Abstract:
:Several viral factors impact the natural course of hepatitis B virus (HBV) infection, the sensitivity of diagnostic tests, or treatment response to interferon-α and nucleos(t)ide analogues. These factors include the viral genotype and serotype but also mutations affecting the HBV surface antigen, basal core promoter/pre-core region, or reverse transcriptase. However, a comprehensive overview of the distribution of HBV variants between HBV genotypes or different geographical locations is lacking. To address this, we performed an in silico analysis of publicly available HBV full-length genome sequences. We found that not only the serotype frequency but also the majority of clinically relevant mutations are primarily associated with specific genotypes. Distinct mutations enriched in certain world regions are not explained by the local genotype distribution. Two HBV variants previously identified to confer resistance to the nucleotide analogue tenofovir in vitro were not identified, questioning their translational relevance. In summary, our work elucidates the differences in the clinical manifestation of HBV infection observed between genotypes and geographical locations and furthermore helps identify suitable diagnostic tests and therapies.
journal_name
Virusesjournal_title
Virusesauthors
Velkov S,Protzer U,Michler Tdoi
10.3390/v12111344subject
Has Abstractpub_date
2020-11-23 00:00:00issue
11issn
1999-4915pii
v12111344journal_volume
12pub_type
杂志文章相关文献
Viruses-Basel文献大全abstract::Beyond acute infections, group B coxsackieviruses (CVB) are also reported to play a role in the development of chronic diseases, like type 1 diabetes. The viral pathogenesis mainly relies on the interplay between the viruses and innate immune response in genetically-susceptible individuals. We investigated the interac...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7112924
更新日期:2015-11-24 00:00:00
abstract::Sequence-independent amplification techniques have become important tools for virus discovery, metagenomics, and exploration of viral diversity at the global scale, especially in remote areas. Here, we describe the detection and genetic characterization of a novel gyrovirus, named GyV11, present in cloacal, oral, and ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11121148
更新日期:2019-12-11 00:00:00
abstract::Several notable human diseases are caused by enveloped RNA viruses: influenza, AIDS, hepatitis C, dengue hemorrhagic fever, microcephaly, and Guillain-Barré Syndrome. Being enveloped, the life cycle of this group of viruses is critically dependent on host lipid biosynthesis. Viral binding and entry involve interaction...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11100912
更新日期:2019-10-01 00:00:00
abstract::Environmental and agricultural pollination services by honey bees, Apis mellifera, and honey production are compromised by high levels of annual colony losses globally. The majority are associated with disease caused by deformed wing virus (DWV), a positive-strand RNA virus, exacerbated by the ectoparasitic mite Varro...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12050532
更新日期:2020-05-12 00:00:00
abstract::The Iridoviridae family are large viruses (∼120-200 nm) that contain a linear double-stranded DNA genome. The genomic size of Iridoviridae family members range from 105,903 bases encoding 97 open reading frames (ORFs) for frog virus 3 to 212,482 bases encoding 211 ORFs for Chilo iridescent virus. The family Iridovirid...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v2071458
更新日期:2010-07-01 00:00:00
abstract::Micro RNAs (miRNAs) are a class of small non-coding single-stranded RNA, which play an important role in modulating host-Influenza A virus (IAV) crosstalk. The interplay between influenza and miRNA interaction is defined by a plethora of complex mechanisms, which are not fully understood yet. Here, we demonstrate that...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040444
更新日期:2020-04-15 00:00:00
abstract::Herpes simplex virus 1 (HSV-1) can infect a wide range of cell types, including cells of the adaptive and innate immunity but, normally, it completes a fully-permissive replication cycle only in epithelial or neural cells. Complex mechanisms controlling this delicate balance in immune cells and consequent restriction ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11050428
更新日期:2019-05-10 00:00:00
abstract::Antigen-specific T lymphocytes play a critical role in controlling viral infections. However, we report here that preexisting virus-specific T cell responses also contribute to promoting adenovirus (Ad) infection. Previously, we found that CD14+ monocytes from Ad-seropositive individuals exhibited an increased suscept...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020154
更新日期:2019-02-13 00:00:00
abstract::The hepatitis B virus (HBV) represents a worldwide public health problem; the virus is present in one third of the global population. However, this rate may in fact be higher due to occult hepatitis B virus infection (OBI). This condition is characterized by the presence of the viral genome in the liver of individuals...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v6041590
更新日期:2014-04-08 00:00:00
abstract::As countries with endemic canine rabies progress towards elimination by 2030, it will become necessary to employ techniques to help plan, monitor, and confirm canine rabies elimination. Sequencing can provide critical information to inform control and vaccination strategies by identifying genetically distinct virus va...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111255
更新日期:2020-11-04 00:00:00
abstract::Extensive surveillance in bat populations in response to recent emerging diseases has revealed that this group of mammals acts as a reservoir for a large range of viruses. However, the oldest known association between a zoonotic virus and a bat is that between rabies virus and the vampire bat. Vampire bats are only fo...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v6051911
更新日期:2014-04-29 00:00:00
abstract::Old world hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) upon zoonotic transmission to humans. In Europe, the Puumala virus (PUUV) is the main causative agent of HFRS. Tula virus (TULV) is also widely distributed in Europe, but there is little knowledge about the pathogenicity of TULV for humans, as r...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11090855
更新日期:2019-09-14 00:00:00
abstract::To further understanding of the structure and morphology of the Orthohantavirus, family Hantaviridae, we have employed cryo-electron microscopy (cryo-EM) for three New World hantaviruses: Andes (ANDV), Sin Nombre (SNV), and Black Creek Canal (BCCV). Building upon our prior cryo-EM and cryo-tomography study of the Old ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11090862
更新日期:2019-09-16 00:00:00
