromes than any other agent in cat...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v4112684
更新日期：2012-10-31 00:00:00
abstract：:The human respiratory syncytial virus (hRSV) and human Metapneumovirus (hMPV) are two of the leading etiological agents of acute lower respiratory tract infections, which constitute the main cause of mortality in infants. However, there are currently approved vaccines for neither hRSV nor hMPV. Moreover, despite the s...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12060637
更新日期：2020-06-12 00:00:00
abstract：:Equine influenza, caused by the H3N8 subtype, is a highly contagious respiratory disease affecting equid populations worldwide and has led to serious epidemics and transboundary pandemics. This study describes the phylogenetic characterization and replication kinetics of recently-isolated H3N8 virus from a nasal swab ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10010031
更新日期：2018-01-11 00:00:00
abstract：:Autophagy is a potent cell autonomous defense mechanism that engages the lysosomal pathway to fight intracellular pathogens. Several autophagy receptors can recognize invading pathogens in order to target them towards autophagy for their degradation after the fusion of pathogen-containing autophagosomes with lysosomes...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v9050123
更新日期：2017-05-22 00:00:00
abstract：:Tetherin (BST2/CD317/HM1.24) has emerged as a key host-cell ·defence molecule that acts by inhibiting the release and spread of diverse enveloped virions from infected cells. We analysed the biological features of canine tetherin and found it to be an unstable hydrophilic type I transmembrane protein with one transmem...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10100565
更新日期：2018-10-16 00:00:00
abstract：:Because of its ecological characteristics, the Caxiuanã National Forest (FLONA) is a potential area of arbovirus circulation. The present study aimed to investigate the occurrence of arbovirus transmission cycles at FLONA de Caxiuanã. Five field trips were performed to capture mosquitoes and sylvatic vertebrates. For ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11090774
更新日期：2019-08-22 00:00:00
abstract：:During the last 25 years, swine vesicular disease (SVD) has occurred in Italy mostly sub-clinically. Therefore, regular testing of fecal samples from suspected holdings and high turnover premises was fundamental to identifying virus circulation and to achieve SVD eradication. In this study, we evaluated diagnostic per...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12111336
更新日期：2020-11-20 00:00:00
abstract：:We recently developed a test based on the Agilent SureSelect target enrichment system capturing genomic fragments from 191 human papillomaviruses (HPV) types for Illumina sequencing. This enriched whole genome sequencing (eWGS) assay provides an approach to identify all HPV types in a sample. Here we present a machine...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12070710
更新日期：2020-06-30 00:00:00
abstract：:In recent decades, chikungunya virus (CHIKV) has become geographically widespread. In 2004, the CHIKV East/Central/South African (ECSA) genotype moved from Africa to Indian ocean islands and India followed by a large epidemic in Southeast Asia. In 2013, the CHIKV Asian genotype drove an outbreak in the Americas. Since...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12111319
更新日期：2020-11-17 00:00:00
