Abstract：
:Viral encephalitis causes acute inflammation of the brain parenchyma and is a significant cause of human morbidity and mortality. Although Herpes Simplex encephalitis is the most frequent known cause of fatal sporadic encephalitis in humans, an increasingly wide range of viruses and other microbial pathogens are implicated. Up to 60% of cases of presumed viral encephalitis remain unexplained due to the failure of conventional laboratory techniques to detect an infectious agent. High-throughput DNA sequencing technologies have the potential to detect any microbial nucleic acid present in a biological specimen without any prior knowledge of the target sequence. While there remain challenges intrinsic to these technologies, they have great promise in virus discovery in unexplained encephalitis.
journal_name
Virusesjournal_title
Virusesauthors
Kennedy PGE,Quan PL,Lipkin WIdoi
10.3390/v9060138subject
Has Abstractpub_date
2017-06-06 00:00:00issue
6issn
1999-4915pii
v9060138journal_volume
9pub_type
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