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Current Peptide and Protein Candidates Challenging HIV Therapy beyond the Vaccine Era.

Abstract：

:Human immunodeficiency virus (HIV) is a causative agent of acquired immune deficiency syndrome (AIDS). Highly active antiretroviral therapy (HAART) can slow down the replication of HIV-1, leading to an improvement in the survival of HIV-1-infected patients. However, drug toxicities and poor drug administration has led to the emergence of a drug-resistant strain. HIV-1 immunotherapy has been continuously developed, but antibody therapy and HIV vaccines take time to improve its efficiency and have limitations. HIV-1-specific chimeric antigen receptor (CAR)-based immunotherapy founded on neutralizing antibodies is now being developed. In HIV-1 therapy, anti-HIV chimeric antigen receptors showed promising data in the suppression of HIV-1 replication; however, autologous transfusion is still a problem. This has led to the development of effective peptides and proteins for an alternative HIV-1 treatment. In this paper, we provide a comprehensive review of potent anti-HIV-1 peptides and proteins that reveal promising therapeutic activities. The inhibitory mechanisms of each therapeutic molecule in the different stages of the HIV-1 life cycle will be discussed herein.

journal_name

Viruses

journal_title

Viruses

authors

Chupradit K,Moonmuang S,Nangola S,Kitidee K,Yasamut U,Mougel M,Tayapiwatana C

doi

10.3390/v9100281

subject

Has Abstract

pub_date

2017-09-29 00:00:00

issue

10

issn

1999-4915

pii

v9100281

journal_volume

9

pub_type

杂志文章,评审

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