Abstract:
:Heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar) was first diagnosed in Norway in 1999. The disease is caused by Piscine orthoreovirus-1 (PRV-1). The virus is prevalent in farmed Atlantic salmon, but not always associated with disease. Phylogeny and sequence analyses of 31 PRV-1 genomes collected over a 30-year period from fish with or without HSMI, grouped the viral sequences into two main monophylogenetic clusters, one associated with HSMI and the other with low virulent PRV-1 isolates. A PRV-1 strain from Norway sampled in 1988, a decade before the emergence of HSMI, grouped with the low virulent HSMI cluster. The two distinct monophylogenetic clusters were particularly evident for segments S1 and M2. Only a limited number of amino acids were unique to the association with HSMI, and they all located to S1 and M2 encoded proteins. The observed co-evolution of the S1-M2 pair coincided in time with the emergence of HSMI in Norway, and may have evolved through accumulation of mutations and/or segment reassortment. Sequences of S1-M2 suggest selection of the HSMI associated pair, and that this segment pair has remained almost unchanged in Norwegian salmon aquaculture since 1997. PRV-1 strains from the North American Pacific Coast and Faroe Islands have not undergone this evolution, and are more closely related to the PRV-1 precursor strains not associated with clinical HSMI.
journal_name
Virusesjournal_title
Virusesauthors
Dhamotharan K,Tengs T,Wessel Ø,Braaen S,Nyman IB,Hansen EF,Christiansen DH,Dahle MK,Rimstad E,Markussen Tdoi
10.3390/v11050465subject
Has Abstractpub_date
2019-05-22 00:00:00issue
5issn
1999-4915pii
v11050465journal_volume
11pub_type
杂志文章相关文献
Viruses-Basel文献大全abstract::The virion proteins of Kaposi sarcoma-associated herpesvirus (KSHV) were initially characterized in 2005 in two separate studies that combined the detection of 24 viral proteins and a few cellular components via LC-MS/MS or MALDI-TOF. Despite considerable advances in the sensitivity and specificity of mass spectrometr...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121382
更新日期:2020-12-02 00:00:00
abstract::The non-structural protein NSs of the Phenuiviridae family members appears to have a role in the host immunity escape. The stability of Toscana virus (TOSV) NSs protein was tested by a cycloheximide (CHX) chase approach on cells transfected with NSs deleted versions fused to a reporter gene. The presence of intrinsica...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12101153
更新日期:2020-10-12 00:00:00
abstract::Glycoprotein B (gB) plays an important role in alphaherpesvirus cellular entry and acts in concert with gD and the gH/gL complex. To evaluate whether functional differences exist between gB1 and gB4, the corresponding genes were exchanged between the two viruses. The gB4-containing-EHV-1 (EHV-1_gB4) recombinant virus ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7020522
更新日期:2015-02-03 00:00:00
abstract::The world's first natural avian-origin H6N1 influenza A virus infection case in dogs was confirmed in Taiwan in 2014. The H6N1 virus in chickens has been endemic in Taiwan since 1972. Whether the dog H6N1 virus has interspecies transmission potential is the key issue we aim to understand. Following one virus passage i...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12070704
更新日期:2020-06-30 00:00:00
abstract::The capsid domain (CA) of the lentiviral Gag polyproteins has two distinct roles during virion morphogenesis. As a domain of Gag, it mediates the Gag-Gag interactions that drive immature particle assembly, whereas as a mature protein, it self-assembles into the conical core of the mature virion. Lentiviral CA proteins...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11090816
更新日期:2019-09-04 00:00:00
abstract::Sea star wasting disease (SSWD) is a condition that has affected asteroids for over 120 years, yet mechanistic understanding of this wasting etiology remains elusive. We investigated temporal virome variation in two Pisaster ochraceus specimens that wasted in the absence of external stimuli and two specimens that did ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111332
更新日期:2020-11-20 00:00:00
abstract::The Protoparvovirus (PtPV) genus of the Parvoviridae family of viruses includes important animal pathogens and reference molecular models for the entire family. Some virus members of the PtPV genus have arisen as promising tools to treat tumoral processes, as they exhibit marked oncotropism and oncolytic activities wh...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9110313
更新日期:2017-10-26 00:00:00
abstract::Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research l...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4123754
更新日期:2012-12-14 00:00:00
abstract::Evidence that Hepatitis D virus (HDV) genotype is involved in HDV infection pathogenesis is increasing. Indeed, HDV genotypes have been shown to be linked to different outcomes in terms of liver fibrosis and treatment response. Herein, we show that the promising HDVdb genotyping tool available online can lead to wrong...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12101066
更新日期:2020-09-23 00:00:00
abstract::Andes orthohantavirus (ANDV) is an important human pathogen causing hantavirus cardiopulmonary syndrome (HCPS) with a fatality rate of 30% in Chile. Around 60% of all cases have a severe clinical course, while the others have a mild clinical course. The main goal of this study was to understand if the genetic variatio...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11080680
更新日期:2019-07-25 00:00:00
abstract::Because of its ecological characteristics, the Caxiuanã National Forest (FLONA) is a potential area of arbovirus circulation. The present study aimed to investigate the occurrence of arbovirus transmission cycles at FLONA de Caxiuanã. Five field trips were performed to capture mosquitoes and sylvatic vertebrates. For ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11090774
更新日期:2019-08-22 00:00:00
abstract::Environmental and agricultural pollination services by honey bees, Apis mellifera, and honey production are compromised by high levels of annual colony losses globally. The majority are associated with disease caused by deformed wing virus (DWV), a positive-strand RNA virus, exacerbated by the ectoparasitic mite Varro...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12050532
更新日期:2020-05-12 00:00:00
abstract::The neutrophil extracellular trap (ET) is a eukaryotic host defense machinery that operates by capturing and concentrating pathogens in a filamentous network manufactured by neutrophils and made of DNA, histones, and many other components. Respiratory virus-induced ETs are involved in tissue damage and impairment of t...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12070723
