Addressing the Challenges of Hepatitis C Cure and Persistent Risk of Hepatocellular Carcinoma.

abstract：:Purinergic receptors are inflammatory mediators activated by extracellular nucleotides released by dying or injured cells. Several studies have described an important role for these receptors in HIV-1 entry, particularly regarding their activity on HIV-1 viral membrane fusion. Several reports identify purinergic recep...

journal_title：Viruses

authors： Freeman TL,Swartz TH

更新日期：2020-03-07 00:00:00

abstract：:Viral encephalitis causes acute inflammation of the brain parenchyma and is a significant cause of human morbidity and mortality. Although Herpes Simplex encephalitis is the most frequent known cause of fatal sporadic encephalitis in humans, an increasingly wide range of viruses and other microbial pathogens are impli...

journal_title：Viruses

authors： Kennedy PGE,Quan PL,Lipkin WI

更新日期：2017-06-06 00:00:00

abstract：:We describe herein, limitations on research at biosafety level 4 (BSL-4) containment laboratories, with regard to biosecurity regulations, safety considerations, research space limitations, and physical constraints in executing experimental procedures. These limitations can severely impact the number of collaborations...

journal_title：Viruses

authors： Shurtleff AC,Garza N,Lackemeyer M,Carrion R Jr,Griffiths A,Patterson J,Edwin SS,Bavari S

更新日期：2012-12-01 00:00:00

abstract：:Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a dearth of published evidence supporting the higher virulence of MAR...

journal_title：Viruses

authors： Blair PW,Keshtkar-Jahromi M,Psoter KJ,Reisler RB,Warren TK,Johnston SC,Goff AJ,Downey LG,Bavari S,Cardile AP

更新日期：2018-11-21 00:00:00

abstract：:: African swine fever is a devastating hemorrhagic infectious disease, which affects domestic and wild swines (Susscrofa) of all breeds and ages, with a high lethality of up to 90-100% in naïve animals. The causative agent, African swine fever virus (ASFV), is a large and complex double-stranded DNA arbovirus which is...

journal_title：Viruses

authors： Montaner-Tarbes S,Pujol M,Jabbar T,Hawes P,Chapman D,Portillo HD,Fraile L,Sánchez-Cordón PJ,Dixon L,Montoya M

更新日期：2019-09-20 00:00:00

abstract：:SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated viral infection are important for studying immunity. Because SARS-CoV-2 is a biosafety-level-3 virus, one way to simplify such assays is ...

journal_title：Viruses

authors： Crawford KHD,Eguia R,Dingens AS,Loes AN,Malone KD,Wolf CR,Chu HY,Tortorici MA,Veesler D,Murphy M,Pettie D,King NP,Balazs AB,Bloom JD

更新日期：2020-05-06 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hooved animals that poses a constant burden on farmers in endemic regions and threatens the livestock industries in disease-free countries. Despite the increased number of publicly available whole genome sequences, FMDV data are biased by...

journal_title：Viruses

authors： Lasecka-Dykes L,Wright CF,Di Nardo A,Logan G,Mioulet V,Jackson T,Tuthill TJ,Knowles NJ,King DP

更新日期：2018-04-13 00:00:00

abstract：:Old world hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) upon zoonotic transmission to humans. In Europe, the Puumala virus (PUUV) is the main causative agent of HFRS. Tula virus (TULV) is also widely distributed in Europe, but there is little knowledge about the pathogenicity of TULV for humans, as r...

journal_title：Viruses

authors： Bourquain D,Bodenstein C,Schürer S,Schaade L

更新日期：2019-09-14 00:00:00

abstract：:The use of the rabies vaccine for post-exposure prophylaxis started as early as 1885, revealing a safe and efficient tool to prevent human rabies cases. Preventive vaccination is the basis for the control of canine-mediated rabies, which has already been eliminated from extensive parts of the world, including Europe. ...

journal_title：Viruses

authors： Echevarría JE,Banyard AC,McElhinney LM,Fooks AR

更新日期：2019-09-24 00:00:00

abstract：:Bats are an important source of viral zoonoses, including paramyxoviruses. The paramyxoviral Pararubulavirus genus contains viruses mostly derived from bats that are common, diverse, distributed throughout the Old World, and known to be zoonotic. Here, we describe a new member of the genus Achimota pararubulavirus 3 (...

journal_title：Viruses

authors： Baker KS,Tachedjian M,Barr J,Marsh GA,Todd S,Crameri G,Crameri S,Smith I,Holmes CEG,Suu-Ire R,Fernandez-Loras A,Cunningham AA,Wood JLN,Wang LF