abstract::Unlike other human herpesviruses, human herpesvirus 6A and 6B (HHV-6A/B) infection can lead to integration of the viral genome in human chromosomes. When integration occurs in germinal cells, the integrated HHV-6A/B genome can be transmitted to 50% of descendants. Such individuals, carrying one copy of the HHV-6A/B ge...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9070160
更新日期:2017-06-26 00:00:00
abstract::Cyclophilins are peptidyl-prolyl cis/trans isomerases important in the proper folding of certain proteins. Mounting evidence supports varied roles of cyclophilins, either positive or negative, in the life cycles of diverse viruses, but the nature and mechanisms of these roles are yet to be defined. The potential for c...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v5071684
更新日期:2013-07-11 00:00:00
abstract::The hypothesis is presented that bacteriophage DNA packaging motors have a cycle comprised of bind/release thermal ratcheting with release-associated DNA pushing via ATP-dependent protein folding. The proposed protein folding occurs in crystallographically observed peptide segments that project into an axial channel o...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v2091821
更新日期:2010-09-01 00:00:00
abstract::Countries rely on good diagnostic tests and appropriate testing schemes to fight against economically important small ruminant lentivirus (SRLV) infections. We undertook an extensive comparative analysis of seven commercially available serological tests and one in-house real-time PCR (qPCR) detecting genotype A and B ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10120696
更新日期:2018-12-08 00:00:00
abstract::Since the development of methods for inserting and expressing genes in baculoviruses, a line of research has focused on developing recombinant baculoviruses that express insecticidal peptides and proteins. These recombinant viruses have been engineered with the goal of improving their pesticidal potential by shortenin...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v7010422
更新日期:2015-01-21 00:00:00
abstract::Viruses protect their genomes by enclosing them into protein capsids that sometimes contain lipid bilayers that either reside above or below the protein layer. Controlled dissociation of virions provides important information on virion composition, interactions, and stoichiometry of virion components, as well as their...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10110579
更新日期:2018-10-23 00:00:00
abstract:UNLABELLED:Cytomegalovirus (CMV) is a prevalent pathogen in the immunocompromised host and invasive pneumonia is a feared complication of the virus in this population. In this pediatric case series we characterized CMV lung infection in 15 non-HIV infected children (median age 3 years; IQR 0.2-4.9 years), using current...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v6052038
更新日期:2014-05-07 00:00:00
abstract::A metagenomic study was performed on 498 female and 40 male Aedes albopictus mosquitos collected in August and September 2019 in Ticino, a region in southern Switzerland, to address the question regarding the risk of the local transmission of zoonotic viruses. A total of 13 viruses from seven different virus families ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12090929
更新日期:2020-08-24 00:00:00
abstract::Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV), an infectious coronavirus first reported in 2012, has a mortality rate greater than 35%. Therapeutic antibodies are key tools for preventing and treating MERS-CoV infection, but to date no such agents have been approved for treatment of this virus. Nanobo...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020166
更新日期:2019-02-19 00:00:00
abstract::Virus diseases greatly affect oilseed rape (Brassica napus) production. Investigating antiviral genes may lead to the development of disease-resistant varieties of oilseed rape. In this study, we examined the effects of the suppressor of gene silencing 3 in Brassica napus (BnSGS3, a putative antiviral gene) with diffe...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7082815
更新日期:2015-07-27 00:00:00
abstract::During flavivirus infection, some viral proteins move to the nucleus and cellular components are relocated from the nucleus to the cytoplasm. Thus, the integrity of the main regulator of the nuclear-cytoplasmic transport, the nuclear pore complex (NPC), was evaluated during infection with dengue virus (DENV) and Zika ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12060583
更新日期:2020-05-26 00:00:00
abstract::Tospovirus is a tripartite negative stranded RNA virus and is considered as one of the most devastating plant viruses. Successful virus infection in plant requires many host factors. To date, very few host factors have been identified as important in Tospovirus infection in plants. We reported earlier that NSm protein...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10110647
更新日期:2018-11-17 00:00:00
abstract::The Filoviridae family of viruses, which includes the genera Ebolavirus (EBOV) and Marburgvirus (MARV), causes severe and often times lethal hemorrhagic fever in humans. Filoviral infections are associated with ineffective innate antiviral responses as a result of virally encoded immune antagonists, which render the h...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v3091634
更新日期:2011-09-01 00:00:00
abstract::Rapid and sensitive detection of prions is important in managing prion diseases. The real-time quaking-induced conversion (RT-QuIC) assay for prion seeding activity has been applied to many prion diseases and provides for specific antemortem diagnostic testing. We evaluated RT-QuIC's long-term consistency and varied m...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8050140
更新日期:2016-05-23 00:00:00
abstract::We studied whether cytosine phosphate-guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs). As a model, we used well-characterized CpG-recoded Zika virus vaccine candidates that p...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12050579
更新日期:2020-05-25 00:00:00
abstract::Potato virus Y (PVY) is the most economically important virus infecting cultivated potato (Solanum tuberosum L.). Accurate diagnosis is crucial to regulate the trade of tubers and for the sanitary selection of plant material for propagation. However, high genetic diversity of PVY represents a challenge for the detecti...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040478
更新日期:2020-04-23 00:00:00
abstract::Zika virus (ZIKV) is a vertically and sexually transmissible virus resulting in severe congenital malformation. The goal of this study was to develop an ovine model of ZIKV infection. Between 28-35 days gestation (DG), four pregnant animals were infected with two doses of 6 × 106 PFU of ZIKV; four control animals rece...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11090795
更新日期:2019-08-29 00:00:00