Abstract:
:There is an epidemic of obesity starting about 1980 in both developed and undeveloped countries definitely associated with multiple etiologies. About 670 million people worldwide are obese. The incidence of obesity has increased in all age groups, including children. Obesity causes numerous diseases and the interaction between genetic, metabolic, social, cultural and environmental factors are possible cofactors for the development of obesity. Evidence emerging over the last 20 years supports the hypothesis that viral infections may be associated with obesity in animals and humans. The most widely studied infectious agent possibly linked to obesity is adenovirus 36 (Adv36). Adv36 causes obesity in animals. In humans, Adv36 associates with obesity both in adults and children and the prevalence of Adv36 increases in relation to the body mass index. In vivo and in vitro studies have shown that the viral E4orf1 protein (early region 4 open reading frame 1, Adv) mediates the Adv36 effect including its adipogenic potential. The Adv36 infection should therefore be considered as a possible risk factor for obesity and could be a potential new therapeutic target in addition to an original way to understand the worldwide rise of the epidemic of obesity. Here, the data indicating a possible link between viral infection and obesity with a particular emphasis to the Adv36 will be reviewed.
journal_name
Virusesjournal_title
Virusesauthors
Ponterio E,Gnessi Ldoi
10.3390/v7072787subject
Has Abstractpub_date
2015-07-08 00:00:00pages
3719-40issue
7issn
1999-4915pii
v7072787journal_volume
7pub_type
杂志文章,评审相关文献
Viruses-Basel文献大全abstract::Virus infections of insects can easily stay undetected, neither showing typical signs of a disease, nor being lethal. Such a stable and most of the time covert infection with Phthorimaea operculella granulovirus (PhopGV) was detected in a Phthorimaea operculella laboratory colony, which originated from Italy (Phop-IT)...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11040337
更新日期:2019-04-09 00:00:00
abstract::Monkeypox is a smallpox-like illness that can be accompanied by a range of significant medical complications. To date there are no standard or optimized guidelines for the clinical management of monkeypox (MPX) patients, particularly in low-resource settings. Consequently, patients can experience protracted illness an...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9120380
更新日期:2017-12-12 00:00:00
abstract::Hepatitis C Virus (HCV) remains an important public health threat with approximately 170 million carriers worldwide who are at risk of developing hepatitis C-associated end-stage liver diseases. Despite improvement of HCV treatment using the novel direct-acting antivirals (DAAs) targeting viral replication, there is a...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10120669
更新日期:2018-11-27 00:00:00
abstract::Retroviruses are well known pathogens of mammals, birds and fish. Their potential to induce cancer in chickens was already described almost 100 years ago and murine retroviruses have been a subject of study for 50 years. The first human retroviruses, HTLV and HIV, were discovered more than 30 years ago, surprising res...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v3081312
更新日期:2011-08-01 00:00:00
abstract::Human respiratory syncytial virus (HRSV) is a major cause of pediatric infection and also causes disease in the elderly and those with underlying respiratory problems. There is no vaccine for HRSV and anti-viral therapeutics are not broadly applicable. To investigate the effect of HRSV biology in children, nasopharyng...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11100926
更新日期:2019-10-10 00:00:00
abstract::Environmental genomics can describe all forms of organisms--cellular and viral--present in a community. The analysis of such eco-systems biology data relies heavily on reference databases, e.g., taxonomy or gene function databases. Reference databases of symbiosis sensu lato, although essential for the analysis of org...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8030066
更新日期:2016-03-01 00:00:00
abstract::Porcine circovirus 3 (PCV3) has been identified as a putative swine pathogen with a subset of infections resulting in stillborn and mummified fetuses, encephalitis and myocarditis in perinatal, and periarteritis in growing pigs. Three PCV3 isolates were isolated from weak-born piglets or elevated stillborn and mummifi...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12020219
更新日期:2020-02-16 00:00:00