更新日期：2020-10-30 00:00:00

abstract：:The development of effective yet nontoxic strategies to target the latent human immunodeficiency virus-1 (HIV-1) reservoir in antiretroviral therapy (ART)-suppressed individuals poses a critical barrier to a functional cure. The 'kick and kill' approach to HIV eradication entails proviral reactivation during ART, coup...

journal_title：Viruses

authors： Kristoff J,Rinaldo CR,Mailliard RB

更新日期：2019-12-28 00:00:00

abstract：:We review the molecular and epidemiological characteristics of cetacean morbillivirus (CeMV) and the diagnosis and pathogenesis of associated disease, with six different strains detected in cetaceans worldwide. CeMV has caused epidemics with high mortality in odontocetes in Europe, the USA and Australia. It represents...

journal_title：Viruses

authors： Van Bressem MF,Duignan PJ,Banyard A,Barbieri M,Colegrove KM,De Guise S,Di Guardo G,Dobson A,Domingo M,Fauquier D,Fernandez A,Goldstein T,Grenfell B,Groch KR,Gulland F,Jensen BA,Jepson PD,Hall A,Kuiken T,Mazzariol S

更新日期：2014-12-22 00:00:00

abstract：:Human parechovirus (HPeV), particularly type 3 (HPeV3), is an important cause of sepsis-/meningitis-like illness in young infants. Laboratory records identified a total of ten HPeV-positive cases in Southeastern Australia between January and July 2019. The HPeV present in these cases were typed by Sanger sequencing of...

journal_title：Viruses

authors： Chamings A,Liew KC,Reid E,Athan E,Raditsis A,Vuillermin P,Yoga Y,Caly L,Druce J,Alexandersen S

更新日期：2019-10-03 00:00:00

abstract：:At the end of my doctoral studies, in 1988, I published a review article on the major steps of transcription and translation during the mammalian reovirus multiplication cycle, a topic that still fascinates me 30 years later. It is in the nature of scientific research to generate further questioning as new knowledge e...

journal_title：Viruses

authors： Lemay G

更新日期：2018-11-27 00:00:00

abstract：:Laboratories throughout the world that perform work with Risk Group 4 Pathogens generally adopt one of two approaches within BSL-4 environments: either the use of positive pressure air-fed suits or using Class III microbiological safety cabinets and isolators for animal work. Within the UK at present, all laboratories...

journal_title：Viruses

authors： Steward JA,Lever MS

更新日期：2012-08-01 00:00:00

abstract：:Autophagy is a potent cell autonomous defense mechanism that engages the lysosomal pathway to fight intracellular pathogens. Several autophagy receptors can recognize invading pathogens in order to target them towards autophagy for their degradation after the fusion of pathogen-containing autophagosomes with lysosomes...

journal_title：Viruses

authors： Petkova DS,Verlhac P,Rozières A,Baguet J,Claviere M,Kretz-Remy C,Mahieux R,Viret C,Faure M

更新日期：2017-05-22 00:00:00

abstract：:Peptides derived from the C-terminal heptad repeat (CHR) region of HIV-1 gp41 is potent viral membrane fusion inhibitors, such as the first clinically approved peptide drug T20 and a group of newly-designed peptides. The resistance profiles of various HIV-1 fusion inhibitors were previously characterized, and the seco...

journal_title：Viruses

authors： Yu D,Su Y,Ding X,Zhu Y,Qin B,Chong H,Cui S,He Y

更新日期：2020-03-18 00:00:00

abstract：:Environmental and agricultural pollination services by honey bees, Apis mellifera, and honey production are compromised by high levels of annual colony losses globally. The majority are associated with disease caused by deformed wing virus (DWV), a positive-strand RNA virus, exacerbated by the ectoparasitic mite Varro...

journal_title：Viruses

authors： Gusachenko ON,Woodford L,Balbirnie-Cumming K,Campbell EM,Christie CR,Bowman AS,Evans DJ

更新日期：2020-05-12 00:00:00

abstract：:An efficacious HIV vaccine is urgently needed to curb the AIDS pandemic. The modest protection elicited in the phase III clinical vaccine trial in Thailand provided hope that this goal might be achieved. However, new approaches are necessary for further advances. As HIV is transmitted primarily across mucosal surfaces...

journal_title：Viruses

authors： Tuero I,Robert-Guroff M

更新日期：2014-08-15 00:00:00

abstract：:It is difficult to observe the molecular choreography between viruses and host cell components, as they exist on a spatial scale beyond the reach of conventional microscopy. However, novel super-resolution microscopy techniques have cast aside technical limitations to reveal a nanoscale view of virus replication and c...

journal_title：Viruses

authors： Grove J

更新日期：2014-03-19 00:00:00

abstract：:Until vaccines and effective therapeutics become available, the practical solution to transit safely out of the current coronavirus disease 19 (CoVID-19) lockdown may include the implementation of an effective testing, tracing and tracking system. However, this requires a reliable and clinically validated diagnostic p...

