Abstract:
:The Iridoviridae family are large viruses (∼120-200 nm) that contain a linear double-stranded DNA genome. The genomic size of Iridoviridae family members range from 105,903 bases encoding 97 open reading frames (ORFs) for frog virus 3 to 212,482 bases encoding 211 ORFs for Chilo iridescent virus. The family Iridoviridae is currently subdivided into five genera: Chloriridovirus, Iridovirus, Lymphocystivirus, Megalocytivirus, and Ranavirus. Iridoviruses have been found to infect invertebrates and poikilothermic vertebrates, including amphibians, reptiles, and fish. With such a diverse array of hosts, there is great diversity in gene content between different genera. To understand the origin of iridoviruses, we explored the phylogenetic relationship between individual iridoviruses and defined the core-set of genes shared by all members of the family. In order to further explore the evolutionary relationship between the Iridoviridae family repetitive sequences were identified and compared. Each genome was found to contain a set of unique repetitive sequences that could be used in future virus identification. Repeats common to more than one virus were also identified and changes in copy number between these repeats may provide a simple method to differentiate between very closely related virus strains. The results of this paper will be useful in identifying new iridoviruses and determining their relationship to other members of the family.
journal_name
Virusesjournal_title
Virusesauthors
Eaton HE,Ring BA,Brunetti CRdoi
10.3390/v2071458subject
Has Abstractpub_date
2010-07-01 00:00:00pages
1458-75issue
7issn
1999-4915pii
viruses-02-01458journal_volume
2pub_type
杂志文章相关文献
Viruses-Basel文献大全abstract::Fruit trees, such as apricot trees, are constantly exposed to the attack of viruses. As they are propagated in a vegetative way, this risk is present not only in the field, where they remain for decades, but also during their propagation. Metagenomic diagnostic methods, based on next generation sequencing (NGS), offer...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10060318
更新日期:2018-06-11 00:00:00
abstract::West Nile virus (WNV) is an important emerging neurotropic virus, responsible for increasingly severe encephalitis outbreaks in humans and horses worldwide. However, the mechanism by which the virus gains entry to the brain (neuroinvasion) remains poorly understood. Hypotheses of hematogenous and transneural entry hav...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v6072796
更新日期:2014-07-18 00:00:00
abstract::Laboratories throughout the world that perform work with Risk Group 4 Pathogens generally adopt one of two approaches within BSL-4 environments: either the use of positive pressure air-fed suits or using Class III microbiological safety cabinets and isolators for animal work. Within the UK at present, all laboratories...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v4081202
更新日期:2012-08-01 00:00:00
abstract::Most cases of hemorrhagic fever with renal syndrome (HFRS) in Europe are caused by the Puumala hantavirus (PUUV). Typical features of the disease are increased vascular permeability, acute kidney injury (AKI), and thrombocytopenia. YKL-40 is an inflammatory glycoprotein involved in various forms of acute and chronic i...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11090767
更新日期:2019-08-21 00:00:00
abstract::Influenza A virus (IAV) in swine, so-called swine influenza A virus (swIAV), causes respiratory illness in pigs around the globe. In Danish pig herds, a H1N2 subtype named H1N2dk is one of the main circulating swIAV. In this cohort study, the infection dynamic of swIAV was evaluated in a Danish pig herd by sampling an...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12091013
更新日期:2020-09-10 00:00:00
abstract::Viruses were recognized as the causative agents of fish diseases, such as infectious pancreatic necrosis and Oregon sockeye disease, in the early 1960s [1], and have since been shown to be responsible for diseases in all marine life from bacteria to protists, mollusks, crustaceans, fish and mammals [2].[...]. ...