更新日期:2020-07-04 00:00:00
abstract::Potato virus Y (PVY) is the most economically important virus infecting cultivated potato (Solanum tuberosum L.). Accurate diagnosis is crucial to regulate the trade of tubers and for the sanitary selection of plant material for propagation. However, high genetic diversity of PVY represents a challenge for the detecti...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040478
更新日期:2020-04-23 00:00:00
abstract::Type-I interferons (IFN-I) play an important role in the innate immune response to several retroviruses. They seem to be effective in controlling the in vivo infection, though many of the clinical signs of retroviral infection may be due to their continual presence which over-stimulates the immune system and activates...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v1030545
更新日期:2009-12-01 00:00:00
abstract::Streptococcus thermophilus is considered one of the most important species for the dairy industry. Due to their diffusion in dairy environments, bacteriophages can represent a threat to this widely used bacterial species. Despite the presence of a CRISPR-Cas system in the S. thermophilus genome, some lysogenic strains...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010007
更新日期:2018-12-22 00:00:00
abstract::Fruit trees, such as apricot trees, are constantly exposed to the attack of viruses. As they are propagated in a vegetative way, this risk is present not only in the field, where they remain for decades, but also during their propagation. Metagenomic diagnostic methods, based on next generation sequencing (NGS), offer...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10060318
更新日期:2018-06-11 00:00:00
abstract::Arboviruses continue to be a significant global health concern. The unbiased metagenomic analyses of mosquito-borne and mosquito-specific viruses are useful to understand viral diversity and for the surveillance of pathogens of medical and veterinary importance. Metagenomic analysis was conducted on 6368 mosquitoes (7...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11030222
更新日期:2019-03-05 00:00:00
abstract::The cell response to virus infection and virus perturbation of that response is dynamic and is reflected by changes in cell susceptibility to infection. In this study, we evaluated the response of human epithelial cells to sequential infections with human respiratory syncytial virus strains A2 and B to determine if a ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v2122782
更新日期:2010-12-01 00:00:00
abstract::Despite worldwide efforts to understand the transmission dynamics of Zika virus (ZIKV), scanty evaluation has been made on the vector competence of Aedes aegypti fed directly on viremic human and non-human primates (NHPs). We blood-fed Ae. aegypti from two districts in Rio de Janeiro on six ZIKV infected pregnant rhes...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121345
更新日期:2020-11-24 00:00:00
abstract::BST-2 or tetherin is a host cell restriction factor that prevents the budding of enveloped viruses at the cell surface, thus impairing the viral spread. Several countermeasures to evade this antiviral factor have been positively selected in retroviruses: the human immunodeficiency virus type 2 (HIV-2) relies on the en...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8100285
更新日期:2016-10-14 00:00:00
abstract::Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness. The 60-year-old man died as a result of renal and respiratory failure after admission to a hospital in Jeddah, Saudi A...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10020093
更新日期:2018-02-24 00:00:00
abstract::Behçet's disease (BD) affects multiple organs. It is mainly characterized by recurrent oral, skin, and genital aphthous ulcers, and eye involvement. Successful management of BD is increasing, although its etiology remains unclear. A number of etiologies have been proposed, including environmental, genetic, viral, and ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10090511
更新日期:2018-09-19 00:00:00
abstract::Bovine rotavirus A (RVA), a major causative pathogen of diarrhea in dairy and Japanese beef calves, has led to severe economic losses in numerous countries. A dual genotyping system based on genomic segments encoding VP7 (G genotype) and VP4 (P genotype), comprising the outer layer of the virion, has been used to unde...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121386
更新日期:2020-12-03 00:00:00
abstract::The progressive loss of immunological memory during aging correlates with a reduced proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that this phenotype is recapitulated during chronic viral infection. The antigenic volume imposed by persistent and latent viruses exposes the immune ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9100289
更新日期:2017-10-05 00:00:00
abstract::The Megalocytivirus genus includes three genotypes, red sea bream iridovirus (RSIV), infectious spleen and kidney necrosis virus (ISKNV), and turbot reddish body iridovirus (TRBIV), and has caused mass mortalities in various marine and freshwater fish species in East and Southeast Asia. Of the three genotypes, TRBIV-l...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12060681
更新日期:2020-06-24 00:00:00
abstract:BACKGROUND:Duck plague virus (DPV) can induce apoptosis in duck embryo fibroblasts (DEFs) and in infected ducks, but the molecular mechanism of DPV-induced apoptosis remains unknown. METHODS:We first used qRT-PCR and a Caspase-Glo assay to determine whether the caspase protein family plays an important role in DPV-ind...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020196
更新日期:2019-02-24 00:00:00
abstract::The recent emergence and rapid geographic expansion of Zika virus (ZIKV) poses a significant challenge for public health. Although historically causing only mild febrile illness, recent ZIKV outbreaks have been associated with more severe neurological complications, such as Guillain-Barré syndrome and fetal microcepha...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10120728
更新日期:2018-12-19 00:00:00
abstract::Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and activated to restrict v...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12040376
更新日期:2020-03-29 00:00:00
abstract::Our loyal friend and colleague, Jan van der Noordaa, passed away unexpectedly at the age of 80 on the evening of 17 June 2015. [...]. ...
journal_title:Viruses
pub_type: 传,历史文章,杂志文章
doi:10.3390/v7092859
更新日期:2015-09-15 00:00:00