abstract::Endemic to West Africa and South America, mammalian arenaviruses can cross the species barrier from their natural rodent hosts to humans, resulting in illnesses ranging from mild flu-like syndromes to severe and fatal haemorrhagic zoonoses. The increased frequency of outbreaks and associated high fatality rates of the...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12070784
更新日期:2020-07-21 00:00:00
abstract::Foot-and-mouth disease virus (FMDV) causes a highly contagious disease with catastrophic economic impact for affected countries. BHK21 suspension cells are preferred for the industrial production of FMDV vaccine antigen, but not all virus strains can be successfully propagated in these cells. Serotype Asia-1 is often ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v9080231
更新日期:2017-08-18 00:00:00
abstract::Porcine reproductive and respiratory syndrome virus (PRRSV) infection strongly modulates the host's immune response. The RNA silencing pathway is an intracellular innate response to viral infections. However, it is unknown whether PRRSV interacts with cellular RNA silencing to facilitate the viral infection. Here, we ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7102893
更新日期:2015-10-23 00:00:00
abstract::Crimean-Congo hemorrhagic fever virus is one the most important and wide spread tick-borne viruses. Very little is known about the transmission from the tick and the early aspects of pathogenesis. Here, we generate human cutaneous antigen presenting cells-dermal dendritic cells and Langerhans cells-from umbilical cord...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10070381
更新日期:2018-07-20 00:00:00
abstract::Bovine viral diarrhea virus (BVDV) is an important pathogen belonging to the Pestivirus genus, Flaviviridae family, which comprises viral species that causes an economic impact in animal production. Cattle are the natural host of BVDV and the main source of infection for pigs and other animal species. Due to its antig...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12060600
更新日期:2020-05-31 00:00:00
abstract::In Europe, cowpox virus (CPXV) infection in South American camelids occurs as a so-called spill-over infection. Although infected animals generally have a mild form of the disease and survive, cases of fatal generalised CPXV infection have also been described. Prevention by prophylactic vaccination is the only way to ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12020234
更新日期:2020-02-20 00:00:00
abstract::During flavivirus infection, some viral proteins move to the nucleus and cellular components are relocated from the nucleus to the cytoplasm. Thus, the integrity of the main regulator of the nuclear-cytoplasmic transport, the nuclear pore complex (NPC), was evaluated during infection with dengue virus (DENV) and Zika ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12060583
更新日期:2020-05-26 00:00:00
abstract::Type-I interferons (IFN-I) play an important role in the innate immune response to several retroviruses. They seem to be effective in controlling the in vivo infection, though many of the clinical signs of retroviral infection may be due to their continual presence which over-stimulates the immune system and activates...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v1030545
更新日期:2009-12-01 00:00:00
abstract::Timely implementation of antiviral treatment and other public health based responses are dependent on accurate and rapid diagnosis of the novel pandemic influenza A(H1N1) strain. In this study we developed a duplex real-time PCR (RT-PCR) (dFLU-TM) assay for the simultaneous detection of a broad range of influenza A su...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v1031204
更新日期:2009-12-01 00:00:00
abstract::As more cases of COVID-19 are studied and treated worldwide, it had become apparent that the lethal and most severe cases of pneumonia are due to an out-of-control inflammatory response to the SARS-CoV-2 virus. I explored the putative causes of this specific feature through a detailed genomic comparison with the close...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12060646
更新日期:2020-06-15 00:00:00
abstract::Heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar) was first diagnosed in Norway in 1999. The disease is caused by Piscine orthoreovirus-1 (PRV-1). The virus is prevalent in farmed Atlantic salmon, but not always associated with disease. Phylogeny and sequence analyses of 31 PRV-1 ge...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11050465
更新日期:2019-05-22 00:00:00
abstract::An outbreak of winter dysentery, complicated by severe respiratory syndrome, occurred in January 2020 in a high production dairy cow herd located in a hilly area of the Calabria region. Of the 52 animals belonging to the farm, 5 (9.6%) died with severe respiratory distress, death occurring 3-4 days after the appearanc...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111331