journal_title：Viruses

authors： Rohaim MA,Clayton E,Sahin I,Vilela J,Khalifa ME,Al-Natour MQ,Bayoumi M,Poirier AC,Branavan M,Tharmakulasingam M,Chaudhry NS,Sodi R,Brown A,Burkhart P,Hacking W,Botham J,Boyce J,Wilkinson H,Williams C,Whittingham-Dow

更新日期：2020-09-01 00:00:00

abstract：:Our loyal friend and colleague, Jan van der Noordaa, passed away unexpectedly at the age of 80 on the evening of 17 June 2015. [...]. ...

journal_title：Viruses

authors： Berkhout B,Bukrinsky M

更新日期：2015-09-15 00:00:00

abstract：:Persistent infection by human papillomaviruses (HPVs), small, double-stranded DNA viruses that infect keratinocytes of the squamous epithelia, can lead to the development of cervical and other cancers. The viral oncoprotein E7 contributes to viral persistence in part by regulating host gene expression through binding ...

journal_title：Viruses

authors： Rice S,Kim SM,Rodriguez C,Songock W,Raikhy G,Lopez R,Henderson L,Yusufji A,Bodily J

更新日期：2020-03-13 00:00:00

abstract：:Respiratory viruses cause disease in humans characterized by an abrupt onset of symptoms. Studies in humans and animal models have shown that symptoms are not immediate and appear days or even weeks after infection. Since the initial symptoms are a manifestation of virus recognition by elements of the innate immune re...

journal_title：Viruses

authors： Hermesh T,Moltedo B,López CB,Moran TM

更新日期：2010-11-01 00:00:00

abstract：:Diagnostic electron microscopy for infectious diseases has the advantage that "everything" in the specimen can be observed, without a priori knowledge of the likely identity of the microorganisms present in the sample. The classical specimen preparation method used employs a droplet of sample, which allows particles t...

journal_title：Viruses

authors： Beniac DR,Siemens CG,Wright CJ,Booth TF

更新日期：2014-09-19 00:00:00

abstract：:Shigella ssp. and enterotoxigenic Escherichiacoli are the most common etiological agents of diarrheal diseases in malnourished children under five years of age in developing countries. The ever-growing issue of antibiotic resistance and the potential negative impact of antibiotic use on infant commensal microbiota are...

journal_title：Viruses

authors： Kaczorowska J,Casey E,Neve H,Franz CMAP,Noben JP,Lugli GA,Ventura M,Sinderen DV,Mahony J

更新日期：2019-09-26 00:00:00

abstract：:Hematopoietic stem cell transplantation from anti-cytomegalovirus immunoglobulin G (anti-CMV-IgG) positive donors facilitated immunological recovery post-transplant, which may indicate that chronic CMV infection has an effect on the immune system. This can be seen in the recipients after reconstitution with donor lymp...

journal_title：Viruses

authors： Jaskula E,Dlubek D,Tarnowska A,Lange J,Mordak-Domagala M,Suchnicki K,Sedzimirska M,Borowik A,Mizia S,Lange A

更新日期：2015-03-23 00:00:00

abstract：:Around 257 million people are living with hepatitis B virus (HBV) chronic infection and 71 million with hepatitis C virus (HCV) chronic infection. Both HBV and HCV infections can lead to liver complications such as cirrhosis and hepatocellular carcinoma (HCC). To take care of these chronically infected patients, one s...

journal_title：Viruses

authors： Loureiro D,Tout I,Narguet S,Benazzouz SM,Mansouri A,Asselah T

更新日期：2020-12-14 00:00:00

abstract：:Due to the emergence of non-endemic mosquito vectors and the recent outbreaks of mosquito-borne diseases, mosquito-borne pathogens are considered an increasing risk to public and animal health in Europe. To obtain a status quo regarding mosquito-borne viruses and their vectors in Germany, 97,648 mosquitoes collected f...

journal_title：Viruses

authors： Scheuch DE,Schäfer M,Eiden M,Heym EC,Ziegler U,Walther D,Schmidt-Chanasit J,Keller M,Groschup MH,Kampen H

更新日期：2018-07-23 00:00:00

abstract：:The smaller tea tortrix, Adoxophyes honmai (Lepidoptera: Tortricidae), is an economically important pest of tea in Japan. Previous work showed that a fast-killing nucleopolyhedrovirus (NPV) isolated from A. orana (AdorNPV) and a slow-killing NPV isolated from A. honmai (AdhoNPV) are both infectious to A. honmai larvae...

journal_title：Viruses

authors： Takahashi M,Nakai M,Saito Y,Sato Y,Ishijima C,Kunimi Y

更新日期：2015-03-18 00:00:00