journal_title:Viruses
pub_type: 社论
doi:10.3390/v9100302
更新日期:2017-10-18 00:00:00
abstract::Samples of two Ageratum conyzoides, one Sonchus oleraceus and one turnip (Brassica rapa var. rapa) exhibiting virus-like symptoms were collected from Pakistan and Nepal. Full-length begomovirus clones were obtained from the four plant samples and betasatellite clones from three of these. The begomovirus sequences were...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7020647
更新日期:2015-02-10 00:00:00
abstract::Chronic hepatitis C virus (HCV) infection is a major cause of liver disease and hepatocellular carcinoma (HCC)-the second leading, and rising, cause of death due to cancer world-wide [...]. ...
journal_title:Viruses
pub_type: 社论
doi:10.3390/v11050441
更新日期:2019-05-15 00:00:00
abstract::Viroids are small non-capsidated non-coding RNA replicons that utilize host factors for efficient propagation and spread through the entire plant. They can incite specific disease symptoms in susceptible plants. To better understand viroid-plant interactions, we employed microarray analysis to observe the changes of g...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10050257
更新日期:2018-05-15 00:00:00
abstract::Ringspot symptoms in European mountain ash (Sorbus aucuparia L.), fig mosaic, rose rosette, raspberry leaf blotch, pigeonpea sterility mosaic (Cajanus cajan) and High Plains disease of maize and wheat were found to be associated with viruses that share several characteristics. They all have single-stranded multipartit...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4091515
更新日期:2012-09-01 00:00:00
abstract::West Nile virus (WNV) is a member of the genus Flavivirus in the family Flaviviridae. Flaviviruses replicate in the cytoplasm of infected cells and modify the host cell environment. Although much has been learned about virion structure and virion-endosomal membrane fusion, the cell receptor(s) used have not been defin...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v6010013
更新日期:2013-12-27 00:00:00
abstract::The potent HIV-1 inhibitor TRIM5α blocks HIV-1 infection by accelerating the uncoating of HIV-1. TRIM5α is known to form higher-order self-association complexes that contribute to the avidity of TRIM5α for the HIV-1 capsid, and are essential to inhibit infection; these higher-order self-association complexes are depen...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v3050423
更新日期:2011-05-01 00:00:00
abstract::Poxviruses are important pathogens of man and numerous domestic and wild animal species. Cross species (including zoonotic) poxvirus infections can have drastic consequences for the recipient host. Bats are a diverse order of mammals known to carry lethal viral zoonoses such as Rabies, Hendra, Nipah, and SARS. Consequ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v6041564
更新日期:2014-04-03 00:00:00
abstract::The objective of this study was to evaluate the effects of A3R phage and Staphylococcus aureus lysate obtained after phage infection on neutrophil degranulation. The exocytosis of primary and secondary granules from neutrophils was investigated in vitro in whole blood specimens by flow cytometry based on the expressio...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v9020036
更新日期:2017-02-21 00:00:00
abstract::Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness. The 60-year-old man died as a result of renal and respiratory failure after admission to a hospital in Jeddah, Saudi A...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10020093
更新日期:2018-02-24 00:00:00
abstract::Autophagy is an essential vacuolar process of the cell, leading to lysosomal degradation and recycling of proteins and organelles, which is extremely important in maintaining homeostasis. Multiple roles have been now associated with autophagy, in particular a pro-survival role in nutrient starvation or in stressful en...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9120372
更新日期:2017-12-04 00:00:00
abstract::The smaller tea tortrix, Adoxophyes honmai (Lepidoptera: Tortricidae), is an economically important pest of tea in Japan. Previous work showed that a fast-killing nucleopolyhedrovirus (NPV) isolated from A. orana (AdorNPV) and a slow-killing NPV isolated from A. honmai (AdhoNPV) are both infectious to A. honmai larvae...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7031271
更新日期:2015-03-18 00:00:00
abstract::Many blood-feeding arthropods are known vectors of viruses that are a source of unprecedented global health concern. Mosquitoes are an integral part of these arthropod vectors. Advancements in next-generation sequencing and bioinformatics has expanded our knowledge on the richness of viruses harbored by arthropods. In...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10010030