更新日期:2020-11-19 00:00:00
abstract::H1N1 swine influenza viruses (SIV) are prevalent in pigs globally, and occasionally emerge in humans, which raises concern about their pandemic threats. To stimulate hemagglutination (HA) of A/Swine/Guangdong/LM/2004 (H1N1) (SW/GD/04) antibody response, eukaryotic expression plasmid pCI-neo-HA was constructed and used...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v9080209
更新日期:2017-08-08 00:00:00
abstract::Influenza A virus is a successful parasite and requires host factors to complete its life cycle. Prop5 is an antisense oligonucleotide, targeting programmed cell death protein 5 (PDCD5). In this study, we tested the antiviral activity of prop5 against mouse-adapted A/FM/1/47 strain of influenza A virus in a mouse mode...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v6020573
更新日期:2014-02-06 00:00:00
abstract::Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades. Dengue is caused by genetically distinct serotypes, DENV-1-4. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and M...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010057
更新日期:2021-01-04 00:00:00
abstract::Arboviruses continue to be a significant global health concern. The unbiased metagenomic analyses of mosquito-borne and mosquito-specific viruses are useful to understand viral diversity and for the surveillance of pathogens of medical and veterinary importance. Metagenomic analysis was conducted on 6368 mosquitoes (7...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11030222
更新日期:2019-03-05 00:00:00
abstract::Influenza D virus is a novel influenza virus, which was first isolated from an ailing swine in 2011 and later detected in cattle, suggesting that these animals may be a primary natural reservoir. To date, few studies have been performed on human samples and there is no conclusive evidence on the ability of the virus t...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12010030
更新日期:2019-12-27 00:00:00
abstract::A wide gap exists between the rapid acceptance of genetically modified (GM) crops for cultivation by farmers in many countries and in the global markets for food and feed, and the often-limited acceptance by consumers. This review contrasts the advances of practical applications of agricultural biotechnology with the ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v7082819
更新日期:2015-07-30 00:00:00
abstract::The DNA damage response (DDR) is a complex signalling network activated when DNA is altered by intrinsic or extrinsic agents. DDR plays important roles in genome stability and cell cycle regulation, as well as in tumour transformation. Viruses have evolved successful life cycle strategies in order to ensure a chronic ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9120390
更新日期:2017-12-19 00:00:00
abstract::During the past ten years, several new hepatitis E viruses (HEVs) have been identified in various animal species. In parallel, the number of reports of autochthonous hepatitis E in Western countries has increased as well, raising the question of what role these possible animal reservoirs play in human infections. The a...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v8100270
更新日期:2016-10-03 00:00:00
abstract::Pestiviruses, which include economically important animal pathogens such as bovine viral diarrhea virus and classical swine fever virus, possess three envelope glycoproteins, namely Erns, E1, and E2. This article discusses the structures and functions of these glycoproteins and their effects on viral pathogenicity in ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v7072783
更新日期:2015-06-29 00:00:00
abstract::Peptides derived from the C-terminal heptad repeat (CHR) region of HIV-1 gp41 is potent viral membrane fusion inhibitors, such as the first clinically approved peptide drug T20 and a group of newly-designed peptides. The resistance profiles of various HIV-1 fusion inhibitors were previously characterized, and the seco...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12030326
更新日期:2020-03-18 00:00:00
abstract::The Human immunodeficiency virus-1 (HIV-1) accessory protein Vpu modulates numerous proteins, including the host proteins CD4 and BST-2/tetherin. Vpu interacts with the Skp, Cullin, F-Box (SCF) ubiquitin ligase through interactions with the F-Box protein βTrCP (1 and/or 2). This interaction is dependent on phosphoryla...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10100573
更新日期:2018-10-19 00:00:00