更新日期:2018-01-12 00:00:00
abstract::Under physiological conditions, the function of astrocytes in providing brain metabolic support is compromised under pathophysiological conditions caused by human immunodeficiency virus (HIV) and opioids. Herein, we examined the role of autophagy, a lysosomal degradation pathway important for cellular homeostasis and ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v9080201
更新日期:2017-07-28 00:00:00
abstract::Andrias davidianus ranavirus (ADRV) is an emerging viral pathogen that causes severe systemic hemorrhagic disease in Chinese giant salamanders. There is an urgent need for developing an effective vaccine against this fatal disease. In this study, DNA vaccines containing the ADRV 2L gene (pcDNA-2L) and the 58L gene (pc...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10020052
更新日期:2018-01-24 00:00:00
abstract::Zika virus (ZIKV) is an emerging mosquito-borne pathogen associated with microcephaly and other congenital abnormalities in newborns as well as neurologic complications in adults. The explosive transmission of the virus in the last ten years put it in the limelight and improved our understanding of its biology and pat...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12090926
更新日期:2020-08-23 00:00:00
abstract::A highly virulent porcine epidemic diarrhea virus (PEDV) appeared in China and spread rapidly to neighbor countries, which have led to great economic losses to the pig industry. In the present study, we isolated a PEDV using Vero cells and serially propagated 100 passages. PEDV SDSX16 was characterized in vitro and in...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040391
更新日期:2020-04-01 00:00:00
abstract::Decay accelerating factor (DAF/CD55) is targeted by many pathogens for cell entry. It has been implicated as a co-receptor for hantaviruses. To examine the binding of hantaviruses to DAF, we describe the use of Protein G beads for binding human IgG Fc domain-functionalized DAF ((DAF)₂-Fc). When mixed with Protein G be...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v6031091
更新日期:2014-03-10 00:00:00
abstract::The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This review focuses on differ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v1020276
更新日期:2009-09-01 00:00:00
abstract::Dengue virus (DENV) infection is one of the most widespread mosquito-borne viral infections. Liver injury is commonly observed in severe DENV infection, and the present study aimed to examine the efficacy of crocetin treatment in an immunocompetent mouse model of DENV infection exhibiting liver injury. The efficacy of...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12080825
更新日期:2020-07-30 00:00:00
abstract::The APOBEC3 family of proteins in mammals consists of cellular cytosine deaminases and well-known restriction factors against retroviruses, including lentiviruses. APOBEC3 genes are highly amplified and diversified in mammals, suggesting that their evolution and diversification have been driven by conflicts with ancie...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v13010124
更新日期:2021-01-17 00:00:00
abstract::Various methods exist to detect an astrovirus infection. Current methods include electron microscopy (EM), cell culture, immunoassays, polymerase chain reaction (PCR) and various other molecular approaches that can be applied in the context of diagnostic or in surveillance studies. With the advent of metagenomics, nov...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9010010
更新日期:2017-01-12 00:00:00
abstract::The porcine epidemic diarrhea virus (PEDV) poses a great threat to the global swine industries and the unreliable protection induced by the currently available vaccines remains a major challenge. We previously generated a genogroup 2b (G2b) PEDV Taiwan Pintung 52 (PEDVPT) strain, PEDVPT-P96, and determined its promisi...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10100543
更新日期:2018-10-04 00:00:00
abstract::P4 is a mobile genetic element (MGE) that can exist as a plasmid or integrated into its Escherichia coli host genome, but becomes packaged into phage particles by a helper bacteriophage, such as P2. P4 is the original example of what we have termed "molecular piracy", the process by which one MGE usurps the life cycle...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12090953
更新日期:2020-08-27 00:00:00
abstract::The HIV/AIDS epidemic remains a global health problem, especially in Sub-Saharan Africa. An effective HIV-1 vaccine is therefore badly required to mitigate this ever-expanding problem. Since HIV-1 infects its host through the mucosal surface, a vaccine for the virus needs to trigger mucosal as well as systemic immune ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v5092062
更新日期:2013-08-28 00:00:00